LOCUS       NM_057146               2094 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus complement C9 (C9), mRNA.
ACCESSION   NM_057146 XM_346615
VERSION     NM_057146.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Spicer,B.A., Law,R.H.P., Caradoc-Davies,T.T., Ekkel,S.M.,
            Bayly-Jones,C., Pang,S.S., Conroy,P.J., Ramm,G., Radjainia,M.,
            Venugopal,H., Whisstock,J.C. and Dunstone,M.A.
  TITLE     The first transmembrane region of complement component-9 acts as a
            brake on its self-assembly
  JOURNAL   Nat Commun 9 (1), 3266 (2018)
   PUBMED   30111885
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Dudkina,N.V., Spicer,B.A., Reboul,C.F., Conroy,P.J., Lukoyanova,N.,
            Elmlund,H., Law,R.H., Ekkel,S.M., Kondos,S.C., Goode,R.J., Ramm,G.,
            Whisstock,J.C., Saibil,H.R. and Dunstone,M.A.
  TITLE     Structure of the poly-C9 component of the complement membrane
            attack complex
  JOURNAL   Nat Commun 7, 10588 (2016)
   PUBMED   26841934
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2094)
  AUTHORS   Su,Z., Wang,X., Gao,X., Liu,Y., Pan,C., Hu,H., Beyer,R.P., Shi,M.,
            Zhou,J., Zhang,J., Serra,A.L., Wuthrich,R.P. and Mei,C.
  TITLE     Excessive activation of the alternative complement pathway in
            autosomal dominant polycystic kidney disease
  JOURNAL   J Intern Med 276 (5), 470-485 (2014)
   PUBMED   24494798
REFERENCE   4  (bases 1 to 2094)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 2094)
  AUTHORS   Hadders,M.A., Bubeck,D., Roversi,P., Hakobyan,S., Forneris,F.,
            Morgan,B.P., Pangburn,M.K., Llorca,O., Lea,S.M. and Gros,P.
  TITLE     Assembly and regulation of the membrane attack complex based on
            structures of C5b6 and sC5b9
  JOURNAL   Cell Rep 1 (3), 200-207 (2012)
   PUBMED   22832194
REFERENCE   6  (bases 1 to 2094)
  AUTHORS   Ren,G., Huynh,C., Bijian,K. and Cybulsky,A.V.
  TITLE     Role of apoptosis signal-regulating kinase 1 in complement-mediated
            glomerular epithelial cell injury
  JOURNAL   Mol Immunol 45 (8), 2236-2246 (2008)
   PUBMED   18178252
  REMARK    GeneRIF: The present study thus defines a novel role for ASK1 as a
            mediator of C5b-9-dependent cell injury.
REFERENCE   7  (bases 1 to 2094)
  AUTHORS   Fischetti,F., Durigutto,P., Pellis,V., Debeus,A., Macor,P.,
            Bulla,R., Bossi,F., Ziller,F., Sblattero,D., Meroni,P. and
            Tedesco,F.
  TITLE     Thrombus formation induced by antibodies to beta2-glycoprotein I is
            complement dependent and requires a priming factor
  JOURNAL   Blood 106 (7), 2340-2346 (2005)
   PUBMED   15956288
REFERENCE   8  (bases 1 to 2094)
  AUTHORS   Grehan,J.F., Levay-Young,B.K., Fogelson,J.L.,
            Francois-Bongarcon,V., Benson,B.A. and Dalmasso,A.P.
  TITLE     IL-4 and IL-13 induce protection of porcine endothelial cells from
            killing by human complement and from apoptosis through activation
            of a phosphatidylinositide 3-kinase/Akt pathway
  JOURNAL   J Immunol 175 (3), 1903-1910 (2005)
   PUBMED   16034134
REFERENCE   9  (bases 1 to 2094)
  AUTHORS   Nauta,A.J., Daha,M.R., Tijsma,O., van de Water,B., Tedesco,F. and
            Roos,A.
  TITLE     The membrane attack complex of complement induces caspase
            activation and apoptosis
  JOURNAL   Eur J Immunol 32 (3), 783-792 (2002)
   PUBMED   11870622
  REMARK    GeneRIF: The membrane attack complex of complement induces caspase
            activation and apoptosis.
REFERENCE   10 (bases 1 to 2094)
  AUTHORS   Lassiter,H.A., Walz,B.M., Wilson,J.L., Jung,E., Calisi,C.R.,
            Goldsmith,L.J., Wilson,R.A., Morgan,B.P. and Feldhoff,R.C.
  TITLE     The administration of complement component C9 enhances the survival
            of neonatal rats with Escherichia coli sepsis
  JOURNAL   Pediatr Res 42 (1), 128-136 (1997)
   PUBMED   9212048
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057146.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52948.1, BC091127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000002.1  57300510-57300643
            135-228             JAXUCZ010000002.1  57311298-57311391
            229-373             JAXUCZ010000002.1  57312010-57312154
            374-521             JAXUCZ010000002.1  57312432-57312579
            522-660             JAXUCZ010000002.1  57320000-57320138
            661-927             JAXUCZ010000002.1  57333541-57333807
            928-1168            JAXUCZ010000002.1  57337380-57337620
            1169-1315           JAXUCZ010000002.1  57340965-57341111
            1316-1494           JAXUCZ010000002.1  57342433-57342611
            1495-1723           JAXUCZ010000002.1  57347491-57347719
            1724-2094           JAXUCZ010000002.1  57348389-57348759
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..2094
                     /gene="C9"
                     /note="complement C9"
                     /db_xref="GeneID:117512"
                     /db_xref="RGD:620319"
     exon            1..134
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1716
                     /gene="C9"
                     /note="complement component C9; complement component 9"
                     /codon_start=1
                     /product="complement component C9 precursor"
                     /protein_id="NP_476487.2"
                     /db_xref="GeneID:117512"
                     /db_xref="RGD:620319"
                     /translation="MLLRTPGLPRRSGMASGVTITLAIAIFALEINAQAPEPTPREEP
                     SADALLPIDCRMSTWSQWSQCDPCLKQRFRSRSIEVFGQFQGKSCADALGDRQHCEPT
                     QECEEVQENCGNDFQCETGRCIKRKLLCNGDNDCGDFSDESDCESDPRLPCRDRVVEE
                     SELGRTAGYGINILGMDPLGTPFDNEFYNGLCDRVRDGNTLTYYRKPWNVAFLAYETK
                     ADKNFRTENYEEQFEMFKTIVRDRTTSFNANLALKFTITEAPIKKVGVDEVSPEKNSS
                     KPKDSSVDFQFSYFKKENFQRLSSYLSQTKKMFLHVRGMIQLGRFVMRNRGVMLTTTF
                     LDDVKALPVSYEKGEYFGFLETYGTHYSSSGSLGGLYELIYVLDKASMKEKGVELSDV
                     KRCLGFNLDVSLYTPLQTTLEGPSLTANVNHSDCLKTGDGKVVNISRDHIIDDVISFI
                     RGGTRKQAVLLKEKLLRGAKTIDVNDFINWASSLDDAPALISQKLSPIYNLIPLTMKD
                     AYAKKQNMEKAIEDYVNEFSARKCYPCQNGGTAILLDGQCMCSCTIKFKGIACEISKQ
                     R"
     exon            135..228
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            229..373
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            374..521
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            522..660
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            661..927
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1168
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1315
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1494
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1723
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2094
                     /gene="C9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgcaaag aaatgcttct caggactcca gggctgccta ggaggagcgg catggcctca
       61 ggcgtgacca tcaccctagc cattgcaatc tttgccttgg agatcaatgc acaggcccca
      121 gagcccactc cccgggaaga gccatcagca gacgccctcc taccaataga ctgcagaatg
      181 agcacatgga gtcagtggtc acagtgtgat ccttgcctca aacaaaggtt tcgctcaaga
      241 agcattgaag tctttggaca gtttcagggg aaaagctgtg ctgatgcttt gggagacaga
      301 caacattgtg aacccactca ggagtgtgaa gaggtacagg aaaactgtgg gaatgacttt
      361 cagtgtgaaa caggcaggtg cataaagagg aaacttctgt gtaatggtga caacgactgt
      421 ggagattttt ctgatgagag tgactgtgaa agtgacccac gcctcccgtg ccgtgaccga
      481 gtggtagaag aatcagaact gggacgaaca gcaggctatg ggatcaacat cttagggatg
      541 gatcccctgg gcacgccttt tgacaatgag ttctacaatg gactctgtga ccgggtacgg
      601 gacggaaaca ctttgacata ctatcgcaaa ccttggaacg tagcatttct ggcctatgaa
      661 accaaggctg acaaaaattt cagaactgag aattatgaag aacagtttga aatgttcaaa
      721 accatcgtcc gagacaggac cacgagtttt aatgcaaatt tagctctaaa attcacaatc
      781 actgaagcac ctataaaaaa agttggagtt gatgaagtca gcccagaaaa aaactcttca
      841 aagcctaaag actcttctgt tgattttcaa ttttcatatt tcaagaaaga aaattttcaa
      901 cgattgtcat cctacttgtc acagacgaaa aagatgtttc tgcacgtgag aggaatgatt
      961 caactgggga gatttgtcat gaggaatcgg ggcgttatgc tgacgacaac tttcctggat
     1021 gatgtaaagg ctttaccagt ttcctatgaa aagggagaat attttggatt tttggaaacc
     1081 tatgggactc actacagtag ctctgggtcc ctgggagggc tctacgaact gatctatgtc
     1141 ttggataaag cttccatgaa agagaaaggt gttgaactga gcgatgtaaa gcggtgtctt
     1201 gggtttaacc tggatgtttc tctatatacg cctctacaaa ccaccttaga aggaccatca
     1261 ttgacagcca atgttaatca cagtgattgc ttaaagacag gggatggtaa agtagtaaac
     1321 atcagccgcg atcacatcat agatgatgtt atttcattca taagaggagg gaccaggaag
     1381 caagcagttc tcctgaaaga gaagcttctc agaggagcca agacgattga tgtgaatgac
     1441 ttcatcaact gggcctcatc cttggatgac gctccagctc tcattagtca aaaactgtcc
     1501 cctatctata atctcattcc tttgacaatg aaagatgcat acgcaaagaa acagaatatg
     1561 gaaaaggcta ttgaagacta tgtgaatgaa ttcagtgcta gaaagtgcta cccatgtcaa
     1621 aacggaggca cagcaattct tctggatgga cagtgcatgt gctcctgcac aatcaagttt
     1681 aaggggattg cctgcgaaat cagtaaacaa agatagcctt caggaaacaa agcaaaacct
     1741 ggttcacatg gaaggtggaa aaaaggacaa aaaaaagaag aagaaggagg aggaggagga
     1801 ggaagaggag gaggaggaaa agaaaaaacc ccaggacttt ccaacttagc atcctaccct
     1861 agagcgaatc ctcactgcca agtagaaagc agcttgcttc atggaaatcc taccaacctc
     1921 tgatgtcgtc tctgtttcag gtctacagtg cctttctccc ctctttaatg cctataatgc
     1981 ttccattttt tttttattcc ctaatgaaga atcggcagtg agatatgcca ggactgcctt
     2041 ttcccacagg caatgccaat ctctcgctaa taaaacaaaa ttaaattaaa aaca
//
