LOCUS       NM_012919               3964 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel auxiliary subunit
            alpha2delta 1 (Cacna2d1), transcript variant 1, mRNA.
ACCESSION   NM_012919
VERSION     NM_012919.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3964)
  AUTHORS   Lu,Y., Wang,J., Li,L. and Zhang,X.
  TITLE     The role of voltage-gated calcium channel alpha2delta-1 in the
            occurrence and development in myofascial orofacial pain
  JOURNAL   BMC Oral Health 24 (1), 552 (2024)
   PUBMED   38735923
  REMARK    GeneRIF: The role of voltage-gated calcium channel alpha2delta-1 in
            the occurrence and development in myofascial orofacial pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3964)
  AUTHORS   Al Katat,A., Zhao,J., Calderone,A. and Parent,L.
  TITLE     Sympathetic Stimulation Upregulates the Ca2+ Channel Subunit,
            CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in Neonatal
            Ventricular Cardiomyocytes
  JOURNAL   Cells 11 (2), 188 (2022)
   PUBMED   35053304
  REMARK    GeneRIF: Sympathetic Stimulation Upregulates the Ca(2+) Channel
            Subunit, CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in
            Neonatal Ventricular Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3964)
  AUTHORS   Fu,M., Liu,F., Zhang,Y.Y., Lin,J., Huang,C.L., Li,Y.L., Wang,H.,
            Zhou,C., Li,C.J. and Shen,J.F.
  TITLE     The alpha2delta-1-NMDAR1 interaction in the trigeminal ganglion
            contributes to orofacial ectopic pain following inferior alveolar
            nerve injury
  JOURNAL   Brain Res Bull 171, 162-171 (2021)
   PUBMED   33811955
  REMARK    GeneRIF: The alpha2delta-1-NMDAR1 interaction in the trigeminal
            ganglion contributes to orofacial ectopic pain following inferior
            alveolar nerve injury.
REFERENCE   4  (bases 1 to 3964)
  AUTHORS   Meyer,J.O. and Dolphin,A.C.
  TITLE     Rab11-dependent recycling of calcium channels is mediated by
            auxiliary subunit alpha2delta-1 but not alpha2delta-3
  JOURNAL   Sci Rep 11 (1), 10256 (2021)
   PUBMED   33986433
  REMARK    GeneRIF: Rab11-dependent recycling of calcium channels is mediated
            by auxiliary subunit alpha2delta-1 but not alpha2delta-3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3964)
  AUTHORS   Martinez San Segundo,P., Terni,B., Burgueno,J., Monroy,X.,
            Dordal,A., Merlos,M. and Llobet,A.
  TITLE     Outside-in regulation of the readily releasable pool of synaptic
            vesicles by alpha2delta-1
  JOURNAL   FASEB J 34 (1), 1362-1377 (2020)
   PUBMED   31914622
  REMARK    GeneRIF: These observations prompt to consider alpha2delta-1 as an
            outside-in signaling platform that binds exogenous and endogenous
            cues for regulating the coupling of voltage-gated calcium channels
            to synaptic vesicles.
REFERENCE   6  (bases 1 to 3964)
  AUTHORS   Chu,P.J. and Best,P.M.
  TITLE     Molecular cloning of calcium channel alpha(2)delta-subunits from
            rat atria and the differential regulation of their expression by
            IGF-1
  JOURNAL   J Mol Cell Cardiol 35 (2), 207-215 (2003)
   PUBMED   12606261
REFERENCE   7  (bases 1 to 3964)
  AUTHORS   Yamada,Y., Nagashima,M., Tsutsuura,M., Kobayashi,T., Seki,S.,
            Makita,N., Horio,Y. and Tohse,N.
  TITLE     Cloning of a functional splice variant of L-type calcium channel
            beta 2 subunit from rat heart
  JOURNAL   J Biol Chem 276 (50), 47163-47170 (2001)
   PUBMED   11604404
REFERENCE   8  (bases 1 to 3964)
  AUTHORS   Bell,D.C., Butcher,A.J., Berrow,N.S., Page,K.M., Brust,P.F.,
            Nesterova,A., Stauderman,K.A., Seabrook,G.R., Nurnberg,B. and
            Dolphin,A.C.
  TITLE     Biophysical properties, pharmacology, and modulation of human,
            neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium
            currents
  JOURNAL   J Neurophysiol 85 (2), 816-827 (2001)
   PUBMED   11160515
REFERENCE   9  (bases 1 to 3964)
  AUTHORS   Kim,H.L., Kim,H., Lee,P., King,R.G. and Chin,H.
  TITLE     Rat brain expresses an alternatively spliced form of the
            dihydropyridine-sensitive L-type calcium channel alpha 2 subunit
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3251-3255 (1992)
   PUBMED   1314383
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1992 Jun 15;89(12):5699]
REFERENCE   10 (bases 1 to 3964)
  AUTHORS   Williams,M.E., Feldman,D.H., McCue,A.F., Brenner,R., Velicelebi,G.,
            Ellis,S.B. and Harpold,M.M.
  TITLE     Structure and functional expression of alpha 1, alpha 2, and beta
            subunits of a novel human neuronal calcium channel subtype
  JOURNAL   Neuron 8 (1), 71-84 (1992)
   PUBMED   1309651
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF286488.1.
            
            On Aug 31, 2012 this sequence version replaced NM_012919.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF286488.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3964              AF286488.1         2-3965
FEATURES             Location/Qualifiers
     source          1..3964
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3964
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /note="calcium voltage-gated channel auxiliary subunit
                     alpha2delta 1"
                     /db_xref="GeneID:25399"
                     /db_xref="RGD:2247"
     exon            1..380
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..3561
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; voltage-dependent calcium channel subunit
                     alpha-2/delta-1; voltage-gated calcium channel subunit
                     alpha-2/delta-1; Calcium channel subunit alpha 2 delta
                     (dihydropyridine - sensitive L-type); calcium channel,
                     voltage-dependent, alpha2/delta subunit 1"
                     /codon_start=1
                     /product="voltage-dependent calcium channel subunit
                     alpha-2/delta-1 isoform 1 precursor"
                     /protein_id="NP_037051.2"
                     /db_xref="GeneID:25399"
                     /db_xref="RGD:2247"
                     /translation="MAAGCLLALTLTLFQSWLIGPSSEEPFPSPVTIKSWVDKMQEDL
                     VTLAKTASGVTQLADIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLAM
                     EAEKVQAAHQWREDFASNEVVYYNAKDDLDPERNESESGSQRIKPVFIEDANFGRQIS
                     YQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKRNRDEDPTLLWQVFGSATGLARYY
                     PASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSV
                     SEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYK
                     KGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQH
                     NYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVY
                     LDALELGLVITGTLPVFNVTGQSENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCP
                     NGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGE
                     KTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQAR
                     SKKGKMKDSETLKPDNFEESGYTFIAPREYCNDLKPSDNNTEFLLNFNEFIDRKTPNN
                     PSCNTDLINRILLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENW
                     QENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVELYIQGKLLKPA
                     VVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYT
                     NQIGRFFGEIDPSMMRHLVNISLYAFNKSYDYQSVCDPGAAPKQGAGHRSAYVPSITD
                     ILQIGWWATAAAWSILQQLLLSLTFPRLLEAVEMEEDDFTASLSKQSCITEQTQYFFK
                     NDTKSFSGLLDCGNCSRIFHVEKLMNTNLVFIMVESKGTCPCDTRLLMQAEQTSDGPD
                     PCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWSIFGLQFILLWLVSGSRH
                     YLW"
     exon            381..462
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            463..579
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            580..639
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            640..681
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            682..811
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            812..943
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1013
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1064
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1164
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1323
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1428
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1507
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1557
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1647
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1725
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1800
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1875
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1947
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2019
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2081
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2158
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2179
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2240
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2338
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2426
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2489
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2593
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2680
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2748
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2787
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2859
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3012
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3065
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3066..3121
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3251
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3361
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3444
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3959
                     /gene="Cacna2d1"
                     /gene_synonym="Cacna2; CCHLA2; DHSCCA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacgagcg gggagccaga gcgcgcgggc gccggcaggc tggccgagct ccgtttccac
       61 agtcgccctt gatggcggcg caggcgaggc agccgtggca cggagcggca gccacgcgct
      121 agagagtccg ctcggccccg cccggccggc ccgcccgtgc cctgccctgc ccgcctctct
      181 cctcgcgccc tccggcagac gtcggcgccc cggctcagtc cctcgccgcg tgcagctccg
      241 ccggctccgg gccggcaggg agggcactga tcttcgatcg cgaagatggc tgctggctgc
      301 ctgctggcct tgactctgac acttttccaa tcttggctga tcggcccctc gagcgaggag
      361 cccttccctt cgcccgtcac tatcaagtca tgggtggata aaatgcagga agaccttgtc
      421 acactggcaa agacagcaag tggagtgact cagcttgctg acatttatga aaaataccaa
      481 gatttgtata ctgtggagcc aaataatgca cgccaactgg ttgaaattgc agctagagac
      541 attgagaaac ttctgagcaa cagatctaaa gccctggtgc gcctggctat ggaagcagag
      601 aaagtccaag ccgcccacca atggagggaa gattttgcaa gcaacgaagt tgtctactac
      661 aacgctaaag acgatcttga tcctgaaaga aatgagagtg agtcaggcag ccaacggatt
      721 aaacctgttt tcatcgaaga cgctaatttt ggacgccaga tatcctatca acatgcagcg
      781 gtccatattc ccacggacat ctatgagggc tcaaccatag tgttaaacga actcaactgg
      841 acaagtgcct tagatgaagt tttcaaaaga aatcgagatg aagaccctac attgctgtgg
      901 caagtgtttg gcagcgccac cggcctggcc cgatattatc cagcttctcc gtgggtggat
      961 aacagcagaa ctccaaacaa gatcgatctc tacgatgtac gcagaagacc atggtacatc
     1021 cagggagctg catcccccaa agacatgctc attctggtgg acgtgagtgg aagtgtgagc
     1081 ggattgactc tgaaactcat ccggacatct gtctctgaga tgttagaaac cctttccgat
     1141 gatgatttcg tgaatgtagc ttcatttaac agcaatgctc aggatgtgag ttgtttccag
     1201 cacctggttc aagcgaatgt aaggaacaag aaggtgctga aggatgcggt gaataacatc
     1261 acagcaaagg ggataacaga ttacaagaaa ggctttagct tcgcgtttga acagctactt
     1321 aattataatg tttccagagc caattgtaat aagatcatca tgttattcac ggatggagga
     1381 gaagagagag cccaggagat atttgccaag tacaataaag acaaaaaagt ccgcgtgttt
     1441 acattttctg ttggtcaaca taattatgac agaggaccta ttcagtggat ggcttgtgaa
     1501 aacaaaggtt attattatga gattccctct attggtgcaa taagaatcaa tactcaggaa
     1561 tatctagatg ttctgggaag accaatggtt ttagccgggg acaaagcaaa gcaagtccag
     1621 tggacaaatg tgtatttgga tgctctggag ctgggacttg tcattactgg aactctaccg
     1681 gtcttcaacg tcactggcca gtctgaaaat aagactaact tgaagaacca gttgattctt
     1741 ggtgtgatgg gcgttgatgt gtctctggaa gatattaaga gattgacacc acgttttaca
     1801 ctgtgcccca acggttacta ttttgcaatc gatcctaatg gttatgtctt actgcatcca
     1861 aatcttcagc caaagaaccc caaatctcag gagccggtca cactggattt tctcgatgct
     1921 gagttagaga atgatattaa agtggagatt cgaaataaaa tgatagacgg agaaagtgga
     1981 gaaaaaacat tcagaactct ggtcaaatct caagatgaga gatatattga caaaggaaat
     2041 cgaacataca catggacacc tgtcaatggc acagattaca gtttggcctt ggtattgcca
     2101 acctacagtt tttactatat aaaagccaaa atagaagaga caataactca ggccagatca
     2161 aaaaagggga aaatgaagga ttcagaaacc ctgaagccag acaattttga agaatctggc
     2221 tacactttca tagcaccaag ggaatactgc aatgacctga aaccttcaga taataacact
     2281 gaatttcttt taaatttcaa tgaatttatt gataggaaaa ctccaaacaa cccttcctgt
     2341 aatacagatt tgattaatag aatcttgctg gatgcgggtt ttacaaatga acttgtccaa
     2401 aattattgga gtaaacagaa aaatatcaaa ggagtgaagg cacgctttgt ggtgactgat
     2461 ggcggaatta caagagttta ccccaaagag gctggagaaa actggcaaga gaacccagag
     2521 acgtatgagg acagcttcta caaacggagc ctagataacg ataactacgt tttcactgcg
     2581 ccctacttca acaaaagtgg acctggtgcc tatgaatctg gaattatggt aagcaaagct
     2641 gtagaactgt acatccaagg aaaacttctt aagcctgcag ttgtgggaat taaaattgac
     2701 gtaaactcct ggatagaaaa ttttaccaaa acttcaatca gggatccgtg tgctggtcca
     2761 gtttgtgact gcaaaagaaa cagtgatgta atggactgtg tcattctaga tgatggtgga
     2821 tttcttctga tggccaatca tgatgattac actaatcaga ttggacgttt ttttggagag
     2881 attgacccga gcatgatgag acacctggtt aatatatcac tttatgcatt caataaatca
     2941 tatgactatc agtctgtgtg tgatccaggg gcagcaccaa agcaaggagc aggacatcgc
     3001 tcagcctatg tgccatcaat tacagacata ctccagattg gctggtgggc cactgctgcc
     3061 gcctggtcta ttctccagca gctactcttg agtttgacat ttccacggct ccttgaggca
     3121 gttgaaatgg aagaggatga cttcacagct tccctgtcta agcagagctg catcacagaa
     3181 caaactcagt acttcttcaa gaacgatact aaatcattca gtggtttact ggactgtgga
     3241 aactgttcca ggatctttca tgttgagaag cttatgaaca ccaacctagt gttcataatg
     3301 gtggagagca agggaacatg tccgtgtgac acgcggctgc tcatgcaagc agaacagact
     3361 tctgatggtc cagatccttg cgacatggtt aagcagccca gataccgaaa aggacctgat
     3421 gtctgctttg ataacaatgt gctggaggat tataccgact gtggtggtgt ttctggatta
     3481 aacccttcct tatggtctat ctttggactc caatttatac tcctttggct ggtatctggc
     3541 agcagacact atctatggtg accctctaaa cccatgatct gcaacttaat tccatgccct
     3601 gccaaaacat gagccctcag ttacattaaa atagagcccg ttgaagaagc tccacagaac
     3661 cttagctggg cctctaccct gatgtaactg tgaggcttag attcctgacc atcgctggct
     3721 gcatgtcagg gtgttggaaa ctgaaactcg tgtgaacatg ctgcatcatc tgtgtccaac
     3781 atcaaagcaa agctctactc attctctgtg ggaggtttgg gagttcgctg ttgcactgtt
     3841 ggagattacg tggaaaaggc tcccccacgc aggccttatg aaaagaagca gtcttgactt
     3901 tgacctagca tttcaacctg ctgcagtttt accaagaaga agaaggaaaa aaaaaaaaaa
     3961 aaaa
//
