LOCUS       NM_017346               3393 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            beta 1 (Cacnb1), mRNA.
ACCESSION   NM_017346
VERSION     NM_017346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3393)
  AUTHORS   Beguin,P., Nagashima,K., Mahalakshmi,R.N., Vigot,R., Matsunaga,A.,
            Miki,T., Ng,M.Y., Ng,Y.J., Lim,C.H., Tay,H.S., Hwang,L.A.,
            Firsov,D., Tang,B.L., Inagaki,N., Mori,Y., Seino,S., Launey,T. and
            Hunziker,W.
  TITLE     BARP suppresses voltage-gated calcium channel activity and
            Ca2+-evoked exocytosis
  JOURNAL   J Cell Biol 205 (2), 233-249 (2014)
   PUBMED   24751537
REFERENCE   2  (bases 1 to 3393)
  AUTHORS   Mezler,M., Barghorn,S., Schoemaker,H., Gross,G. and Nimmrich,V.
  TITLE     A beta-amyloid oligomer directly modulates P/Q-type calcium
            currents in Xenopus oocytes
  JOURNAL   Br J Pharmacol 165 (5), 1572-1583 (2012)
   PUBMED   21883149
REFERENCE   3  (bases 1 to 3393)
  AUTHORS   Catterall,W.A.
  TITLE     Voltage-gated calcium channels
  JOURNAL   Cold Spring Harb Perspect Biol 3 (8), a003947 (2011)
   PUBMED   21746798
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3393)
  AUTHORS   Obermair,G.J., Schlick,B., Di Biase,V., Subramanyam,P., Gebhart,M.,
            Baumgartner,S. and Flucher,B.E.
  TITLE     Reciprocal interactions regulate targeting of calcium channel beta
            subunits and membrane expression of alpha1 subunits in cultured
            hippocampal neurons
  JOURNAL   J Biol Chem 285 (8), 5776-5791 (2010)
   PUBMED   19996312
REFERENCE   5  (bases 1 to 3393)
  AUTHORS   Abiria,S.A. and Colbran,R.J.
  TITLE     CaMKII associates with CaV1.2 L-type calcium channels via selected
            beta subunits to enhance regulatory phosphorylation
  JOURNAL   J Neurochem 112 (1), 150-161 (2010)
   PUBMED   19840220
REFERENCE   6  (bases 1 to 3393)
  AUTHORS   Burgess,D.L., Biddlecome,G.H., McDonough,S.I., Diaz,M.E.,
            Zilinski,C.A., Bean,B.P., Campbell,K.P. and Noebels,J.L.
  TITLE     beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel
            subunit compositions in lethargic mouse brain
  JOURNAL   Mol Cell Neurosci 13 (4), 293-311 (1999)
   PUBMED   10328888
REFERENCE   7  (bases 1 to 3393)
  AUTHORS   Conklin,M.W., Powers,P., Gregg,R.G. and Coronado,R.
  TITLE     Ca2+ sparks in embryonic mouse skeletal muscle selectively
            deficient in dihydropyridine receptor alpha1S or beta1a subunits
  JOURNAL   Biophys J 76 (2), 657-669 (1999)
   PUBMED   9929471
REFERENCE   8  (bases 1 to 3393)
  AUTHORS   Gregg,R.G., Messing,A., Strube,C., Beurg,M., Moss,R., Behan,M.,
            Sukhareva,M., Haynes,S., Powell,J.A., Coronado,R. and Powers,P.A.
  TITLE     Absence of the beta subunit (cchb1) of the skeletal muscle
            dihydropyridine receptor alters expression of the alpha 1 subunit
            and eliminates excitation-contraction coupling
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13961-13966 (1996)
   PUBMED   8943043
REFERENCE   9  (bases 1 to 3393)
  AUTHORS   Perez-Reyes,E., Castellano,A., Kim,H.S., Bertrand,P., Baggstrom,E.,
            Lacerda,A.E., Wei,X.Y. and Birnbaumer,L.
  TITLE     Cloning and expression of a cardiac/brain beta subunit of the
            L-type calcium channel
  JOURNAL   J Biol Chem 267 (3), 1792-1797 (1992)
   PUBMED   1370480
REFERENCE   10 (bases 1 to 3393)
  AUTHORS   Pragnell,M., Sakamoto,J., Jay,S.D. and Campbell,K.P.
  TITLE     Cloning and tissue-specific expression of the brain calcium channel
            beta-subunit
  JOURNAL   FEBS Lett 291 (2), 253-258 (1991)
   PUBMED   1657644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 19, 2021 this sequence version replaced NM_017346.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61394.1, SRR26643288.43044.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               JAXUCZ010000010.1  83514871-83515146   c
            277-363             JAXUCZ010000010.1  83512241-83512327   c
            364-483             JAXUCZ010000010.1  83509211-83509330   c
            484-606             JAXUCZ010000010.1  83506073-83506195   c
            607-743             JAXUCZ010000010.1  83505401-83505537   c
            744-820             JAXUCZ010000010.1  83505097-83505173   c
            821-840             JAXUCZ010000010.1  83503842-83503861   c
            841-921             JAXUCZ010000010.1  83503506-83503586   c
            922-980             JAXUCZ010000010.1  83503073-83503131   c
            981-1090            JAXUCZ010000010.1  83502774-83502883   c
            1091-1242           JAXUCZ010000010.1  83502482-83502633   c
            1243-1338           JAXUCZ010000010.1  83498712-83498807   c
            1339-1524           JAXUCZ010000010.1  83498122-83498307   c
            1525-3393           JAXUCZ010000010.1  83494509-83496377   c
FEATURES             Location/Qualifiers
     source          1..3393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..3393
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /note="calcium voltage-gated channel auxiliary subunit
                     beta 1"
                     /db_xref="GeneID:50688"
                     /db_xref="RGD:68382"
     exon            1..276
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1986
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /note="calcium channel voltage-dependent subunit beta 1;
                     brain calcium channel beta 1 subunit; calcium channel,
                     voltage-dependent, beta 1 subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-1"
                     /protein_id="NP_059042.2"
                     /db_xref="GeneID:50688"
                     /db_xref="RGD:68382"
                     /translation="MVQKSGMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGS
                     TSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVA
                     FAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIP
                     SPVKLDSLRLLQEQTLRQNRLSSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTE
                     HVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLA
                     KRSVLNNPSKHIIIERSNTRSSLAEVQSEIERIFELARTLQLVALDADTINHPAQLSK
                     TSLAPIIVYIKITSPKVLQRLIKSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDEN
                     QLEDACEHLAEYLEAYWKATHPPSSTPPNPLLNRTMATAALAASPAPVSNLQGPYLAS
                     GDQPLDRATGEHASVHEYPGELGQPPGLYPSNHPPGRAGTLRALSRQDTFDADTPGSR
                     NSAYTEPGDSCVDMETDPSEGPGPGDPAGGGTPPARQGSWEEEEDYEEEMTDNRNRGR
                     NKARYCAEGGGPVLGRNKNELEGWGQGVYIR"
     exon            277..363
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..483
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..606
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..743
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..820
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..840
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..921
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..980
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1090
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1242
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1338
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1524
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..3393
                     /gene="Cacnb1"
                     /gene_synonym="CAB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg gcggcggccg cagagagcag agcgcgagcc gggagggcag caaggcggcg
       61 agcgtgcagc tgggcgactg cacccggtgc tggctgcgcg acgccgcgct gctctcggct
      121 cggacggcct ctcccatgcg ctgagggccc ccggctgtgc cgggagggcg gccggaccgg
      181 aggatcctct ccatggtcca gaagagcggc atgtcccggg gcccttaccc accttcccaa
      241 gagatcccta tggaggtctt cgaccccagc ccacagggca aatacagcaa gaggaaaggg
      301 cggttcaaaa ggtcagatgg gagcacctcc tcagatacca catccaacag ctttgtccgt
      361 cagggctcag cagagtccta cacgagccgg ccgtcagact ccgacgtgtc cctggaggag
      421 gaccgggaag ccttaaggaa ggaggcagag cgccaggcct tagcccagct cgagaaagcc
      481 aagaccaaac cagtggcctt tgctgttcgg acaaatgttg gctacaatcc gtctccagga
      541 gatgaggtgc cagtgcaggg agtggccatc acctttgagc ccaaggactt cctgcacatc
      601 aaggagaaat acaataatga ctggtggatc gggaggctgg tgaaggaagg ctgtgaggtt
      661 ggtttcatcc ccagccctgt caaactggac agccttcgcc tgctgcagga acagacgctg
      721 cgccaaaacc gcctcagctc cagcaagtca ggtgacaact ccagttccag tctgggagat
      781 gtggtgactg gcacccgccg ccccacaccc cccgccagtg ccaaacagaa gcagaagtcg
      841 acagagcacg tgccccccta tgacgtggtg ccttccatga ggcccatcat cctggtggga
      901 ccatcgctca agggctatga ggtaactgac atgatgcaga aggcgttgtt tgacttcttg
      961 aagcatcggt ttgatggcag gatttccatc acccgggtaa cggctgacat ttccctggcc
     1021 aagcgctcgg tcctcaacaa ccccagcaaa cacattatca tcgagcgctc caacactcgc
     1081 tccagcctgg ctgaggtaca gagtgaaatc gagcggatct tcgagctggc ccggaccttg
     1141 cagctggttg ccctggacgc cgacaccatc aaccacccag cccagctctc taaaacctcg
     1201 ctggccccca tcattgttta catcaagatc acatccccca aggtactgca gaggctcatc
     1261 aaatcccgag ggaagtctca atccaaacac ctcaatgtcc aaatagcagc ctcggagaag
     1321 ctggcacagt gtccccccga aatgtttgac ataatcctgg acgagaacca attggaagat
     1381 gcctgcgagc acctggcgga gtacttggaa gcctactgga aggccacaca cccgcctagc
     1441 agcacgccac ccaatccgct gctgaaccgc accatggcta ccgccgctct ggctgccagc
     1501 cctgcccccg tctccaacct ccagggaccc taccttgctt ccggggacca gccgctggac
     1561 cgggccactg gggagcatgc cagtgtgcac gagtaccccg gggagctggg ccagccccca
     1621 ggcctttacc ccagcaacca cccacctggc cgggcaggca ccctgcgggc gctatcccgc
     1681 caagacacct ttgatgctga cacccccggc agccgaaact ctgcctacac ggagccagga
     1741 gactcgtgtg tggacatgga gacagacccc tcagagggcc cagggcctgg agaccctgca
     1801 gggggaggta caccaccagc tcggcagggc tcctgggaag aggaggaaga ttatgaggag
     1861 gagatgaccg acaacaggaa ccggggccgg aataaggccc gctactgtgc ggagggtggt
     1921 gggccggttc tggggcgcaa taagaatgag ctggagggct ggggacaagg cgtctacatc
     1981 cgctgagagg caggggcagt tctgggagag aagaggctct gaactcgggg aggggagggc
     2041 agaggggcgc accacccaag atgtgtcttg cctccagggg gcgctttgtc cctcattttc
     2101 agatgccttt gctcaaagct tggggtttct ttggtggtta tcattcccaa ctcctgggag
     2161 gtccttaatc cccagctgta ggtttttccc taaactgctg tgggtggatg ggggaatacc
     2221 tactttctga agtgccccct ttccccatct ttggggcttt ctccctccca gagaaaaggt
     2281 gcacttcctt aactttttac tcggggctgt aagcggaggt cctaattggg gtggggtgga
     2341 ggggtttctt ctaccaacgc aggggtactt gggaaaggtt gggtgctttt cctgaagaga
     2401 acccgctgaa tcttccacaa accccagacc cgggatcccc caccatatcc attccataac
     2461 ctagtttcct agcagcattc tctggtgggt gaaagccaca gcttggaaac ccatgaagag
     2521 cttgctttgg ggagcagagc tgggtgcaaa ctgacgggca tcagtgtgtg ctctctgccc
     2581 tccatggtca tggcaagaaa gcagggccta gaaacttgag gagtgagcaa ctcaagatgc
     2641 tgccccccgc aaccccttcc agcccttgtc tccccccggg aatgagcttt gtctacagca
     2701 taccctgcct gctgccatca gaagagaggg gccctctgca tctgagcccc acatctccgt
     2761 gccgcctggg tgtggagacc atgagaccat gaatacgttg ggtccacctc attctaaacc
     2821 aaaaaacctg ctctttcacc ttcaccccga ggccccaggg aacaggctct atgtgttggt
     2881 gcccatgagg tgaccgccat tcaggggctt cctgaggacc ttgggtctcc cctaggggtc
     2941 ttggttgctg ctgcttctct gtatttgcct cttgtgatcc tgtcctttcc cgtgtccact
     3001 ttccccaaga gaggcctcgg tagcccctca cccctggggt tcccttagcc tcggcatccc
     3061 tgtagtccag cagccctgcc cctccccagc atcacagctg gtccagagag agccgattgt
     3121 gccaacgagg actgggccct gcccagctgc ccacctcagg gatgggcacc tcatgcctgt
     3181 ctcgccacct cctgtgccaa tgttgcccca ccccttccgg gggtggggca cagcttccac
     3241 taacaggtta gaagatagca ctgcccaacc tttcgctccc cgtccccatc tactgtctcg
     3301 tgcccatctg tctgtctgtc tgtctgtact cctctaggag agatattttg ccacatataa
     3361 aaccgcagtt ctgtcctttg cggccacctc ctg
//
