LOCUS       NM_019294               7367 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus calcium voltage-gated channel subunit alpha1 E
            (Cacna1e), mRNA.
ACCESSION   NM_019294 XM_213918
VERSION     NM_019294.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7367)
  AUTHORS   Helbig,K.L., Lauerer,R.J., Bahr,J.C., Souza,I.A., Myers,C.T.,
            Uysal,B., Schwarz,N., Gandini,M.A., Huang,S., Keren,B., Mignot,C.,
            Afenjar,A., Billette de Villemeur,T., Heron,D., Nava,C.,
            Valence,S., Buratti,J., Fagerberg,C.R., Soerensen,K.P., Kibaek,M.,
            Kamsteeg,E.J., Koolen,D.A., Gunning,B., Schelhaas,H.J., Kruer,M.C.,
            Fox,J., Bakhtiari,S., Jarrar,R., Padilla-Lopez,S., Lindstrom,K.,
            Jin,S.C., Zeng,X., Bilguvar,K., Papavasileiou,A., Xing,Q., Zhu,C.,
            Boysen,K., Vairo,F., Lanpher,B.C., Klee,E.W., Tillema,J.M.,
            Payne,E.T., Cousin,M.A., Kruisselbrink,T.M., Wick,M.J., Baker,J.,
            Haan,E., Smith,N., Sadeghpour,A., Davis,E.E., Katsanis,N.,
            Corbett,M.A., MacLennan,A.H., Gecz,J., Biskup,S., Goldmann,E.,
            Rodan,L.H., Kichula,E., Segal,E., Jackson,K.E., Asamoah,A.,
            Dimmock,D., McCarrier,J., Botto,L.D., Filloux,F., Tvrdik,T.,
            Cascino,G.D., Klingerman,S., Neumann,C., Wang,R., Jacobsen,J.C.,
            Nolan,M.A., Snell,R.G., Lehnert,K., Sadleir,L.G., Anderlid,B.M.,
            Kvarnung,M., Guerrini,R., Friez,M.J., Lyons,M.J., Leonhard,J.,
            Kringlen,G., Casas,K., El Achkar,C.M., Smith,L.A., Rotenberg,A.,
            Poduri,A., Sanchis-Juan,A., Carss,K.J., Rankin,J., Zeman,A.,
            Raymond,F.L., Blyth,M., Kerr,B., Ruiz,K., Urquhart,J., Hughes,I.,
            Banka,S., Hedrich,U.B.S., Scheffer,I.E., Helbig,I., Zamponi,G.W.,
            Lerche,H. and Mefford,H.C.
  CONSRTM   Task Force for Neonatal Genomics; Deciphering Developmental
            Disorders Study
  TITLE     De Novo Pathogenic Variants in CACNA1E Cause Developmental and
            Epileptic Encephalopathy with Contractures, Macrocephaly, and
            Dyskinesias
  JOURNAL   Am J Hum Genet 103 (5), 666-678 (2018)
   PUBMED   30343943
  REMARK    Erratum:[Am J Hum Genet. 2019 Mar 7;104(3):562. doi:
            10.1016/j.ajhg.2019.02.015.. PMID: 30849329]
REFERENCE   2  (bases 1 to 7367)
  AUTHORS   Qian,A., Song,D., Li,Y., Liu,X., Tang,D., Yao,W. and Yuan,Y.
  TITLE     Role of voltage gated Ca2+ channels in rat visceral
            hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic
            acid
  JOURNAL   Mol Pain 9, 15 (2013)
   PUBMED   23537331
  REMARK    GeneRIF: Cav1.2 and Cav2.3 in colonic primary sensory neurons play
            an important role in visceral inflammatory hyperalgesia, which
            maybe the potential therapeutic targets.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7367)
  AUTHORS   Parajuli,L.K., Nakajima,C., Kulik,A., Matsui,K., Schneider,T.,
            Shigemoto,R. and Fukazawa,Y.
  TITLE     Quantitative regional and ultrastructural localization of the
            Ca(v)2.3 subunit of R-type calcium channel in mouse brain
  JOURNAL   J Neurosci 32 (39), 13555-13567 (2012)
   PUBMED   23015445
REFERENCE   4  (bases 1 to 7367)
  AUTHORS   Shakeri,B., Bourdin,B., Demers-Giroux,P.O., Sauve,R. and Parent,L.
  TITLE     A quartet of leucine residues in the guanylate kinase domain of
            CaVbeta determines the plasma membrane density of the CaV2.3
            channel
  JOURNAL   J Biol Chem 287 (39), 32835-32847 (2012)
   PUBMED   22846999
  REMARK    GeneRIF: quartet of leucine residues in the guanylate kinase domain
            of CaVbeta determines the plasma membrane density of the CaV2.3
            channel.
REFERENCE   5  (bases 1 to 7367)
  AUTHORS   Catterall,W.A.
  TITLE     Voltage-gated calcium channels
  JOURNAL   Cold Spring Harb Perspect Biol 3 (8), a003947 (2011)
   PUBMED   21746798
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7367)
  AUTHORS   Lin,Z., Lin,Y., Schorge,S., Pan,J.Q., Beierlein,M. and Lipscombe,D.
  TITLE     Alternative splicing of a short cassette exon in alpha1B generates
            functionally distinct N-type calcium channels in central and
            peripheral neurons
  JOURNAL   J Neurosci 19 (13), 5322-5331 (1999)
   PUBMED   10377343
REFERENCE   7  (bases 1 to 7367)
  AUTHORS   Kamphuis,W. and Hendriksen,H.
  TITLE     Expression patterns of voltage-dependent calcium channel alpha 1
            subunits (alpha 1A-alpha 1E) mRNA in rat retina
  JOURNAL   Brain Res Mol Brain Res 55 (2), 209-220 (1998)
   PUBMED   9582423
REFERENCE   8  (bases 1 to 7367)
  AUTHORS   Piedras-Renteria,E.S., Chen,C.C. and Best,P.M.
  TITLE     Antisense oligonucleotides against rat brain alpha1E DNA and its
            atrial homologue decrease T-type calcium current in atrial myocytes
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14936-14941 (1997)
   PUBMED   9405717
REFERENCE   9  (bases 1 to 7367)
  AUTHORS   Williams,M.E., Marubio,L.M., Deal,C.R., Hans,M., Brust,P.F.,
            Philipson,L.H., Miller,R.J., Johnson,E.C., Harpold,M.M. and
            Ellis,S.B.
  TITLE     Structure and functional characterization of neuronal alpha 1E
            calcium channel subtypes
  JOURNAL   J Biol Chem 269 (35), 22347-22357 (1994)
   PUBMED   8071363
REFERENCE   10 (bases 1 to 7367)
  AUTHORS   Soong,T.W., Stea,A., Hodson,C.D., Dubel,S.J., Vincent,S.R. and
            Snutch,T.P.
  TITLE     Structure and functional expression of a member of the low
            voltage-activated calcium channel family
  JOURNAL   Science 260 (5111), 1133-1136 (1993)
   PUBMED   8388125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 20, 2020 this sequence version replaced NM_019294.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               JAXUCZ010000013.1  69444535-69444810   c
            277-382             JAXUCZ010000013.1  69419769-69419874   c
            383-522             JAXUCZ010000013.1  69418869-69419008   c
            523-626             JAXUCZ010000013.1  69360563-69360666   c
            627-779             JAXUCZ010000013.1  69359604-69359756   c
            780-961             JAXUCZ010000013.1  69358431-69358612   c
            962-1065            JAXUCZ010000013.1  69288981-69289084   c
            1066-1181           JAXUCZ010000013.1  69224155-69224270   c
            1182-1235           JAXUCZ010000013.1  69219878-69219931   c
            1236-1325           JAXUCZ010000013.1  69219139-69219228   c
            1326-1535           JAXUCZ010000013.1  69217624-69217833   c
            1536-1648           JAXUCZ010000013.1  69216820-69216932   c
            1649-1761           JAXUCZ010000013.1  69214722-69214834   c
            1762-1893           JAXUCZ010000013.1  69214326-69214457   c
            1894-1966           JAXUCZ010000013.1  69213800-69213872   c
            1967-2084           JAXUCZ010000013.1  69212785-69212902   c
            2085-2152           JAXUCZ010000013.1  69210530-69210597   c
            2153-2250           JAXUCZ010000013.1  69209019-69209116   c
            2251-2904           JAXUCZ010000013.1  69202993-69203646   c
            2905-3218           JAXUCZ010000013.1  69202248-69202561   c
            3219-3378           JAXUCZ010000013.1  69199915-69200074   c
            3379-3508           JAXUCZ010000013.1  69198669-69198798   c
            3509-3568           JAXUCZ010000013.1  69197941-69198000   c
            3569-3675           JAXUCZ010000013.1  69196687-69196793   c
            3676-3687           JAXUCZ010000013.1  69185285-69185296   c
            3688-3784           JAXUCZ010000013.1  69183274-69183370   c
            3785-3945           JAXUCZ010000013.1  69180173-69180333   c
            3946-4083           JAXUCZ010000013.1  69179501-69179638   c
            4084-4285           JAXUCZ010000013.1  69178555-69178756   c
            4286-4450           JAXUCZ010000013.1  69176633-69176797   c
            4451-4561           JAXUCZ010000013.1  69176001-69176111   c
            4562-4645           JAXUCZ010000013.1  69171314-69171397   c
            4646-4771           JAXUCZ010000013.1  69170469-69170594   c
            4772-4837           JAXUCZ010000013.1  69166472-69166537   c
            4838-4929           JAXUCZ010000013.1  69161278-69161369   c
            4930-5095           JAXUCZ010000013.1  69160650-69160815   c
            5096-5223           JAXUCZ010000013.1  69153902-69154029   c
            5224-5320           JAXUCZ010000013.1  69149015-69149111   c
            5321-5426           JAXUCZ010000013.1  69147002-69147107   c
            5427-5534           JAXUCZ010000013.1  69146069-69146176   c
            5535-5635           JAXUCZ010000013.1  69145437-69145537   c
            5636-5742           JAXUCZ010000013.1  69145065-69145171   c
            5743-5854           JAXUCZ010000013.1  69140742-69140853   c
            5855-5983           JAXUCZ010000013.1  69138006-69138134   c
            5984-6164           JAXUCZ010000013.1  69136802-69136982   c
            6165-6355           JAXUCZ010000013.1  69135172-69135362   c
            6356-7367           JAXUCZ010000013.1  69132305-69133316   c
FEATURES             Location/Qualifiers
     source          1..7367
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..7367
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /note="calcium voltage-gated channel subunit alpha1 E"
                     /db_xref="GeneID:54234"
                     /db_xref="RGD:2246"
     exon            1..276
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..6898
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /note="voltage-dependent calcium channel alpha1-E subunit;
                     voltage gated calcium channel alpha1E subunit; BII; RBE2;
                     RBE-II; brain calcium channel II; voltage-gated calcium
                     channel subunit alpha Cav2.3; calcium channel, L type,
                     alpha-1 polypeptide; calcium channel, voltage-dependent, L
                     type, alpha 1E subunit; calcium channel,
                     voltage-dependent, R type, alpha 1E subunit"
                     /codon_start=1
                     /product="voltage-dependent R-type calcium channel subunit
                     alpha-1E"
                     /protein_id="NP_062167.3"
                     /db_xref="GeneID:54234"
                     /db_xref="RGD:2246"
                     /translation="MARFGEAVVVGRPGSGDGDSDQSRNRQGTPVPASGPAAAYKQSK
                     AQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIA
                     NCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNG
                     WNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKA
                     MVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPA
                     GYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIP
                     LIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAE
                     EVMLAEENKNSGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKS
                     TKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTACVAIVHHNQPQWLTHL
                     LYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS
                     FGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ
                     LFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAI
                     YFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMS
                     APNMPSIERERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLNPLSP
                     LNPLNAHPSLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSVLDNQRSPL
                     SLGKREPPWLPRSCHGNCDPTQQETGGGETVVTFEDRARHRQSQRRSRHRRVRTEGKE
                     SASASRSRSASQERSLDEGVSIDGEKEHEPQSSHRSKEPTIHEEERTQDLRRTNSLMV
                     PRGSGLVGALDEAETPLVQPQPELEVGKDAALTEQEAEGSSEQALLADVQLDVGRGIS
                     QSEPDLSCMTTNMDKATTESTSVTVAIPDMDPLVDSTVVNISNKTDGEASPLKEAETK
                     EEEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRKACHYIVNLRYFEMCILLVI
                     AASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDL
                     WNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVF
                     DCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHE
                     KNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSN
                     RMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISA
                     KPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPWTYELALK
                     YLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSG
                     FNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ
                     VFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAP
                     SGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDE
                     FVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDM
                     TVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPK
                     ASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIISNAKA
                     LPYLQQDPVSGLSGRSGYPSMSPLSPQEIFQLACMDPADDGQFQEQQSLEPEVSELKS
                     VQSSNHGIYLPPDTQEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRSNSSW
                     LEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKH
                     LLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSISDT
                     STPRRSRRQLPPVPPKPRPLLSYSSLMRHTGGISPPPDGSEGGSPLASQALESNSACL
                     TESSNSLHPQQGQHPSPQHYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNT
                     IGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVSDLLSDTEEDDKC"
     exon            277..382
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            383..522
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..626
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..779
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..961
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1065
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1181
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1235
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1325
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1535
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1648
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1761
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1893
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1966
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2084
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2152
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2250
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2904
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3218
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3378
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3508
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3568
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3675
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3676..3687
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3784
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3945
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4083
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4285
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4286..4450
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4561
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4562..4645
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4646..4771
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4772..4837
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4838..4929
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            4930..5095
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5096..5223
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5224..5320
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5321..5426
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5427..5534
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5535..5635
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5636..5742
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5743..5854
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5855..5983
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            5984..6164
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            6165..6355
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            6356..7367
                     /gene="Cacna1e"
                     /gene_synonym="CACHA1E; Cav2.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcaggatg gctcgcttcg gggaggcggt ggtcgttggc agaccaggct caggcgatgg
       61 agactcggac cagagcagga accgacaagg aacccccgta ccggcctcgg ggccggcggc
      121 cgcctacaag cagtcaaaag cgcagagggc gcggactatg gctttgtaca accccatacc
      181 agtccggcag aactgtttca cggtcaacag atccctgttc atcttcggag aagataacat
      241 tgtcaggaaa tatgccaaga agctcatcga ttggccgcca tttgagtaca tgatcctggc
      301 caccatcatt gccaactgca tcgtcttggc cctggagcag catcttcctg aggatgacaa
      361 gaccccaatg tcccgaagac tggagaagac agaaccatat tttattggaa tcttctgctt
      421 tgaagctggg atcaaaatcg tggctctagg attcatcttc cataagggtt cgtacctccg
      481 taacggctgg aatgtcatgg acttcattgt ggtcctcagt ggcatcctgg ccactgcagg
      541 aacccatttc aacacccacg tggacctgcg gaccctccgg gctgtgcgtg tcctgaggcc
      601 cttaaagctc gtgtcaggaa tacctagcct gcagatcgtg ctgaagtcca tcatgaaggc
      661 catggtgcct cttctgcaga ttggccttct gctcttcttt gccattctca tgtttgccat
      721 cattggcttg gagttctaca gtggcaagtt gcatcgagca tgcttcatga acaattcagg
      781 tattctagag ggatttgatc ctcctcaccc gtgtggtgta cagggctgcc cggctggtta
      841 tgaatgtaag gactggatcg gccccaatga cgggatcacc cagtttgaca acatcctttt
      901 tgctgtgctg actgtcttcc aatgcatcac tatggaaggg tggaccactg tgctgtacaa
      961 taccaatgat gccttaggag ccacctggaa ctggctgtac ttcatccccc tcatcatcat
     1021 cggatccttc tttgttctca accttgtcct gggcgtgctt tccggggaat ttgccaaaga
     1081 aagagagaga gtggagaacc gaagagcatt catgaagctc cggcgtcagc aacagattga
     1141 gcgcgagttg aatggctacc gcgcctggat agacaaagca gaggaagtca tgcttgctga
     1201 agaaaataaa aactcgggaa catcagcctt ggaagtgctt cgaagggcaa ccatcaaaag
     1261 gagccggacg gaggccatga cccgagactc cagcgatgag cactgcgttg atatctcttc
     1321 agtgggcaca cctcttgcca gagccagtat caagagcaca aaagtagatg gagcctccta
     1381 tttccggcac aaggaacggc ttctgcgtat ctctatccga cacatggtca agtcgcaagt
     1441 gttctactgg atcgtcctga gtgttgtggc tctcaatact gcctgtgtgg ccatcgttca
     1501 tcacaaccag ccacagtggc tcactcacct cctctactat gcagaatttt tgtttctggg
     1561 actcttcctg ttggagatgt ccctgaagat gtatggcatg gggccacgcc tttattttca
     1621 ctcatccttc aactgctttg attttggggt cacagtgggc agcatctttg aggtcgtttg
     1681 ggcaatcttc cgacctggca catcttttgg aatcagtgtc ttacgagctc tccggctcct
     1741 aaggatattt aaaataacca agtattgggc atccctccgg aatctggttg tttccttgat
     1801 gagctccatg aagtctatca tcagcttact cttcctcctc ttcctcttca ttgttgtctt
     1861 tgctctcctg ggaatgcagc tctttggagg caggtttaac tttaatgatg ggactccttc
     1921 ggctaatttt gataccttcc ctgcagctat catgacagtg ttccagatcc tgacggggga
     1981 agactggaat gaagtgatgt ataacggcat ccgctcccag ggtggggtga gctcaggcat
     2041 gtggtctgcc atctacttca ttgtgctcac cttgtttgga aactacacac tgctgaatgt
     2101 attcttggct atcgctgtgg acaatctcgc caatgcccag gaactgacca aggatgagca
     2161 ggaggaagaa gaagccttca accagaaaca tgcactgcag aaggccaagg aggtcagccc
     2221 gatgtctgct cccaacatgc cttccattga gagggagagg agacgccgac accacatgtc
     2281 tgtgtgggaa cagcgcacca gccagctgag gaggcacatg caaatgtcta gccaagaagc
     2341 cctcaacaaa gaggaggccc caccaatgaa ccccctcaat ccactcaacc cactgagtcc
     2401 tctcaaccca ctcaatgctc atcctagcct ctatcggagg cccaggccca ttgagggcct
     2461 agccctgggc ttgggtcttg aaaaatgtga agaggagcgt atcagccgtg gaggttctct
     2521 caagggggac ataggtggcc tgactagcgt cctggacaac cagaggagcc ctttgtccct
     2581 gggcaaacgg gagccaccgt ggctgcccag atcctgtcat ggaaactgtg acccaaccca
     2641 gcaggagact gggggaggag agactgtggt gacttttgag gaccgggcca ggcacaggca
     2701 gagtcagagg cgaagccggc atcgccgagt caggactgag ggcaaggagt ctgcctctgc
     2761 ctccagaagc aggtctgcca gccaggagcg gagtctggat gaaggggtgt ccatcgatgg
     2821 ggagaaggaa cacgagcctc agagcagcca caggagcaag gagccaacca tccatgaaga
     2881 agagagaact caggacttaa ggaggaccaa cagtctgatg gtccccaggg gctcaggact
     2941 ggtaggagct cttgatgagg cagaaacacc tctagtccag ccccaacctg agctggaagt
     3001 ggggaaggat gcagctctga cagagcagga ggctgaaggc agcagcgagc aagccctgct
     3061 tgcggatgta cagctggatg tgggccgggg cattagccag agtgaacctg acctctcctg
     3121 catgacaacc aacatggaca aggctaccac tgagagcacc agtgtcacag tcgccatccc
     3181 tgacatggac cccttggtgg actcaacagt ggtgaacatt agcaacaaga cggatggaga
     3241 agccagtccc ttgaaggaag cagagaccaa agaggaagag gaagaggtgg aaaagaagaa
     3301 gcagaagaag gagaagcggg agactggaaa agccatggtg ccccatagct ctatgttcat
     3361 cttcagcacc actaacccga tccgcaaggc ttgccactac attgtgaatc tacgctactt
     3421 tgagatgtgc attctcttgg tgattgcggc cagcagcatt gccctggcag ctgaggaccc
     3481 tgtactaact aactcagagc gtaacaaagt cctgagatat ttcgactatg ttttcacagg
     3541 agtgtttacc tttgagatgg tgataaagat gatagaccaa ggcttgatcc tgcaggatgg
     3601 atcgtacttc cgagacctct ggaatatcct ggactttgtg gtagtggttg gtgcattggt
     3661 agcatttgct ctggcgaacg ctttgggaac caacaagggg cgggatatca agacgatcaa
     3721 gtctctgagg gtacttcgag ttctgcgacc actgaaaacc atcaagcgct tgcccaaact
     3781 gaaggctgtg tttgactgcg tggtgacctc cttgaagaat gtcttcaaca tactcattgt
     3841 ctacaagctc tttatgttca tctttgccgt cattgctgtt cagttattca agggaaagtt
     3901 cttttattgc accgacagtt ccaaggacac agagaaggaa tgcataggca actatgtaga
     3961 ccacgagaaa aacaagatgg aggtgaaggg ccgggagtgg aagcgtcatg aattccacta
     4021 tgacaacatc atctgggccc tgctgaccct cttcaccgtc tccacggggg aaggatggcc
     4081 tcaggttctg cagcactcgg tagatgtgac agaggaggac agaggcccaa gccgcagcaa
     4141 ccgcatggag atgtccatct tctatgtggt ctactttgtg gtcttccctt tcttctttgt
     4201 caatatcttc gtggccctca ttatcatcac cttccaggag caaggggaca agatgatgga
     4261 ggagtgtagc ctagaaaaga atgagcgggc atgcatcgac ttcgccatta gtgccaaacc
     4321 tctcacccgc tacatgccac aaaacaggca caccttccag taccgcgtgt ggcacttcgt
     4381 agtctcgcca tcctttgagt ataccatcat ggccatgatt gccttgaaca ccgttgtgct
     4441 gatgatgaag tactattctg ctccttggac ctatgagctc gccctaaagt acctgaacat
     4501 cgccttcact atggtgtttt ccctagaatg tgtcctaaag gtcatcgctt tcggcttctt
     4561 gaactatttc cgagatacct ggaacatctt tgacttcatt accgtgatcg gcagtatcac
     4621 agaaattatc ctgacagaca gcaagctggt gaacaccagt ggcttcaata tgagctttct
     4681 gaagctcttc cgagctgcac ggctcataaa gcttctgcga cagggctaca ccatccgcat
     4741 cttactgtgg accttcgtgc agtcctttaa ggctctcccc tatgtctgcc ttctgattgc
     4801 catgcttttc ttcatctacg ctatcattgg gatgcaggtg tttggaaaca taaagttaga
     4861 tgaggagagt catatcaacc ggcacaacaa ctttcggagt ttcttcgggt ctctcatgct
     4921 gcttttcagg agcgccacag gggaggcttg gcaggagatt atgttgtcat gtctgggcga
     4981 gaagggctgt gagcctgaca ccactgcacc ctcagggcag aacgagagtg agcgctgtgg
     5041 cactgacctg gcctacgttt attttgtctc cttcatcttc ttctgctcct tcctgatgct
     5101 caacctgttt gtggctgtta tcatggacaa ctttgagtac ctgactcgag attcgtccat
     5161 cctggggcct caccacttgg atgaatttgt ccgtgtctgg gcagagtatg acagagcagc
     5221 atgtggccgc atccattaca ctgagatgta tgaaatgctg actctcatgt caccaccgct
     5281 aggcctcggc aagagatgtc cctccaaagt ggcctataag aggttggtcc tgatgaatat
     5341 gccagtggct gaggacatga cagtccattt cacctccaca cttatggctc tgatccggac
     5401 agctctggac attaaaatcg ccaaaggtgg tgcagacaga cagcagctag actcagagct
     5461 acaaaaagag accctggcca tttggcctca cctgtcccaa aagatgttgg atctgctagt
     5521 gcccatgccc aaagcctctg acctgactgt gggcaagatc tatgcagcaa tgatgattat
     5581 ggactactat aaacagagta aggtaaagaa acagagacag cagctggaag aacagaaaaa
     5641 tgcacccatg ttccagcgca tggagccctc ctcactgcct caggagatca tttctaatgc
     5701 caaagccctg ccttatctcc agcaggaccc tgtttctggc ctgagtggtc ggagtggata
     5761 cccttcaatg agtccactct cccctcaaga aatattccag ttggcttgta tggacccagc
     5821 ggatgatgga caattccagg aacagcaatc gctggagcca gaggttagtg aattaaaaag
     5881 tgtgcagtcc tctaaccatg gcatctacct tcctccggac acccaggagc atgcgggatc
     5941 tgggagggca tcctctatgc cacgtctgac tatggatccc caggtggtaa cagaccctag
     6001 ctctatgcga cgttcatttt ctacaattcg ggataagcgt tcaaattcct cctggttgga
     6061 ggagttctcc atggaacgta gcagtgaaaa cacctacaag tcacgacgca gaagttacca
     6121 ttcctccctg aggctgtcag cccaccgcct gaattctgac tctggtcaca agtctgacac
     6181 tcaccgctca ggaggcaggg agagaggccg atccaaagaa cgaaagcatc tcctctctcc
     6241 ggatgtctcc cgctgcaatt ctgaggagcg aggaacccag gctgactggg agtccccaga
     6301 acgtcgccag tccaggtcac ccagtgaggg aaggtcacaa acccccaaca gacagggtac
     6361 aggttcactg agtgagagct ccattccctc tatctccgac accagcaccc caagacgaag
     6421 tcgtcgccag ctcccacctg tgccaccaaa gcctcggccc ctcctctcct acagctccct
     6481 gatgagacac actggcggca tctctccacc tcctgatgga agtgagggtg gatccccact
     6541 ggcctctcaa gctctggaaa gcaacagcgc ttgcctaacc gagtcttcca actccttgca
     6601 cccccagcag ggccagcacc cttccccaca gcactacatc tctgagccct atctggccct
     6661 ccatgaagac tcccacgcct cagactgtgg cgaggaggag acactcacct ttgaggcagc
     6721 cgtagctact agcttgggcc ggtccaatac cattggctct gccccacccc tacggcacag
     6781 ctggcagatg cctaatgggc actatcggcg gcggaggcgt ggggggcctg ggcctggcat
     6841 gatgtgtgga gctgtcagtg acctcctgag tgacacggaa gaagacgata agtgctagag
     6901 gctgccatcc cctccgatgc atgctcttct ctcacaggga gaaaaccaag accaaattgg
     6961 gaagccagtg cggcccgggg gggaggaaga gggagaagga agatggagaa aggacaggac
     7021 gccatgcatc ctcagaagag aggaagtaaa agacagatgg aaaaaccagt caaacccacc
     7081 aaattgcatc atttcccttt gcaagatggg cactgccata gtcctgcctc tttgctgggg
     7141 aaagaaaata caggaatgtg ggggtttatt cccatgggag aagggacatg aaggtggctt
     7201 gacttccgtt gccccttccc acttttcaat aagctgcaac aggatctggc tgacctgtgt
     7261 ctaagctcat tgccctgagc agctgggaag acttcccagc accttagtga gggaagagtt
     7321 gaaatagcag gagaagaatc tcctcaccag ctcttgcatt ttggctg
//
