LOCUS       NM_175592               3502 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            alpha2delta 2 (Cacna2d2), mRNA.
ACCESSION   NM_175592
VERSION     NM_175592.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Zhang,J., Wu,L., Li,Z. and Fu,G.
  TITLE     miR-1231 exacerbates arrhythmia by targeting calciumchannel gene
            CACNA2D2 in myocardial infarction
  JOURNAL   Am J Transl Res 9 (4), 1822-1833 (2017)
   PUBMED   28469787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Li,B., Zhao,Q., Wang,L.X., Deng,C.Y., Zeng,F., Wu,T.G., Jiang,Z.F.
            and Xu,D.L.
  TITLE     Effect of beta3-adrenergic receptor on atrial L-type Ca(2+) current
            in rats with chronic heart failure
  JOURNAL   Heart Lung Circ 23 (4), 369-377 (2014)
   PUBMED   24055266
  REMARK    GeneRIF: There was no difference in the mRNA expression of
            alpha2delta-2 (Cacna2d2) between the BRL group and CHF control
            group (0.264 +/- 0.005 vs. 0.243 +/- 0.017, P>0.05), which was also
            higher than in the normal control group (0.137 +/- 0.013, P<0.01).
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Eroglu,C., Allen,N.J., Susman,M.W., O'Rourke,N.A., Park,C.Y.,
            Ozkan,E., Chakraborty,C., Mulinyawe,S.B., Annis,D.S.,
            Huberman,A.D., Green,E.M., Lawler,J., Dolmetsch,R., Garcia,K.C.,
            Smith,S.J., Luo,Z.D., Rosenthal,A., Mosher,D.F. and Barres,B.A.
  TITLE     Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin
            receptor responsible for excitatory CNS synaptogenesis
  JOURNAL   Cell 139 (2), 380-392 (2009)
   PUBMED   19818485
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Kaja,S., Todorov,B., van de Ven,R.C., Ferrari,M.D., Frants,R.R.,
            van den Maagdenberg,A.M. and Plomp,J.J.
  TITLE     Redundancy of Cav2.1 channel accessory subunits in transmitter
            release at the mouse neuromuscular junction
  JOURNAL   Brain Res 1143, 92-101 (2007)
   PUBMED   17320843
REFERENCE   5  (bases 1 to 3502)
  AUTHORS   Hatano,S., Yamashita,T., Sekiguchi,A., Iwasaki,Y., Nakazawa,K.,
            Sagara,K., Iinuma,H., Aizawa,T. and Fu,L.T.
  TITLE     Molecular and electrophysiological differences in the L-type Ca2+
            channel of the atrium and ventricle of rat hearts
  JOURNAL   Circ J 70 (5), 610-614 (2006)
   PUBMED   16636499
  REMARK    GeneRIF: The level of the alpha1C (Cacna1c) (Cav1.2) protein was
            decreased (approximately 0.5-fold) and that of alpha2 delta-1
            (Cacna2d1) was increased (approximately 2-fold) in the atrium
            compared with the ventricle
REFERENCE   6  (bases 1 to 3502)
  AUTHORS   Walter,J.T., Alvina,K., Womack,M.D., Chevez,C. and Khodakhah,K.
  TITLE     Decreases in the precision of Purkinje cell pacemaking cause
            cerebellar dysfunction and ataxia
  JOURNAL   Nat Neurosci 9 (3), 389-397 (2006)
   PUBMED   16474392
REFERENCE   7  (bases 1 to 3502)
  AUTHORS   Cole,R.L., Lechner,S.M., Williams,M.E., Prodanovich,P.,
            Bleicher,L., Varney,M.A. and Gu,G.
  TITLE     Differential distribution of voltage-gated calcium channel alpha-2
            delta (alpha2delta) subunit mRNA-containing cells in the rat
            central nervous system and the dorsal root ganglia
  JOURNAL   J Comp Neurol 491 (3), 246-269 (2005)
   PUBMED   16134135
  REMARK    GeneRIF: The alpha2delta-2 subunit is also found in brain regions
            known to be involved in olfaction, somatic motor control, fluid
            homeostasis, ingestive and defensive behaviors, neuroendocrine
            functions, and circadian rhythm.
REFERENCE   8  (bases 1 to 3502)
  AUTHORS   Chu,P.J. and Best,P.M.
  TITLE     Molecular cloning of calcium channel alpha(2)delta-subunits from
            rat atria and the differential regulation of their expression by
            IGF-1
  JOURNAL   J Mol Cell Cardiol 35 (2), 207-215 (2003)
   PUBMED   12606261
REFERENCE   9  (bases 1 to 3502)
  AUTHORS   Barclay,J., Balaguero,N., Mione,M., Ackerman,S.L., Letts,V.A.,
            Brodbeck,J., Canti,C., Meir,A., Page,K.M., Kusumi,K.,
            Perez-Reyes,E., Lander,E.S., Frankel,W.N., Gardiner,R.M.,
            Dolphin,A.C. and Rees,M.
  TITLE     Ducky mouse phenotype of epilepsy and ataxia is associated with
            mutations in the Cacna2d2 gene and decreased calcium channel
            current in cerebellar Purkinje cells
  JOURNAL   J Neurosci 21 (16), 6095-6104 (2001)
   PUBMED   11487633
REFERENCE   10 (bases 1 to 3502)
  AUTHORS   Holz,A., Frank,M., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Schwab,M.E.
  TITLE     Chromosomal localization of the myelin-associated oligodendrocytic
            basic protein and expression in the genetically linked neurological
            mouse mutants ducky and tippy
  JOURNAL   J Neurochem 69 (5), 1801-1809 (1997)
   PUBMED   9349522
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF486277.1.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by NM_175592.3.
            
            On Jun 3, 2003 this sequence version replaced NM_175592.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF486277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3502
                     /gene="Cacna2d2"
                     /note="calcium voltage-gated channel auxiliary subunit
                     alpha2delta 2"
                     /db_xref="GeneID:300992"
                     /db_xref="RGD:631360"
     CDS             1..3474
                     /gene="Cacna2d2"
                     /note="voltage-dependent calcium channel subunit
                     alpha-2/delta-2; voltage-gated calcium channel subunit
                     alpha-2/delta-2; calcium channel, voltage dependent,
                     alpha2/delta subunit 2; calcium channel,
                     voltage-dependent, alpha 2/delta subunit 2"
                     /codon_start=1
                     /product="voltage-dependent calcium channel subunit
                     alpha-2/delta-2 precursor"
                     /protein_id="NP_783182.1"
                     /db_xref="GeneID:300992"
                     /db_xref="RGD:631360"
                     /translation="MAVPARTCGASWPGPVRTARPWPGRGPRPCPDPRGPASGPARPL
                     LLLLPPLLLLPLLTAPGASAYSFPQQHTMQHWARRLEQEIDGVMRIFGGVQQLREIYK
                     DNRNLFDVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEE
                     DIMYYDAKADAELDDPESEDMERGSKTSALRLDFIEEPNFKNKVNYSYTAVQIPTDIY
                     KGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDL
                     YDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVAS
                     FNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITR
                     ANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACTNKG
                     YYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAKQVQWTNVYEDALGLGLVVTGTLPV
                     FNLTQDGPGDKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPN
                     LKPQITNFREPVTLDFLDAELEDENKEEIRRSMIDGDKGHKQIRTLVKSLDERYIDEV
                     IRNYTWVPIRSTNYSLGLVLPPYSTYYLQANLSDQILQVKLPISKLKDFEFLLPSSFE
                     SEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGIT
                     QQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLD
                     NRGYIFKPPHQDSLLRPLELENDTVGVLVSTAVELSLGRRTLRPAVVGVKLDLEAWAE
                     KFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQ
                     VGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTIADFL
                     NLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVN
                     ASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEVGRLLQKETHCPADGPEQ
                     CELVQRPRYRTGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQP
                     QIHSFTPSRRL"
     exon            1..215
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..297
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..414
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..474
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..519
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..661
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..793
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..851
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..902
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1002
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1161
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1269
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1348
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1398
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1488
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1560
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1635
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1710
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1782
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1854
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1916
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1993
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2014
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2075
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2173
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2264
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2327
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2431
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2530
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2619
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2670
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2742
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2895
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..2948
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3004
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3131
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3241
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3330
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3502
                     /gene="Cacna2d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcggtgc cggctcggac ctgcggcgct tcttggcccg gcccggtgcg gaccgctcgc
       61 ccctggcccg gtcgcggtcc ccggccctgc cctgaccccc ggggcccagc gtccgggccc
      121 gcacgcccgc tcttgctact gctgccgcct ctgctgcttt taccgctgct caccgccccc
      181 ggcgcctctg cctacagctt cccccagcag cacacgatgc agcactgggc ccggcgcctg
      241 gagcaggaga ttgacggtgt gatgcggatt tttggaggcg tgcagcagct ccgagagatc
      301 tacaaggaca atcggaacct gtttgatgtg caggagaatg aaccacagaa actagtggag
      361 aaggtggcag gggacattga gagcctgctg gacagaaagg tccaggcctt gaagagactg
      421 gctgacgctg cagagaattt ccagaaagcc caccgctggc aagacaacat caaggaggaa
      481 gacatcatgt actatgacgc caaggctgac gccgagctgg atgatcctga gagtgaggat
      541 atggagaggg gatccaagac cagcgcctta aggctggact tcatcgagga gccaaacttc
      601 aagaacaaag tcaactattc atacacggcg gtgcagatcc ccacagatat ctacaaaggc
      661 tctaccgtca tcctcaatga gcttaactgg acggaggccc tggagaatgt cttcattgag
      721 aaccgtaggc aagaccctac actgttgtgg caagtcttcg gcagtgccac gggagtcacc
      781 cgctattacc cagccacacc gtggcgagcc cccaagaaga ttgacctgta cgatgtcaga
      841 agacgaccct ggtatataca gggggcctca tcacccaagg acatggtcat cattgtggat
      901 gtgagtggca gtgtgagcgg cctgacgctg aagctgatga agacgtctgt ctgtgagatg
      961 ctagacacac tctccgatga tgactatgtg aatgtggcct cattcaacga gaaggcgcag
     1021 cctgtgtctt gcttcacaca cctggtgcag gccaatgtgc ggaacaagaa ggtgttcaag
     1081 gaagctgtgc agggcatggt ggccaagggc accacaggct acaaggctgg ctttgagtat
     1141 gcctttgacc agctacagaa ttccaacatc acccgtgcta actgcaataa gatgatcatg
     1201 atgttcacgg acgggggaga ggatcgcgtg caggacgtct ttgaaaagta taattggccc
     1261 aatcggacgg tacgcgtctt cacgttctcc gtaggacagc ataactatga tgtcacaccc
     1321 ctgcagtgga tggcttgtac taacaaaggt tactattttg agatcccttc catcggagcc
     1381 atccgcatca acacacagga atacctggat gtgctgggta ggcccatggt cctggcaggc
     1441 aaggacgcca agcaagtgca atggacaaac gtgtatgaag atgcgctggg gctggggttg
     1501 gtggtaacag ggactctccc tgttttcaac ctgacacagg atggccctgg ggacaagaag
     1561 aaccagctaa tcctgggtgt catgggcata gatgtggccc tgaatgacat caaaaggctg
     1621 actcccaact acacacttgg cgccaatggc tacgtgttcg ccatcgacct gaatggctat
     1681 gtgttgctac atcccaatct caagccccag attaccaact tccgggagcc tgtgaccttg
     1741 gacttcctgg atgcagagct ggaagatgag aacaaggagg agatccgtcg tagtatgatt
     1801 gacggagaca aaggccacaa gcagatcaga accttggtca aatccctgga tgagaggtac
     1861 atagatgaag tgattcggaa ctacacctgg gtgcctataa ggagtaccaa ctacagcctg
     1921 gggctggtgc tcccacccta cagcacctac tacctccaag ccaacctcag cgaccagatc
     1981 ctgcaggtca agttgccaat cagcaaactg aaggattttg agttcctgct ccccagcagc
     2041 tttgagtctg aaggacatgt tttcattgct cccagagagt attgcaagga tttgaatgcc
     2101 tcagacaaca acaccgagtt cctgaaaaac ttcattgagc tcatggagaa agtgactccg
     2161 gactccaagc agtgcaataa cttccttctg cataacttga ttttggacac gggcattacg
     2221 cagcagttag tggaacgcgt ctggcgggac caagatctca acacgtacag cctgctagct
     2281 gtatttgctg ccactgacgg tggcatcaca cgtgtcttcc cgaacaaggc agctgaagac
     2341 tggacagaaa accctgaacc cttcaatgcc agcttctacc gccgcagcct ggataaccgt
     2401 ggttatatct tcaagccccc gcaccaggac tccctgttaa ggccactgga gctggagaat
     2461 gacacagtag gcgtcctcgt cagcacagct gtagagctca gtctgggtcg ccgcacactg
     2521 aggccagcag tggtgggtgt caaactggac ctagaggctt gggctgaaaa gttcaaggtg
     2581 cttgccagca accgtaccca tcaggaccaa cctcagaagc agtgcggccc cagcagccac
     2641 tgtgagatgg actgcgaggt aaacaacgag gacctactct gtgtcctcat tgatgacggg
     2701 ggattcctgg tgctgtcaaa ccaaaaccac cagtgggacc aggttggcag gttcttcagt
     2761 gaggtggatg ccaacctgat gctggcactg tacaataact ccttctacac cagaaaggag
     2821 tcctatgact atcaggcagc ttgtgcccct cagcctcctg gcaacctggg tgctgcaccc
     2881 aggggtgtct ttgtgcccac cattgcagat ttccttaact tggcctggtg gacctctgct
     2941 gccgcctggt ccttattcca gcaactactt tatggtctca tctatcacag ctggttccag
     3001 gcagacccgg cagaagccga gggcagcccc gagacgcgcg agagcagctg cgtcatgaaa
     3061 caaacccagt actacttcgg ctcggtgaac gcgtcctata acgccatcat cgactgcgga
     3121 aactgcagca ggctgttcca cgcgcagaga ctgaccaaca ccaaccttct gttcgtggtg
     3181 gcggagaagc cgctgtgcag ccagtgcgag gtcggccggc tgctacaaaa ggagacacac
     3241 tgcccagcgg acggcccgga gcagtgtgag ctggtgcaga gaccgcgata ccgaacaggc
     3301 ccgcacatct gttttgacta caatgcgacg gaagatacct cagactgtgg ccgcggagcc
     3361 tccttccctc cgtcgctggg cgtcttggtt tccctgcagc tgttgctcct cctaggcctg
     3421 ccacctcggc cgcagcctca aatccattcc ttcacgccct ctcgccgcct ctgaactacc
     3481 cacacacaca catcatagcc cc
//
