LOCUS       NM_001415691            3092 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Cdk5 and Abl enzyme substrate 1 (Cables1),
            transcript variant 2, mRNA.
ACCESSION   NM_001415691 XM_039096928
VERSION     NM_001415691.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Hirao,N., Sato,S., Gotoh,T., Maruoka,M., Suzuki,J., Matsuda,S.,
            Shishido,T. and Tani,K.
  TITLE     NESH (Abi-3) is present in the Abi/WAVE complex but does not
            promote c-Abl-mediated phosphorylation
  JOURNAL   FEBS Lett 580 (27), 6464-6470 (2006)
   PUBMED   17101133
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Zukerberg,L.R., Patrick,G.N., Nikolic,M., Humbert,S., Wu,C.L.,
            Lanier,L.M., Gertler,F.B., Vidal,M., Van Etten,R.A. and Tsai,L.H.
  TITLE     Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine
            phosphorylation, kinase upregulation, and neurite outgrowth
  JOURNAL   Neuron 26 (3), 633-646 (2000)
   PUBMED   10896159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 23, 2022 this sequence version replaced XM_039096928.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.53335.1,
                                           SRR26643298.72480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-995               JAXUCZ010000018.1  3351652-3352646
            996-1067            JAXUCZ010000018.1  3395393-3395464
            1068-1160           JAXUCZ010000018.1  3399651-3399743
            1161-1238           JAXUCZ010000018.1  3414863-3414940
            1239-1335           JAXUCZ010000018.1  3431887-3431983
            1336-1492           JAXUCZ010000018.1  3433148-3433304
            1493-1596           JAXUCZ010000018.1  3434571-3434674
            1597-1703           JAXUCZ010000018.1  3449999-3450105
            1704-1911           JAXUCZ010000018.1  3451454-3451661
            1912-3092           JAXUCZ010000018.1  3454776-3455956
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3092
                     /gene="Cables1"
                     /note="Cdk5 and Abl enzyme substrate 1"
                     /db_xref="GeneID:307585"
                     /db_xref="RGD:1305516"
     exon            1..995
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..2052
                     /gene="Cables1"
                     /note="isoform 2 is encoded by transcript variant 2; CDK5
                     and ABL1 enzyme substrate 1"
                     /codon_start=1
                     /product="CDK5 and ABL1 enzyme substrate 1 isoform 2"
                     /protein_id="NP_001402620.1"
                     /db_xref="GeneID:307585"
                     /db_xref="RGD:1305516"
                     /translation="MAAATATAGTAACSSSSSSSSRGGGTDAAATGGVQPPPPPATAP
                     PEPLRKPRMDPRRRQAALSFLTNISLDGRPPLQDHEWGGGEEGGAAKPGARARFSLLA
                     AGCNAFSAPGTAAAPWIAGSGSSPCPLPPSLVPRVLGEPSQPPRSAPAVTGAQLQLPD
                     GPGGAGQEELEEDDAFTNVQVPPASFLGSGTPGSASGSRGRLNSFTQGILPIAFSRQN
                     SQNYCALEQSGQGGSTTALEQLQRSRRRLISQRSSLETLEDIEENAPLRRCRTLSGSP
                     RPKNFKKIHFIKNMRQHDTRNGRIVLISGRRSFCSIFSVLPYRDSTQVGDLKLDGGRQ
                     SAGAMSLKEIIGLEGVELGADGKTVSYTQFLSPTNAFGTRRNTIDSTSSFSQFRSLSH
                     RSLSMGRTGSTQGSLDAGNDLGDFIDYDPNLLDDPQWPCGKHKRVLTFPSYMTTVIDY
                     VKPSDLKKDMNETFKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFE
                     KLALRGKLNKQNRKLCAGACVLLAAKVGSDLKKHEVKHLIDKLEEKFRLNRRELIAFE
                     FPVLVALEFALHLPEHEVMPHYRRLIQSS"
     exon            996..1067
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1160
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1238
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1335
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1492
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1596
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1703
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1911
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..3092
                     /gene="Cables1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgatcgcgc ggcacggagg gcccggccag gcgcgcgtgg gtcccggacg cggagggtga
       61 gccaggcgcg tgtgggtccc agcggcgccc gagcgcccag ggccgagcat ggcccgcccg
      121 cgggagggca gggccgcctc gcacaccgcc cgcgccccgc gccctgccca gcccgggtcg
      181 ccggggctcg cggccgccgc ttagcactcg gcacccgcca ctcgcttctc cggcaccgcg
      241 gaactgacgc cgcacacgga cacaatggcg gcggcgaccg ccaccgcggg cacggccgct
      301 tgcagcagca gcagcagcag cagcagtcgc ggcggcggca cggacgccgc ggccaccggc
      361 ggggtgcagc cgccgccgcc tcccgccacc gcgccgcccg aacctctccg taagccgcgc
      421 atggacccgc ggcgccgcca ggctgctctg tccttcctca ccaacatttc tctggacgga
      481 cggccgccgc tgcaggacca cgagtggggc ggcggcgagg agggcggcgc ggccaagccc
      541 ggagcaagag ctcggttcag cctgctggcc gccggctgca acgcgttctc agcaccgggc
      601 acggcggccg cgccgtggat cgccggctcc ggttccagcc cttgcccgct gcctccgtcc
      661 ctggtccccc gggtgttggg agagccatct cagccgcccc gctcagcccc agccgtcact
      721 ggtgctcagc tgcagttgcc tgacgggccc ggaggcgcag ggcaggagga actggaggag
      781 gacgatgcct tcaccaacgt gcaggtgcca ccggccagct tcttgggctc cgggaccccc
      841 gggagtgcga gcggcagtcg gggccgcctc aactcgttca ctcagggaat cctgcccatc
      901 gccttctcca ggcagaactc gcagaactac tgcgctttgg agcagtcagg ccagggtggc
      961 agcactaccg ccttggagca gctgcagagg tcccgacgtc gcctcatctc ccagagatca
     1021 tctttggaga ccctggaaga cattgaggag aatgcccctc tccggagatg tcgaacactc
     1081 tcgggttctc ccagaccaaa gaattttaag aaaattcatt ttatcaagaa catgcgacag
     1141 cacgatacca ggaatggcag aatagtcctt atcagtggca gaagatcctt ctgtagtata
     1201 ttttccgtgc tgccgtatcg agacagtacc caagtcgggg acctgaagtt ggatggaggg
     1261 agacagtcag caggggccat gagcctgaag gagatcattg gccttgaagg tgtggaactg
     1321 ggtgctgacg ggaagacagt gtcttatacc cagtttctat cacccacaaa tgccttcgga
     1381 acccgtagaa ataccataga ttccacctcc tccttctccc agtttcggag cctgagccat
     1441 cgaagcctct ccatgggccg gactggcagc acccagggga gccttgatgc aggaaatgac
     1501 ctgggagact ttatcgacta cgacccaaac ctcctggatg acccccagtg gccttgtggc
     1561 aagcacaagc gagtcctgac attcccttcg tacatgacca cagtgattga ctatgtgaag
     1621 ccctcagatc tcaagaagga catgaatgaa accttcaagg agaagtttcc tcacattaag
     1681 ttaacactca gcaaaatcag gagcctgaag agagagatgc ggaagctcgc ccaggaggac
     1741 tgtggttttg aggagcccac ggtggctatg gcctttgtct actttgagaa gctggccctc
     1801 aggggaaagc tgaacaagca gaaccggaaa ctctgtgcgg gagcctgtgt gctgctagca
     1861 gccaaggtcg gaagtgacct caaaaagcat gaagtcaagc atctaatcga taaactggaa
     1921 gagaagttcc ggctgaaccg aagagaactg atcgcctttg aattcccagt gttagtggcc
     1981 ttggagtttg cacttcacct gccagagcac gaagtcatgc ctcactatag acgcctgatc
     2041 cagagctcct agcaccggcc ccaggagggc tgagactgct tcctcagtgc agtggagcct
     2101 cacttactac cagacagggg agaggcgaag cggccaccac tgagctcagt ctccttgcag
     2161 ctccgctctc acagagaagc ctaagttcct ggagagacta gggagagctc aggcttgatg
     2221 aggaggcatg agctggggat gatggaggcc ctcccagctc cgcagacaga gctcagctgt
     2281 gcccagctct tcctctcagg cacatgtgaa gcttgacgct gcctcagagc ctttcctacg
     2341 ggaccggtcc tgaacttgta gcatggtgtg ctgggacaga ggagggaacg gattcgggga
     2401 cactgcttca tgttccctca ccctgtgtca agagcgtgcc aacctatttt tatatctacc
     2461 atcggaagtg cacttccctg gggcacaggg gtatgggtgt gcaagtgtcc aaggggcact
     2521 gtgacactca acctcaaagc caatccccca ccttctatgg agctgacttg taatgccttc
     2581 taggtaacaa cgactcaaat ccagattgat atctctgctc ttaggagata acactgttca
     2641 tgaaaccgta cctgccaccc attggaaagg gtgacagttc tcagtgtagg tagggtaagt
     2701 cacttgcaga gtggtgcgct ccgaactcct gctgtcccat cacggccgca gtttaaccct
     2761 ctagctcttg cctgtggaga cacgagggct gcactccata gcgtgtattc ctgtgctcta
     2821 tgttagagtg cataatgagc gcgtttattg tgctaattac atgtgtgttt tataaaagtc
     2881 tgtactgggg gtaagacgca tgatcggtgt cttgtggttt ttgcagctgg gacaaactac
     2941 atttcaagct gtggttgaac tgatcgttag tacaaaattg tgacttgtcc tgaagcattg
     3001 gccatgctgt caccaggcgg tcattcaggt gtgcccttcc tgacgagagc ctgtggtcat
     3061 ggaaaattaa aatattttgt tgtttacata ta
//
