LOCUS       NM_001106670            3626 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus complement C8 alpha chain (C8a), mRNA.
ACCESSION   NM_001106670 XM_001064004 XM_233251
VERSION     NM_001106670.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Hadders,M.A., Bubeck,D., Roversi,P., Hakobyan,S., Forneris,F.,
            Morgan,B.P., Pangburn,M.K., Llorca,O., Lea,S.M. and Gros,P.
  TITLE     Assembly and regulation of the membrane attack complex based on
            structures of C5b6 and sC5b9
  JOURNAL   Cell Rep 1 (3), 200-207 (2012)
   PUBMED   22832194
REFERENCE   3  (bases 1 to 3626)
  AUTHORS   Ren,G., Huynh,C., Bijian,K. and Cybulsky,A.V.
  TITLE     Role of apoptosis signal-regulating kinase 1 in complement-mediated
            glomerular epithelial cell injury
  JOURNAL   Mol Immunol 45 (8), 2236-2246 (2008)
   PUBMED   18178252
  REMARK    GeneRIF: The present study thus defines a novel role for ASK1 as a
            mediator of C5b-9-dependent cell injury.
REFERENCE   4  (bases 1 to 3626)
  AUTHORS   Xiong,Z.Q., Qian,W., Suzuki,K. and McNamara,J.O.
  TITLE     Formation of complement membrane attack complex in mammalian
            cerebral cortex evokes seizures and neurodegeneration
  JOURNAL   J Neurosci 23 (3), 955-960 (2003)
   PUBMED   12574424
REFERENCE   5  (bases 1 to 3626)
  AUTHORS   Parker,C.L. and Sodetz,J.M.
  TITLE     Role of the human C8 subunits in complement-mediated bacterial
            killing: evidence that C8 gamma is not essential
  JOURNAL   Mol Immunol 39 (7-8), 453-458 (2002)
   PUBMED   12413696
REFERENCE   6  (bases 1 to 3626)
  AUTHORS   Lehto,T., Morgan,B.P. and Meri,S.
  TITLE     Binding of human and rat CD59 to the terminal complement complexes
  JOURNAL   Immunology 90 (1), 121-128 (1997)
   PUBMED   9038722
REFERENCE   7  (bases 1 to 3626)
  AUTHORS   Sawant-Mane,S., Piddlesden,S.J., Morgan,B.P., Holers,V.M. and
            Koski,C.L.
  TITLE     CD59 homologue regulates complement-dependent cytolysis of rat
            Schwann cells
  JOURNAL   J Neuroimmunol 69 (1-2), 63-71 (1996)
   PUBMED   8823377
REFERENCE   8  (bases 1 to 3626)
  AUTHORS   Vakeva,A., Morgan,B.P., Tikkanen,I., Helin,K., Laurila,P. and
            Meri,S.
  TITLE     Time course of complement activation and inhibitor expression after
            ischemic injury of rat myocardium
  JOURNAL   Am J Pathol 144 (6), 1357-1368 (1994)
   PUBMED   7515561
REFERENCE   9  (bases 1 to 3626)
  AUTHORS   Ng,S.C. and Sodetz,J.M.
  TITLE     Biosynthesis of C8 by hepatocytes. Differential expression and
            intracellular association of the alpha-gamma- and beta-subunits
  JOURNAL   J Immunol 139 (9), 3021-3027 (1987)
   PUBMED   3312411
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473998.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064004.1, XM_233251.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211202.1, FQ211244.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3626
                     /gene="C8a"
                     /note="complement C8 alpha chain"
                     /db_xref="GeneID:298288"
                     /db_xref="RGD:1308355"
     exon            1..116
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1803
                     /gene="C8a"
                     /note="complement component C8 alpha chain; complement
                     component 8, alpha polypeptide; complement component 8
                     alpha subunit"
                     /codon_start=1
                     /product="complement component C8 alpha chain precursor"
                     /protein_id="NP_001100140.1"
                     /db_xref="GeneID:298288"
                     /db_xref="RGD:1308355"
                     /translation="MFTVAFFGLSLMAWHSGVTAQEKVNQRVTRAVTPGAVACQLSDW
                     SEWTDCFPCQNEKYRYRSLLQPSKFGGTICSGDIWDKANCDSPTPCLRQAQCGQDFQC
                     RETGRCLKRHLVCNGDQDCLDGSDEDNCDDARVIEDDCRQYEPIPGSERAALGYNILT
                     QEEGQSVYDAKYYGGQCETVYNGDWRRLQYDPTCERLYYGEDEKYFRKPYNFLKYHFE
                     ALADTLISSEFYDDANDLFSKIQRDKSQSNSVTFGISPAKSPITLDASVSWSDESSFM
                     KELSKYNEKKYSFMRVSTKVQTAHFKMRRHNIVLDEGMMESLMELPEQFNYGMYSKFI
                     NDYGTHYITSGTMGGIYEYVLVLDKEKMRIHGITVEDVKKCIGGGVGLQFGEKIIGEG
                     DLSGESCVMTGDGNQDKRKKDLAVEDIISRVQGGSSRWSTGLAHNSSAITYRSWGRSL
                     KYNPVVIDFEMQPIYQLLQHTNLGPLETKRRNLRRALDQYLMEFNACRCGPCFNNGVP
                     ILEGTSCSCQCSMGRQGPACESMVLEAMEGAKADGRWSCWSSWSECRGGSRERRRQCN
                     NPAPQNGGAPCLGKSLQTQAC"
     exon            117..210
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            211..355
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            356..503
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            504..693
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            694..894
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1135
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1261
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1419
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1651
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..3626
                     /gene="C8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcttttcca tagatgctaa gtggtgactt ctggatgaga tgtttacagt tgctttcttt
       61 ggtttgtctc tgatggcatg gcactccggg gtaactgcac aagagaaggt gaaccagcgg
      121 gtcacccgag ctgtgacccc aggagcggtt gcctgtcagt tgagtgactg gtcagaatgg
      181 acagattgtt ttccatgtca gaacgaaaag taccgatacc ggagcctctt gcagccaagc
      241 aagtttggag gaaccatctg cagtggtgat atatgggata aggccaactg tgacagcccc
      301 acaccttgtc taaggcaagc acagtgtgga caggatttcc agtgtagaga gacaggtcgc
      361 tgcctgaaac gccacctggt atgcaatgga gatcaggact gccttgatgg ctctgatgag
      421 gataactgtg atgatgccag ggtcattgaa gatgattgcc gtcagtatga accaatccca
      481 ggatcagaaa gggcagcctt ggggtacaat atcctgactc aagaagaagg ccagagtgtg
      541 tatgatgcta agtattatgg aggccagtgt gaaactgtgt acaatggaga ctggagaagg
      601 ctgcagtacg accccacctg tgagcgcctc tactatgggg aggatgagaa atacttccgg
      661 aagccctaca acttccttaa gtaccacttt gaagccctgg cggatacttt aatctcttca
      721 gagttttatg atgatgcaaa tgaccttttt tctaagatac agagggacaa atcccagtca
      781 aatagtgtaa catttggcat aagcccagca aaaagtccta tcacactaga cgcgtccgta
      841 tcctggtccg atgaatcttc cttcatgaag gagttaagca agtataatga gaagaaatat
      901 agcttcatga gagtgtccac gaaggtacag acggcacatt ttaagatgag gaggcacaat
      961 attgtgctgg atgaagggat gatggagtca ctgatggagc tcccagagca gtttaactac
     1021 ggcatgtact ccaagttcat caatgactat ggcacccact acatcacctc tggaaccatg
     1081 ggtggcattt acgaatatgt tctggtgctt gacaaagaga aaatgagaat tcatggcatt
     1141 actgtggaag atgtcaaaaa atgcatcgga ggtggcgttg gcctgcagtt tggagagaaa
     1201 ataattggtg aaggagattt atcaggagag tcttgtgtca tgactggaga tggcaaccag
     1261 gacaaaagga agaaggactt ggcagtggag gacatcattt ctcgggtaca aggtggaagt
     1321 tctcgctgga gcactggctt ggcacacaac agcagtgcta ttacataccg gtcttggggg
     1381 agatcattaa agtataaccc tgttgttatc gattttgaga tgcagcccat ctatcagcta
     1441 ctgcagcaca caaacctggg gcctctggag actaaacgtc ggaacctgcg cagggctttg
     1501 gaccagtacc tgatggaatt taatgcctgc cgctgtgggc cctgcttcaa caatggggta
     1561 cccatactcg agggcaccag ctgctcgtgt caatgtagca tgggccggca gggccctgcc
     1621 tgtgagagca tggtattgga agcgatggag ggagccaaag ctgatggtcg ttggagctgc
     1681 tggagttcct ggtcagagtg tagaggaggg tcccgggaga ggaggagaca gtgcaacaat
     1741 ccagcacccc agaatggagg tgccccatgc ctagggaaga gcctgcagac ccaggcctgc
     1801 tgagtagctc tggaggcaga cttggaagga agctgtagat gctgctgcct gtcctggctg
     1861 ctggttagga ctgattgctg ctctgagtaa atgcaaaccc acgaaggctg ttcccttcac
     1921 acactcattt ttttttctag taccaacctc ataatcttta gcctctacca ataacctggc
     1981 tctaggttgc ctccttgtcc cagagggtcg ctacccttta catctcagaa ccacctccct
     2041 atcttattcc attcaggatg ctcaataata aactgggtgt ggtttagaca catcagaaat
     2101 aattcctcac aattctggag gcataaactg caagatgaag gttccagcag gtctagggtc
     2161 tggagaggct gtgttctatt ttatatatgt cctttcattg ggttattaca tggcagaggg
     2221 gtagcaagtc tctaggtcct ctttagtaag gacaccagtc ctactcatga gaatgttgcc
     2281 tttatgactt catcatctcc cgaagtccag cctcctcttt tgacactggg tgtaggtctt
     2341 ccatgtggag aacttagaga gacctcaaca ttcagacccc agaatatctt ttgttactct
     2401 ctctcagtaa gcaatcatat ttgaaggcat catatttgaa ggcagaaact gggccagttt
     2461 tattcagcat agcgtcttta gatgcgaagg ctatgcattg cagactgtag gggatctcat
     2521 cagcaatggt tgctggacaa gcagacagat caagagtcag ttcatgggtg aggtctgtac
     2581 tggtcagtct tgcagagctg tgggtggact tggaagggtc aatcagtaaa gatcaacatc
     2641 cattctctga tcttctcaag aagagccagt cacagcagcc agcctagtgt tcctacatac
     2701 tctaaaccat gtgcatgttc agcattgact taattggggt ttctcctgcc atgagaaaac
     2761 atcatgagta aaagcaactg gggcaaaaag ggttaacttc agcttgcatg ccccactcgc
     2821 agtctatcat gaaaagaagt cagagcagga actcaagtca ggaacctggt ggcaggaact
     2881 gaagcagaga tcatagaggg gtgctgctta ctgacttcct cctcataatt ttctctgcct
     2941 gttaggtatg gcaacaccca gagtgaactg ggccctccca cattaatcag taatttttaa
     3001 aaaacagttc actacagact tgctcagagg ccagtctagt gggctccctc tacccctaac
     3061 tgaagttccc tcttccaaaa tgtgtcaagt tgatgaaaaa ctagataaat caacaaccca
     3121 ggcttaccct tggcttctct ttgaagttgg tagactttgt agatatgaag ccttcagaaa
     3181 cagagggcaa ctgtataaat gaaaaagagg aggatcttgg gctactggga ataaattatt
     3241 gacatcaaca tatgtagcat ccaagtgatt gctgagggag aacaagtcaa gagagtgcag
     3301 tcttcacatg ttatatatac atcaggggca gcaagtgcag ggtctatctg atctggatgg
     3361 acttttaaca gatcagcagg gaggagactt ttgaagagga aatccatctt gatacaaagc
     3421 cagatggtga gacagaacat ggggaccggg aactcgcagg tgaatgtgtt ggacattggg
     3481 gactgggaaa aacagtaaca aagtcagggt gtgtaagacc cacctcagtg cctgccacat
     3541 ggcaaatcat taccatcatt gttgttattt ccattgtgaa aacgtggttc agaattttat
     3601 ctaaataaac ttggctcttc tagctg
//
