LOCUS       NM_001033676            1557 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus calcium binding protein 1 (Cabp1), transcript
            variant 3, mRNA.
ACCESSION   NM_001033676
VERSION     NM_001033676.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Mikhaylova,M., Bar,J., van Bommel,B., Schatzle,P., YuanXiang,P.,
            Raman,R., Hradsky,J., Konietzny,A., Loktionov,E.Y., Reddy,P.P.,
            Lopez-Rojas,J., Spilker,C., Kobler,O., Raza,S.A., Stork,O.,
            Hoogenraad,C.C. and Kreutz,M.R.
  TITLE     Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin
            Remodeling in Dendritic Spines
  JOURNAL   Neuron 97 (5), 1110-1125 (2018)
   PUBMED   29478916
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Kiran,U., Regur,P., Kreutz,M.R., Sharma,Y. and Chakraborty,A.
  TITLE     Intermotif Communication Induces Hierarchical Ca2+ Filling of
            Caldendrin
  JOURNAL   Biochemistry 56 (19), 2467-2476 (2017)
   PUBMED   28437073
  REMARK    GeneRIF: Data suggest that during the transition from the apo to
            the holo state, guided by the stepwise filling of Ca2+, caldendrin
            passes through distinct states and acquires a stable conformational
            state when only binding site EF3 (one of four EF-hand motifs) is
            occupied by Ca2+.
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Sinha,R., Lee,A., Rieke,F. and Haeseleer,F.
  TITLE     Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell
            Responses
  JOURNAL   eNeuro 3 (5) (2016)
   PUBMED   27822497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Reddy,P.P., Raghuram,V., Hradsky,J., Spilker,C., Chakraborty,A.,
            Sharma,Y., Mikhaylova,M. and Kreutz,M.R.
  TITLE     Molecular dynamics of the neuronal EF-hand Ca2+-sensor Caldendrin
  JOURNAL   PLoS One 9 (7), e103186 (2014)
   PUBMED   25058677
  REMARK    GeneRIF: Caldendrin exhibits very little change in surface
            hydrophobicity and secondary as well as tertiary structure upon
            Ca2+-binding to Mg2+-saturated protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Li,C., Enomoto,M., Rossi,A.M., Seo,M.D., Rahman,T.,
            Stathopulos,P.B., Taylor,C.W., Ikura,M. and Ames,J.B.
  TITLE     CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol
            trisphosphate receptors by clamping intersubunit interactions
  JOURNAL   Proc Natl Acad Sci U S A 110 (21), 8507-8512 (2013)
   PUBMED   23650371
  REMARK    GeneRIF: that InsP3 attenuates cross-linking, whereas CaBP1
            promotes it. We conclude that CaBP1 inhibits InsP3R activity by
            restricting the intersubunit movements that initiate gating.
REFERENCE   6  (bases 1 to 1557)
  AUTHORS   Smalla,K.H., Seidenbecher,C.I., Tischmeyer,W., Schicknick,H.,
            Wyneken,U., Bockers,T.M., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Kainate-induced epileptic seizures induce a recruitment of
            caldendrin to the postsynaptic density in rat brain
  JOURNAL   Brain Res Mol Brain Res 116 (1-2), 159-162 (2003)
   PUBMED   12941472
REFERENCE   7  (bases 1 to 1557)
  AUTHORS   Landwehr,M., Redecker,P., Dieterich,D.C., Richter,K., Bockers,T.M.,
            Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     Association of Caldendrin splice isoforms with secretory vesicles
            in neurohypophyseal axons and the pituitary
  JOURNAL   FEBS Lett 547 (1-3), 189-192 (2003)
   PUBMED   12860411
  REMARK    GeneRIF: Caldendrin is a neuronal calcium-binding protein. Two
            additional splice variants derive from the caldendrin gene, which
            have unrelated N-termini were identified in neurohypophyseal axons
            and on secretory granules of endocrine cells.
REFERENCE   8  (bases 1 to 1557)
  AUTHORS   Laube,G., Seidenbecher,C.I., Richter,K., Dieterich,D.C.,
            Hoffmann,B., Landwehr,M., Smalla,K.H., Winter,C., Bockers,T.M.,
            Wolf,G., Gundelfinger,E.D. and Kreutz,M.R.
  TITLE     The neuron-specific Ca2+-binding protein caldendrin: gene
            structure, splice isoforms, and expression in the rat central
            nervous system
  JOURNAL   Mol Cell Neurosci 19 (3), 459-475 (2002)
   PUBMED   11906216
  REMARK    GeneRIF: The presence of caldendrin in the PSD of distinct synapses
            may have important implications for Ca2+-modulated processes of
            synaptic plasticity.
REFERENCE   9  (bases 1 to 1557)
  AUTHORS   Lee,A., Westenbroek,R.E., Haeseleer,F., Palczewski,K., Scheuer,T.
            and Catterall,W.A.
  TITLE     Differential modulation of Ca(v)2.1 channels by calmodulin and
            Ca2+-binding protein 1
  JOURNAL   Nat Neurosci 5 (3), 210-217 (2002)
   PUBMED   11865310
  REMARK    GeneRIF: enhances inactivation, causes a depolarizing shift in the
            voltage dependence of activation, and does not support
            Ca2+-dependent facilitation of Ca(v)2.1 channels
REFERENCE   10 (bases 1 to 1557)
  AUTHORS   Seidenbecher,C.I., Langnaese,K., Sanmarti-Vila,L., Boeckers,T.M.,
            Smalla,K.H., Sabel,B.A., Garner,C.C., Gundelfinger,E.D. and
            Kreutz,M.R.
  TITLE     Caldendrin, a novel neuronal calcium-binding protein confined to
            the somato-dendritic compartment
  JOURNAL   J Biol Chem 273 (33), 21324-21331 (1998)
   PUBMED   9694893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y17048.2 and AI111711.1.
            
            Transcript Variant: This variant (3) is the longest transcript and
            encodes the longest isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y17048.2, CB586826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1388              Y17048.2           1-1388
            1389-1557           AI111711.1         1-169               c
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1557
                     /gene="Cabp1"
                     /note="calcium binding protein 1"
                     /db_xref="GeneID:171051"
                     /db_xref="RGD:620385"
     exon            1..657
                     /gene="Cabp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1116
                     /gene="Cabp1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     caldendrin"
                     /codon_start=1
                     /product="calcium-binding protein 1 isoform 3"
                     /protein_id="NP_001028848.1"
                     /db_xref="GeneID:171051"
                     /db_xref="RGD:620385"
                     /translation="MGGGDGAAFKRPGDGARLQRVLGLGSRRAPRSLPSGGPAPPPPG
                     HASAGPAAMSSHIAKSESKTSLLKAAAASGGSRAPRHSSARDPGLRGRRLPGPCPDSP
                     ATCGDPSSRRPLCRPVPRDEGARGSRRGLPQAHCRPRETLPPARGRDGEERGLAPALS
                     LRGSLRSRGRGDPAPAGTPEADPFLHQLRPMLSSAFGQDRSLRPEEIEELREAFREFD
                     KDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELMGPKLLA
                     ETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLN
                     GDGRVDFEEFVRMMSR"
     exon            658..688
                     /gene="Cabp1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..832
                     /gene="Cabp1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..942
                     /gene="Cabp1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1090
                     /gene="Cabp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1541
                     /gene="Cabp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagatccg cagcgccggc cgccgggagc tcgaggctcc gggcgcagag gctgcgctgt
       61 cacatgggcg gcggcgacgg ggccgcattt aagcggccag gggacggcgc ccgcctgcag
      121 cgcgtcctcg ggctcggctc ccgccgggcg ccccgctccc tgccctccgg gggccccgcg
      181 ccacccccgc cgggccatgc gagcgcgggc cccgccgcga tgagctcgca catcgccaag
      241 agcgagtcca agacgtcgct gctcaaggcg gcggcggcga gcgggggcag ccgggctccc
      301 cgccacagct ctgcgcggga ccccgggctg cgtggccgca ggctgcccgg tccctgcccc
      361 gactcgcctg caacgtgcgg ggaccccagc tcgcggaggc ccctgtgccg gccggtgccg
      421 cgggacgagg gcgcgcgcgg gagccggcgt gggctgcccc aggcgcactg caggccccgg
      481 gagacgctac cgccggcccg cgggcgcgat ggggaggaac gggggctggc gccggctctc
      541 agtctacggg gctccctgcg atcgcggggt cgcggggacc cggctcccgc tggcaccccc
      601 gaggcggacc cgttcctcca ccagctgcgc cccatgctca gctccgcctt cggtcaggat
      661 agatcgttac gaccagagga gatcgaagag ctccgagagg ccttccggga atttgacaag
      721 gacaaagatg gctacatcaa ctgccgggac ctggggaact gcatgcgcac catgggctac
      781 atgcccactg agatggaact catcgagctg tcccagcaga tcaacatgaa cctgggtggc
      841 cacgtggatt tcgatgactt tgtggaactg atgggcccta aactcctggc ggagacagca
      901 gatatgatcg gtgtaaagga actgagagac gcctttcggg agtttgacac caacggtgac
      961 ggggagataa gcacgagcga gctgcgagag gccatgagga agctcctggg tcatcaggtg
     1021 ggacaccggg acatagagga aattatccga gacgtggacc tcaatggaga tggacgagtg
     1081 gacttcgaag agtttgtccg gatgatgtct cgctgaggcc gctgaggggc tcctccaggt
     1141 ctgccaactc ccacaggcgg ggagaagagc tgagctcgcc tcaccccgca gtagctgccg
     1201 agagcccagg atgtactggc ggatggggcc tgcctgcacc ccggggaggt gcccaccccg
     1261 gacccccacc cctctgcact gtgaaagact cacaactcct gcaactggaa aagggggcgc
     1321 ccgccggcga ggaggccaca gtgccaagcc ggtagaggac acgcaaggcg ccaagtgcca
     1381 tctgcccagc cgctgctggc tgggtgggcc agggagcccg ccagcagacc ccacacagca
     1441 tgtctgcccc gagggcagag cctttcagcg ccctcccgat gcccgtccca gctcgcctag
     1501 ccctttgatc tcagaaccaa taaaaaaaac ggagaatgac aaaaaaaaaa aaaaaaa
//
