LOCUS       NM_001191751            4741 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            alpha2delta 4 (Cacna2d4), mRNA.
ACCESSION   NM_001191751 XM_039107650 XM_232320
VERSION     NM_001191751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Wycisk,K.A., Zeitz,C., Feil,S., Wittmer,M., Forster,U.,
            Neidhardt,J., Wissinger,B., Zrenner,E., Wilke,R., Kohl,S. and
            Berger,W.
  TITLE     Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes
            autosomal recessive cone dystrophy
  JOURNAL   Am J Hum Genet 79 (5), 973-977 (2006)
   PUBMED   17033974
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Qin,N., Yagel,S., Momplaisir,M.L., Codd,E.E. and D'Andrea,M.R.
  TITLE     Molecular cloning and characterization of the human voltage-gated
            calcium channel alpha(2)delta-4 subunit
  JOURNAL   Mol Pharmacol 62 (3), 485-496 (2002)
   PUBMED   12181424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Jul 26, 2021 this sequence version replaced
            XM_039107650.1, NM_001191751.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               JAXUCZ010000004.1  154080877-154081220
            345-426             JAXUCZ010000004.1  154083098-154083179
            427-543             JAXUCZ010000004.1  154084872-154084988
            544-603             JAXUCZ010000004.1  154085360-154085419
            604-766             JAXUCZ010000004.1  154086789-154086951
            767-898             JAXUCZ010000004.1  154088010-154088141
            899-959             JAXUCZ010000004.1  154111007-154111067
            960-1110            JAXUCZ010000004.1  154111511-154111661
            1111-1185           JAXUCZ010000004.1  154113185-154113259
            1186-1275           JAXUCZ010000004.1  154113624-154113713
            1276-1389           JAXUCZ010000004.1  154113814-154113927
            1390-1468           JAXUCZ010000004.1  154114347-154114425
            1469-1602           JAXUCZ010000004.1  154116386-154116519
            1603-1680           JAXUCZ010000004.1  154119066-154119143
            1681-1761           JAXUCZ010000004.1  154119798-154119878
            1762-1836           JAXUCZ010000004.1  154120160-154120234
            1837-1923           JAXUCZ010000004.1  154123550-154123636
            1924-1995           JAXUCZ010000004.1  154124103-154124174
            1996-2057           JAXUCZ010000004.1  154141650-154141711
            2058-2125           JAXUCZ010000004.1  154142615-154142682
            2126-2171           JAXUCZ010000004.1  154144259-154144304
            2172-2269           JAXUCZ010000004.1  154144375-154144472
            2270-2363           JAXUCZ010000004.1  154145996-154146089
            2364-2459           JAXUCZ010000004.1  154150437-154150532
            2460-2587           JAXUCZ010000004.1  154151860-154151987
            2588-2668           JAXUCZ010000004.1  154155557-154155637
            2669-2730           JAXUCZ010000004.1  154178850-154178911
            2731-2775           JAXUCZ010000004.1  154180276-154180320
            2776-2838           JAXUCZ010000004.1  154180509-154180571
            2839-2909           JAXUCZ010000004.1  154186465-154186535
            2910-2985           JAXUCZ010000004.1  154186803-154186878
            2986-3038           JAXUCZ010000004.1  154187363-154187415
            3039-3091           JAXUCZ010000004.1  154187870-154187922
            3092-3112           JAXUCZ010000004.1  154188195-154188215
            3113-3230           JAXUCZ010000004.1  154189855-154189972
            3231-3343           JAXUCZ010000004.1  154191370-154191482
            3344-3426           JAXUCZ010000004.1  154191701-154191783
            3427-4741           JAXUCZ010000004.1  154192464-154193778
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4741
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /note="calcium voltage-gated channel auxiliary subunit
                     alpha2delta 4"
                     /db_xref="GeneID:312668"
                     /db_xref="RGD:1562038"
     exon            1..344
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3531
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /note="calcium channel, voltage-dependent, alpha 2/delta
                     subunit 4"
                     /codon_start=1
                     /product="voltage-dependent calcium channel subunit
                     alpha-2/delta-4"
                     /protein_id="NP_001178680.2"
                     /db_xref="GeneID:312668"
                     /db_xref="RGD:1562038"
                     /translation="MPRDLGGSKFVHSRSTVLLPCPSPSGNTMARSPTLSSSHSWGHR
                     GQQTAAWTFLRKMPIVLWLLLLDTSLPTARSQATIPLETVKLWAETFGRDLYSTVTRY
                     SGSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRRKVEAVESLVEAAEEADL
                     NHEFNASLVFNYYNSVLINEKDDKGNYVELGAEFLLESDAHFNNLRVNVSMSSVQLPT
                     NVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYPGIKWTPDEN
                     GVIAFDCRNRGWYIQAATSPKDIVILVDMSGSMKGLRMAIAKHTVTTILDTLGENDFV
                     NIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGIVSQALIEAFQILK
                     QFQESRQGSLCNQAIMLVTDGAVEDYEPVFETYNWPDRKVRVFTYLIGREVTFADRMK
                     WIACNNKGYYTQISTLADAQENVMEYLHVLSRPMVINHDHDIIWTEAYMDSRLLTSEA
                     QSLMLLTTVAMPVFSKKNETRSHGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNT
                     NNGYILSHPDLRPLYREGKKLKPKPNYNSVDLSEVEWEDQAEILRTAMINGETGSHSM
                     DVKVPLDKGKRVLFLTNDYFFTDISDTPFSLGVVLTRGHGEYILLGNTSVEEGLHDLL
                     HPDLTLASDWIYCITDIDPDHRKLSQLEAVVRFLTGVDPDLECDEELVREVLFDAVVT
                     APMEAYWTALALNISEESEPGVEVAFLGTRAGLLRRSLFVGSEKVSDRKFLTPEDEAS
                     IFTMDHFPLWYRQASEQPPGSFVFNLRWAEGPDSPGKPVAVRASTAITVTVDGKTAIA
                     AAVGIQMQADYLQRQFWAAMQQCNTVEGPCPKRCQDTDLDCFVIDNNGFILISERPQE
                     IGRLLGEADGALMTQLLSMGVFSRVTMYDYQAMCKPPDHHHSAAESLISPLSAFLTVA
                     KWLLHECLLFLFEWSAWGSWQDKGSEAKAVFHHSHKHKKQDLLHPCDTEYPVFVHQTA
                     IREANGIIECGGCQKTFVMQQIPSSNLLLLVTDRTCDCSAYSPILQEATEVKYNASVK
                     CNRMRSQKPRRRPGSCHAFHPEENAQDCGGASDTLPSSPLLLLALWAWRLPPQLLW"
     exon            345..426
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            427..543
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            544..603
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            604..766
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            767..898
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            899..959
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1110
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1185
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1275
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1389
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1468
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1602
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1680
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1761
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1836
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1923
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..1995
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2057
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2125
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2171
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2269
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2363
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2459
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2587
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2668
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2730
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2775
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2838
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..2909
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..2985
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3038
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3091
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3112
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3230
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3343
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3426
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..4741
                     /gene="Cacna2d4"
                     /gene_synonym="RGD1562038"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgcctccc ccctgatctc ctggggggac cctctgtcag atgcagctgg aggcggcatc
       61 tcttacttgg gactggccag cagggagaac gcttgcatgc ccagggacct gggtggcagc
      121 aagttcgttc acagcaggag cactgtcctc ctcccctgtc cctcccccag tgggaacacc
      181 atggcaagaa gccccacatt gtcctccagc cacagctggg gccaccgtgg acagcagaca
      241 gctgcatgga ccttcctgcg gaaaatgcca attgtcctgt ggctgctgct cttggacacc
      301 tccctgccga ctgcaaggag ccaggctaca attcctctgg aaacagtgaa gctctgggct
      361 gaaaccttcg gcagggatct gtacagcacg gtgaccagat actcgggttc tctcctgctg
      421 cagaagaagt acaaggatgc agaacccagt ctgaagatca aagaggtgga tggcttggag
      481 ctggtgaaga agttctcaga ggacatggag accatgcttc ggaggaaagt tgaggctgtg
      541 gagagcctgg tggaggccgc tgaggaggct gacctgaacc atgagttcaa tgcgtctctg
      601 gtgtttaact actacaactc agtactgatc aatgagaagg atgacaaggg caactatgtg
      661 gagctgggag ctgagtttct tctcgagtcc gacgcccact tcaacaacct gagggtgaat
      721 gtctccatga gcagcgtgca gctacccacc aatgtgtaca acaaagaccc agacatttta
      781 aatggcgtct atatgtccga agccctgaac cctgtgtttg tggagaactt tcagagagac
      841 cccacattga cctggcagta ttttggcagt tcaactgggt tcttcaggat ctatccaggg
      901 ataaagtgga cacctgatga aaatggagtc atcgccttcg actgcagaaa ccgtggctgg
      961 tacatacaag ccgccacttc tcccaaggac atcgtcatcc tggtggacat gagcggcagc
     1021 atgaaggggc tgaggatggc cattgccaaa cacaccgtca caaccatatt ggacaccctg
     1081 ggggagaacg acttcgtgaa catcatcgcg tacaatgact atgtccacta catcgagccc
     1141 tgcttcaaag gcatcctcgt ccaagcggat cgagacaacc gagagcattt caagcagttg
     1201 gtggatgagc tgatggtcaa aggcgtgggt atcgtgagtc aagctctaat tgaagctttc
     1261 cagatcctga agcagttcca agagtccaga caaggaagcc tctgcaacca ggctatcatg
     1321 cttgtcaccg acggggctgt ggaagactat gagcccgtgt ttgagaccta taactggcca
     1381 gaccgtaagg tccgagtttt cacctacctt attggaagag aagtgacttt cgctgaccgc
     1441 atgaaatgga tcgcctgcaa caataaaggt tactacacac agatctccac gctggctgat
     1501 gcgcaggaga acgtgatgga gtacctgcac gtgctcagcc gtcccatggt catcaaccac
     1561 gaccacgaca tcatctggac agaggcttat atggacagcc ggctccttac ctcagaggca
     1621 caaagcctga tgctcctcac cacagtggcc atgccagtct tcagcaaaaa gaacgaaaca
     1681 cgatcccatg gcattctcct gggtgtggtg ggctctgacg tgaccctaag agagctcatg
     1741 aagctggcac cccgatataa gctcggggta catggctatg cctttttgaa cactaacaat
     1801 ggctacatcc tctctcatcc tgacctccga cctttgtaca gagaaggcaa gaagttgaaa
     1861 cccaagccca actacaacag tgtggacctc tcagaagtgg agtgggagga ccaagctgaa
     1921 atcctgagga ccgccatgat caatggggaa acagggtctc actccatgga cgtgaaggtg
     1981 ccactggata aagggaaacg agttctattc ctgaccaatg actatttctt cacggacatc
     2041 agtgacacgc ctttcagctt gggagtggtg ctcaccaggg gccatggaga atacatcctc
     2101 ctggggaaca cgtctgtgga ggaaggccta catgacttgc ttcatccgga tctgaccctg
     2161 gccagtgact ggatctattg tatcacggat atcgacccgg accaccggaa gctcagccaa
     2221 ctggaagctg tggtccgttt tctgacaggg gtggatccag acctggagtg tgatgaggag
     2281 ctggtgcggg aggtgctgtt tgacgcagtg gtgaccgcac ccatggaagc ctactggaca
     2341 gcactggcgc tcaacatctc cgaagagtca gagcctggtg tggaagtggc ctttctgggg
     2401 acccgggctg gccttctaag aagaagcttg ttcgtaggct ccgagaaggt ctctgatagg
     2461 aagttcctga cacctgaaga tgaagccagt atttttacca tggaccactt cccactgtgg
     2521 tatcggcagg cctctgagca gcccccaggc agctttgtct tcaatctccg ctgggcagag
     2581 ggaccagata gccccggcaa accagtggcg gtaagggcca gcacggcaat aactgtgaca
     2641 gtggacggga agacggccat tgcagcagcc gtgggcatcc agatgcaagc ggactacctc
     2701 cagcgccagt tctgggcagc catgcagcag tgcaacactg tagaggggcc ctgcccgaag
     2761 cgctgccagg acactgatct ggactgcttc gtcatagaca acaatggctt catcctgatc
     2821 tcagagagac cccaagagat tggaagactt ctgggggaag cggatggtgc tctcatgacg
     2881 cagcttctca gcatgggggt gttcagccgt gtgaccatgt atgactacca agccatgtgc
     2941 aagcccccgg atcaccacca cagtgcagcc gaatccctga tcagtcctct ctctgccttc
     3001 ctgacggtgg ccaagtggct actacatgaa tgtctgctat tcctgttcga gtggagtgct
     3061 tggggatctt ggcaggacaa agggtcagag gccaaagctg tcttccatca ctcccacaag
     3121 cacaagaagc aagacctcct gcacccctgt gacacagagt acccagtgtt cgtgcaccag
     3181 acggccatcc gggaggccaa cgggatcatc gagtgtgggg gctgccagaa gacattcgtg
     3241 atgcaacaga ttcccagcag caacctgctc ctgctagtga cagaccgtac ctgtgactgc
     3301 agcgcctact ctcccatcct ccaggaggcc acagaagtca aatataacgc ctccgtcaag
     3361 tgcaacagga tgcgctccca gaagccccgg agacgaccag gctcctgcca tgccttccat
     3421 cccgaggaaa atgcccagga ctgtggcggt gcttcagaca ctctgccttc atcccctctg
     3481 ctcctgctgg cactgtgggc ctggcgtctt ccgccccagc ttctgtggtg actccatccc
     3541 atctgacttt cacagaagtc tcacaggaca ttctacaaag tgatcagcca atgagagccc
     3601 agctcactgc tgtagggcgt ctccttggtt tcagtcctgg gctacaagtc tctgcctctt
     3661 agagattgct agagggctcc ccaaggctct tcaagccttc tactcttgtc tcaagtggag
     3721 gaaggacagg cgttagtcac tcgtttaccg aagagttgcc tgtttcccag gctggtctcc
     3781 tgcagatccg aggagttctg ggggctggaa ttgagcagtg aggcccttgc agaggctgtg
     3841 gcaagagcgt gcttgccacc aaaaggaggg tacttttatc cattacagat taatgcaagg
     3901 gaggacctgg tggtgcacac ctttaatccc agcacaaacg gaaacaacag gaacacagta
     3961 gagtcctggg aactctcagc acccttcatc actgaagatg cccacccttt ttacactaac
     4021 catctgaagg agagtgggag gaatatatgg gaagatttgg agggaaaggg aagggagaaa
     4081 tgttgtaatt agtctcagaa aggaaaagaa aagctattag gatggctccc cgtctgctgc
     4141 actgggcacc agcatggcac tgggcaggta cgatccagaa gaggtgataa gaaaaagcag
     4201 aacctggaca agctcctctc acagacctca gtaaagtaga gagctaggtg aggtctccaa
     4261 gacccgtggt gggctggctt tctgtggctc gtgatttaca aaagaaacta gactgtttct
     4321 ggggaaagtc ccggaggttg gaaaatagca cataatcctt gccacactgt tcaagtaagt
     4381 tctacaattt acctgcacct ttttggcatt ttttgatagg tatctctggg tatttgtgta
     4441 cctgtttgta caaagatgtg gaggccagag gtgatgttgg ctttcttcct caaccacccc
     4501 tgtacttttc ttaaagataa gatcgctcac aaaatctggg ccctccaatt cagccagact
     4561 agctggccag ccagccccag aaacccttct gccactgtct ccctaaggct ggggctccaa
     4621 gtgtgccctg ctattgccct tgtgtttcaa taatttagga acctaacttg ggtcctcaca
     4681 ctctactggc tgcccctctc aagtcccaca atttacctgt ctattaaatc aggaaactaa
     4741 a
//
