LOCUS       NM_020084               9696 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel subunit alpha1 I
            (Cacna1i), mRNA.
ACCESSION   NM_020084 XM_039079797 XM_346806
VERSION     NM_020084.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9696)
  AUTHORS   Chemin,J., Stamenic,T.T., Cazade,M., Llinares,J., Blesneac,I.,
            Todorovic,S.M. and Lory,P.
  TITLE     A novel phospho-modulatory mechanism contributes to the
            calcium-dependent regulation of T-type Ca2+ channels
  JOURNAL   Sci Rep 9 (1), 15642 (2019)
   PUBMED   31666636
  REMARK    GeneRIF: A novel phospho-modulatory mechanism contributes to the
            calcium-dependent regulation of T-type Ca(2+) channels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9696)
  AUTHORS   Wen,X., Liang,H., Li,H., Ou,W., Wang,H.B., Liu,H. and Li,S.
  TITLE     In vitro neurotoxicity by ropivacaine is reduced by silencing
            Cav3.3 T-type calcium subunits in neonatal rat sensory neurons
  JOURNAL   Artif Cells Nanomed Biotechnol 46 (8), 1617-1624 (2018)
   PUBMED   28974111
  REMARK    GeneRIF: Cav3.3 overexpression aggravated DRG injury induced by
            ropivacaine hydrochloride and inhibition of Cav3.3 expression
            improved the cell damages. Cav3.3 can regulate CaMKIIgamma mRNA and
            protein expression.
REFERENCE   3  (bases 1 to 9696)
  AUTHORS   Xie,Y., Huang,D., Wei,L. and Luo,X.J.
  TITLE     Further evidence for the genetic association between CACNA1I and
            schizophrenia
  JOURNAL   Hereditas 155, 16 (2018)
   PUBMED   29308060
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9696)
  AUTHORS   Xu,W., Liu,Y., Chen,J., Guo,Q., Liu,K., Wen,Z., Zhou,Z., Song,Z.,
            Zhou,J., He,L., Yi,Q. and Shi,Y.
  TITLE     Genetic risk between the CACNA1I gene and schizophrenia in Chinese
            Uygur population
  JOURNAL   Hereditas 155, 5 (2017)
   PUBMED   28725167
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9696)
  AUTHORS   Gonzalez,B., Rivero-Echeto,C., Muniz,J.A., Cadet,J.L.,
            Garcia-Rill,E., Urbano,F.J. and Bisagno,V.
  TITLE     Methamphetamine blunts Ca(2+) currents and excitatory synaptic
            transmission through D1/5 receptor-mediated mechanisms in the mouse
            medial prefrontal cortex
  JOURNAL   Addict Biol 21 (3), 589-602 (2016)
   PUBMED   25871318
REFERENCE   6  (bases 1 to 9696)
  AUTHORS   Ma,Y.P. and Pan,Z.H.
  TITLE     Spontaneous regenerative activity in mammalian retinal bipolar
            cells: roles of multiple subtypes of voltage-dependent Ca2+
            channels
  JOURNAL   Vis Neurosci 20 (2), 131-139 (2003)
   PUBMED   12916735
  REMARK    GeneRIF: T-type Ca2+ channels appear to be essential for the
            initiation of the spontaneous activity in mammalian bipolar cells.
REFERENCE   7  (bases 1 to 9696)
  AUTHORS   Murbartian,J., Arias,J.M., Lee,J.H., Gomora,J.C. and Perez-Reyes,E.
  TITLE     Alternative splicing of the rat Ca(v)3.3 T-type calcium channel
            gene produces variants with distinct functional properties(1)
  JOURNAL   FEBS Lett 528 (1-3), 272-278 (2002)
   PUBMED   12297319
  REMARK    GeneRIF: alternative splicing produces channels with distinct
            properties
REFERENCE   8  (bases 1 to 9696)
  AUTHORS   Lee,J.H., Kim,E.G., Park,B.G., Kim,K.H., Cha,S.K., Kong,I.D.,
            Lee,J.W. and Jeong,S.W.
  TITLE     Identification of T-type alpha1H Ca2+ channels (Ca(v)3.2) in major
            pelvic ganglion neurons
  JOURNAL   J Neurophysiol 87 (6), 2844-2850 (2002)
   PUBMED   12037187
  REMARK    GeneRIF: T-type alpha1H Ca2+ channels (Ca(v)3.2) in major pelvic
            ganglion neurons.
REFERENCE   9  (bases 1 to 9696)
  AUTHORS   McRory,J.E., Santi,C.M., Hamming,K.S., Mezeyova,J., Sutton,K.G.,
            Baillie,D.L., Stea,A. and Snutch,T.P.
  TITLE     Molecular and functional characterization of a family of rat brain
            T-type calcium channels
  JOURNAL   J Biol Chem 276 (6), 3999-4011 (2001)
   PUBMED   11073957
  REMARK    Erratum:[J Biol Chem 2001 Aug 10;276(32):30571-4]
REFERENCE   10 (bases 1 to 9696)
  AUTHORS   Lee,J.H., Daud,A.N., Cribbs,L.L., Lacerda,A.E., Pereverzev,A.,
            Klockner,U., Schneider,T. and Perez-Reyes,E.
  TITLE     Cloning and expression of a novel member of the low
            voltage-activated T-type calcium channel family
  JOURNAL   J Neurosci 19 (6), 1912-1921 (1999)
   PUBMED   10066244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Feb 26, 2021 this sequence version replaced
            XM_039079797.1, NM_020084.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF290214.4 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA5760393,
                                    SAMEA5760433 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000007.1  113716266-113716524
            260-510             JAXUCZ010000007.1  113726978-113727228
            511-622             JAXUCZ010000007.1  113748464-113748575
            623-756             JAXUCZ010000007.1  113749472-113749605
            757-854             JAXUCZ010000007.1  113764391-113764488
            855-1014            JAXUCZ010000007.1  113776670-113776829
            1015-1330           JAXUCZ010000007.1  113783379-113783694
            1331-1423           JAXUCZ010000007.1  113784869-113784961
            1424-1736           JAXUCZ010000007.1  113787498-113787810
            1737-2146           JAXUCZ010000007.1  113790452-113790861
            2147-2298           JAXUCZ010000007.1  113797002-113797153
            2299-2484           JAXUCZ010000007.1  113797937-113798122
            2485-2602           JAXUCZ010000007.1  113798574-113798691
            2603-2758           JAXUCZ010000007.1  113798837-113798992
            2759-2852           JAXUCZ010000007.1  113799408-113799501
            2853-3055           JAXUCZ010000007.1  113800108-113800310
            3056-3529           JAXUCZ010000007.1  113800794-113801267
            3530-3630           JAXUCZ010000007.1  113801528-113801628
            3631-3754           JAXUCZ010000007.1  113802128-113802251
            3755-3823           JAXUCZ010000007.1  113802548-113802616
            3824-4008           JAXUCZ010000007.1  113803077-113803261
            4009-4135           JAXUCZ010000007.1  113803766-113803892
            4136-4261           JAXUCZ010000007.1  113804140-113804265
            4262-4351           JAXUCZ010000007.1  113805215-113805304
            4352-4544           JAXUCZ010000007.1  113806755-113806947
            4545-4696           JAXUCZ010000007.1  113807615-113807766
            4697-4806           JAXUCZ010000007.1  113809010-113809119
            4807-4940           JAXUCZ010000007.1  113809684-113809817
            4941-5011           JAXUCZ010000007.1  113811003-113811073
            5012-5090           JAXUCZ010000007.1  113816967-113817045
            5091-5212           JAXUCZ010000007.1  113817598-113817719
            5213-5605           JAXUCZ010000007.1  113818289-113818681
            5606-5752           JAXUCZ010000007.1  113818920-113819066
            5753-5875           JAXUCZ010000007.1  113820003-113820125
            5876-6041           JAXUCZ010000007.1  113820780-113820945
            6042-6238           JAXUCZ010000007.1  113822849-113823045
            6239-9696           JAXUCZ010000007.1  113824213-113827670
FEATURES             Location/Qualifiers
     source          1..9696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..9696
                     /gene="Cacna1i"
                     /note="calcium voltage-gated channel subunit alpha1 I"
                     /db_xref="GeneID:56827"
                     /db_xref="RGD:68944"
     exon            1..259
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            260..510
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..6880
                     /gene="Cacna1i"
                     /note="voltage-dependent calcium channel; caVT.3; calcium
                     channel, voltage-dependent, T type, alpha 1I subunit;
                     voltage-gated calcium channel subunit alpha Cav3.3;
                     hypothetical gene supported by NM_020084; low
                     voltage-activated T-type calcium channel alpha-1 subunit
                     (CACNA1I); calcium channel, voltage-dependent, alpha 1I
                     subunit"
                     /codon_start=1
                     /product="voltage-dependent T-type calcium channel subunit
                     alpha-1I"
                     /protein_id="NP_064469.4"
                     /db_xref="GeneID:56827"
                     /db_xref="RGD:68944"
                     /translation="MADSNLPPSSAAAPAPEPGITEQPGPRSPPPSPPGLEEPLEGTN
                     PDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDD
                     MECLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGM
                     VEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVF
                     FIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLTGDNGIM
                     GCHEIPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKG
                     AINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCL
                     VVIATQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRR
                     ALGLYQALQNRRQAMGPGTPAPAKPGPHAKEPSHCKLCPRHSPLDPTPHTLVQPISAI
                     LASDPSSCPHCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANGDGPQSSEDGVSSDL
                     GKEEEQEDGAARLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPE
                     ELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQAD
                     GGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH
                     IFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTTPWASL
                     YFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEEFDKLPEGLDNS
                     RDLKLCPIPMTPNGHLDPSLPLGAHLGPAGTMGTAPRLSLQPDPVLVALDSRKSSVMS
                     LGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGEGGGS
                     CVRACEGAREEAPTRTAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLGELV
                     PVVGAHSRAAWRGAGQAPGHEDCNGRMPNIAKDVFTKMDDCRDRGEDEEEIDYTLCFR
                     VRKMIDVYKPDWCEVREDWSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITI
                     ALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDG
                     FLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSL
                     KPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCVAANYRWVHHKY
                     NFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVS
                     FFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCPTR
                     LLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAV
                     LKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIA
                     RVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENP
                     CEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLY
                     FVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAEIELEMAHGLGPCPGPCPG
                     PCPCPCPCPCPGPRLPTSSPGAPGRGSGGAGAGGDTESHLCRHCYSPAQETLWLDSVS
                     LIIKDSLEGELTIIDNLSGSVFHHYASPDGCGKCHHDKQEVQLAETEAFSLNSDRSSS
                     ILLGDDLSLEDPTACPQGPKESKGELEPPEPMQAGDLDECFFPFASEPVSTGPESLLC
                     EMGAIPFNPVQSWLKHESSQAPQSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMS
                     AGTLPKIALQGSWASLRSPSVNCTLLRQATVSDASLDASPSSSAGSLQTTLEDSLTLS
                     DSPRRALGPPVQVPGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGC
                     THHDSMDPSDEEGRGGAGGGGAGSEHSETLSSLSLTSLFCLPPTLPPPGLTPARKFNS
                     TSSLAAGPGRPGSTVSARGLVRSPSWAADRSKDPPGQAQLVSGLGSSAPGPQPPPGES
                     TDAASKRKR"
     exon            511..622
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            623..756
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            757..854
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1014
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1330
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1423
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1736
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..2146
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2298
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2484
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2602
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2758
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2852
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            2853..3055
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3529
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3630
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3754
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3823
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..4008
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4135
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4261
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4351
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4544
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4696
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4806
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4940
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            4941..5011
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5090
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            5091..5212
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            5213..5605
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            5606..5752
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..5875
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            5876..6041
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            6042..6238
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
     exon            6239..9696
                     /gene="Cacna1i"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctccaact ccgcgcggtc cgccgctcgt ccgcgccacc cgcctcgagc cgcggcgacc
       61 cgcccgccat ggcccgcgcc cccgggcccg ccgccctgca tgcgccgtcc ccctcgcccc
      121 gggggcgcag ctgatcccgg aatccgaggc gtggggccgg cggggcgcgg ggtccctctc
      181 cacgccggct tcggggacac gcgtcaaccc cgcgtctctg cccgggacga ccccgctgcc
      241 cggccacgtc catgccaagg gctccctgct ccacgctgac atggctgaca gcaacttacc
      301 gccctcatct gcagcagccc cggcccctga gccgggaatc actgagcagc cggggccccg
      361 gagtccccct ccatcccctc caggcctgga ggagccattg gaaggaacca accctgacgt
      421 cccacatcca gacctggctc ctgttgcttt cttctgcctg cgccagacca cgagcccacg
      481 gaactggtgc atcaagatgg tttgtaaccc gtggttcgag tgtgtgagca tgctggttat
      541 tctgctgaac tgtgtgaccc tgggcatgta ccagccatgt gatgacatgg agtgcctgtc
      601 ggaccgttgc aagatcctgc aggtcttcga tgacttcatc ttcatcttct ttgccatgga
      661 gatggtgctt aagatggtgg ccctgggcat ttttggcaag aagtgctacc tcggagacac
      721 atggaaccgc ctggatttct tcattgtcat ggcagggatg gttgagtact ctctggacct
      781 acagaacatc aacctgtcag ccatccgcac tgtgcgtgtc ctgaggcctc tcaaagccat
      841 caaccgtgta cccagcatgc ggatcctggt gaacctgctg ctcgacacgc tgcccatgct
      901 ggggaacgtg ctcctgctct gtttcttcgt cttcttcatc ttcggcatca ttggcgtgca
      961 gctctgggca ggcctgctac ggaaccgctg cttcctggaa gagaacttca ccatacaagg
     1021 ggatgtggcc ctgccccctt attaccaacc agaggaggat gacgagatgc cctttatctg
     1081 ctccctgact ggggacaatg gcatcatggg ctgccacgag atccccccac tgaaggagca
     1141 gggccgggaa tgctgcctgt ccaaagatga tgtgtatgac ttcggggcgg ggcgccagga
     1201 cctcaacgcc agcggtctgt gcgtcaactg gaaccgctac tacaacgtct gccgcacggg
     1261 caacgccaac cctcacaagg gcgccatcaa ctttgacaac attggctatg cctggattgt
     1321 gattttccag gtgatcactc tggaaggctg ggtggagatc atgtactatg tgatggacgc
     1381 acattctttc tacaacttca tctacttcat tctgctcatc atagtgggct ccttcttcat
     1441 gatcaacttg tgcctcgttg tcatagcaac ccagttctct gagaccaagc aacgggagca
     1501 ccggctgatg ctggagcaac gccagcgcta cctgtcctcc agcacggtgg ccagttacgc
     1561 tgagcccggt gattgctatg aggagatctt ccaatatgtc tgtcacatcc ttcgcaaagc
     1621 caagcgccgt gccctaggcc tctaccaggc cctgcagaac cggcgccagg ccatgggccc
     1681 ggggacacca gcccctgcca agcctgggcc ccatgccaag gagcccagcc actgcaagct
     1741 gtgcccacga cacagccccc tggaccccac tccccacaca ctggtgcagc ccatctctgc
     1801 cattctggcc tctgacccca gcagctgccc tcactgccag cacgaggcag gcaggcggcc
     1861 ctctggcctg ggcagcactg actcaggcca ggaaggctca ggttctggtg gctctgcaga
     1921 ggccgaagcc aatggggatg gaccccagag cagtgaggat ggggtctcct cggacctggg
     1981 gaaggaggag gaacaggagg acggggcagc ccgactgtgt ggggatgtgt ggcgcgagac
     2041 acgagccaag ctgcggggca tcgtggacag caagtacttc aacagaggta tcatgatggc
     2101 tatcctggtg aacacagtca gcatgggcat cgagcaccac gaacagcccg aggagctgac
     2161 caacatcctg gagatctgca atgtggtctt caccagtatg tttgccctgg agatgatcct
     2221 gaaactggcc gcctttgggc tcttcgacta cctgcggaac ccttacaaca tctttgacag
     2281 catcatcgtc atcatcagca tctgggaaat cgtggggcag gcagacggtg gcctgtctgt
     2341 gctgcgcacc ttccggttgc tgcgggtgct gaagctggtg cgcttcatgc cggcgctgcg
     2401 gcgccagctc gtggtgctca tgaagaccat ggacaacgtg gccaccttct gcatgctact
     2461 catgctgttc atcttcatct tcagcatcct tgggatgcat atctttggct gcaaattcag
     2521 cctccgcacg gacacgggag acaccgttcc tgacaggaag aacttcgatt ccttactgtg
     2581 ggccatcgtc acagtgttcc agatcctcac tcaggaggac tggaacgttg tcctgtacaa
     2641 tggcatggcc tccaccaccc cctgggcctc cctctatttt gttgccctca tgacctttgg
     2701 caactacgtt ctcttcaatc tcctggtggc tatcctggta gagggtttcc aggctgaggg
     2761 tgatgctaat cgttcctact ctgatgagga ccagagctca tccaatttgg aggagtttga
     2821 caagctccca gagggcctgg acaacagtag agatctcaag ctctgcccaa tacccatgac
     2881 acccaatgga cacctggacc ctagcctccc tctgggtgcg catctgggtc ctgctggtac
     2941 catgggtact gccccccgcc tctcactgca gccagacccg gtactggtgg ccctagactc
     3001 tcggaaaagc agtgtcatgt ccctgggcag gatgagctat gatcagcgat ccttgtccag
     3061 ctcccggagc tcctactacg ggccctgggg ccgcagtggg acctgggcta gccgccgctc
     3121 cagctggaac agcctgaaac acaagccgcc ctcagctgag catgagtcct tactgtctgg
     3181 ggagggtgga ggtagctgcg tcagggcctg tgaaggcgcc cgggaggagg cgccaactcg
     3241 caccgcaccc ctgcatgctc cacacacgca ccacgcgcac catggacccc acctggcaca
     3301 ccgtcaccga caccaccgcc ggactctgtc ccttgatacc agggactctg ttgacctggg
     3361 agagctggtg cccgtggtgg gtgcccactc acgggccgct tggagggggg cgggtcaggc
     3421 ccctgggcac gaggactgca atggcagaat gcccaacata gccaaggatg tcttcaccaa
     3481 gatggatgac tgccgcgacc gcggggagga cgaggaggag atcgactata ccctgtgttt
     3541 ccgggtccgc aagatgattg atgtgtacaa gccggactgg tgcgaagtcc gcgaggactg
     3601 gtcggtctac ctcttctccc ccgagaacaa gttccggatc ctgtgtcaga ctatcattgc
     3661 tcacaagctt tttgactacg tggtcttggc ctttatcttc ctcaactgta tcaccattgc
     3721 tctggagaga ccccagattg aagctggtag cactgagcgc atcttcctca cggtgtctaa
     3781 ctacatcttc acagccatct tcgtgggcga gatgacactg aaggtggttt ctctgggcct
     3841 gtactttggt gagcaggcgt acctgcgtag cagctggaat gtactggatg gtttcctggt
     3901 ctttgtgtcc atcatcgata tcgtagtgtc cgtggcctct gctgggggag ccaagattct
     3961 gggggtcctc cgggtcctgc ggctcctgcg taccttacgt cctttgaggg ttatcagccg
     4021 ggcccctggg ctgaagctgg tggtagagac gctcatctcc tccctcaagc ccattgggaa
     4081 catcgtcctc atctgctgtg ccttcttcat catcttcggc atcctggggg tgcagctttt
     4141 caaaggcaag ttctaccatt gtttgggagt ggacacccga aacatcacca accgatctga
     4201 ctgcgtggcg gccaactacc gctgggtgca tcacaaatac aactttgaca acctgggcca
     4261 ggcattgatg tccctctttg tcttggcctc caaggacggc tgggtgaaca tcatgtataa
     4321 tggattagat gctgttgctg tggaccagca gccagtgacg aaccacaacc cctggatgct
     4381 actgtacttc atttcgttcc tgctcatcgt cagcttcttt gtgctcaaca tgtttgtggg
     4441 cgtggtcgtg gagaacttcc acaagtgccg gcagcaccag gaggctgagg aggcgcggag
     4501 gcgtgaggag aaacggctgc ggcgcctgga aaagaagcgc cgtaaggctc agaggctgcc
     4561 ctactatgct acctactgtc ccacaaggct gctcatccac tccatgtgca ccagccacta
     4621 cctggacatc ttcattacct tcatcatctg cctcaatgtt gtcaccatgt ccctggagca
     4681 ctacaaccag cctacatccc tagagacagc ccttaagtac tgcaactaca tgttcaccac
     4741 tgtctttgtg ctggaggctg tgctgaagct ggtggcattt ggcctgaggc gtttcttcaa
     4801 ggaccgatgg aaccagctgg acctggccat tgtgctgctg tccgtcatgg gcatcacact
     4861 ggaggagatc gagatcaatg ccgcccttcc catcaacccc accatcatcc gtatcatgcg
     4921 tgttctgcgt atcgcccggg tgttgaagct attgaagatg gccacaggaa tgcgggccct
     4981 gctggacaca gtggtacagg ctctgcccca ggtgggcaac ctgggcctgc tcttcatgct
     5041 gctcttcttc atctatgctg ctctgggagt ggagctcttc ggaaagctgg tctgcaatga
     5101 cgagaacccg tgtgagggca tgagccggca cgccaccttt gaaaacttcg gcatggcctt
     5161 cctcacgctc ttccaggtct ccacaggcga taactggaat ggaattatga aggacaccct
     5221 gcgagactgt acccatgatg agcgcagctg cctaagcagc ctgcagtttg tgtcaccgct
     5281 ctactttgtg agcttcgtgc tcacagctca gttcgtgctc atcaacgtgg tggtggccgt
     5341 gctgatgaaa catctggatg acagcaacaa ggaggcccag gaggatgcag agatggatgc
     5401 tgagatcgag ctggagatgg cccatggcct cggcccctgc cctggcccct gccctggtcc
     5461 ctgcccctgc ccctgcccct gcccctgtcc tggcccgagg ctgcccacta gttcacctgg
     5521 ggctccgggg cgaggatcgg gaggggcagg tgctggaggc gacaccgaga gtcacctgtg
     5581 ccggcactgc tattctccag cccaggagac cctgtggctg gacagcgtct ctttaatcat
     5641 caaggactcc ttggaggggg agctgaccat cattgacaac ctgtctgggt ccgtcttcca
     5701 ccactacgcc tcacctgacg gctgtggcaa gtgtcaccat gacaagcaag aggtgcagct
     5761 ggctgagaca gaggccttct ccctgaactc agacaggtct tcatccatcc tgctggggga
     5821 tgacctgagt cttgaggacc ccacggcctg cccacagggc cccaaggaga gcaagggtga
     5881 actagagcct ccggagccca tgcaggctgg agacctggat gaatgctttt tcccctttgc
     5941 cagtgagcca gtgtccacag gcccagagag cctgctgtgc gagatggggg ccattccatt
     6001 caaccctgtc cagtcctggc tcaaacacga gagcagccaa gcaccccaga gccctttctc
     6061 cccggatggc tccagccctc tcctgcagat gcctgctgag ttcttccacc ctgctgtgtc
     6121 tgccagccag aaggggcagg aaccgggcat gagtgcagga accctgccca agattgcact
     6181 tcaggggtcc tgggcatcgc tgaggtcacc gagtgtcaac tgcaccctct tgcgccaggc
     6241 tactgtgagt gacgcgtcct tggatgccag tcctagcagc tcagcgggca gcctacagac
     6301 cacactggaa gacagtctga ctctgagtga cagtccccgg cgtgccctgg ggccgccggt
     6361 ccaggtgcct gggccacggg ctagcctgtc accggccacc cggcgccgcc tcagcctgcg
     6421 gggccgtggc ctgtttagtc tgcgtgggct gcgggcccat cagcgtagcc acagcagtgg
     6481 cggctccacc agccctggct gcactcacca cgactccatg gacccctctg atgaggaggg
     6541 ccgcgggggc gcaggtggcg ggggtgcagg cagtgagcac tcggagaccc tcagcagcct
     6601 gtcactcaca tctctcttct gcctaccacc cacgctgcca ccacccggcc tcaccccagc
     6661 caggaagttc aacagtacca gcagcctggc cgctggacct ggccgtcctg gctccactgt
     6721 ctcagcccgt ggtctggtca gaagcccctc atgggctgca gaccgcagca aggacccacc
     6781 aggccaagct cagctggtct caggcttggg ctcctcagca cccgggccac agccacctcc
     6841 cggggagtca actgatgctg cgagcaaaag gaagagatga ggggccgcag gggctgcggg
     6901 ggacctgcta cccgctatcc tcccgcctgc cccatcttgc cttcttttac ctcaggagcc
     6961 agggagcaga cagcaatact ttgcccacac ctgggagtgg cataggggcc agccagcgcc
     7021 aggccactgg gcaggcgacc gagagggtct gagttagccg aggctcagat gtggccccat
     7081 ccgaggccct tccagtgcat atgcagatat atacatatat atatagagac agacatatat
     7141 ttatttattt tttttactga gagcttatga attccagaaa gtgctaaagt tgagggtgta
     7201 ggccagaggc ccaaacaggg gtctcgtctg ttggttagca cacaggcctt cacagcgcag
     7261 atgcttctgc tgggcatcgg tggctgtagt tttaggggtc tccccgagtt gagagcagct
     7321 tgggagggcg ttcagggccc aggagacaga agagaagcaa ttcagggtgc actttttttt
     7381 cccttttaag agactctact aagttcccca acccctaccc acacgtcagg gtatcagtct
     7441 tgtccctctg actattgtgt tgttgtgaag tctttcgtta gacactccgg acgcaaactt
     7501 tcttagccag ctagatgttc cctttagaaa aaccaggggg gattttagtc atatttctta
     7561 gagcagggtt gggggacagg gtagttctag gctgggcagg gggctcaggg tgcagttttg
     7621 acttcagtga gcactttggg ggacagttca accccagctc cccaaaggca gcaaacagga
     7681 ataattcaca caagagagag ggcagggaag ggggccagtg gtacttgctt ggtccacgca
     7741 gacgcccggg tacctgggct gtcacttgca tgggaacttt ctgtccttct ccactatgaa
     7801 ggccacatac ttcagcattc ctggggattg cggtcaccta cccggagcag ccccacccct
     7861 gccccagagg tgtttggggg taagaaatct gaagtgggct gagaacaccc gcccaaagcc
     7921 tggctctagc ctttccctgc cccaacactc agcctctagc cagttacccg gacattcacg
     7981 tcctcggact catcgctgtc tcaagctgca ggctgggtct cacaatggtc ctgcttcctg
     8041 aaccagttca ggacgggtgt ttttctacct gaaaggcttt cacaggctaa gctctaaagt
     8101 ggctgggttt aaaatcagct ggaagagtgt ggcctcctgc tgctggctgc tgttcagggc
     8161 agtatcatgg ggtgctcgct cacattacta agggtcacca tgggccctgc taagagcagg
     8221 agtgtgtctt gtctctgctc ccaaaccccg agttctcaga agtgggcttc tagccaggtt
     8281 agtgagcagc agctgctgtg tttgtaggtt atggggtgtt cctacctagc acaggggttc
     8341 ccgtctagcg caggggtgtg cctgtaaaac ccttcttgga ggtgaggagt gggaaagtgg
     8401 ttactagacc cactttacac atgggtaaaa cggaggctct ttgttagtga aacaaccatt
     8461 tggccctggc atcaatgagc ctgggtcaac tgtgaggggt cctggcctga acatctggac
     8521 cccccccacc aacacacaca gacacacggt tgcaaggagg catgtaattg gttgtggctg
     8581 ggcccatgct cttcagagat ggtgtttaat agcatcccat accctctgct ttctgggtcc
     8641 agtcagtcag ttacctcagc cttcctgatg tctctgtgtg gttcatgctg ctctccagag
     8701 tcagcgctct cccaatccgg gctctgaggc tgaggaggga tgttcaggca tccatgattt
     8761 tacactgtga ccccagagca agcagacaca ttgaagggtg ttctagggaa atgggcaagg
     8821 tttaattaag ggctgtagct aggcatagca aggcatccag agagaagcac ggcaaccttc
     8881 cccagggtgg gtttccctag gatcaagatc ccaggtattt ggccttgtgt ctctgaggag
     8941 gggattaggg actacaggag ctgctagctc ttggcaagat gagctggaaa gggttggggt
     9001 gccccttctt tgaccttgtg gcttggggct gtggccttag gccaagcctg tccatcatca
     9061 aagcacaaac ttccccaatc cacatgggcc ggtctgtgag gagagtggga acctaggtcc
     9121 caatgcccta aagctgttca tttgcctgac tgtgtggtgt ggaggctgca gggcaccacg
     9181 gcagctgtag agaaggttct ggagccagat agggcctgcc ctggcttctt cgtgtcttct
     9241 gctctagtcc tggcttttcc tcagaggagg atgaatcgtg agcagtactc acctgtctgc
     9301 ttgcccctac tatttcttct ggagctccca gggtcacctc cgtgcccttt tgctgcccgg
     9361 ggtaagggct tggggtctta gaagctgccg ttttagctcc cccacccaca cttttgcttt
     9421 gttttttgtt ttggtctttg tgcaataatc gatgtccctg gcagagccag ggctgaactg
     9481 gggcctgggc agaggccatc ttgtccagcc agccccccag cctggctctg ctgctgtgac
     9541 tcacttccgg tcactgtaca gtttctacag tgtgaacgaa cttccccctc ctagttgctg
     9601 aaggcgctgg tccctgctgg cccagatggc ctgggcatag ggaaaccaag ccacaccgcc
     9661 agccagcgtt gttttgaata aaaccccaga aaccta
//
