LOCUS       NM_001389225            9072 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel subunit alpha1 D
            (Cacna1d), mRNA.
ACCESSION   NM_001389225 XM_017600063
VERSION     NM_001389225.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9072)
  AUTHORS   Wang,H., Zhu,J.K., Cheng,L., Mao,G., Chen,H., Wu,X., Hong,H.,
            Wang,C., Lin,P., Chen,J., Maboh,R.N. and Chen,H.
  TITLE     Dominant role of CACNA1D exon mutations for blood pressure
            regulation
  JOURNAL   J Hypertens 40 (4), 819-834 (2022)
   PUBMED   35142739
  REMARK    GeneRIF: Dominant role of CACNA1D exon mutations for blood pressure
            regulation.
REFERENCE   2  (bases 1 to 9072)
  AUTHORS   Jeong,S., Rhee,J.S. and Lee,J.H.
  TITLE     Snapin Specifically Up-Regulates Cav1.3 Ca2+ Channel Variant with a
            Long Carboxyl Terminus
  JOURNAL   Int J Mol Sci 22 (20), 11268 (2021)
   PUBMED   34681928
  REMARK    GeneRIF: Snapin Specifically Up-Regulates Cav1.3 Ca(2+) Channel
            Variant with a Long Carboxyl Terminus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9072)
  AUTHORS   Fan,P., Pu,D., Lv,X., Hu,N., Feng,X., Hao,Z., Sun,Y. and He,L.
  TITLE     Cav 1.3 damages the osteogenic differentiation in osteoporotic rats
            by negatively regulating Spred 2-mediated autophagy-induced cell
            senescence
  JOURNAL   J Cell Mol Med 24 (23), 13863-13875 (2020)
   PUBMED   33124763
  REMARK    GeneRIF: Cav 1.3 damages the osteogenic differentiation in
            osteoporotic rats by negatively regulating Spred 2-mediated
            autophagy-induced cell senescence.
REFERENCE   4  (bases 1 to 9072)
  AUTHORS   Loya-Lopez,S., Sandoval,A., Gonzalez-Ramirez,R.,
            Calderon-Rivera,A., Avalos-Fuentes,A., Rodriguez-Sanchez,M.,
            Caballero,R., Tovar-Soto,D., Felix,R. and Floran,B.
  TITLE     Cdk5 phosphorylates CaV1.3 channels and regulates GABAA-mediated
            miniature inhibitory post-synaptic currents in striato-nigral
            terminals
  JOURNAL   Biochem Biophys Res Commun 524 (1), 255-261 (2020)
   PUBMED   31983427
  REMARK    GeneRIF: Cdk5 phosphorylates CaV1.3 channels and regulates
            GABAA-mediated miniature inhibitory post-synaptic currents in
            striato-nigral terminals.
REFERENCE   5  (bases 1 to 9072)
  AUTHORS   Fedorenko,O.A., Pulbutr,P., Banke,E., Akaniro-Ejim,N.E.,
            Bentley,D.C., Olofsson,C.S., Chan,S. and Smith,P.A.
  TITLE     CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white
            fat adipocytes
  JOURNAL   J Endocrinol 244 (2), 369-381 (2020)
   PUBMED   31770099
  REMARK    GeneRIF: CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in
            rat white fat adipocytes.
REFERENCE   6  (bases 1 to 9072)
  AUTHORS   Yu,A.S., Hebert,S.C., Brenner,B.M. and Lytton,J.
  TITLE     Molecular characterization and nephron distribution of a family of
            transcripts encoding the pore-forming subunit of Ca2+ channels in
            the kidney
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10494-10498 (1992)
   PUBMED   1279681
REFERENCE   7  (bases 1 to 9072)
  AUTHORS   Dubel,S.J., Starr,T.V., Hell,J., Ahlijanian,M.K., Enyeart,J.J.,
            Catterall,W.A. and Snutch,T.P.
  TITLE     Molecular cloning of the alpha-1 subunit of an
            omega-conotoxin-sensitive calcium channel
  JOURNAL   Proc Natl Acad Sci U S A 89 (11), 5058-5062 (1992)
   PUBMED   1317580
REFERENCE   8  (bases 1 to 9072)
  AUTHORS   Williams,M.E., Feldman,D.H., McCue,A.F., Brenner,R., Velicelebi,G.,
            Ellis,S.B. and Harpold,M.M.
  TITLE     Structure and functional expression of alpha 1, alpha 2, and beta
            subunits of a novel human neuronal calcium channel subtype
  JOURNAL   Neuron 8 (1), 71-84 (1992)
   PUBMED   1309651
REFERENCE   9  (bases 1 to 9072)
  AUTHORS   Hui,A., Ellinor,P.T., Krizanova,O., Wang,J.J., Diebold,R.J. and
            Schwartz,A.
  TITLE     Molecular cloning of multiple subtypes of a novel rat brain isoform
            of the alpha 1 subunit of the voltage-dependent calcium channel
  JOURNAL   Neuron 7 (1), 35-44 (1991)
   PUBMED   1648940
REFERENCE   10 (bases 1 to 9072)
  AUTHORS   Snutch,T.P., Leonard,J.P., Gilbert,M.M., Lester,H.A. and
            Davidson,N.
  TITLE     Rat brain expresses a heterogeneous family of calcium channels
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3391-3395 (1990)
   PUBMED   1692134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001389225.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               JAXUCZ010000016.1  5527065-5527549     c
            486-795             JAXUCZ010000016.1  5524804-5525113     c
            796-901             JAXUCZ010000016.1  5520887-5520992     c
            902-1041            JAXUCZ010000016.1  5377442-5377581     c
            1042-1184           JAXUCZ010000016.1  5368338-5368480     c
            1185-1337           JAXUCZ010000016.1  5363922-5364074     c
            1338-1534           JAXUCZ010000016.1  5363327-5363523     c
            1535-1638           JAXUCZ010000016.1  5356672-5356775     c
            1639-1808           JAXUCZ010000016.1  5329150-5329319     c
            1809-1896           JAXUCZ010000016.1  5316497-5316584     c
            1897-1956           JAXUCZ010000016.1  5316177-5316236     c
            1957-1983           JAXUCZ010000016.1  5315147-5315173     c
            1984-2144           JAXUCZ010000016.1  5311616-5311776     c
            2145-2370           JAXUCZ010000016.1  5310118-5310343     c
            2371-2578           JAXUCZ010000016.1  5309827-5310034     c
            2579-2699           JAXUCZ010000016.1  5306031-5306151     c
            2700-2814           JAXUCZ010000016.1  5303838-5303952     c
            2815-2884           JAXUCZ010000016.1  5303295-5303364     c
            2885-2951           JAXUCZ010000016.1  5302438-5302504     c
            2952-3099           JAXUCZ010000016.1  5301703-5301850     c
            3100-3229           JAXUCZ010000016.1  5298651-5298780     c
            3230-3289           JAXUCZ010000016.1  5295679-5295738     c
            3290-3396           JAXUCZ010000016.1  5293522-5293628     c
            3397-3484           JAXUCZ010000016.1  5291277-5291364     c
            3485-3592           JAXUCZ010000016.1  5290120-5290227     c
            3593-3645           JAXUCZ010000016.1  5289986-5290038     c
            3646-3792           JAXUCZ010000016.1  5289115-5289261     c
            3793-3994           JAXUCZ010000016.1  5287563-5287764     c
            3995-4153           JAXUCZ010000016.1  5285525-5285683     c
            4154-4264           JAXUCZ010000016.1  5283938-5284048     c
            4265-4348           JAXUCZ010000016.1  5278976-5279059     c
            4349-4477           JAXUCZ010000016.1  5272219-5272347     c
            4478-4543           JAXUCZ010000016.1  5269162-5269227     c
            4544-4635           JAXUCZ010000016.1  5268730-5268821     c
            4636-4795           JAXUCZ010000016.1  5267057-5267216     c
            4796-4923           JAXUCZ010000016.1  5266373-5266500     c
            4924-5020           JAXUCZ010000016.1  5266152-5266248     c
            5021-5123           JAXUCZ010000016.1  5263939-5264041     c
            5124-5225           JAXUCZ010000016.1  5262290-5262391     c
            5226-5356           JAXUCZ010000016.1  5257325-5257455     c
            5357-5470           JAXUCZ010000016.1  5244598-5244711     c
            5471-5835           JAXUCZ010000016.1  5243531-5243895     c
            5836-5862           JAXUCZ010000016.1  5242834-5242860     c
            5863-6012           JAXUCZ010000016.1  5241724-5241873     c
            6013-6176           JAXUCZ010000016.1  5240503-5240666     c
            6177-6298           JAXUCZ010000016.1  5238520-5238641     c
            6299-6619           JAXUCZ010000016.1  5236549-5236869     c
            6620-9072           JAXUCZ010000016.1  5233690-5236142     c
FEATURES             Location/Qualifiers
     source          1..9072
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..9072
                     /gene="Cacna1d"
                     /note="calcium voltage-gated channel subunit alpha1 D"
                     /db_xref="GeneID:29716"
                     /db_xref="RGD:70973"
     exon            1..485
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..6913
                     /gene="Cacna1d"
                     /note="voltage-gated calcium channel pore forming subunit
                     CaV1.3alpha1 IVS3-IVS4 extracellular linker; RBD; brain
                     class D; voltage-gated calcium channel subunit alpha
                     Cav1.3; calcium channel, L type, alpha-1 polypeptide;
                     calcium channel alpha-1 subunit; voltage-dependent calcium
                     channel subunit alpha1D; calcium channel,
                     voltage-dependent, L type, alpha 1D subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     alpha-1D"
                     /protein_id="NP_001376154.1"
                     /db_xref="GeneID:29716"
                     /db_xref="RGD:70973"
                     /translation="MMMMMMMKKMQHQRQQQEDHANEANYARGTRLPISGEGPTSQPN
                     SSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRP
                     ARALFCLSLNNPIRRACISIVDWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHN
                     LEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLT
                     KETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIAL
                     LVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCAFSGNGRQCAANGTECR
                     SGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIIL
                     GSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDP
                     ENEEEGGEEGKRNTSMPTSETESVNTENVSGEGETQGCCGSLWCWWKRRGAAKTGPSG
                     CRRWGQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYN
                     QPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETIL
                     VELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFII
                     IFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGG
                     PSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIA
                     RKESLENKKNNKPEVNQIANSDNKVTIDDYQEEAEDKDPYPPCDVPVGEEEEEEEEDE
                     PEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILV
                     FIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCR
                     NYFNLLDMLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFV
                     AIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVD
                     SPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRV
                     EISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARP
                     LRRYIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNM
                     VFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISI
                     TFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFG
                     KVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPDSDYNPGE
                     EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIW
                     SEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFN
                     ATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGK
                     FYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQ
                     DDEPEDSKPEEEDVFKRNGALLGNYVNHVNSDRRESLQQTNTTHRPLHVQRPSIPPAS
                     DTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKAAHGKRPSIGDLEHV
                     SENGHYSYKHDRELQRRSSIKRTRYYETYIRSESGDEQLPTICREDPEIHGYFRDPRC
                     FGEQEYFSSEECCEDDSSPTWSRQNYSYYNRYPGSSMDFERPRGYHHPQGFLEDDDSP
                     IGYDSRRSPRRRLLPPTPPSHRRSSFNFECLRRQNSQDDVLPSPALPHRAALPLHLMQ
                     QQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPCYTPLIQVDRSESMDQVN
                     GSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGL
                     GRYARDPKFVSATKHEIADACDLTIDEMESAASTLLNGSVCPRANGDMGPISHRQDYE
                     LQDFGPGYSDEEPDPGREEEDLADEMICITTL"
     exon            486..795
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            796..901
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1041
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1184
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1337
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1534
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1638
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1808
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1896
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1956
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..1983
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2144
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2370
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2578
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2699
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2814
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2884
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2951
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3099
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3229
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3289
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3290..3396
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3484
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3592
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3645
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3646..3792
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3994
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..4153
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4264
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4348
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4477
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4543
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4544..4635
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..4795
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4923
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            4924..5020
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5021..5123
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5124..5225
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5226..5356
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5357..5470
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5471..5835
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..5862
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..6012
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6176
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            6177..6298
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            6299..6619
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
     exon            6620..9072
                     /gene="Cacna1d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggggggc gcgtcgagcg gccccggcgg ccgggcgggc accaccgcgg tgtccctccg
       61 ctagaggagg ggaccaagcc aattctcctt tgcagcaaaa aaagagaaaa aagaaaaaaa
      121 agaaaaattt acatgtatat attactaaga taatatatac atctgatttt attttttaca
      181 aaaagtttat tttgctccat ttttcaaaaa aagaaggagc gtgggtggca ggcggttttt
      241 ataaattatt cttatttttg attatttgtc tctgtccttc cccaccccct gctgaagcga
      301 aaataagggc agggaccgcg gctcctacct atcagtaacc tcccataccc gttcctcccc
      361 ctccctaacg ctgagcatag tgccctgcac acagtaggcg ctcaataaat gttcgtggat
      421 gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag aggaccacgc
      481 gaacgaggca aactatgcaa gaggcaccag actccctatt tctggtgaag gaccaacttc
      541 tcagccgaac agctccaagc aaaccgtcct gtcttggcaa gctgcaattg atgctgctag
      601 acaggccaag gccgcccaga ccatgagcac gtctgcaccc ccacctgtag gatctctctc
      661 ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ctaacagccg
      721 acctgcccgt gccctcttct gtttatccct caataacccc atccgaagag cctgcattag
      781 tatagtggat tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt
      841 ggccttagct atttacatcc cgttccctga agatgattct aattcaacaa atcataactt
      901 ggaaaaagta gaatatgcct tcctgattat ttttacagtg gagacatttc tgaagattat
      961 agcgtacgga ctgctgctgc atcctaatgc ttacgttagg aacggatgga acttactgga
     1021 ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac
     1081 agaaggcggg aaccactcta gtggcaaatc aggaggcttt gatgtcaaag ccctccgtgc
     1141 cttccgagtg ttaagaccgc ttcgacttgt atcaggagtg cccagtttac aagttgttct
     1201 gaactccatt ataaaagcca tggtccccct cctccacata gcccttttgg tgttattcgt
     1261 aattatcatc tatgcgatta tagggttgga actttttatt ggaaaaatgc acaaaacctg
     1321 tttttttgct gactcagata tagtagctga agaggaccca gctccatgcg cgttctcagg
     1381 gaatggacgc cagtgtgccg ccaatggcac ggaatgtagg agcggctggg tcggccccaa
     1441 tggaggcatc actaattttg acaactttgc ctttgccatg ctcactgtgt tccagtgcat
     1501 caccatggag ggctggacag atgtgctcta ctgggttaat gatgcgatag gatgggagtg
     1561 gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt
     1621 tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggctaaag cacgtggaga
     1681 tttccagaag cttcgggaga agcagcagct ggaagaggat ctcaagggct acttggactg
     1741 gatcacccag gcagaagaca tagatcctga gaatgaagag gagggtggag aggagggcaa
     1801 acgaaacact agcatgccca ccagtgagac cgaatctgtg aacacagaga acgtaagtgg
     1861 tgaaggcgag acccagggat gctgtggaag tctctggtgc tggtggaaaa gaagaggcgc
     1921 ggccaagact gggccctctg ggtgtcggcg gtggggccaa gccatctcaa aatccaagct
     1981 cagccgtcgg tggcgtcgct ggaaccggtt caatcgcagg agatgcaggg cagctgtgaa
     2041 gtctgtcacg ttttactggc tggtgatcgt tctggtgttt ctcaacactc tgacgatttc
     2101 ctctgagcat tacaatcagc cagactggct gacgcagatt caagatatag cgaacaaagt
     2161 gctcttggct ttgttcacct gtgagatgct ggtgaagatg tacagcctgg gcctccaggc
     2221 ctacttcgtc tctctcttca accgcttcga ttgctttgtg gtgtgtgggg gaatcaccga
     2281 aaccatcctg gtggaactgg agctcatgtc tcccctgggc gtctctgtgt tccggtgtgt
     2341 acgtctcctg aggatcttca aagtgaccag gcactggact tccctgagca acttggtggc
     2401 gtccctgtta aactccatga agtccatcgc ctctctgctg ttgctgctct tcctcttcat
     2461 catcatcttc tccctgctgg gaatgcagct gttcggaggg aagttcaatt tcgatgagac
     2521 acagaccaag cgaagcacct tcgacaactt cccacaggcg ctcctgactg tgttccagat
     2581 cctgacgggc gaagactgga atgcggtgat gtatgacggc atcatggcct acggaggccc
     2641 gtcctcctct ggaatgattg tctgtattta cttcatcatc cttttcatct gtggtaacta
     2701 tatcctgctg aacgtcttct tggccattgc tgtagacaat ttggctgatg ctgaaagtct
     2761 gaacactgct cagaaagagg aagccgaaga aaaagaaagg aaaaaaattg ccagaaaaga
     2821 aagcctagaa aacaaaaaaa acaacaaacc agaggtcaac cagatagcca acagtgacaa
     2881 caaggttact attgatgact atcaagagga ggctgaagat aaggaccctt atccaccctg
     2941 cgatgtgcca gtaggtgaag aggaagagga ggaggaagag gacgagcctg aggttcctgc
     3001 tggtccccgt cctcgaagaa tctcagagtt gaacatgaag gagaaaattg cacccatccc
     3061 cgaaggaagc gcattcttca ttcttagcaa gaccaacccg atccgtgtgg gttgccacaa
     3121 actcatcaac caccacatct tcaccaacct catcctggtc ttcatcatgc tgagcagcgc
     3181 tgccctggcc gcagaggatc ccatccgcag ccactccttc cgcaacacta tactgggcta
     3241 ctttgactat gctttcacag ccatctttac ggttgaaatc ctgttaaaga tgacaacttt
     3301 tggagcgttc ttgcacaaag gggctttctg taggaactac ttcaatttgc tggacatgct
     3361 ggtcgttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct cggttgtgaa
     3421 gattctgagg gtcttaaggg tcttgaggcc tctcagagca atcaacagag caaaaggact
     3481 taagcacgtg gtccagtgtg tctttgtggc catccgaacc atcggcaaca tcatgatcgt
     3541 cacgaccctg ctccagttca tgtttgcttg cattggggtc cagctgttca aggggaagtt
     3601 ctaccgttgc acagatgagg ccaaaagtaa ccccgaggag tgcagggggc ttttcatcct
     3661 ttataaggac ggcgatgtcg acagtcccgt ggtccgtgag aggatctggc aaaacagtga
     3721 tttcaatttc gacaatgtcc tttcggctat gatggcgctc ttcacggtct cgacttttga
     3781 gggctggccc gcgttgctgt acaaagctat cgactcaaac ggagagaacg ttggtcctgt
     3841 ctacaactac cgtgtggaga tctccatctt cttcattatc tacatcatca tcgtggcctt
     3901 cttcatgatg aatatcttcg tgggcttcgt catcgtcacc ttccaggagc agggagaaaa
     3961 ggagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgtggaat atgccttgaa
     4021 ggcccgcccc ttaaggagat acatccccaa aaacccatac cagtacaagt tctggtacgt
     4081 ggtgaactcc tcgcctttcg aatatatgat gtttgtcctc atcatgctca acacgctctg
     4141 cctggccatg cagcactatg agcaatccaa gatgttcaat gacgccatgg acattctgaa
     4201 catggtcttc acgggggtct tcaccgttga gatggttttg aaagtcatcg catttaagcc
     4261 caaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat
     4321 tatagacgtg gcactcagcg aagctgacaa ctctgaagag agcaatagaa tctccatcac
     4381 ctttttccgt cttttccgag tgatgcggtt ggtgaagctt ctcagcagag gggaaggcat
     4441 ccggactctg ctatggacct tcattaagtc cttccaggca ctcccatatg tcgccctcct
     4501 cattgccatg ctcttcttca tctacgccgt cattggcatg cagatgtttg ggaaggttgc
     4561 catgagagat aacaaccaga tcaataggaa caacaacttc cagacgtttc cccaggcagt
     4621 gctgctgctc ttcaggtgtg caacagggga ggcctggcag gagatcatgc tcgcctgcct
     4681 ccctgggaag ctgtgtgacc cggactcaga ttacaaccca ggagaggaat atacttgtgg
     4741 gagcaacttt gccattgtct acttcatcag cttttacatg ctctgtgcgt tcctgatcat
     4801 caacctcttc gtggctgtca tcatggacaa ttttgactat ctgacgaggg actggtctat
     4861 tctggggcct caccacttgg acgaattcaa aagaatatgg tctgaatatg accccgaggc
     4921 aaagggaagg ataaaacacc ttgatgtggt cactttgctc cgacgtatcc agcctcccct
     4981 gggatttgga aagttgtgtc cacaccgagt ggcgtgtaag agattggtcg ccatgaacat
     5041 gcctctcaac agtgatggga cagtcatgtt caatgcaact ctgtttgctt tggtacggac
     5101 ggctctcaag atcaagactg aaggcaacct ggagcaagct aatgaagagc tccgcgctgt
     5161 gataaagaaa atctggaaga agacaagcat gaagctactt gaccaagttg tccctccagc
     5221 tggtgatgat gaggtaaccg tggggaagtt ctatgccact ttcctgatac aggactactt
     5281 taggaaattc aagaagcgga aagagcaagg cctggtgggg aaataccctg cgaagaacac
     5341 cacgatcgcc ctacaggcgg gattaaggac cctgcatgac attgggccag aaatccgacg
     5401 ggctatatcc tgtgacttgc aagatgacga accagaagac tccaaaccag aagaggaaga
     5461 tgtattcaaa agaaatggtg ccctgcttgg aaactatgtc aatcatgtta atagtgatag
     5521 gagagagtcc cttcagcaga ccaataccac ccaccgtccc ctgcatgtcc aaaggccttc
     5581 aattccacct gcaagtgata ctgagaaacc gctgtttcct ccagcaggaa attcggtgtg
     5641 tcataaccat cataaccata attccatagg gaagcaagtt cccacctcca caaatgccaa
     5701 tctcaataac gccaatatgt ccaaagctgc ccacggaaag cggcccagca ttggggacct
     5761 tgagcatgtg tctgaaaacg gccattactc ctacaagcac gaccgagagc ttcaaagaag
     5821 gtccagtatt aaaagaaccc gctattatga aacttacatt aggtctgagt caggagacga
     5881 gcagcttcca accatttgcc gtgaagaccc tgagatacac ggctacttcc gagacccccg
     5941 ctgcttcggg gagcaggaat atttcagtag cgaggagtgc tgtgaggatg acagttctcc
     6001 cacctggagc aggcaaaact acagctatta caacaggtac ccaggcagct ccatggactt
     6061 tgagaggccc cgaggctacc atcaccccca aggtttctta gaagatgacg actctcccat
     6121 tggctatgac tcacggagat ctccaagaag acgccttcta cctcctaccc caccatccca
     6181 tcggaggtcc tccttcaact ttgagtgtct gcgcaggcaa aacagccaag atgacgtcct
     6241 tccgtcgcct gccctgcctc accgcgctgc cctgcccctg caccttatgc agcagcagat
     6301 catggccgtt gcaggcctag attccagtaa agcccagaag tactcgccga gccactctac
     6361 ccggtcatgg gccacccctc cagcaacccc tccgtaccga gactggaccc catgctacac
     6421 ccctttgatc caggtggatc gctcagagtc tatggaccag gtcaatggca gcctgccgtc
     6481 gctacaccgc agttcctggt atacagatga acccgacatc tcctatagga ctttcacacc
     6541 ggccagcctg accgtcccca gcagcttccg gaacaaaaac agcgacaagc agaggagtgc
     6601 agacagcctg gtggaagcag tcctgatatc cgaaggcttg ggacgctacg caagggaccc
     6661 aaaatttgtc tcagcaacaa aacatgagat cgccgatgcc tgtgacctaa ccatagacga
     6721 gatggagagc gcggccagca ccctgctcaa tggaagcgtg tgtcctcgag ccaacgggga
     6781 catgggcccc atctcacacc gccaggacta tgagctccag gactttggtc ctggctacag
     6841 tgacgaggaa ccagaccctg ggcgagagga agaggacctg gcagatgaaa tgatttgcat
     6901 caccaccttg tagcccagcg agagcaggct tggctccagc ctgggatggg cacaggaggg
     6961 ccagggataa agtgcctcat aattaggaaa gtttaggcac tagttgggag gaaaatgctc
     7021 aattagactt ttgtacgagt gatttcacgc ctcaaggaag ccataaacct ggtaggagca
     7081 ggttctgagc ggccaggcat gtgctacgca tgccacatgc tcgggcccag ccccagaaga
     7141 cagaatgtct ggccccaccg agaggatggg cgagagcagc agcctggcct gcacagagac
     7201 caggactgcc caggagtcca tgtctgccac ccagggctca tgcccacgcc cctttgcctg
     7261 cagacacgag agaggtcaaa ggtgatgaca gtcaccatgc ctgtgtcgtt acctcaacca
     7321 tcggtctagc atatcagacg ctcgctgggc ccggcatatc cgtgtctgag cccccctccc
     7381 ccagagcact ggttcctggt ttctgtgcag ccgttctgag tggcgcacac cagaacccag
     7441 ccgctagtgg tcgcgatgag gggagtggga ccggaccgtt ttgttaagcg atgccagttt
     7501 acataaagag aacatcactc agacggtcag ttctgtcaca ttaagggcaa ttgtaaactg
     7561 gaagggtagc gcacttgcaa accaggtaaa acttagatac attagtttgt ttaaaaatta
     7621 tagatttact gtacatgact tgtaatatac gatttgtatt tgtaaagaga tggtctatat
     7681 tttgtaatta tcgtaccgta tttgaactgc agcaatatcc cacgggtcct aacaatcgta
     7741 gtttcccacc aaaacctaga aattattagt atttttactc gggctaaaca gaactaggag
     7801 aattagaggc aattctcaca tattcagtaa aaagaatctt ttggggataa acttttgagt
     7861 tcataagaac ttgacacttc agaacttttt ctaaagtatt ttgagttact ataaacctat
     7921 ctttacataa gatacccagt cgactatttg gagtcttttc tttgggttct atgattttat
     7981 attgcacctc tcatccacat gggttgccgc tgtctttggc ttagttttaa taatcctctg
     8041 gtcagttagc tgtatagcgg gtccagccgg ctactcagcc cagtggcatc cattgggtct
     8101 gacttcctca gctgcccatg caggatgctt ctgggtctct gttgcagaac cccataggtg
     8161 aacggcccac atctgctcac atccccaagg aggcttaaga actacggggt gtactgtatg
     8221 ggggcagagg gtagcactgt gggaacctat gaatgccggg gtctgtgaag gcctgatgcc
     8281 ttgcacagct gctgtgcagg gttctttgag cgctgtcacc cacagctgat tgggggctga
     8341 agttttcacg ggaacgcaag cactgtgcac gcctggggac agttaggttt ggaaccatta
     8401 caaccgtcaa ggtttctgtc agcgtcacgt gatcacatcc catcactctg ctaaggattc
     8461 tctgcaatca aaactacagg tagcaatttg ggttcaaaat ttttaactag tacacagaca
     8521 acctgtggag acaatttttt ttttttgtaa ataaatgtta ttataaagac ctcgcaaacc
     8581 tcttcggaag acattcttaa ctccagatgc aggcaaaaca cttcaaggtt tgtaaatgac
     8641 tatttcctga cataaagcct ttttttttat taaaatgcga aacattcttc agaataaact
     8701 gtgtaataat ttcattgtat ggggagctct cctcacacag ctggctctgc cgtgagagct
     8761 ccaggcagct tcttctgcca tgggtctcct ccgaggccga tagtaatttc acaccagctg
     8821 cagagagtgc tgttctccta aagggctaaa ccatcatcag catttacctt ggactctgtc
     8881 ttgctgggtg tctgtctgtc tgaccgtgca acgtaacatc ggcagatcac cctcgctgtg
     8941 tgttctgcaa tgggtgatct ttccccaagt cagccgtcaa tgatgccgcc tggcttttca
     9001 ggctgtccca cttcccagta tgtctgctta agcctggttc aacctctcat ctaatattaa
     9061 atttctcttt gt
//
