LOCUS       NM_053575               7260 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus calcineurin binding protein 1 (Cabin1), mRNA.
ACCESSION   NM_053575 XM_003753457 XM_003753458
VERSION     NM_053575.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7260)
  AUTHORS   Wen,Y., Chen,J., Liu,L., Guo,G., Zeng,Y., Zhang,Y., Zeng,Z.,
            Wang,Z., Peng,X. and Liang,J.
  TITLE     Cabin1 involves in renal tubular epithelial cells mitochondrial
            dysfunction through SIRT1/p53 pathway
  JOURNAL   J Recept Signal Transduct Res 40 (2), 141-147 (2020)
   PUBMED   32000560
  REMARK    GeneRIF: Cabin1 involves in renal tubular epithelial cells
            mitochondrial dysfunction through SIRT1/p53 pathway.
REFERENCE   2  (bases 1 to 7260)
  AUTHORS   Wen,Y., Liu,L., Xu,Q., Zhou,P., Li,H., Wang,Z. and Liang,J.
  TITLE     Knocking down Cabin1 induces glomerular podocyte injury
  JOURNAL   Int Urol Nephrol 50 (5), 983-991 (2018)
   PUBMED   29368245
  REMARK    GeneRIF: Knocking down Cabin1 induces the disruption of
            cytoskeleton and mitochondrial dysfunction in podocyte. Cabin1
            could be a crucial factor in podocyte damage.
REFERENCE   3  (bases 1 to 7260)
  AUTHORS   Wen,Y., Li,H., Zhou,P., Liu,L., Wang,Z. and Liang,J.
  TITLE     Upregulation of Cabin1 During Injury to Renal Tubular Epithelial
            Cells in Rats
  JOURNAL   Iran J Kidney Dis 11 (6), 430-437 (2017)
   PUBMED   29190603
  REMARK    GeneRIF: Injury to renal tubular epithelial cells results in
            up-regulation of cabin1 expression.
REFERENCE   4  (bases 1 to 7260)
  AUTHORS   Wen,Y., Zhou,P., Liu,L., Wang,Z., Zhang,Y. and Liang,J.
  TITLE     Effect of the knockdown of Cabin1 on p53 in glomerular podocyte
  JOURNAL   J Recept Signal Transduct Res 36 (2), 173-180 (2016)
   PUBMED   26400065
  REMARK    GeneRIF: In conclusion, Cabin1 expression significantly increases
            during podocyte injury. Knockdown of Cabin1 induces p53 expression
            decrease in cultured podocyte. Cabin1 may provide a new target to
            investigate podocyte injury.
REFERENCE   5  (bases 1 to 7260)
  AUTHORS   Yi,J.K., Kim,H.J., Yu,D.H., Park,S.J., Shin,M.J., Yuh,H.S.,
            Bae,K.B., Ji,Y.R., Kim,N.R., Park,S.J., Kim,J.Y., Lee,H.S.,
            Lee,S.G., Yoon du,H., Hyun,B.H., Kim,W.U. and Ryoo,Z.Y.
  TITLE     Regulation of inflammatory responses and fibroblast-like
            synoviocyte apoptosis by calcineurin-binding protein 1 in mice with
            collagen-induced arthritis
  JOURNAL   Arthritis Rheum 64 (7), 2191-2200 (2012)
   PUBMED   22275266
REFERENCE   6  (bases 1 to 7260)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   7  (bases 1 to 7260)
  AUTHORS   Kim,M.J., Jo,D.G., Hong,G.S., Kim,B.J., Lai,M., Cho,D.H., Kim,K.W.,
            Bandyopadhyay,A., Hong,Y.M., Kim,D.H., Cho,C., Liu,J.O.,
            Snyder,S.H. and Jung,Y.K.
  TITLE     Calpain-dependent cleavage of cain/cabin1 activates calcineurin to
            mediate calcium-triggered cell death
  JOURNAL   Proc Natl Acad Sci U S A 99 (15), 9870-9875 (2002)
   PUBMED   12114545
REFERENCE   8  (bases 1 to 7260)
  AUTHORS   Lai,M.M., Luo,H.R., Burnett,P.E., Hong,J.J. and Snyder,S.H.
  TITLE     The calcineurin-binding protein cain is a negative regulator of
            synaptic vesicle endocytosis
  JOURNAL   J Biol Chem 275 (44), 34017-34020 (2000)
   PUBMED   10931822
REFERENCE   9  (bases 1 to 7260)
  AUTHORS   Lai,M.M., Burnett,P.E., Wolosker,H., Blackshaw,S. and Snyder,S.H.
  TITLE     Cain, a novel physiologic protein inhibitor of calcineurin
  JOURNAL   J Biol Chem 273 (29), 18325-18331 (1998)
   PUBMED   9660798
REFERENCE   10 (bases 1 to 7260)
  AUTHORS   van Deursen,J., Boer,J., Kasper,L. and Grosveld,G.
  TITLE     G2 arrest and impaired nucleocytoplasmic transport in mouse embryos
            lacking the proto-oncogene CAN/Nup214
  JOURNAL   EMBO J 15 (20), 5574-5583 (1996)
   PUBMED   8896451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF061947.1, JAXUCZ010000020.1 and DV716961.1.
            
            On or before Jul 7, 2012 this sequence version replaced
            XM_003753457.1, XM_003753458.1, NM_053575.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061947.1, SRR26643429.57528.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AF061947.1         7-308
            303-313             JAXUCZ010000020.1  12911315-12911325
            314-472             AF061947.1         310-468
            473-483             JAXUCZ010000020.1  12911315-12911325
            484-761             AF061947.1         470-747
            762-772             JAXUCZ010000020.1  12911315-12911325
            773-1284            AF061947.1         749-1260
            1285-1295           JAXUCZ010000020.1  12911315-12911325
            1296-2475           AF061947.1         1272-2451
            2476-2521           JAXUCZ010000020.1  12943795-12943840
            2522-3405           AF061947.1         2453-3336
            3406-3451           JAXUCZ010000020.1  12943795-12943840
            3452-4092           AF061947.1         3338-3978
            4093-4138           JAXUCZ010000020.1  12943795-12943840
            4139-7192           AF061947.1         4025-7078
            7193-7380           DV716961.1         157-344
FEATURES             Location/Qualifiers
     source          1..7260
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..7260
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /note="calcineurin binding protein 1"
                     /db_xref="GeneID:94165"
                     /db_xref="RGD:620263"
     exon            1..254
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            255..328
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..6874
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /note="calcineurin inhibitor; calcineurin-binding protein
                     cabin-1-like"
                     /codon_start=1
                     /product="calcineurin-binding protein cabin-1"
                     /protein_id="NP_446027.2"
                     /db_xref="GeneID:94165"
                     /db_xref="RGD:620263"
                     /translation="MIRIAALNASSTIEDDHEGSFKSHKIQTKEAQEAEAFALYHKAL
                     DLQKHDRFEESAKAYHELLEARLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQ
                     REDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRLPLARHAFEEGLRCNPDHWPC
                     LDNLITVLYTLSDYTTCLYFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLK
                     CDMSVHEVSVNAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGES
                     LLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQLLAPSVVVTPVSVVQPSPVCTNPTVA
                     VAEPVLSYTSVTTTSFPLHSPGLLDTGTPMGDVSGGDKSKKGVKRKKTLEESGETAKR
                     RSARVRNTKCKKEEKVDFQGLLVKFLPSRLRKLDPEEEDDPFNNYEVQSEAKLESFSN
                     VGPHRLSFDSATFMESEKQDVHAFLMENLTNGGVLELMMRYLKSMGHKFLLKWPPGLA
                     EVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSTV
                     SPRNCPAGVVTGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARF
                     LALQGDMEQALENYDICTEILQSSTALQAQAGAEQRDIVIRLPNLHNDSIVSLEEIDK
                     NLKSLERCQSLEEIQRLFEAGDYKAVVQLLRPTLCTSGFDRAKHLEFMTSIPERPAQL
                     LLLQDSLLRLEEHRQCFECSDVALNEAVQQMLNSSDSAAKEEWAATVTQLLLGMEQAL
                     SSDSRGSILKESSSPTGLVRLTNNLIQVIDCSMAVQEEPKEPYVSSVLPWIILHRIIW
                     QEEDTFRSLCHQQQLQNPTEEGISEMPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLR
                     FYVHVLQKELAASASEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVD
                     LTWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTEKPALSMDKVS
                     AYIEGTSAEVPCLPDGADPAPPVLNELYYLLADYHFKNKEQSKAIKFYMHDICICPNR
                     FDSWAGMALARASRIQDKLNSNELKSDGPIWRHATPVLNCFRRALEIDSSNLSLWIEY
                     GTMSYALHSFASRQLKQWRAELPPEVVQQMEDRRDSMLETARHCFTSAAHCEGDGDEE
                     EWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALE
                     VYFRLHASILKLLGKPDSGVSAEVLVSFMKEAAEGPFARGEEKNTPKASEKEKACLVD
                     EDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPRQQATPDDRSQDS
                     TAVALSDSSSTQDFFNEPTSLLDGSRKLLPEKRISGLSAQAGPSGKDLPGPTEERGKT
                     EESLESTEAFRVVEPSVQKPVADSSASAYIPSKPAVSTPPPWDGKKRSDPLGEPVAFP
                     QGLPAGAEEQRQFLTEQCIASFCLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDV
                     LLGSSIPWQQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLL
                     KVLAQLRDHSTLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELA
                     EGLEHPGSKACGLSGARMTTDVSHKASPEDGQESLPHPKKLPLADGSGPGPEPGGKVG
                     PLHQLPVATDTRDNTEQGGEPKDKERPPVGPTEPMDTGETAARHPDLEPTPRLLPGRP
                     PRDRGPESRSAELSLEELSISTRQQPAPLVPSPVTPTTAAPTTMGARAAGHPEEAPPR
                     PNRKRKLLQDTESGKTLLLDAYRVWQQGQKAMAYDLSRIEKIMSETYMLIKQVDEETA
                     LEQAVKFCQVHLGAAAQRQASGDAPTTPKHPKDSRENFFPATVAPSAPDTTAPDALQR
                     PSDSHLKPGLAAAITCPPSASASTPDPGIPQPHRPEAVPSRAPLSPDGEEVSGVTEGP
                     SFLSQEPRHSHQMKMAATGPLAEQHCWPVEAACQTGAEPTFSQATSTKVPSSGSTQTP
                     ESHQGKTESSRAKSRLLPNMPKLVIPSATTKFPPEITVTPPTPTLLSPKGSISEETKQ
                     KLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDFMDV"
     exon            329..421
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            422..535
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            536..670
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            671..851
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            852..981
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1131
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1418
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1587
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1724
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1942
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2021
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2209
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2362
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2557
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2800
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2957
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3073
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3235
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3442
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3588
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            3589..3850
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..4111
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            4112..4263
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            4264..4442
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            4443..4625
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            4626..4957
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            4958..5071
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..5235
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            5236..5332
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            5333..6007
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6082
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6338
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            6339..6503
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            6504..6730
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
     exon            6731..7260
                     /gene="Cabin1"
                     /gene_synonym="Cain"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggaggtc cgtgcagggc tccggtgagc gcgaggaggt gggaacacgc gacgcccgct
       61 ctccattacg ggcgcggtgg gccgaagcct ggctcgagac ccgaaggcgc tgacaaggac
      121 cttctggcca cgcctgctcc tccgcgcgcc ccgccgctgc gcccggaggc gcccagggtg
      181 ggtcactggg accgcagctc gaagccatcc ctttctgtgc gtcctttcat tcaccttcac
      241 agcagcccag agagggactg tcaactggca catcccccac cagtgatggg aagtgatcct
      301 ccgtggtggc gctgaatctc tgaatatgat tcgaattgca gccttaaatg ccagctccac
      361 aattgaagat gaccatgaag gaagctttaa aagtcacaaa atccagacaa aggaggctca
      421 ggaagcagaa gcctttgccc tataccacaa ggccctggat ctacagaaac atgacaggtt
      481 tgaggagtct gccaaggcct accatgaact cctggaggct cgcctgctgc gagaggcagt
      541 ttcatccgga gatgagaagg aagggctgaa gcaccctgga ctgatactga aatattctac
      601 gtataagaac ctggcccagc tggcagccca gcgggaggac ctggagacag ccatggagtt
      661 ttatttggag gccgtgatgc tggattccac agacgtcaac ctttggtaca agattggaca
      721 tgtggccctg aggctcatcc gacttcccct ggctcgccat gcttttgagg aagggctccg
      781 gtgtaatcct gaccactggc cctgcttgga caacctcatc actgttttgt acaccctcag
      841 cgattacaca acatgtcttt acttcatctg caaagcactg gagaaagact gccgctacag
      901 caaaggcctg gttctcaagg agaagatttt tgaagagcaa ccttgtctcc gaaaggactc
      961 actccgaatg ttcctcaaat gtgacatgtc agttcacgag gtgtcagtga atgcagcaga
     1021 gacacaggcc attgtagacg aggctctggg gctgcggaag aagaggcagg cgttgatcgt
     1081 gcgggaaaag gagccagacc tgaaactagt gcagcccatc cctttcttca cgtggaagtg
     1141 ccttggagag agcttgcttg ccatgtacaa tcacctcacc acgtgtgagc ctcccaggcc
     1201 cagcctgggc aagaggattg acctgtctga ctaccaggat cccagccagc tgctagcccc
     1261 ctccgtcgtg gttactcctg tcagtgtggt ccagccaagt cctgtttgca ccaatccaac
     1321 tgttgctgtg gccgagcctg tgctctccta cacctctgtg accacaacca gcttcccact
     1381 gcacagtcct ggcctgctgg acacgggcac tcctatgggt gatgtttccg gaggagataa
     1441 atctaaaaaa ggggtgaagc gtaagaagac tttagaggaa agtggggaga cagcaaagcg
     1501 gaggtctgcc cgtgtccgca acaccaagtg caaaaaagaa gagaaggtgg atttccaggg
     1561 gcttctggta aagttcctgc cgtccaggtt aagaaaactg gaccctgagg aggaagatga
     1621 tccatttaac aactatgaag ttcagtcaga agccaaactg gagagcttct cgaacgtggg
     1681 acctcatcga ctgtccttcg attcagccac attcatggaa tctgagaagc aggatgtgca
     1741 tgcgttcctg atggagaacc tgaccaatgg gggcgtcctg gagctcatga tgcgctacct
     1801 gaagagcatg ggccacaagt tcctgctgaa gtggccccca ggcctggcgg aggtcgtact
     1861 tagcgtctac cacagctgga ggaggcacag taccagcctg cccaacccat tgctgaggga
     1921 ctgcagcaac aagcacatca aggacatgat gctgatgtct ctttcctgca tggagctcca
     1981 actggaccag tggcttctga ccaaaggcag aagctccacg gtgtctcccc ggaactgccc
     2041 tgctggtgtg gtgacaggca ggtttgggcc agacttccca ggaacccact gcctgggtga
     2101 cctcctgcag ctgtcatttg cgtcatctca gcgggatctg tttgaggacg gctggctgga
     2161 gtttgtggtc cgtgtttact ggctgaaggc acgtttcttg gcactacagg gcgatatgga
     2221 gcaagctttg gagaactatg atatctgcac agagatactc cagagctcca cggctctcca
     2281 agcccaggca ggggctgagc aaagggacat tgtcatccgg ctgcccaacc tgcacaatga
     2341 ctccattgtt tctctggagg aaattgataa gaacctgaag tctctggaaa ggtgccagtc
     2401 cctggaggag attcagcggc tgtttgaggc gggcgactac aaggctgtgg tgcagctgct
     2461 ccggcccact ctgtgcacca gtggctttga ccgagccaaa cacctggagt ttatgacttc
     2521 cattcccgag aggccggccc agctgcttct gctgcaggac tctctgctcc ggctggagga
     2581 gcacaggcag tgctttgaat gctctgacgt ggccctcaat gaagctgtcc agcagatgct
     2641 gaactcgagt gactctgcgg ccaaggagga gtgggcggcc acagtgacgc agctgctgct
     2701 aggcatggag caggcactgt catcagacag caggggcagc atcctgaagg agtcctcctc
     2761 tcccacgggc cttgtccggc tcaccaacaa cctcattcag gtcatcgact gcagcatggc
     2821 tgtgcaggag gagcccaagg agccctatgt ctcctccgtg ctgccctgga tcatcctcca
     2881 caggatcatc tggcaggagg aagacacttt ccggtctctg tgccaccagc agcagctcca
     2941 gaacccaacg gaagaaggga tctcggagat gcccatgctc ccatcttccc tcatgctgct
     3001 caacacagca catgagtacc tgggcaggag gtcctggtgc tgcaattcag atggagcgct
     3061 gctgcgattc tatgtgcacg ttctccaaaa ggagcttgct gcgtctgcct ctgaggacac
     3121 tcacccctac aaggaggagc tggagaccgc cttggagcag tgtttctact gcctctacag
     3181 cttccccagc aagaagagca aggccaggta cctggaggag cactcagccc agcaggtgga
     3241 cctcacctgg gaggacgccc tgttcatgtt tgagtacttc aagcccaaga ccctccctga
     3301 gtttgacagc tacaagacca gcaccgtctc cgcggacttg gcaaacctgt tgaaaagaat
     3361 cgccaccatt gtgccgcgca cagagaagcc cgccctgagc atggacaaag tctctgccta
     3421 cattgaggga acctcagcgg aggtgccctg ccttcctgac ggggcagacc ccgcccctcc
     3481 agtgctgaat gagctctact acctcctggc tgactatcac ttcaaaaaca aagagcagtc
     3541 caaagccatc aagttctaca tgcatgacat ttgcatctgc cctaacaggt ttgattcctg
     3601 ggcaggcatg gctctggccc gggccagccg aattcaggac aagctgaact caaatgagct
     3661 gaagagtgat ggacccatct ggagacatgc cacacctgtt ctgaactgct tccggagggc
     3721 ccttgagatt gacagctcta acttgtcctt gtggattgag tatggcacca tgtcctatgc
     3781 cttgcactca ttcgcgtccc gtcagctgaa gcagtggcga gccgagctgc ctcctgaggt
     3841 tgtgcagcag atggaggatc ggcgagacag catgctggag acagccaggc actgtttcac
     3901 gtctgcagcc cactgcgagg gtgatggcga tgaggaggag tggctcattc actacatgct
     3961 gggcaaagtg gccgagaagc agcagcagcc gccgaccgtg tacctgctgc actaccgcca
     4021 ggcgggccac tacttacacg aggaggccgc ccgctaccct aagaagattc actaccacaa
     4081 cccgcccgag ctggccatgg aagccctgga ggtgtacttc cggctccatg cgtccatcct
     4141 gaagctcctg ggcaaacctg actctggggt tagcgcagag gtcctggtca gctttatgaa
     4201 ggaagcagca gaaggacctt ttgccagggg cgaggagaag aatacaccta aagcttcaga
     4261 aaaggagaag gcctgcctgg tggatgagga ctcccactct tcagctggga cactgccggg
     4321 ccccggagcc tcccttccct cctcctctgg cccaggtctg acatccccac cttacacagc
     4381 cactccgatt gaccacgatt acgtcaaatg taaaaaaccc cgtcagcagg cgacgccgga
     4441 cgaccgaagc caggacagca cagctgtggc actgtcagac tccagctcaa cacaggactt
     4501 ctttaatgag cccacaagtt tgctggacgg ttctcgaaag ctccttccag agaagaggat
     4561 ctctgggctc agtgctcaag caggaccaag tggtaaagac cttccagggc ccacagagga
     4621 aagaggaaaa acggaggagt ctttggagag cacagaggcc ttccgggttg tagaaccaag
     4681 cgtccagaag cctgtggcag attcctcggc ctctgcttac atccccagca agcccgcagt
     4741 gtccacgccc cctccgtggg atgggaagaa gaggagtgac cccctagggg agccagtggc
     4801 tttccctcag gggctgccag caggtgctga ggaacagcgc cagttcctca cagagcagtg
     4861 catcgcctcc ttctgcctgt gcttgagtcg cttcccacag cactacaaga gtctctaccg
     4921 gctggccttt ctctacacct acagcaagac tcaccggaac ctccagtggg cccgtgatgt
     4981 gttgctaggc agcagtatcc catggcaaca actgcagcac atgccggcac aggggctctt
     5041 ctgcgagagg aacaagacca atttcttcaa cggcatctgg cggatccccg tggatgagat
     5101 tgaccggccc ggcagcttcg cctggcacat gaaccgctcc atcgtgctgc tactcaaggt
     5161 tctagcccag ctccgggacc acagcaccct gttgaaggtg tcctccatgc tgcagcggac
     5221 accagaccag ggcaagaaat atctgcgaga tgctgaccgc caggtgctgg cacagcgcgc
     5281 cttcatcctc actgtgaagg tgctggagga cacactgagt gagcttgcag aggggttaga
     5341 gcacccagga tccaaggcct gtggcctctc tggagccagg atgaccaccg atgtctcaca
     5401 caaagccagt cccgaggatg gccaggaaag cctcccacac cccaagaagc tacctctagc
     5461 tgatggctca ggaccagggc ctgagccagg gggcaaagtg ggccctctcc accaattgcc
     5521 agtggccaca gacacaaggg acaacacaga gcagggtggg gagccgaaag acaaagagcg
     5581 tcccccggtg gggcccacag aacccatgga caccggcgag actgctgctc gccacccaga
     5641 cttggaaccg acgccacgtc tgttgccagg ccgcccccca agggaccggg gtcccgagag
     5701 ccgctctgct gagctttccc tggaggagct gagcatcagc acccggcagc agcctgcccc
     5761 acttgtacca tccccagtaa cccccaccac agctgctccc actaccatgg gggccagggc
     5821 agcggggcac cccgaggagg caccgccaag gcctaatcga aagaggaaac tcctgcagga
     5881 cacagagtct ggcaagacgc tccttttgga cgcctaccgt gtgtggcagc agggccagaa
     5941 ggccatggcc tatgacctga gccgcatcga gaagatcatg tcggagactt acatgctcat
     6001 caagcaggtg gacgaggaga ctgcactgga gcaggctgtg aagttctgtc aggtccacct
     6061 cggggctgct gcccagagac aggcctcagg agatgcaccc actaccccca agcaccccaa
     6121 ggacagccga gagaatttct tccctgcaac agtggccccc tcagcacctg acaccacagc
     6181 acctgacgct ctccagcggc ccagtgactc ccacctcaag cctgggttgg ctgctgccat
     6241 cacctgccct ccctcagcat cagcctctac cccagaccct ggaattcccc agccacacag
     6301 gccagaggct gtgcccagca gggcccctct gagtcctgat ggagaagagg tgtcaggagt
     6361 gacagagggt cccagctttc tatcccaaga accacggcac agtcaccaga tgaaaatggc
     6421 tgccactggt cccctggccg agcagcactg ctggccagtg gaggctgctt gccagacagg
     6481 tgccgagccc accttcagcc aagccaccag caccaaggtc cccagcagtg gaagtaccca
     6541 gacacctgag agccatcaag gcaaaactga gtccagcaga gccaagtccc gcctcctgcc
     6601 caacatgcca aagctggtga tcccctcggc caccaccaag ttcccccctg agatcaccgt
     6661 cacaccacct acccccaccc tgctctcccc caaaggcagc atctcagagg agaccaagca
     6721 gaagctgaag tctgccatcc tgtctgccca atctgccgcc aatgtgagga aggagagcct
     6781 gtgccagcca gccctggagg ttctggagac atccagccag gagtcctcat tggagagtga
     6841 gacagacgag gacgatgact ttatggacgt atgacgggtt cacccagagg cagggcctgg
     6901 ggtccctttg gtccagaccc tgggcaaggc cagaagccta ttgaggtatg gttccctgtg
     6961 gtctcctaag cctgcccagc cccctctttg cagcaccctg ccctggctca ggctgtccag
     7021 agcgtgctgg tccagaggac ggtacggcct gtcttaggca catgcactgc tgtggtctgc
     7081 acagccggga tgctgccgcc gccgccgctt ctttttttaa tgagatactg actttctcta
     7141 caagcccgtg tgtactgacc aggcccacag tccagtgccg aggagacatc aggagcctag
     7201 ctctccccac accctttttt gtcattgttg cttctttttc taataaagat ggaaaatggt
//
