LOCUS       NM_001191759            2395 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus complement C8 beta chain (C8b), mRNA.
ACCESSION   NM_001191759 XM_233250
VERSION     NM_001191759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2395)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   2  (bases 1 to 2395)
  AUTHORS   Hadders,M.A., Bubeck,D., Roversi,P., Hakobyan,S., Forneris,F.,
            Morgan,B.P., Pangburn,M.K., Llorca,O., Lea,S.M. and Gros,P.
  TITLE     Assembly and regulation of the membrane attack complex based on
            structures of C5b6 and sC5b9
  JOURNAL   Cell Rep 1 (3), 200-207 (2012)
   PUBMED   22832194
REFERENCE   3  (bases 1 to 2395)
  AUTHORS   Xiong,Z.Q., Qian,W., Suzuki,K. and McNamara,J.O.
  TITLE     Formation of complement membrane attack complex in mammalian
            cerebral cortex evokes seizures and neurodegeneration
  JOURNAL   J Neurosci 23 (3), 955-960 (2003)
   PUBMED   12574424
REFERENCE   4  (bases 1 to 2395)
  AUTHORS   Nakashima,S., Qian,Z., Rahimi,S., Wasowska,B.A. and Baldwin,W.M.
            3rd.
  TITLE     Membrane attack complex contributes to destruction of vascular
            integrity in acute lung allograft rejection
  JOURNAL   J Immunol 169 (8), 4620-4627 (2002)
   PUBMED   12370401
REFERENCE   5  (bases 1 to 2395)
  AUTHORS   Nauta,A.J., Daha,M.R., Tijsma,O., van de Water,B., Tedesco,F. and
            Roos,A.
  TITLE     The membrane attack complex of complement induces caspase
            activation and apoptosis
  JOURNAL   Eur J Immunol 32 (3), 783-792 (2002)
   PUBMED   11870622
REFERENCE   6  (bases 1 to 2395)
  AUTHORS   Lehto,T., Morgan,B.P. and Meri,S.
  TITLE     Binding of human and rat CD59 to the terminal complement complexes
  JOURNAL   Immunology 90 (1), 121-128 (1997)
   PUBMED   9038722
REFERENCE   7  (bases 1 to 2395)
  AUTHORS   Sawant-Mane,S., Piddlesden,S.J., Morgan,B.P., Holers,V.M. and
            Koski,C.L.
  TITLE     CD59 homologue regulates complement-dependent cytolysis of rat
            Schwann cells
  JOURNAL   J Neuroimmunol 69 (1-2), 63-71 (1996)
   PUBMED   8823377
REFERENCE   8  (bases 1 to 2395)
  AUTHORS   Kershaw,E.E., Chua,S.C., Williams,J.A., Murphy,E.M. and Leibel,R.L.
  TITLE     Molecular mapping of SSRs for Pgm1 and C8b in the vicinity of the
            rat fatty locus
  JOURNAL   Genomics 27 (1), 149-154 (1995)
   PUBMED   7665162
REFERENCE   9  (bases 1 to 2395)
  AUTHORS   Vakeva,A., Morgan,B.P., Tikkanen,I., Helin,K., Laurila,P. and
            Meri,S.
  TITLE     Time course of complement activation and inhibitor expression after
            ischemic injury of rat myocardium
  JOURNAL   Am J Pathol 144 (6), 1357-1368 (1994)
   PUBMED   7515561
REFERENCE   10 (bases 1 to 2395)
  AUTHORS   Ng,S.C. and Sodetz,J.M.
  TITLE     Biosynthesis of C8 by hepatocytes. Differential expression and
            intracellular association of the alpha-gamma- and beta-subunits
  JOURNAL   J Immunol 139 (9), 3021-3027 (1987)
   PUBMED   3312411
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jul 17, 2010 this sequence version replaced XM_233250.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.17181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000005.1  124764114-124764202
            90-246              JAXUCZ010000005.1  124770428-124770584
            247-388             JAXUCZ010000005.1  124776379-124776520
            389-530             JAXUCZ010000005.1  124778743-124778884
            531-663             JAXUCZ010000005.1  124780352-124780484
            664-861             JAXUCZ010000005.1  124782648-124782845
            862-1102            JAXUCZ010000005.1  124786230-124786470
            1103-1231           JAXUCZ010000005.1  124788497-124788625
            1232-1395           JAXUCZ010000005.1  124789929-124790092
            1396-1549           JAXUCZ010000005.1  124796910-124797063
            1550-1618           JAXUCZ010000005.1  124797939-124798007
            1619-2395           JAXUCZ010000005.1  124800746-124801522
FEATURES             Location/Qualifiers
     source          1..2395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2395
                     /gene="C8b"
                     /note="complement C8 beta chain"
                     /db_xref="GeneID:313421"
                     /db_xref="RGD:2239"
     CDS             1..1770
                     /gene="C8b"
                     /note="complement component C8 beta chain; complement
                     component 8, beta subunit; complement component 8 subunit
                     beta; complement component 8, beta polypeptide"
                     /codon_start=1
                     /product="complement component C8 beta chain precursor"
                     /protein_id="NP_001178688.1"
                     /db_xref="GeneID:313421"
                     /db_xref="RGD:2239"
                     /translation="MKTGAQVWRALAKSCLLCAALGCLHLPGARGEKPDFFETNAVNG
                     SLVRSRPVRSVDVTPAPTDCQLSTWSSWTACDPCQKKRYRHTYLLRPSQFYGELCDFS
                     DKEVEDCVTNRACRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKK
                     CSQDMEQYWAIGNLASGINLFTNTFEGPVLDHRYYAGACSPHYILNTNFRKPYNVESY
                     TPQTQGKYEFALTEYESYFDFEHNVTEKATSKSSFKFGFKLDGLVEFGVRKESNEGRH
                     YISRTKRFSHTKSKFLHARSVLEVAHYKLKSRQLMLHYEFLQRVKSLPLEYSYGEYRD
                     LLRDFGTHFITEAVLGGIYEYTLIMNKDAMERGDYTLDHVSACAGGGFQIGGNVYKVY
                     LKLGVSEKKCSDILNEIKDRNKRRTMVEDLVVLVRGGTSEYITSLAYKDLPTAELMKE
                     WGDAVQYNPAIIKLKAEPLYELVTATDFAYSSTVKQNMKKALEEFQMEVSSCRCAPCR
                     NNGVPILKESRCECICPAGFQGVACEVTNRKDIPIDGKWSCWSDWSPCSGGRKTRQRQ
                     CNNPAPQRGGSPCSGPASETLDC"
     exon            1..89
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            90..246
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            247..388
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            389..530
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            531..663
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            664..861
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1102
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1231
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1395
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1549
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1618
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..2395
                     /gene="C8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagacag gggcccaggt ttggagggca ctggcaaagt catgtcttct ttgtgctgcc
       61 cttggatgtc tccatctccc tggtgcaaga ggtgagaagc cagatttctt tgagacaaat
      121 gcagtcaatg gaagccttgt taggagcaga ccagtacgga gtgtggatgt caccccagca
      181 cctactgact gtcaactatc cacctggtcc tcctggactg catgtgaccc ctgtcagaag
      241 aaaaggtaca gacacactta cttgctccgg ccctctcagt tctatgggga actgtgtgac
      301 ttctccgaca aggaagttga agactgtgtt accaaccgag cctgcagaag tcaagtacga
      361 tgtgaaggct ttgtgtgtgc acagacaggg aggtgtgtga atcgcagact cctctgcaat
      421 ggagacaatg actgtggaga ccaatcagat gaagccaact gtaggaggat ttataaaaaa
      481 tgctcacagg atatggaaca gtactgggca attggcaatc tggccagcgg gataaatctg
      541 ttcacgaaca cttttgaggg cccagttctc gatcaccggt attatgctgg cgcttgctcc
      601 ccccactaca tcctgaacac caattttagg aagccataca acgtagagag ctacacccca
      661 cagacccaag gcaaatatga atttgcactt acagaatatg aatcctattt cgattttgaa
      721 cataatgtga cagaaaaagc aaccagcaag tctagtttca agtttggttt taaactggat
      781 ggcctggttg agtttggagt gagaaaagaa agcaacgagg gcagacatta cattagcaga
      841 accaaacggt tctcccacac taaaagcaag tttctgcacg cgcgctctgt ccttgaagtg
      901 gcgcattaca agctgaagtc cagacagctc atgctccatt acgaattcct tcagagggtc
      961 aagagcctgc ccctggagta cagctatgga gaataccgag atctccttcg tgactttggg
     1021 acccatttca tcaccgaagc cgtgcttggg ggcatctacg agtacacgct tatcatgaac
     1081 aaagacgcca tggagcgagg agattacact ctggaccatg tttcagcctg tgccggagga
     1141 ggtttccaga ttggtggtaa cgtctataaa gtctacctca aattgggtgt gtccgaaaag
     1201 aaatgcagtg acattctgaa tgaaatcaaa gacagaaata agagacgcac catggtagaa
     1261 gacttggtag ttcttgtgcg aggagggaca agtgagtaca tcacctcctt ggcatacaag
     1321 gatctgccaa cagcagagct gatgaaggaa tggggcgatg ctgtgcagta caacccagcc
     1381 atcatcaagc tcaaggctga gcccctgtat gaacttgtga cagccacaga ctttgcgtac
     1441 tccagcacag tgaaacagaa catgaagaag gccctagaag aattccagat ggaggtcagc
     1501 tcctgccgct gtgctccgtg caggaacaat ggagtcccca tcctgaaaga atcccgctgt
     1561 gagtgcatct gtcctgctgg cttccaaggt gtagcctgtg aggtcaccaa tcggaaagat
     1621 atccccatag atgggaagtg gagttgctgg tctgactggt ctccatgctc tggaggacgc
     1681 aaaacaagac aaaggcagtg caacaacccg gcacctcaga gaggaggcag cccctgctca
     1741 ggtcctgctt cagaaacact cgactgttaa agggagggaa cacagccggc aggtgatcag
     1801 cagggctcta accctctcac acttagccag gctttagcac accagctccc acccagggct
     1861 accacaacaa aaagcaatgc cactctgccc tttaaaggct ttagtttctt cagtgcatgt
     1921 taattccagt aaacagtggg tggagcaaaa ccctaagtcc ttgcatggtg aaactccctt
     1981 tgctcactgc acttttgtta ccgtcccatg gtccgggagc cagaaacttt cttggtcacc
     2041 atgggtcacc atgtagtgac aaaggcacat agtaggtgtt gaattatgaa gcagtaaatt
     2101 gataagaagc tgttcatccc ttggtaagca cagagtgttc ttcagtaata aagacagcca
     2161 atctcgataa aaatgatctt ctgtgtgcca ccaatccatc ccccatgaca accttgcaag
     2221 acaaatatct gggaaacagg cttgggggat ataatgactt gtcccaggtc atacaattag
     2281 gaaatgccag aattgtgcag ccaacaaggc tctggattcg atgaggctcg tctttttctg
     2341 aatgagcgtg cagttagcaa agaattgttc atggaataaa acgcaacaga aagcc
//
