LOCUS       NM_012517               8257 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus calcium voltage-gated channel subunit alpha1 C
            (Cacna1c), mRNA.
ACCESSION   NM_012517
VERSION     NM_012517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8257)
  AUTHORS   Carrillo,E.D., Alvarado,J.A., Hernandez,A., Lezama,I., Garcia,M.C.
            and Sanchez,J.A.
  TITLE     Thyroid Hormone Upregulates Cav1.2 Channels in Cardiac Cells via
            the Downregulation of the Channels' beta4 Subunit
  JOURNAL   Int J Mol Sci 25 (19), 10798 (2024)
   PUBMED   39409130
  REMARK    GeneRIF: Thyroid Hormone Upregulates Cav1.2 Channels in Cardiac
            Cells via the Downregulation of the Channels' beta4 Subunit.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8257)
  AUTHORS   Zhang,Y., Xu,Z., Shan,M., Cao,J., Zhou,Y., Chen,Y. and Shi,L.
  TITLE     Arterial Smooth Muscle Cell AKAP150 Mediates Exercise-Induced
            Repression of CaV1.2 Channel Function in Cerebral Arteries of
            Hypertensive Rats
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), 1202-1221 (2024)
   PUBMED   38602101
  REMARK    GeneRIF: Arterial Smooth Muscle Cell AKAP150 Mediates
            Exercise-Induced Repression of CaV1.2 Channel Function in Cerebral
            Arteries of Hypertensive Rats.
REFERENCE   3  (bases 1 to 8257)
  AUTHORS   Fender,H., Walter,K., Kiper,A.K., Plackic,J., Kisko,T.M.,
            Braun,M.D., Schwarting,R.K.W., Rohrbach,S., Wohr,M., Decher,N. and
            Kockskamper,J.
  TITLE     Calcium Handling Remodeling Underlies Impaired Sympathetic Stress
            Response in Ventricular Myocardium from Cacna1c Haploinsufficient
            Rats
  JOURNAL   Int J Mol Sci 24 (12), 9795 (2023)
   PUBMED   37372947
  REMARK    GeneRIF: Calcium Handling Remodeling Underlies Impaired Sympathetic
            Stress Response in Ventricular Myocardium from Cacna1c
            Haploinsufficient Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8257)
  AUTHORS   Ritzer,A., Roeschl,T., Nay,S., Rudakova,E. and Volk,T.
  TITLE     Rapid Pacing Decreases L-type Ca2+ Current and Alters Cacna1c
            Isogene Expression in Primary Cultured Rat Left Ventricular
            Myocytes
  JOURNAL   J Membr Biol 256 (3), 257-269 (2023)
   PUBMED   36995425
  REMARK    GeneRIF: Rapid Pacing Decreases L-type Ca[2+] Current and Alters
            Cacna1c Isogene Expression in Primary Cultured Rat Left Ventricular
            Myocytes.
REFERENCE   5  (bases 1 to 8257)
  AUTHORS   Gasalla,P., Manahan-Vaughan,D., Dwyer,D.M., Hall,J. and
            Mendez-Couz,M.
  TITLE     Characterisation of the neural basis underlying appetitive
            extinction & renewal in Cacna1c rats
  JOURNAL   Neuropharmacology 227, 109444 (2023)
   PUBMED   36724867
  REMARK    GeneRIF: Characterisation of the neural basis underlying appetitive
            extinction & renewal in Cacna1c rats.
            Review article
REFERENCE   6  (bases 1 to 8257)
  AUTHORS   Ma,W.J., Holz,R.W. and Uhler,M.D.
  TITLE     Expression of a cDNA for a neuronal calcium channel alpha 1 subunit
            enhances secretion from adrenal chromaffin cells
  JOURNAL   J Biol Chem 267 (32), 22728-22732 (1992)
   PUBMED   1385406
REFERENCE   7  (bases 1 to 8257)
  AUTHORS   Diebold,R.J., Koch,W.J., Ellinor,P.T., Wang,J.J., Muthuchamy,M.,
            Wieczorek,D.F. and Schwartz,A.
  TITLE     Mutually exclusive exon splicing of the cardiac calcium channel
            alpha 1 subunit gene generates developmentally regulated isoforms
            in the rat heart
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1497-1501 (1992)
   PUBMED   1311102
REFERENCE   8  (bases 1 to 8257)
  AUTHORS   Snutch,T.P., Tomlinson,W.J., Leonard,J.P. and Gilbert,M.M.
  TITLE     Distinct calcium channels are generated by alternative splicing and
            are differentially expressed in the mammalian CNS
  JOURNAL   Neuron 7 (1), 45-57 (1991)
   PUBMED   1648941
REFERENCE   9  (bases 1 to 8257)
  AUTHORS   Koch,W.J., Ellinor,P.T. and Schwartz,A.
  TITLE     cDNA cloning of a dihydropyridine-sensitive calcium channel from
            rat aorta. Evidence for the existence of alternatively spliced
            forms
  JOURNAL   J Biol Chem 265 (29), 17786-17791 (1990)
   PUBMED   2170396
REFERENCE   10 (bases 1 to 8257)
  AUTHORS   Snutch,T.P., Leonard,J.P., Gilbert,M.M., Lester,H.A. and
            Davidson,N.
  TITLE     Rat brain expresses a heterogeneous family of calcium channels
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3391-3395 (1990)
   PUBMED   1692134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1, AF394939.1, M67516.1 and DQ538522.1.
            
            On Oct 12, 2007 this sequence version replaced NM_012517.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000004.1  154051600-154051748 c
            150-640             AF394939.1         1-491
            641-648             JAXUCZ010000004.1  153905418-153905425 c
            649-1833            AF394939.1         500-1684
            1834-1847           JAXUCZ010000004.1  153537598-153537611 c
            1848-2125           AF394939.1         1699-1976
            2126-2170           JAXUCZ010000004.1  153535727-153535771 c
            2171-2378           JAXUCZ010000004.1  153526334-153526541 c
            2379-2614           M67516.1           2858-3093
            2615-2735           JAXUCZ010000004.1  153522691-153522811 c
            2736-6118           DQ538522.1         2555-5937
            6119-6190           AF394939.1         5970-6041
            6191-6789           DQ538522.1         6010-6608
            6790-8257           JAXUCZ010000004.1  153436427-153437894 c
FEATURES             Location/Qualifiers
     source          1..8257
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..8257
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /note="calcium voltage-gated channel subunit alpha1 C"
                     /db_xref="GeneID:24239"
                     /db_xref="RGD:2245"
     exon            1..324
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..6698
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /note="L-type calcium channel alpha-1 subunit; RBC; brain
                     class C; calcium channel, voltage-dependent, L type, alpha
                     1C subunit; voltage-gated calcium channel subunit alpha
                     Cav1.2; calcium channel, voltage-dependent, alpha 1C
                     subunit"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     alpha-1C"
                     /protein_id="NP_036649.2"
                     /db_xref="GeneID:24239"
                     /db_xref="RGD:2245"
                     /translation="MIRAFAQPSTPPYQPLSSCLSEDTERKFKGKVVHEAQLNCFYIS
                     PGGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAARQAKLMGSAGNAT
                     ISTVSSTQRKRQQYGKPKKQGGTTATRPPRALLCLTLKNPIRRACISIVEWKSFEIII
                     LLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPN
                     AYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLR
                     LVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGI
                     IDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITM
                     EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGD
                     FQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTEN
                     VAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFL
                     NTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCF
                     IVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIA
                     SLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNS
                     VMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKE
                     EEEEKERKKLARTASPEKKQEVMEKPAVEESKEEKIELKSITADGESPPTTKINMDDL
                     QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFS
                     PNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTT
                     IFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVL
                     RVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC
                     SDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEG
                     WPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE
                     QEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLN
                     TICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALI
                     VVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRT
                     LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAV
                     LLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCA
                     FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLR
                     RIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQ
                     ANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQG
                     LVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIF
                     RRAGGLFGNHVSYYQSDSRSNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFT
                     PSSYSSTGSNANINNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLS
                     SKRCHSRESQGATVSQDMFPDETRSSVRLSEEVEYCSEPSLLSTDILSYQDDENRQLT
                     CLEEDKREIQPSPKRSFLRSASLGRRASFHLECLKRQKDQGGDISQKTALPLHLVHHQ
                     ALAVAGLSPLLQRSHSPSTFPRPRPTPPVTPGSRGRPLQPIPTLRLEGAESSEKLNSS
                     FPSIHCSSWSEETTACSGGSSMARRARPVSLTVPSQAGAPGRQFHGSASSLVEAVLIS
                     EGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQSPNGTLLPFVNCR
                     DPGQDRAVVPEDESCVYALGRGRSEEALPDSRSYVSNL"
     exon            325..648
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            649..752
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            753..892
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1032
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1191
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1388
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1492
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1665
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1756
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1783
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1944
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2170
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2378
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2499
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2614
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2735
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2805
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2938
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3068
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3069..3128
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3235
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3323
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3431
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3484
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3631
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3833
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3834..3992
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4103
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4104..4187
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4220
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4349
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4350..4415
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4416..4507
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..4673
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4801
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..4898
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..5001
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..5103
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5104..5231
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5232..5366
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5367..5719
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5720..5848
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5849..5955
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            5956..6059
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            6060..6395
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
     exon            6396..8257
                     /gene="Cacna1c"
                     /gene_synonym="RATIVS302"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagaattcta aatctgagag caaaagctca aattcactgc caagcgataa ggccgtatga
       61 gattttatgg ccttcaaacg tggccacaga cattgtttct gagtttttaa aaagtacaag
      121 gaaaaataca agtgggatag ctgttcagtt gtgacatcag ctgttggtcc ccaactggag
      181 tcacaatgat tcgggccttc gctcagccat ccacaccccc ataccagccg ctctccagtt
      241 gcctgtctga ggacacagag aggaagttca agggcaaggt ggtacacgaa gctcaactca
      301 actgtttcta catttctcct ggaggttcca actatgggag cccacgccca gctcatgcca
      361 acatgaatgc caatgcagct gcaggacttg cccccgagca catccctact ccaggggcag
      421 cactgtcctg gcaggcagcc atcgatgccg cccggcaggc caagttaatg ggcagtgctg
      481 gcaatgcgac catctctacc gtcagttcca cacagcggaa gcggcagcag tatgggaaac
      541 ccaagaagca ggggggcaca actgccacac ggccgccccg ggctctgctc tgcctgactc
      601 tgaagaaccc catcaggagg gcatgcatca gcattgttga atggaaatca tttgaaataa
      661 ttattttatt gacgattttt gccaattgtg tggccttagc aatctatatt ccctttccgg
      721 aagatgactc caacgccacc aactccaacc tggaacgggt ggagtatctc ttcctcatca
      781 tttttaccgt ggaagcattt ttaaaagtga ttgcctacgg actactcttc caccccaacg
      841 cttacctccg caacggttgg aatttactag attttataat cgtggttgta gggcttttta
      901 gtgcaatttt agaacaagca accaaagctg acggggccaa cgctctggga gggaaaggag
      961 cgggattcga tgtgaaggca ctgagagctt tccgtgtgct tcgtcccctg cggctggtgt
     1021 ctggagtccc aagtctccag gtggtcctga actccatcat caaggccatg gtgcccctgc
     1081 tgcacattgc cctcctcgtg ctcttcgtca tcatcatcta tgccattatc ggcctggagc
     1141 tcttcatggg gaagatgcac aagacctgct acaaccagga gggcataata gatgttccag
     1201 cggaagagga tccctcccct tgtgctttgg agacaggcca tgggcgacag tgtcagaacg
     1261 ggaccgtgtg caagcccggg tgggatgggc ccaagcacgg catcaccaac ttcgacaact
     1321 tcgccttcgc catgctgacg gtgttccagt gtatcaccat ggagggctgg acagacgtgc
     1381 tgtactggat gcaagacgct atgggctatg agttgccctg ggtgtatttt gtcagtctgg
     1441 tcatctttgg atcctttttc gttctaaatc tggttctcgg tgttttgagc ggagagtttt
     1501 ccaaagagag ggagaaagcc aaagctcgag gagacttcca gaagcttcgt gagaagcagc
     1561 agctagaaga agatctcaaa ggctacctgg actggatcac ccaggcggaa gacatagacc
     1621 ctgagaatga ggacgagggc atggatgaag acaaaccccg aaacatgagc atgcccacaa
     1681 gtgagactga gtctgtcaac accgaaaacg tggctggagg tgacatcgag ggtgaaaact
     1741 gtggagcccg gcttgcccac cggatctcca aatccaagtt cagccgctac tggcgccggt
     1801 ggaatagatt ctgcagaaga aagtgccgtg ccgcagttaa gtccaatgtc ttctactggc
     1861 tggtgatctt cctggtgttc ctcaacaccc tcaccattgc ctccgaacac tacaaccagc
     1921 ctcattggct cacagaagtg caagacacgg ccaacaaggc cctcctggcc cttttcacgg
     1981 cagaaatgct cctgaagatg tacagcctgg gtctgcaggc ctactttgta tccctcttca
     2041 accgctttga ctgtttcatt gtgtgcgggg gcatcctgga gaccatcctg gtggagacga
     2101 agatcatgtc gcccctgggc atctctgtgc tgagatgtgt gcggctgctc aggattttca
     2161 agatcaccag gtactggaac tccctgagca acctcgtggc gtccttgctg aactcagtgc
     2221 gctccatcgc ctccctgctg ctactcctct tcctcttcat catcatcttc tccctcctgg
     2281 ggatgcagct gtttggtgga aagttcaact ttgatgagat gcagacccgt aggagcacgt
     2341 ttgataactt cccacagtct ctcctcactg tgtttcagat cctgaccggg gaggactgga
     2401 attcggtgat gtatgatggg atcatggctt atggcggccc ctcttttcca gggatgttag
     2461 tctgtattta cttcatcatc ctcttcatct gtggaaatta tatcctactg aatgtgttct
     2521 tggccattgc ggtggacaac ctggctgatg cggagagcct gacctctgcc caaaaagagg
     2581 aagaagaaga gaaggagaga aagaagctgg ccaggactgc cagcccagaa aagaaacagg
     2641 aggtgatgga gaaaccagca gtagaggaga gcaaagagga gaaaattgag ctgaagtcca
     2701 ttacagcaga tggagaatcc ccacccacta ccaagatcaa catggatgac ctccagccca
     2761 gtgaaaatga ggacaagagt ccccactcca acccagacac tgcaggtgaa gaggatgagg
     2821 aggagcccga gatgcctgtg ggcccacgcc cccggcccct gtctgagctg caccttaagg
     2881 aaaaggcagt ccccatgccg gaagccagtg catttttcat cttcagccca aacaacaggt
     2941 tccgcctgca gtgccaccgc attgtcaatg acacgatctt caccaacctc atcctcttct
     3001 tcattctgct cagtagcatc tccctggcgg ctgaggaccc cgtccagcac acctccttca
     3061 ggaaccacat tctgttttat tttgacattg tttttaccac cattttcacc attgaaattg
     3121 ctctaaagat gactgcttac ggggctttcc tgcacaaggg ctctttctgc cgaaattact
     3181 tcaatatcct ggacctgctg gtggttagcg tgtccctcat ctcctttggc attcagtcca
     3241 gcgcgatcaa cgttgtgaag attttaagag tgcttcgtgt cctcaggccc ctgagggcca
     3301 tcaacagggc caaggggcta aagcacgtcg ttcagtgtgt gtttgtggcc atccggacca
     3361 ttggaaacat tgtaattgtc accactctgc tgcagttcat gttcgcctgc attggggtcc
     3421 agctcttcaa gggaaagctc tatacctgtt cggatagttc caaacagacg gaggcagaat
     3481 gcaagggtaa ctatataaca tacaaagacg gagaagttga ccaccccatt atccagcctc
     3541 gaagttggga gaacagcaag ttcgactttg acaatgttct ggcagccatg atggccctct
     3601 ttaccgtctc caccttcgag gggtggccag agctgctgta ccgctccatt gactcccaca
     3661 cagaagacaa gggtcccatc tacaactatc gtgtggagat ctccatcttc ttcatcatct
     3721 acatcatcat cattgccttc ttcatgatga acatcttcgt gggtttcgtc attgtcacct
     3781 tccaggagca gggggaacaa gaatacaaga actgtgagct ggacaagaac cagagacaat
     3841 gtgtggaata tgccctcaag gcccgaccct tgcgaaggta catccccaag aaccagcacc
     3901 agtacaaagt gtggtacgtg gtcaactcca cctacttcga gtatctgatg ttcgtcctca
     3961 tcctgctcaa caccatctgc ctggccatgc agcactacgg ccagagctgc ctcttcaaaa
     4021 tcgccatgaa tatactcaac atgcttttca ctggcctctt cacggtggag atgatcctga
     4081 agctcattgc cttcaaaccc aagcactatt tctgtgatgc atggaataca tttgacgcct
     4141 tgattgttgt gggtagcatt gttgatatag caatcaccga ggtacaccca gctgaacata
     4201 cccaatgctc tccctctatg agtgcagagg agaactcccg catctccatc accttcttcc
     4261 gcctcttccg ggtcatgcgc ctggtgaagc tgctgagccg aggggaaggc atccggaccc
     4321 tgctgtggac cttcatcaag tccttccagg ccctgcccta tgtggccctt ttgattgtga
     4381 tgctgttctt tatctatgca gtgattggga tgcaggtatt tgggaagatt gccctgaatg
     4441 acaccacaga gatcaatcgg aacaacaact tccagacgtt ccctcaggct gtgctactgc
     4501 tcttcaggtg cgccactggg gaggcctggc aggatatcat gctagcctgt atgccaggca
     4561 agaagtgtgc tccagagtct gagcccagca acagcacgga aggggagaca ccctgtggca
     4621 gcagtttcgc tgtcttctac ttcatcagct tctacatgct ctgtgccttc ctgatcatca
     4681 acctctttgt agctgttatc atggacaact ttgactacct gactagggat tggtctatcc
     4741 ttggtcccca tcacctggat gaattcaaga gaatctgggc cgaatatgac cctgaagcca
     4801 agggtcggat caaacacttg gatgtggtga ccctcctccg tcgaattcag cccccactgg
     4861 gttttgggaa gttgtgtcct caccgtgtgg cctgcaaacg cctggtgtcc atgaacatgc
     4921 ctctgaacag tgatgggacg gtcatgttca atgctacact gtttgccctt gtcaggacag
     4981 ccctgaggat caaaacagaa gggaacctag agcaagccaa tgaggagctg agagccatca
     5041 tcaagaaaat ctggaagagg accagcatga agctgttgga ccaggtggtg ccccctgcag
     5101 gtgatgacga ggtcacagtg ggcaagttct atgccacctt cctgatccaa gagtacttca
     5161 ggaaattcaa gaagcgaaaa gagcaggggc tggtcggcaa gccctcgcag aggaatgcac
     5221 tgtctctgca ggctggctta cgcaccttgc atgacattgg gcctgagatc cggagagcca
     5281 tctctgggga tctgacggct gaggaggagc tggacaaggc tatgaaggag gcagtgtctg
     5341 ctgcctccga agacgacatc ttcaggaggg ctggaggcct gtttggcaac cacgtcagct
     5401 actaccagag tgacagcagg agcaacttcc ctcagacgtt tgccacccaa cgcccactgc
     5461 acatcaacaa gacagggaac aaccaagcgg acaccgaatc accgtcccat gagaagctgg
     5521 tggactccac tttcaccccc agcagctact catccacggg ctccaatgcc aacatcaaca
     5581 atgccaacaa cactgccctg ggccgcttcc cccaccctgc tggctactcc agcacggtca
     5641 gcactgtgga gggccatggg cctcccttgt cccctgctgt ccgggtacag gaggcagcat
     5701 ggaaactcag ctctaagagg tgccactccc gagagagcca gggggccacg gtgagtcagg
     5761 atatgtttcc agatgagacc cgcagcagcg tgaggctgag cgaagaagtt gagtactgca
     5821 gtgagcccag cctgctctcc acagatatac tctcctacca ggacgatgaa aaccgacaac
     5881 tgacctgtct agaggaggac aagagggaga tccagccatc tccgaagagg agtttccttc
     5941 gctctgcctc tctaggtcga agggcctcct tccatctgga atgtctaaag cgacaaaagg
     6001 atcaaggggg agacatctct cagaagacag ccttgccctt gcatctggtt catcaccagg
     6061 cattggcagt ggcaggcttg agccccctcc tgcagagaag ccattctcct tccacgttcc
     6121 ccaggccacg ccccacgccc cctgtcactc caggcagccg gggcaggccc ctacagccca
     6181 tccctaccct gcggctggag ggggcggagt ccagtgagaa actcaacagc agcttcccgt
     6241 ccatccactg cagctcctgg tcagaggaga ccacagcctg tagtgggggc agcagcatgg
     6301 cccggagagc ccggcccgtc tccctcaccg tgcccagcca ggctggagct ccaggcagac
     6361 agttccacgg cagcgccagc agcctggtgg aagcggtctt gatttcagaa ggactgggac
     6421 agtttgctca agatcccaag ttcatcgagg tcaccacaca ggagctggct gacgcctgcg
     6481 atatgacaat agaggagatg gagaacgccg cagacaacat cctcagcggg ggcgcccagc
     6541 agagccccaa cggcaccctc ttaccttttg tgaactgcag ggacccaggg caggacaggg
     6601 ctgtggtccc agaggacgag agctgtgtat atgccctggg gcgaggccgg agcgaggaag
     6661 cgctcccgga cagcaggtcc tatgtcagca acctgtagtc cgcagggctg gcgagacgcg
     6721 ggtgtttttt attcgtttca atgttcctaa tgggttcgtt tcagaagtgc ctcactgttc
     6781 tcgtgacctg gaggtaaccg gaacagcgtc ttcattcact gctgtcggga taagcctcag
     6841 agctgggcgg tgtacgaagt cggcttttca ggggagaagg ccaaggccgt ggtgcggggg
     6901 ctccagcacc ttcccacggc agcaccgccc aaaggacccc acccccccct aagcaaaagg
     6961 gtgttttccc cttgcttgta taaacagtca tttgcacatg ttctgtctga gcctggccgt
     7021 ctctatggag cagggcccca gggatctatg gcaggaatgg gccagtgtcc ccagtaggag
     7081 ccggaaggtg gctgcaaggt tcccagcagt gcagatctgg tccctatggt cccttcaggg
     7141 acccttcccc tgctggaact gaggagcagg tggcaggagc cagtgcagac cacaccacct
     7201 gccctcagct agccagacct gggggcgcag gctgcttgcc tggtgctctg ggtttcatag
     7261 tttgatggtt cttgtcagca tgttgcggtt ttctaggttt tgatttcttt attactattt
     7321 gttgtgtttt cccacgggga ggggaggaag aagagcgttt acaactgcgc agcctcactt
     7381 caccggttcc acatttgcat atttaagttg gatttggttt tattgtattc tttaaatggt
     7441 gcggtccacc cccaccctca cccctattgg agcaagggtt cattatcacc acggggaggt
     7501 tttacctgct ctgtgtatgc ccaagtaacg tgttacaatt ttccttaagt caaagcaact
     7561 ttttttcccc cttttcggtt tggttgagca tcacgacctg caggttaaca gtcagtttag
     7621 ataaggcggt gtgtgcctgg gcgactgagc tgggctcctt tctgggcata tggattggtt
     7681 caggagagaa gaaatatggg catctttgcg tcacacgtgt gtccatagtg ggtcgtcttg
     7741 tgtgtctgtg catccacacg gtacgtgagc accccacccc acccccgcac aaagtctgta
     7801 gatccccgtt cgggtttgac tgcagggagt tcaaaatctg gggctattcg aaagcaagaa
     7861 caaaccactg tctctgcttc tgcttctgaa acgagaatct ggtaactgca ttttctgtcc
     7921 cacgagatat gcaaaagcaa tgcaataata tccattttaa aatacgattg tgagttgtgt
     7981 cagcattaaa attctatttt aaaaaaacat gaaatttaag gggaaaaact caagaagaca
     8041 ttttgcttcg atatattctg tgtaatgttt tattgcattg ataatgtttc tgttgaagaa
     8101 actgttatac ttgaattcag gtcagtttca gtatttttca aatatttttt taaaactgaa
     8161 ttgcaattgt gccaagcaaa tataatgact taagtttgtt ttaaaattca cttcttgtat
     8221 attttgctgc atgtaaagta aatcattttg tatttgg
//
