LOCUS       NM_001191758            4559 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cache domain containing 1 (Cachd1), mRNA.
ACCESSION   NM_001191758 XM_233227
VERSION     NM_001191758.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   Dahimene,S., Page,K.M., Kadurin,I., Ferron,L., Ho,D.Y.,
            Powell,G.T., Pratt,W.S., Wilson,S.W. and Dolphin,A.C.
  TITLE     The alpha2delta-like Protein Cachd1 Increases N-type Calcium
            Currents and Cell Surface Expression and Competes with
            alpha2delta-1
  JOURNAL   Cell Rep 25 (6), 1610-1621 (2018)
   PUBMED   30404013
  REMARK    GeneRIF: Cachd1 influences both CaV2.2 trafficking and function and
            can inhibit responses to alpha2delta-1.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jul 17, 2010 this sequence version replaced XM_233227.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.20077.1,
                                           SRR26643299.23450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               JAXUCZ010000005.1  120527224-120527463
            241-303             JAXUCZ010000005.1  120616324-120616386
            304-452             JAXUCZ010000005.1  120647239-120647387
            453-559             JAXUCZ010000005.1  120666822-120666928
            560-686             JAXUCZ010000005.1  120694854-120694980
            687-831             JAXUCZ010000005.1  120697735-120697879
            832-1048            JAXUCZ010000005.1  120698600-120698816
            1049-1198           JAXUCZ010000005.1  120705394-120705543
            1199-1432           JAXUCZ010000005.1  120709265-120709498
            1433-1582           JAXUCZ010000005.1  120714115-120714264
            1583-1706           JAXUCZ010000005.1  120715052-120715175
            1707-1824           JAXUCZ010000005.1  120716170-120716287
            1825-1993           JAXUCZ010000005.1  120718142-120718310
            1994-2136           JAXUCZ010000005.1  120723085-120723227
            2137-2318           JAXUCZ010000005.1  120723879-120724060
            2319-2429           JAXUCZ010000005.1  120725187-120725297
            2430-2552           JAXUCZ010000005.1  120729756-120729878
            2553-2652           JAXUCZ010000005.1  120731968-120732067
            2653-2769           JAXUCZ010000005.1  120732157-120732273
            2770-2930           JAXUCZ010000005.1  120736301-120736461
            2931-3017           JAXUCZ010000005.1  120736775-120736861
            3018-3134           JAXUCZ010000005.1  120737973-120738089
            3135-3286           JAXUCZ010000005.1  120739389-120739540
            3287-3448           JAXUCZ010000005.1  120741321-120741482
            3449-3526           JAXUCZ010000005.1  120742747-120742824
            3527-3628           JAXUCZ010000005.1  120743443-120743544
            3629-4559           JAXUCZ010000005.1  120751755-120752685
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..4559
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /note="cache domain containing 1"
                     /db_xref="GeneID:298267"
                     /db_xref="RGD:1310770"
     CDS             1..3867
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /codon_start=1
                     /product="VWFA and cache domain-containing protein 1"
                     /protein_id="NP_001178687.1"
                     /db_xref="GeneID:298267"
                     /db_xref="RGD:1310770"
                     /translation="MAREPEEEETVRTAALVRRCPRCPGWPGAPRPPFWLLCLVACWI
                     LGAVADADFSILDEAQVLASQMRRLAAEELGVVTMQRIFNSLVYTEKISNGESEVQQL
                     AKKIREKFNRYLDVVNRNKQVVEASYTAHLTSPLTAIQDCCTIPPSMMEFDGNFNTNV
                     SRTVSCDRLSTTVNSRAFNPGRDLNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKF
                     RCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVTDTQLQIAKDAAQVILSAIDEHD
                     KISVLTVADTVRTCSLDQCYKTYLSPATSETKRKMSTFVSSVKPSDSPTQHAVGFHRA
                     FQLIRSTSNNTRFQANTDMVIIYLSAGITSKDSSEEDKKATLRVINEENGFLNNSVMI
                     LTYALMNDGVTGLKELAFLRDLAEQNSGKYGIPDRTALPVIKGSMMVLNQLSNLETTV
                     GRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLLGIVGVDVNLAYILE
                     DVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHYENIPKFELVRQN
                     ILSLPLGSQIITVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSFILCIVVIQPE
                     IPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTVMLSAGSFSSPYEH
                     LSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQMEMSSLNT
                     YIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVGGAGY
                     VVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFIME
                     DRGYLVAHPTLVDPKGHAPLEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQR
                     SYKFNTSLVGDLTNLVHGSHCSKYRLTRIPGTNAFVGIVNETCDSLAFCACSMVDRLC
                     LNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDAL
                     HQCVNSRCNQRMESGDCFGVLDCEWCVVDSDGKTHLDKSYCAPQKECFGGIVGAKSPY
                     VDDMGAIGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPL
                     AAQEMSVRMSNLENDRDEREDDSHEDRGIISNTRFIAAVMERHAHSPERRRRYWGRSG
                     TESDHGYSTMSPQEDSENPPCNNDPLSAGVDVGNHDDDLDLDTPPQTAALLSHKFHHY
                     RSHHPTLHHSHHLQAAVTVHTVDAEC"
     exon            1..240
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            241..303
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            304..452
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            453..559
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            560..686
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            687..831
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1048
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1198
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1432
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1582
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1706
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1824
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1993
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2136
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2318
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2429
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2552
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2652
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2769
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2930
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3017
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3134
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3286
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3448
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3526
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3628
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..4559
                     /gene="Cachd1"
                     /gene_synonym="RGD1310770"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcccgcg agcccgagga agaggagacc gtaaggacgg ccgctctggt ccgtcgctgt
       61 ccccgctgcc ctggctggcc tggggccccg cggccgccct tctggctgct ctgccttgtg
      121 gcatgctgga tcttgggcgc cgtggcggac gccgacttct ccatcctgga cgaggcgcaa
      181 gtgctagcga gccagatgcg gaggctggct gccgaggagc tgggggtggt caccatgcag
      241 aggatcttca actccttggt ttacacagag aagatctcaa acggagagag cgaagttcag
      301 cagctagcca aaaaaatccg ggagaagttc aaccgttacc tggacgtggt caatcggaac
      361 aagcaagttg tagaagcctc ctatacagcc cacctgacct ccccgctgac cgccatccag
      421 gactgctgca caattccacc ctccatgatg gagtttgatg ggaacttcaa taccaatgtg
      481 tctagaacag tgagctgcga tcgactctct actactgtga acagccgagc cttcaatcca
      541 ggacgagact taaattcagt tcttgcagac aacctgaaat ctaaccctgg aatcaagtgg
      601 caatatttca gctcagaaga aggaattttc actgtcttcc cagcacacaa gttccggtgt
      661 aagggcagct atgagcaccg cagtcggccc atctatgtct ctaccgtccg gccgcagtcc
      721 aaacacatag tcgtgatcct ggaccacggg gcctcagtca cggacaccca gctccagatt
      781 gccaaggacg ccgctcaggt catcctcagt gccattgatg aacacgacaa gatttctgta
      841 ttgactgtgg cagacaccgt caggacctgt tcgttggacc agtgctataa gacgtacctg
      901 tctccagcca ccagtgagac aaaaaggaaa atgtccacat ttgttagcag tgtcaaaccc
      961 tccgacagcc ccacccagca cgcagtaggg tttcataggg cgttccagtt gattcgaagc
     1021 accagcaata acactcggtt ccaagcaaac acagacatgg tcatcattta cctgtcagcg
     1081 ggtatcacat caaaggactc ctcggaagag gataaaaagg caactctccg cgtcatcaac
     1141 gaagaaaatg gcttcctgaa caactctgta atgattctta cctacgccct catgaatgat
     1201 ggggtgactg gtttgaagga actggcgttc ctcagggatc tggctgaaca gaactctggg
     1261 aagtatggaa tcccagaccg gacggccttg cctgtgatta agggcagcat gatggtgctg
     1321 aaccagctga gcaacctgga gaccactgtt ggcaggttct ataccaacct tcccaaccgg
     1381 atgattgacg aggccgtctt cagcctcccc ttctctgatg agatgggaga tggtctgatc
     1441 atgactgtga gtaaaccctg ttactttgga aaccttctcc tggggatcgt aggtgtggat
     1501 gtgaatctgg cttacattct cgaagatgtg acatattacc aagactcttt agcttcctat
     1561 acttttctca tagatgacaa agggtacaca cttatgcacc cgtctctcac caggccatac
     1621 ttactgtcag agcctcccct tcataccgac atcatacatt atgaaaatat ccccaagttt
     1681 gaattggttc gacaaaatat cctaagcctc cctctaggca gccagatcat cacagtgcct
     1741 gttaactcgt ccctgtcttg gcacatcaac aagctgaggg agactggaaa ggaggcctac
     1801 aatgtgagct atgcctggaa gatggtacag gacacttcct tcattctgtg tattgtggtg
     1861 atacaaccag aaatacctgt caaacaattg aagaacctca acaccgtacc cagcagcaag
     1921 ctgctgtacc acaggctaga ccttctgggc caacccagtg cttgtctcca cttcaagcag
     1981 ctggcaacac tagaaagtcc aaccgtcatg ctgtctgccg gcagcttttc ctccccctat
     2041 gagcacctca gccagccaga gaccaagcgc atggtggagc attacacggc ctatctcagt
     2101 gacaacactc gcctcattgc taacccaggg ctcaaattct ctgtcagaaa cgaagtaatg
     2161 gcgaccagcc acgtcacaga tgaatggatg acacaaatgg aaatgagcag cctgaacacg
     2221 tacattgtcc gccgttacat agcaacaccc aatggcgtcc tcagaattta tcctggttcc
     2281 ctcatggaca aagcatttga tcccacgagg agacagtggt atcttcatgc agtagccaat
     2341 ccagggctga tttccttgac gggcccttac ctagatgttg gaggagctgg ctatgtcgtg
     2401 acaatcagcc acacaattca ctcatccagt acccagctgt cttccggaca cactgtggct
     2461 gtgatgggca tcgacttcac actgaggtac ttctacaagg ttctgatgga tctcttacca
     2521 gtttgtaacc aagatggtgg caacaaaata aggtgcttca taatggagga cagaggttat
     2581 ctggtagctc atccaaccct cgttgacccc aaaggtcatg cacctctgga acagcaacac
     2641 atcacccaca aggagcccct ggtagcaaac gatatcctga accatcccaa ctttgtgaag
     2701 aagaacttgt gcaacagctt cagtgaccgg acagtgcaga gatcttacaa gttcaacacc
     2761 agcctggtgg gggatttgac aaaccttgtg catggcagcc actgttctaa ataccgcctg
     2821 acaaggatcc caggaaccaa cgcgtttgtc ggcatcgtca atgagacctg cgactctctt
     2881 gccttctgcg cttgcagcat ggtggaccgt ctctgtctca actgtcaccg aatggagcaa
     2941 aatgaatgtg aatgtccttg tgagtgcccc ctggaggtca atgagtgtac tggcaacctc
     3001 accaatgcag agaacagaaa cccgagctgt gaggtccacc aggagccagt gacatacaca
     3061 gctatcgatc ctggcctgca agatgccctg caccagtgtg tcaacagtcg atgtaaccag
     3121 aggatggaaa gtggggactg tttcggagtg ctggactgcg agtggtgcgt ggtggacagt
     3181 gacggaaaga ctcacctgga caaatcctac tgtgcgcccc agaaagaatg ctttggaggg
     3241 atcgtgggag ccaaaagtcc ctacgttgat gacatgggag ccatcggtga tgaggtgatc
     3301 acactgaaca tgattaagag cgccccagtg ggccctgtgg ccggagggat catgggctgc
     3361 atcatggtgc tggtccttgc cgtctacgct taccgccacc agatccatcg ccggagccac
     3421 cagcatatgt ctcctcttgc tgctcaagaa atgtcagtgc gtatgtccaa cctggagaat
     3481 gacagagatg aaagagagga tgacagtcac gaagacagag gcatcatcag caacactcgg
     3541 ttcatagctg cagtcatgga gcggcacgca cacagcccgg aaaggaggcg acgctactgg
     3601 ggccgctcgg gaaccgaaag tgatcatggg tacagcacca tgagcccgca ggaagacagt
     3661 gagaaccctc catgcaacaa tgaccctttg tcagctgggg tggatgtagg gaaccatgat
     3721 gacgacttgg acctggacac cccgcctcag actgcagccc tgctgagcca caagttccac
     3781 cactaccgct cacaccaccc gaccctccat cacagccacc acctgcaggc ggccgtgaca
     3841 gtgcacacgg tggatgctga gtgctaacag ccctcccttc acctccagaa gcaggatgct
     3901 ctgagggaga aaagaaaatg agccggcata cagtcctgtc acatcacacg ctttgtccag
     3961 tgtggttccg ccggcgtggc tgcctgcggg cgtgtttaaa aactgaaacc acaaggtcct
     4021 gtttgtgaga atctgatgct ggttctgtaa tgtggagggg gagcctgata aactgagctg
     4081 ccgtgatgga atgggacagt aggcatacct ccaacagaga cacgtggaga gggaaccgag
     4141 ccagaggaat gctcccagca ccagaagcac tcagcccctt aactggaaga aagctggagc
     4201 agaggccagg aacgtggcac accagatgcc accagctgct ggatggactc ccacgtttcc
     4261 tagcggtacc tggatgccac cataactgta cagagctcac cttaagctct aaatgatgca
     4321 tctcaaaatt tctaagtaaa ggattatttt tctactattt attgaacttt caaactttgt
     4381 ggggggaaag gaaacgagag attctcggcc gtaaccctgg ctgttgtgtg tgatgatgtg
     4441 gttctttgac taaggagttg tgtttcttat ttaactggtg atctgcccac tgccctcatc
     4501 caccaccacc accaccccca aaaaactagg ggggaaatga agaaatcttt ctctggctt
//
