LOCUS       NM_001308302            8084 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel subunit alpha1 G
            (Cacna1g), transcript variant 1, mRNA.
ACCESSION   NM_001308302 XM_008767995
VERSION     NM_001308302.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8084)
  AUTHORS   Obaid,A.A., Almasmoum,H., Almaimani,R.A., El-Boshy,M., Aslam,A.,
            Idris,S., Ghaith,M.M., El-Readi,M.Z., Ahmad,J., Farrash,W.F.,
            Mujalli,A., Eid,S.Y., Elzubier,M.E. and Refaat,B.
  TITLE     Vitamin D and calcium co-therapy mitigates pre-established cadmium
            nephropathy by regulating renal calcium homeostatic molecules and
            improving anti-oxidative and anti-inflammatory activities in rat
  JOURNAL   J Trace Elem Med Biol 79, 127221 (2023)
   PUBMED   37244046
REFERENCE   2  (bases 1 to 8084)
  AUTHORS   Zheng,Z., Wang,X., Wang,Y., King,J.A.C., Xie,P. and Wu,S.
  TITLE     CaMK4 is a downstream effector of the alpha1G T-type calcium
            channel to determine the angiogenic potential of pulmonary
            microvascular endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 321 (6), C964-C977 (2021)
   PUBMED   34586897
  REMARK    GeneRIF: CaMK4 is a downstream effector of the alpha1G T-type
            calcium channel to determine the angiogenic potential of pulmonary
            microvascular endothelial cells.
REFERENCE   3  (bases 1 to 8084)
  AUTHORS   Zhang,B., Chen,L., Bai,Y.G., Song,J.B., Cheng,J.H., Ma,H.Z., Ma,J.
            and Xie,M.J.
  TITLE     miR-137 and its target T-type CaV 3.1 channel modulate
            dedifferentiation and proliferation of cerebrovascular smooth
            muscle cells in simulated microgravity rats by regulating
            calcineurin/NFAT pathway
  JOURNAL   Cell Prolif 53 (3), e12774 (2020)
   PUBMED   32034930
  REMARK    GeneRIF: The present work demonstrated that miR-137 and its target
            T-type CaV 3.1 channel modulate the dedifferentiation and
            proliferation of rat cerebrovascular smooth muscle cells under
            simulated microgravity by regulating calcineurin/NFATc3 pathway.
REFERENCE   4  (bases 1 to 8084)
  AUTHORS   Yu,J., Shi,Y., Zhao,K., Yang,G., Yu,L., Li,Y., Andersson,E.M.,
            Ammala,C., Yang,S.N. and Berggren,P.O.
  TITLE     Enhanced expression of beta cell CaV3.1 channels impairs insulin
            release and glucose homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 117 (1), 448-453 (2020)
   PUBMED   31871187
  REMARK    GeneRIF: Recombinant adenovirus encoding enhanced green fluorescent
            protein-CaV3.1 subunit (Ad-EGFP-CaV3.1) efficiently transduced rat
            and human islets as well as dispersed islet cells. Ad-EGFP-CaV3.1
            transduction reduced phosphorylated FoxO1 in the cytoplasm of rat
            INS-1E cells, elevated FoxO1 nuclear retention, and decreased
            syntaxin 1A, SNAP-25, and synaptotagmin III.
REFERENCE   5  (bases 1 to 8084)
  AUTHORS   Tracy,M.E., Tesic,V., Stamenic,T.T., Joksimovic,S.M., Busquet,N.,
            Jevtovic-Todorovic,V. and Todorovic,S.M.
  TITLE     CaV3.1 isoform of T-type calcium channels supports excitability of
            rat and mouse ventral tegmental area neurons
  JOURNAL   Neuropharmacology 135, 343-354 (2018)
   PUBMED   29578032
  REMARK    GeneRIF: Results confirm the idea that T-channels critically
            support rebound burst firing following periods of membrane
            hyperpolarization, similar to those that occur during inhibitory
            synaptic potentials in the ventral tegmental area. Behavioral
            results indicate that deletion of CaV3.1 channels disrupts the
            hyperlocomotion.
REFERENCE   6  (bases 1 to 8084)
  AUTHORS   Cribbs,L.L., Martin,B.L., Schroder,E.A., Keller,B.B., Delisle,B.P.
            and Satin,J.
  TITLE     Identification of the t-type calcium channel (Ca(v)3.1d) in
            developing mouse heart
  JOURNAL   Circ Res 88 (4), 403-407 (2001)
   PUBMED   11230107
REFERENCE   7  (bases 1 to 8084)
  AUTHORS   McRory,J.E., Santi,C.M., Hamming,K.S., Mezeyova,J., Sutton,K.G.,
            Baillie,D.L., Stea,A. and Snutch,T.P.
  TITLE     Molecular and functional characterization of a family of rat brain
            T-type calcium channels
  JOURNAL   J Biol Chem 276 (6), 3999-4011 (2001)
   PUBMED   11073957
  REMARK    Erratum:[J Biol Chem 2001 Aug 10;276(32):30571-4]
REFERENCE   8  (bases 1 to 8084)
  AUTHORS   Zhuang,H., Bhattacharjee,A., Hu,F., Zhang,M., Goswami,T., Wang,L.,
            Wu,S., Berggren,P.O. and Li,M.
  TITLE     Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells
  JOURNAL   Diabetes 49 (1), 59-64 (2000)
   PUBMED   10615950
REFERENCE   9  (bases 1 to 8084)
  AUTHORS   Kase,M., Kakimoto,S., Sakuma,S., Houtani,T., Ohishi,H., Ueyama,T.
            and Sugimoto,T.
  TITLE     Distribution of neurons expressing alpha 1G subunit mRNA of T-type
            voltage-dependent calcium channel in adult rat central nervous
            system
  JOURNAL   Neurosci Lett 268 (2), 77-80 (1999)
   PUBMED   10400082
REFERENCE   10 (bases 1 to 8084)
  AUTHORS   Perez-Reyes,E., Cribbs,L.L., Daud,A., Lacerda,A.E., Barclay,J.,
            Williamson,M.P., Fox,M., Rees,M. and Lee,J.H.
  TITLE     Molecular characterization of a neuronal low-voltage-activated
            T-type calcium channel
  JOURNAL   Nature 391 (6670), 896-900 (1998)
   PUBMED   9495342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 26, 2021 this sequence version replaced NM_001308302.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF125161.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-727               JAXUCZ010000010.1  79918908-79919634   c
            728-839             JAXUCZ010000010.1  79911838-79911949   c
            840-973             JAXUCZ010000010.1  79911514-79911647   c
            974-1071            JAXUCZ010000010.1  79911091-79911188   c
            1072-1231           JAXUCZ010000010.1  79909028-79909187   c
            1232-1532           JAXUCZ010000010.1  79907649-79907949   c
            1533-1625           JAXUCZ010000010.1  79907391-79907483   c
            1626-2409           JAXUCZ010000010.1  79904805-79905588   c
            2410-2789           JAXUCZ010000010.1  79902703-79903082   c
            2790-2941           JAXUCZ010000010.1  79888283-79888434   c
            2942-3127           JAXUCZ010000010.1  79887413-79887598   c
            3128-3242           JAXUCZ010000010.1  79887206-79887320   c
            3243-3398           JAXUCZ010000010.1  79886970-79887125   c
            3399-3467           JAXUCZ010000010.1  79883914-79883982   c
            3468-3552           JAXUCZ010000010.1  79882227-79882311   c
            3553-3749           JAXUCZ010000010.1  79881951-79882147   c
            3750-4181           JAXUCZ010000010.1  79876906-79877337   c
            4182-4282           JAXUCZ010000010.1  79875911-79876011   c
            4283-4406           JAXUCZ010000010.1  79875673-79875796   c
            4407-4475           JAXUCZ010000010.1  79873867-79873935   c
            4476-4660           JAXUCZ010000010.1  79873503-79873687   c
            4661-4787           JAXUCZ010000010.1  79872476-79872602   c
            4788-4913           JAXUCZ010000010.1  79870812-79870937   c
            4914-5003           JAXUCZ010000010.1  79869866-79869955   c
            5004-5196           JAXUCZ010000010.1  79869207-79869399   c
            5197-5250           JAXUCZ010000010.1  79866908-79866961   c
            5251-5402           JAXUCZ010000010.1  79862129-79862280   c
            5403-5512           JAXUCZ010000010.1  79861299-79861408   c
            5513-5646           JAXUCZ010000010.1  79860452-79860585   c
            5647-5717           JAXUCZ010000010.1  79860131-79860201   c
            5718-5796           JAXUCZ010000010.1  79859956-79860034   c
            5797-5918           JAXUCZ010000010.1  79859736-79859857   c
            5919-6272           JAXUCZ010000010.1  79859079-79859432   c
            6273-6450           JAXUCZ010000010.1  79854889-79855066   c
            6451-6620           JAXUCZ010000010.1  79854482-79854651   c
            6621-8084           JAXUCZ010000010.1  79851886-79853349   c
FEATURES             Location/Qualifiers
     source          1..8084
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..8084
                     /gene="Cacna1g"
                     /note="calcium voltage-gated channel subunit alpha1 G"
                     /db_xref="GeneID:29717"
                     /db_xref="RGD:68942"
     exon            1..727
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..7352
                     /gene="Cacna1g"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-dependent T-type calcium channel subunit alpha-1G;
                     voltage-gated calcium channel subunit alpha Cav3.1;
                     calcium channel, voltage-dependent, T type, alpha 1G
                     subunit"
                     /codon_start=1
                     /product="voltage-dependent T-type calcium channel subunit
                     alpha-1G isoform 1"
                     /protein_id="NP_001295231.2"
                     /db_xref="GeneID:29717"
                     /db_xref="RGD:68942"
                     /translation="MDEEEDGAGAEESGQPRSFTQLNDLSGAGGRQGPGSTEKDPGSA
                     DSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFR
                     PCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIV
                     IAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLC
                     FFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLEPYYQTENEDESPFICSQPRE
                     NGMRSCRSVPTLRGEGGGGPPCSLDYETYNSSSNTTCVNWNQYYTNCSAGEHNPFKGA
                     INFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLV
                     VIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARR
                     LAQVSRAIGVRAGLLSSPVARSGQEPQPSGSCTRSHRRLSVHHLVHHHHHHHHHYHLG
                     NGTLRVPRASPEIQDRDANGSRRLMLPPPSTPTPSGGPPRGAESVHSFYHADCHLEPV
                     RCQAPPPRCPSEASGRTVGSGKVYPTVHTSPPPEILKDKALVEVAPSPGPPTLTSFNI
                     PPGPFSSMHKLLETQSTGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESAD
                     HVMPDSDSEAVYEFTQDAQHSDLRDPHSRRRQRSLGPDAEPSSVLAFWRLICDTFRKI
                     VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY
                     GPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQL
                     VVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAI
                     VTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEE
                     IGKREDASGQLSCIQLPVNSQGGDATKSESEPDFFSPSVDGDGDRKKRLALVALGEHA
                     ELRKSLLPPLIIHTAATPMSLPKSSSTGVGEALGSGSRRTSSSGSAEPGAAHHEMKSP
                     PSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEE
                     SSEEDRASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRSSASEHQDCNGK
                     SASGRLARTLRTDDPQLDGDDDNDEGNLSKGERIQAWVRSRLPACCRERDSWSAYIFP
                     PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFT
                     AVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM
                     LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF
                     KGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIM
                     YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEE
                     EARRREEKRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPYYSDYSRFRLLVHHLC
                     TSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVFESVFKLVAFG
                     FRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLK
                     MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRH
                     ATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQF
                     VLVNVVIAVLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGV
                     NSPDSPKPGAPHTTAHIGAASGFSLEHPTMVPHPEEVPVPLGPDLLTVRKSGVSRTHS
                     LPNDSYMCRNGSTAERSLGHRGWGLPKAQSGSILSVHSQPADTSCILQLPKDVHYLLQ
                     PHGAPTWGAIPKLPPPGRSPLAQRPLRRQAAIRTDSLDVQGLGSREDLLSEVSGPSCP
                     LTRSSSFWGGSSIQVQQRSGIQSKVSKHIRLPAPCPGLEPSWAKDPPETRSSLELDTE
                     LSWISGDLLPSSQEEPLSPRDLKKCYSVETQSCRRRPGSWLDEQRRHSIAVSCLDSGS
                     QPRLCPSPSSLGGQPLGGPGSRPKKKLSPPSISIDPPESQGSRPPCSPGVCLRRRAPA
                     SDSKDPSVSSPLDSTAASPSPKKDTLSLSGLSSDPTDMDP"
     exon            728..839
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            840..973
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1071
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1231
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1532
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1625
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..2409
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2789
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2941
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3127
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3242
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3398
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3399..3467
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3552
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3749
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..4181
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4282
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4406
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4407..4475
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4476..4660
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4661..4787
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4788..4913
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            4914..5003
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5004..5196
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5250
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5251..5402
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5403..5512
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5513..5646
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5647..5717
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5718..5796
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5918
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            5919..6272
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            6273..6450
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            6451..6620
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
     exon            6621..8084
                     /gene="Cacna1g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtctctgg cgcggagccg ggacgatgct gaccccttag atcctgctcc agctgcgccg
       61 agggaagagg gggcgcccct ccccggaccc ccgccctcca tcgggtggcc cctttttttt
      121 ctcttcctct cgggggctgc ttcgccgaag gtagcgcctg ttcgggcaac cggagcctgg
      181 gcgcgaagcg aagaagccgg aacaaagtga ggggaagccg gccggctagt cggggagccc
      241 ccgggaaccc aggggaagcg ggactctagc caggcggggc ttccctgaga cccggcgccc
      301 cgcgggcagc atgcccctga gggcaggggg agctgagctg aactggccct cctggggact
      361 cagcaagctc tctagagccc cccacatgct cccccaccgg ggtcccccgg ttgcgtgagg
      421 acacctcctc tgaggggctc cgctcgcccc tcttcggacc ccccggggcc ccggctggcc
      481 agaggatgga cgaggaggag gatggagcgg gcgccgagga gtcgggacag ccccgtagct
      541 tcacgcagct caacgacctg tccggggccg ggggccggca ggggccgggg tcgacggaaa
      601 aggacccggg cagcgcggac tccgaggcgg aggggctgcc gtacccggcg ctagccccgg
      661 tggttttctt ctacttgagc caggacagcc gcccgcggag ctggtgtctc cgcacggtct
      721 gtaacccgtg gttcgagcga gtcagtatgc tggtcattct tctcaactgt gtgactctgg
      781 gtatgttcag gccgtgtgag gacattgcct gtgactccca gcgctgccgg atcctgcagg
      841 ccttcgatga cttcatcttt gccttctttg ctgtggaaat ggtggtgaag atggtggcct
      901 tgggcatctt tgggaagaaa tgttacctgg gagacacttg gaaccggctt gactttttca
      961 ttgtcattgc agggatgctg gagtattcgc tggacctgca gaacgtcagc ttctccgcag
     1021 tcaggacagt ccgtgtgctg cgaccgctca gggccattaa ccgggtgccc agcatgcgca
     1081 ttctcgtcac attactgctg gacaccttgc ctatgctggg caacgtcctg ctgctctgtt
     1141 tcttcgtctt tttcatcttt ggcatcgtgg gcgtccagct gtgggcagga ctgcttcgca
     1201 accgatgctt cctccccgag aacttcagcc tccccctgag cgtggacctg gagccttatt
     1261 accagacaga gaatgaggac gagagcccct tcatctgctc tcagcctcgg gagaatggca
     1321 tgagatcctg caggagtgtg cccacactgc gtggggaagg cggtggtggc ccaccctgca
     1381 gtctggacta tgagacctat aacagttcca gcaacaccac ctgtgtcaac tggaaccagt
     1441 actataccaa ctgctctgcg ggcgagcaca accccttcaa aggcgccatc aactttgaca
     1501 acattggcta tgcctggatc gccatcttcc aggtcatcac actggagggc tgggtcgaca
     1561 tcatgtactt cgtaatggac gctcactcct tctacaactt catctacttc attcttctca
     1621 tcatcgtggg ctccttcttc atgatcaacc tgtgcctggt ggtgattgcc acgcagttct
     1681 ccgagaccaa acagcgggag agtcagctga tgcgggagca gcgtgtacga ttcctgtcca
     1741 atgctagcac cctggcaagc ttctctgagc caggcagctg ctatgaggag ctactcaagt
     1801 acctggtgta catcctccga aaagcagccc gaaggctggc ccaggtctct agggctatag
     1861 gcgtgcgggc tgggctgctc agcagcccag tggcccgtag tgggcaggag ccccagccca
     1921 gtggcagctg cactcgctca caccgtcgtc tgtctgtcca ccacctggtc caccaccatc
     1981 accaccacca tcaccactac cacctgggta atgggacgct cagagttccc cgggccagcc
     2041 cagagatcca ggacagggat gccaatgggt ctcgccggct catgctacca ccaccctcta
     2101 cacccactcc ctctgggggc cctccgaggg gtgcggagtc tgtacacagc ttctaccatg
     2161 ctgactgcca cttggagcca gtccgttgcc aggcaccccc tcccagatgc ccatcggagg
     2221 catctggtag gactgtgggt agtgggaagg tgtaccccac tgtgcatacc agccctccac
     2281 cagagatact gaaggataaa gcactagtgg aggtggcccc cagccctggg ccccccaccc
     2341 tcaccagctt caacatccca cctgggccct tcagctccat gcacaagctc ctggagacac
     2401 agagtacggg agcctgccat agctcctgca aaatctccag cccttgctcc aaggcagaca
     2461 gtggagcctg cgggccggac agttgtccct actgtgcccg gacaggagca ggagagccag
     2521 agtccgctga ccatgtcatg cctgactcag acagcgaggc tgtgtatgag ttcacacagg
     2581 acgctcagca cagtgacctc cgggatcccc acagccggcg gcgacagcgg agcctgggcc
     2641 cagatgcaga gcctagttct gtgctggctt tctggaggct gatctgtgac acattccgga
     2701 agatcgtaga tagcaaatac tttggccggg gaatcatgat cgccatcctg gtcaatacac
     2761 tcagcatggg catcgagtac cacgagcagc ccgaggagct caccaacgcc ctggaaatca
     2821 gcaacatcgt cttcaccagc ctcttcgcct tggagatgct gctgaaactg cttgtctacg
     2881 gtccctttgg ctacattaag aatccctaca acatctttga tggtgtcatt gtggtcatca
     2941 gtgtgtggga gattgtgggc cagcagggag gtggcctgtc ggtgctgcgg accttccgcc
     3001 tgatgcgggt gctgaagctg gtgcgcttcc tgccggccct gcagcgccag ctcgtggtgc
     3061 tcatgaagac catggacaac gtggccacct tctgcatgct cctcatgctg ttcatcttca
     3121 tcttcagcat cctgggcatg catctctttg gttgcaagtt cgcatctgaa cgggatgggg
     3181 acacgttgcc agaccggaag aatttcgact ccctgctctg ggccatcgtc actgtctttc
     3241 agattctgac tcaggaagac tggaataaag tcctctacaa cggcatggcc tccacatcgt
     3301 cttgggctgc tctttacttc atcgccctca tgacttttgg caactatgtg ctctttaacc
     3361 tgctggtggc cattcttgtg gaaggcttcc aggcagagga aatcggcaaa cgggaagatg
     3421 cgagtggaca gttaagctgt attcagctgc ctgtcaactc tcagggggga gatgccacca
     3481 agtctgagtc agagcctgat ttcttttcgc ccagtgtgga tggtgatggg gacagaaaga
     3541 agcgcttggc cctggtggct ttgggagaac acgcggaact acgaaagagc cttttgccac
     3601 ccctcatcat ccatacggct gcgacaccaa tgtcactacc caagagctcc agcacaggtg
     3661 tgggggaagc actgggctct ggctctcgac gtaccagtag cagtgggtcc gctgagcctg
     3721 gagctgccca ccatgagatg aaatctccgc caagtgcccg cagctccccg cacagtccct
     3781 ggagtgcggc aagcagctgg accagcaggc gctccagcag gaacagcctg ggccgggccc
     3841 ccagcctaaa gcggaggagc ccgagcgggg agcggaggtc cctgctgtct ggagagggcc
     3901 aggagagtca ggatgaggag gaaagttcag aagaggaccg ggccagccca gcaggcagtg
     3961 accatcgcca caggggttcc ttggaacgtg aggccaagag ttcctttgac ctgcctgaca
     4021 ctctgcaggt gccggggctg caccgcacag ccagcggccg gagctctgcc tctgagcacc
     4081 aagactgtaa tggcaagtcg gcttcagggc gtttggcccg caccctgagg actgatgacc
     4141 cccaactgga tggggatgat gacaatgatg agggaaatct gagcaaaggg gaacgcatac
     4201 aagcctgggt cagatcccgg cttcctgcct gttgccgaga gcgagattcc tggtcggcct
     4261 atatctttcc tcctcagtca aggtttcgtc tcctgtgtca ccggatcatc acccacaaga
     4321 tgtttgacca tgtggtcctc gtcatcatct tcctcaactg tatcaccatc gctatggagc
     4381 gccccaaaat tgacccccac agcgctgagc gcatcttcct gaccctctcc aactacatct
     4441 tcacggcagt ctttctagct gaaatgacag tgaaggtggt ggcactgggc tggtgctttg
     4501 gggagcaggc ctacctgcgc agcagctgga atgtgctgga cggcttgctg gtgctcatct
     4561 ccgtcatcga catcctggtc tccatggtct ccgacagcgg caccaagatc cttggcatgc
     4621 tgagggtgct gcggctgctg cggaccctgc gtccactcag ggtcatcagc cgggcccagg
     4681 gactgaagct ggtggtagag actctgatgt catccctcaa acccattggc aacattgtgg
     4741 tcatttgctg tgccttcttc atcatttttg gaattctcgg ggtgcagctc ttcaaaggga
     4801 agttcttcgt gtgtcagggt gaggacacca ggaacatcac taacaaatcc gactgcgctg
     4861 aggccagcta ccgatgggtc cggcacaagt acaactttga caacctgggc caggctctga
     4921 tgtccctgtt tgtgctggcc tccaaggatg gttgggttga catcatgtat gatgggctgg
     4981 atgctgtggg tgtggatcag cagcccatca tgaaccacaa cccctggatg ctgctatact
     5041 tcatctcctt cctcctcatc gtggccttct ttgtcctgaa catgtttgtg ggcgtggtgg
     5101 tggagaactt ccataagtgc agacagcacc aggaggagga ggaggcgagg cggcgtgagg
     5161 agaagcgact acggaggctg gagaaaaaga gaaggaatct aatgttggac gatgtaattg
     5221 cttccggcag ctcagccagc gctgcgtcag aagcccagtg caagccctac tactctgact
     5281 actcgagatt ccggctcctt gtccaccacc tgtgtaccag ccactacctg gacctcttca
     5341 tcactggtgt catcgggctg aacgtggtca ctatggccat ggaacattac cagcagcccc
     5401 agatcctgga cgaggctctg aagatctgca attacatctt taccgtcatc tttgtctttg
     5461 agtcagtttt caaacttgtg gcctttggct tccgccgttt cttccaggac aggtggaacc
     5521 agctggacct ggctattgtg cttctgtcca tcatgggcat cacactggag gagattgagg
     5581 tcaatgcttc gctgcccatc aaccccacca tcatccgtat catgagggtg ctccgcattg
     5641 ctcgagttct gaagctgttg aagatggctg tgggcatgcg ggcactgctg gacacggtga
     5701 tgcaggccct gccccaggtg gggaacctgg gacttctctt catgttattg tttttcatct
     5761 ttgcagctct gggcgtggag ctctttggag acctggagtg tgatgagaca cacccttgtg
     5821 agggcttggg tcggcatgcc acctttagga actttggtat ggcctttctg accctcttcc
     5881 gagtctccac tggtgacaac tggaatggta ttatgaagga caccctccgg gactgtgacc
     5941 aggagtccac ctgctacaac actgtcatct cccctatcta ctttgtgtcc ttcgtgctga
     6001 cggcccagtt tgtgctggtc aacgtggtca tagctgtgct gatgaagcac ctggaagaaa
     6061 gcaacaaaga ggccaaggag gaggccgagc tcgaggccga gctggagctg gagatgaaga
     6121 cgctcagccc gcagccccac tccccgctgg gcagcccctt cctctggccc ggggtggagg
     6181 gtgtcaacag tcctgacagc cctaagcctg gggctccaca caccactgcc cacattggag
     6241 cagcctcggg cttctccctt gagcacccca cgatggtacc ccaccccgag gaggtgccag
     6301 tccccctagg accagacctg ctgactgtga ggaagtctgg tgtcagccgg acgcactctc
     6361 tgcccaatga cagctacatg tgccgcaatg ggagcactgc tgagagatcc ctaggacaca
     6421 ggggctgggg gctccccaaa gcccagtcag gctccatctt gtccgttcac tcccaaccag
     6481 cagacaccag ctgcatccta cagcttccca aagatgtgca ctatctgctc cagcctcatg
     6541 gggcccccac ctggggcgcc atccctaaac tacccccacc tggccgctcc cctctggctc
     6601 agaggcctct caggcgccag gcagcaataa ggactgactc cctggatgtg cagggcctgg
     6661 gtagccggga agacctgttg tcagaggtga gtgggccctc ctgccctctg acccggtcct
     6721 catccttctg gggcgggtcg agcatccagg tgcagcagcg ttccggcatc cagagcaaag
     6781 tctccaagca catccgcctg ccagcccctt gcccaggcct ggaacccagc tgggccaagg
     6841 accctccaga gaccagaagc agcttagagc tggacacgga gctgagctgg atttcaggag
     6901 acctccttcc cagcagccag gaagaacccc tgtccccacg ggacctgaag aagtgctaca
     6961 gtgtagagac ccagagctgc aggcgcaggc ctgggtcctg gctagatgaa cagcggagac
     7021 actccattgc tgtcagctgt ctggacagcg gctcccaacc ccgcctatgt ccaagcccct
     7081 caagcctcgg gggccaacct cttgggggtc ctgggagccg gcctaagaaa aaactcagcc
     7141 cacccagtat ctctatagac cccccggaga gccagggctc tcggccccca tgcagtcctg
     7201 gtgtctgcct caggaggagg gcgccggcca gtgactctaa ggatccctcg gtctccagcc
     7261 cccttgacag cacggctgcc tcaccctccc caaagaaaga cacgctgagt ctctctggtt
     7321 tgtcttctga cccaacagac atggacccct gagtcctacc cactctcccc catcaccttt
     7381 ctccaccggg tgcagatcct agctccgcct cctgggcagc gtttctgaaa agtcccacgt
     7441 aagcagcaag cagccacgag gcacctcacc tgccttcttc agtggctggt ggggatgacg
     7501 agcagaactt ccggagagtc gatctgaaga gaacacagcc ctggagcccc tgcctccggg
     7561 aagaaggaaa aggagaaagc ccagtgtggc caaggctccc gacaccagga gctgttggga
     7621 gaaagcaata cgtttgtgca gaatctctat gtatattcta ttttattaaa ttaattgaat
     7681 ctagtatatg ctggatgtac gacattttgt gactgaagag acttggttcc ttctactttt
     7741 atgtgtctca gaatattttt gaggcgaaag cgtctgtctc ttggctattt taacctaaaa
     7801 taaccagtct agttatattc cctcttcttg taaagcacaa gctgggagcg tgagtgtatt
     7861 acaacccaac ggcggcccat cttcagcagg aagcaagaac cattttggaa actgtcatgt
     7921 aacttacttt ctcctttaac ctcgtcatcg ttttctgtag ggggaaaaaa aacagagaaa
     7981 aagagaaaaa aatgagtttt acaaatgaaa tggaaccttt ttatatatac atacatacat
     8041 atctatatat ctatataaaa taaagtaatt ttccaaaata aaaa
//
