LOCUS       NM_001401625            3804 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus calcium binding protein 39 (Cab39), transcript
            variant 2, mRNA.
ACCESSION   NM_001401625 XM_006245373
VERSION     NM_001401625.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3804)
  AUTHORS   Jiang,L., Yan,Q., Fang,S., Liu,M., Li,Y., Yuan,Y.F., Li,Y., Zhu,Y.,
            Qi,J., Yang,X., Kwong,D.L.W. and Guan,X.Y.
  TITLE     Calcium-binding protein 39 promotes hepatocellular carcinoma growth
            and metastasis by activating extracellular signal-regulated kinase
            signaling pathway
  JOURNAL   Hepatology 66 (5), 1529-1545 (2017)
   PUBMED   28605041
  REMARK    Erratum:[Hepatology. 2020 Oct;72(4):1501. PMID: 33464579]
REFERENCE   2  (bases 1 to 3804)
  AUTHORS   Bhuiyan,M.I.H., Song,S., Yuan,H., Begum,G., Kofler,J., Kahle,K.T.,
            Yang,S.S., Lin,S.H., Alper,S.L., Subramanya,A.R. and Sun,D.
  TITLE     WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic
            brain damage in hypertensive rats
  JOURNAL   J Cereb Blood Flow Metab 37 (8), 2780-2794 (2017)
   PUBMED   27798271
REFERENCE   3  (bases 1 to 3804)
  AUTHORS   Behunin,S.M., Lopez-Pier,M.A., Mayfield,R.M., Danilo,C.A.,
            Lipovka,Y., Birch,C., Lehman,S., Tardiff,J.C., Gregorio,C.C. and
            Konhilas,J.P.
  TITLE     Liver Kinase B1 complex acts as a novel modifier of myofilament
            function and localizes to the Z-disk in cardiac myocytes
  JOURNAL   Arch Biochem Biophys 601, 32-41 (2016)
   PUBMED   26971467
REFERENCE   4  (bases 1 to 3804)
  AUTHORS   Ponce-Coria,J., Markadieu,N., Austin,T.M., Flammang,L., Rios,K.,
            Welling,P.A. and Delpire,E.
  TITLE     A novel Ste20-related proline/alanine-rich kinase
            (SPAK)-independent pathway involving calcium-binding protein 39
            (Cab39) and serine threonine kinase with no lysine member 4 (WNK4)
            in the activation of Na-K-Cl cotransporters
  JOURNAL   J Biol Chem 289 (25), 17680-17688 (2014)
   PUBMED   24811174
  REMARK    GeneRIF: Cab39 differentially interacts with WNK4 and SPAK/OSR1 to
            switch the classic two kinase cascade into a signal kinase
            transduction
REFERENCE   5  (bases 1 to 3804)
  AUTHORS   de Los Heros,P., Alessi,D.R., Gourlay,R., Campbell,D.G., Deak,M.,
            Macartney,T.J., Kahle,K.T. and Zhang,J.
  TITLE     The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and
            inhibit the K+-Cl- co-transporters
  JOURNAL   Biochem J 458 (3), 559-573 (2014)
   PUBMED   24393035
REFERENCE   6  (bases 1 to 3804)
  AUTHORS   Denison,F.C., Hiscock,N.J., Carling,D. and Woods,A.
  TITLE     Characterization of an alternative splice variant of LKB1
  JOURNAL   J Biol Chem 284 (1), 67-76 (2009)
   PUBMED   18854309
REFERENCE   7  (bases 1 to 3804)
  AUTHORS   Branvold,D.J., Allred,D.R., Beckstead,D.J., Kim,H.J., Fillmore,N.,
            Condon,B.M., Brown,J.D., Sudweeks,S.N., Thomson,D.M. and
            Winder,W.W.
  TITLE     Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB,
            and PGC-1alpha in rat muscle
  JOURNAL   J Appl Physiol (1985) 105 (4), 1218-1227 (2008)
   PUBMED   18669938
  REMARK    GeneRIF: Examine thyroid hormone effects on LKB1, MO25,
            phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle.
REFERENCE   8  (bases 1 to 3804)
  AUTHORS   Taylor,E.B., Hurst,D., Greenwood,L.J., Lamb,J.D., Cline,T.D.,
            Sudweeks,S.N. and Winder,W.W.
  TITLE     Endurance training increases LKB1 and MO25 protein but not
            AMP-activated protein kinase kinase activity in skeletal muscle
  JOURNAL   Am J Physiol Endocrinol Metab 287 (6), E1082-E1089 (2004)
   PUBMED   15292028
  REMARK    GeneRIF: Endurance training markedly increased skeletal muscle LKB1
            and MO25 protein without increasing AMPKK activity.
REFERENCE   9  (bases 1 to 3804)
  AUTHORS   Hardie,D.G.
  TITLE     The AMP-activated protein kinase pathway--new players upstream and
            downstream
  JOURNAL   J Cell Sci 117 (Pt 23), 5479-5487 (2004)
   PUBMED   15509864
  REMARK    Review article
REFERENCE   10 (bases 1 to 3804)
  AUTHORS   Hawley,S.A., Boudeau,J., Reid,J.L., Mustard,K.J., Udd,L.,
            Makela,T.P., Alessi,D.R. and Hardie,D.G.
  TITLE     Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and
            MO25 alpha/beta are upstream kinases in the AMP-activated protein
            kinase cascade
  JOURNAL   J Biol 2 (4), 28 (2003)
   PUBMED   14511394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Feb 16, 2022 this sequence version replaced XM_006245373.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.1949952.1,
                                           SRR26643297.32206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               JAXUCZ010000009.1  93911099-93911470
            373-529             JAXUCZ010000009.1  93936729-93936885
            530-694             JAXUCZ010000009.1  93954959-93955123
            695-813             JAXUCZ010000009.1  93957069-93957187
            814-982             JAXUCZ010000009.1  93962630-93962798
            983-1042            JAXUCZ010000009.1  93965398-93965457
            1043-1108           JAXUCZ010000009.1  93968257-93968322
            1109-1252           JAXUCZ010000009.1  93969245-93969388
            1253-3804           JAXUCZ010000009.1  93969991-93972542
FEATURES             Location/Qualifiers
     source          1..3804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..3804
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /note="calcium binding protein 39"
                     /db_xref="GeneID:301574"
                     /db_xref="RGD:1306390"
     exon            1..372
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            373..529
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1441
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="calcium-binding protein 39 isoform 2"
                     /protein_id="NP_001388554.1"
                     /db_xref="GeneID:301574"
                     /db_xref="RGD:1306390"
                     /translation="MPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVS
                     KNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIF
                     NNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKII
                     LWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLL
                     HSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFH
                     VFKVFVANPNKTQPILDILLKNQTKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLK
                     RAAQQEA"
     exon            530..694
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            695..813
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            814..982
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1042
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1108
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1252
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..3804
                     /gene="Cab39"
                     /gene_synonym="MO25; MO25alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaggccgg agctgggcgc ggggcgccag gagccgcgcg gcctgagaga gtctggggct
       61 tcagtagtcg cgcgaaggct gaggcaacct cagaggcgaa ggcagtgccg gaccacacag
      121 ccacagccgc agccggaccg agcgcagcag cgcggcggcc acagcaggaa cccctgggcc
      181 accgtccacc cgcgcagccg ccgccgccgc cgcgggagcc cgtcgccccg agcagctgca
      241 ggcggaggac aacggagggc cggagcttcc gagccgcacc gcggggaccg agcgagcagc
      301 ccgaggcggc ggcggccgag gacggggacg gagacgacac ggagagggag ctccctggcc
      361 cggcccagcc ccgtcaagca ggtagagtgc agtggaagcc tctggtgctg ccgtcatgcc
      421 gttcccattt ggcaagtctc acaagtctcc ggcagatatt gtgaagaatt tgaaggagag
      481 catggctgtt ttggaaaagc aggacatttc tgacaaaaag gcagaaaagg ctacagaaga
      541 agtttccaaa aatttggttg ccatgaaaga aattctgtac ggcacaaatg agaaggagcc
      601 ccagacagag gccgtagcac agctggctca ggagctgtac aatagtggcc tcctcagcac
      661 cctggtggct gacttacagc tcattgactt tgagggcaaa aaagacgtgg ctcaaatttt
      721 caacaatatt ctcagaagac aaattggtac aagaactcct actgttgaat acatctgcac
      781 ccaacagaat attttgttca tgttattgaa agggtatgaa tctccagaaa tagctcttaa
      841 ttgtgggata atgttaagag aatgcatcag acacgaacca ctcgcaaaaa tcattttgtg
      901 gtcggaacag ttttatgact tcttcagata tgttgaaatg tcaacatttg acatagcttc
      961 agatgcattt gctacgttca aggatttact tacaagacat aagttgctca gtgcagaatt
     1021 tttggagcaa cattatgata gatttttcag tgaatatgaa aagctacttc attcagaaaa
     1081 ttatgtgaca aagagacagt cactgaagct tctgggtgaa ctgctgttag acagacacaa
     1141 cttcactatt atgacgaaat acatcagtaa acctgagaac ctcaagttaa tgatgaacct
     1201 cctccgagac aagagccgta acatccagtt tgaggccttt cacgtgttca aggtgtttgt
     1261 ggccaacccc aacaagacac agcccatcct agacatcctc ctcaagaacc agaccaaact
     1321 catcgagttc ctcagcaaat ttcagaacga caggacggaa gacgagcagt tcaatgatga
     1381 gaagacctac ttagtcaagc agatcaggga tttgaagaga gcagcccagc aagaagccta
     1441 gtctgcagca cgccctgccg tccacccacg ctcagcactt gctgtcagct cctcagcacc
     1501 aggccctcgg cgcatgggga gcattctgct aatctgctgt taagtgaacg gtttttcatt
     1561 ttaccttttt gtttttcagt ccaggttgga gaacgtagct gctgctgctt gcacattaga
     1621 gcgcacgtgg tctttccctt gatctctgtg tcatttcaga actcacagac tccatttgct
     1681 acaggagttc tgaacatggc tgggttcatg aaagcaaatg tacagtgaga gtggtctagg
     1741 gaaagaagag aacgtgatga catggactga cacctgcctg gccatcagca ctgctctctc
     1801 cagtctgtgc agtgcggcac gggcacaccc accctggtgc cgggtcatcc gtctctgccg
     1861 caggaagacg gtgtacacag gggtctactg gagatcagaa gggaggactg catccagtgt
     1921 gagctttggg gaggataaag ttgatgtgca aataaattga tactgaaact tagcgacttc
     1981 tcgagtgtgg aacttcataa ggtcataaga aagtgtatat atgctttttc acagctttct
     2041 agaacttttt gacatttgat tttcttgaaa cttgtaaacc tggatatgtt gaggggtgtt
     2101 tgttatttta cttttgaagg tgttttaaag cagtagcgct agcagcaaca cccagtgttt
     2161 catttcaaca ctgcttacag gtttcttctg tatataattc ttagaatgct catttctttt
     2221 aaatcgttta atttgtacag cagaggaatg ttattgtagt agtatgtaac tattacctga
     2281 gttttgcaaa aaaaaaaaaa aaagaatgct catatgtaat tgaaatactt gagattacat
     2341 gaaaatgctg attttaacat ttaaggatca cagcattaaa agaaaaaaaa accaatccct
     2401 tgtattcagt tacccaatgg ggtgccgttg gcaggcagaa ctacaaaccg ggaacgcggt
     2461 ctgtacatac tcttgcagaa ccttggcctt actcatttaa atgcgtccta agattgccat
     2521 atctatgaat gatacagatc atgctaaaca atgctgattt tttttgttgg ggggggacct
     2581 cttgtagagc accctttctt tagagtaagt aatatccagt acagtagtcg tgaaactgaa
     2641 taattaaaac tttggcttct cttaggaaaa gaagagccct ggtcctagat gtcctcgggg
     2701 agattgatgg tttttaatgt ccttttcctt aatgctgcaa attatcagta tttataaagt
     2761 aactgatttt gcacctcttt ttgtgactgt gaccacagca gaacagtgtc tcctagactg
     2821 tatctacata aagttactag aatggtgtct gtctgtctta gttgacacac ggatcacaac
     2881 taacaactta aaatcagagt ttgcccgatc caattcagca tggctgtagc tgactaaaaa
     2941 aatttacata attattcttt gctagcctct cttactaact gaattattca ttggccagta
     3001 aaaggagtct cctagctgat gttttaggtt ttaaggtttc cttcaaggaa tacaagtcag
     3061 aaaaaccact ccagaaaata caggtctgtt ctatttcatc taaatggcag tcttcaataa
     3121 aggatttcca aggctttctt taccggtgtg cgtacgtgcg tgataactca tgttctccag
     3181 tagagataga gaaagtattc aatctcctgg acaaggaaat cctcagctgg gtaggaagca
     3241 gactcagctg agctaagtga cccagtcctt gccaccctcg ctgagtcagg atctggtgac
     3301 agcagccatt acaccgaatg gaaggggtgt cttgttgcct agccagctct gagaacttga
     3361 ggcaacaatg cagcttccac ttgggcaaac acagagtagt actagagcct tgctgtggca
     3421 gatgggtgcc atgtgtcaga gaactgggtc actaatgaac gcactggaag aggaaggcag
     3481 agaaggctct ggattgtttt taaacagaac aatgtgaaaa cattcaagat tgaaaagttg
     3541 catttaaagt gtgatcattt cctaggttcc tattaccaga acgattatcc tgggtgtggt
     3601 ttctttggtg ttgtaaaggg ttaattttac ttaaggcagt tacttaatgt gatttttttt
     3661 tttaaccctt aaaaaaagtg ggagatgtat acaattgtta atgacatgga agtgtttcct
     3721 ttctcctgag gaaaagtgaa tttcttatca gaatatctgg ctggccctgt aatttaaatt
     3781 aaaataaaat tttggagaaa ctgt
//
