LOCUS       NM_175595               3276 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            alpha2delta 3 (Cacna2d3), mRNA.
ACCESSION   NM_175595
VERSION     NM_175595.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3276)
  AUTHORS   Meyer,J.O. and Dolphin,A.C.
  TITLE     Rab11-dependent recycling of calcium channels is mediated by
            auxiliary subunit alpha2delta-1 but not alpha2delta-3
  JOURNAL   Sci Rep 11 (1), 10256 (2021)
   PUBMED   33986433
  REMARK    GeneRIF: Rab11-dependent recycling of calcium channels is mediated
            by auxiliary subunit alpha2delta-1 but not alpha2delta-3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3276)
  AUTHORS   Perez de Sevilla Muller,L., Sargoy,A., Fernandez-Sanchez,L.,
            Rodriguez,A., Liu,J., Cuenca,N. and Brecha,N.
  TITLE     Expression and cellular localization of the voltage-gated calcium
            channel alpha2delta3 in the rodent retina
  JOURNAL   J Comp Neurol 523 (10), 1443-1460 (2015)
   PUBMED   25631988
  REMARK    GeneRIF: The expression of the alpha(2)delta(3) calcium channel
            subunit to multiple cell types suggests that this subunit
            participates widely in Ca-channel-mediated signaling in the retina.
REFERENCE   3  (bases 1 to 3276)
  AUTHORS   Davies,A., Kadurin,I., Alvarez-Laviada,A., Douglas,L.,
            Nieto-Rostro,M., Bauer,C.S., Pratt,W.S. and Dolphin,A.C.
  TITLE     The alpha2delta subunits of voltage-gated calcium channels form
            GPI-anchored proteins, a posttranslational modification essential
            for function
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1654-1659 (2010)
   PUBMED   20080692
  REMARK    GeneRIF: all of the alpha(2)delta subunits studied,
            alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of
            the properties expected of glycosylphosphatidylinositol-anchored
            proteins, both when heterologously expressed and in native
            tissues.[Cacna2d3
REFERENCE   4  (bases 1 to 3276)
  AUTHORS   Chu,P.J. and Best,P.M.
  TITLE     Molecular cloning of calcium channel alpha(2)delta-subunits from
            rat atria and the differential regulation of their expression by
            IGF-1
  JOURNAL   J Mol Cell Cardiol 35 (2), 207-215 (2003)
   PUBMED   12606261
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF486278.1.
            
            On Jun 3, 2003 this sequence version replaced NM_175595.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF486278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132263,
                                           SAMD00132279 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3276
                     /gene="Cacna2d3"
                     /note="calcium voltage-gated channel auxiliary subunit
                     alpha2delta 3"
                     /db_xref="GeneID:306243"
                     /db_xref="RGD:631361"
     CDS             1..3258
                     /gene="Cacna2d3"
                     /note="voltage-dependent calcium channel subunit
                     alpha-2/delta-3; voltage-gated calcium channel subunit
                     alpha-2/delta-3; calcium channel, voltage-dependent, alpha
                     2/delta 3 subunit; calcium channel, voltage-dependent,
                     alpha2/delta subunit 3"
                     /codon_start=1
                     /product="voltage-dependent calcium channel subunit
                     alpha-2/delta-3 precursor"
                     /protein_id="NP_783185.1"
                     /db_xref="GeneID:306243"
                     /db_xref="RGD:631361"
                     /translation="MAGPGSLCCASRGASALLATALLYAALGDVVRSEQQIPLSVVKL
                     WASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQLVKKLAKNMEEMFHKK
                     SEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDKDGNFLELGKEFILAPNDHF
                     NNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLIWQYFGSAK
                     GFFRQYPGIKWEPDENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLTIAK
                     QTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKG
                     IGMLDIALNEAFNVLSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPERKVRI
                     FTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQEHDV
                     VWTEAYIDSTLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIP
                     KYKLGIHGYAFAITNNGYILTHPELRPLYEEGKKRRKPNYSSVDLSEVEWEDRDDVLR
                     NAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFSLGVALSRGHGKYFFR
                     GNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDK
                     ELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQL
                     TNQDFLKARDKENIFNADHFPLWYRRAAEQIPGSFVYSIPFSTGTVNKSNVVTASTSI
                     QLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVNCYLIDNN
                     GFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGL
                     LDPYKAFLSAAKWIVTELVLFLVEFNLCSWWHSDMTAKAQKLKQTLEPCDTEYPAFVS
                     ERTIKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNE
                     SLKCERLKAQKIRRRPESCHGFHPEENARECGGASSLQAQVALLLLPLVSSLFSR"
     exon            1..122
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            123..204
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            205..321
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..381
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            382..544
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            545..676
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..737
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..888
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..963
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1053
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1167
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1246
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1380
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1452
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1533
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1608
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1692
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1764
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1826
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1894
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1940
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2038
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2132
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2228
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2350
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2431
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2493
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2538
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2601
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2672
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2748
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2801
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..2857
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2969
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3082
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3165
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3276
                     /gene="Cacna2d3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggccgggc cgggctcgct gtgctgcgcg tcccgggggg cctcggcgct cctagccaca
       61 gcgcttctct acgccgcgct gggggacgtg gtgcgctccg agcagcagat cccgctctcc
      121 gtagtgaagc tctgggcctc cgcttttggt ggggagataa aatccattgc tgccaagtac
      181 tcgggttccc agcttctgca aaagaaatac aaagagtatg agaaagacgt tgccattgaa
      241 gaaatcgacg gtctccaact ggtgaaaaag ctggccaaga acatggaaga gatgtttcac
      301 aagaagtccg aggcagtgcg gcgtctcgtg gaggctgcag aggaagcaca cctgaagcat
      361 gaatttgacg ccgacttgca gtatgaatac ttcaatgccg tgctgatcaa cgagagagac
      421 aaagatggga actttttgga attgggaaag gagttcatct tggcccccaa tgaccatttt
      481 aataatttgc ctgtgaacat cagtctgagt gatgtccaag tgccaacgaa catgtacaac
      541 aaagatcctg ccatagtcaa tggagtgtat tggtctgaat ctctaaacaa agtttttgta
      601 gacaacttcg atcgggaccc gtctctcata tggcagtact ttggaagtgc aaagggcttt
      661 ttcagacagt acccagggat taaatgggaa ccagacgaga atggagtcat tgcctttgac
      721 tgcaggaaca ggaaatggta catccaggca gcaacttctc caaaggatgt ggtcattttg
      781 gtggacgtca gcgggagcat gaaaggactc cgcctgacca tcgccaagca aacagtctcc
      841 tcgatactgg acaccctggg cgatgatgac ttcttcaaca tcatcacgta taacgaagag
      901 cttcactatg tggaaccttg tctgaatgga acactggttc aagcggacag gaccaacaag
      961 gagcacttca gggagcattt ggacaaactt tttgccaaag ggattggaat gctcgatatt
     1021 gcgctgaacg aggccttcaa tgtactgagc gatttcaacc acaccggaca aggaagcatt
     1081 tgcagccagg ccattatgct cataaccgac ggggcagtgg acacctacga caccatcttt
     1141 gcaaagtaca attggccaga gcgaaaggtt cgaatcttca cttacctcat tggacgagag
     1201 gctgcttttg cagacaatct caagtggatg gcttgtgcta acaaaggatt tttcacccag
     1261 atctccacct tggctgatgt gcaggaaaat gtcatggaat acctccatgt actcagtcga
     1321 cccaaagtca tcgaccagga acatgatgtg gtgtggaccg aagcgtacat cgacagcact
     1381 cttgctgatg atcagggcct cgtcttgatg accacagtgg ccatgcctgt gtttagtaag
     1441 cagaacgaaa ctaggtcaaa gggcattctt ctgggtgtgg ttggcacaga tgtcccagta
     1501 aaagagcttc tgaagaccat ccccaaatac aagttaggaa ttcatggtta tgcctttgcc
     1561 atcacgaata atggatacat cttgacacac ccggagctca ggcccctgta tgaagaaggg
     1621 aaaaagcgaa ggaagcctaa ttacagtagt gtggatctct cggaagtcga gtgggaagat
     1681 cgggatgatg tgttacgaaa tgccatggtg aatcggaaga ctgggaaatt ctccatggaa
     1741 gtgaagaaga ctgtggacaa agggaaacgg gttttggtga tgaccaatga ctactactac
     1801 acagacatca agggtgctcc tttcagttta ggtgtggcgc tctccagggg ccacgggaaa
     1861 tacttcttcc gagggaatgt aaccattgaa gaagggctcc atgacttaga acatcctgac
     1921 gtgtccttgg cagatgaatg gtcctactgc aacactgatc tgcacccaga gcaccgccat
     1981 ctctctcaac tggaagcgat taagctctac ctcaaaggca aggagcctct gcttcaatgt
     2041 gacaaagaat tgattcaaga agtccttttt gatgctgtgg taagcgcccc tatcgaagcc
     2101 tattggacca gcctggccct caacaaatct gagaattctg acaagggtgt agaggtcgcc
     2161 ttcctcggca ctcgcacagg cctctcaaga atcaacctgt ttgtgggggc tgaacagctc
     2221 accaatcagg actttctgaa ggctagagac aaagagaaca ttttcaacgc agatcatttc
     2281 cctctctggt acagaagagc tgccgagcag attccaggaa gttttgtcta ctccatcccc
     2341 ttcagcacag gaacggtcaa caaaagcaat gtggtgacag caagtacctc catccaactc
     2401 ctggatgagc gaaaatctcc tgtggtggca gctgtaggca ttcagatgaa acttgaattc
     2461 ttccaaagga agttctggac ggccagcaga cagtgtgcct ccctggatgg taaatgctcc
     2521 ataagctgcg acgatgagac tgtgaactgt tacctcatag acaataacgg gttcattctg
     2581 gtgtctgaag actacacaca gactggagat ttttttggtg aggtcgaagg agctgtcatg
     2641 aacaagttgt taacaatggg ctcctttaaa agaataacct tgtatgacta ccaagccatg
     2701 tgtagagcca acaaggagag tagtgacagt gcccacggac tcctggaccc ctataaggcc
     2761 ttcctctctg cagccaagtg gatagtgacg gaacttgtct tgttcctggt ggagtttaac
     2821 ctttgcagtt ggtggcactc tgacatgaca gctaaagccc agaaactgaa acagaccctg
     2881 gagccttgtg atactgaata cccagccttt gtttccgaac gcaccatcaa ggagaccaca
     2941 gggaacattg cttgtgaaga ctgctccaag tcctttgtca tccagcaaat cccaagtagc
     3001 aatctgttca tggtggtggt ggacagtagc tgtctctgtg agtctgtggc tcctatcacc
     3061 atggcaccca ttgaaatcag gtataatgaa tcccttaagt gtgaacggtt aaaggctcag
     3121 aagatcagac gacgtccgga atcctgccac ggcttccatc ctgaggagaa tgcgagagag
     3181 tgtgggggtg catcaagtct ccaggcccag gtggccttgc tgctgctccc cctggtttcg
     3241 agtctcttct caaggtgaca ctaactaatg ggatgt
//
