LOCUS       NM_176074               3170 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus complement C6 (C6), mRNA.
ACCESSION   NM_176074 XM_008760749
VERSION     NM_176074.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3170)
  AUTHORS   Sta,M., Cappaert,N.L., Ramekers,D., Ramaglia,V., Wadman,W.J. and
            Baas,F.
  TITLE     C6 deficiency does not alter intrinsic regeneration speed after
            peripheral nerve crush injury
  JOURNAL   Neurosci Res 87, 26-32 (2014)
   PUBMED   25011063
  REMARK    GeneRIF: Findings suggest that C6 deficiency by itself does not
            alter the regrowth capacity of the peripheral nerve after crush
            injury.
REFERENCE   2  (bases 1 to 3170)
  AUTHORS   Hadders,M.A., Bubeck,D., Roversi,P., Hakobyan,S., Forneris,F.,
            Morgan,B.P., Pangburn,M.K., Llorca,O., Lea,S.M. and Gros,P.
  TITLE     Assembly and regulation of the membrane attack complex based on
            structures of C5b6 and sC5b9
  JOURNAL   Cell Rep 1 (3), 200-207 (2012)
   PUBMED   22832194
REFERENCE   3  (bases 1 to 3170)
  AUTHORS   Holtman,L., van Vliet,E.A., Baas,F., Aronica,E. and Gorter,J.A.
  TITLE     Complement protein 6 deficiency in PVG/c rats does not lead to
            neuroprotection against seizure induced cell death
  JOURNAL   Neuroscience 188, 109-116 (2011)
   PUBMED   21575686
  REMARK    GeneRIF: C6 deficiency did not lead to neuroprotection after status
            epilepticus
REFERENCE   4  (bases 1 to 3170)
  AUTHORS   Ramaglia,V., Tannemaat,M.R., de Kok,M., Wolterman,R., Vigar,M.A.,
            King,R.H., Morgan,B.P. and Baas,F.
  TITLE     Complement inhibition accelerates regeneration in a model of
            peripheral nerve injury
  JOURNAL   Mol Immunol 47 (2-3), 302-309 (2009)
   PUBMED   19833392
  REMARK    GeneRIF: Pathology showed improved nerve regeneration in tibials of
            C6 deficient animals compared to wildtypes.
REFERENCE   5  (bases 1 to 3170)
  AUTHORS   Ruseva,M.M., Hughes,T.R., Donev,R.M., Sivasankar,B.,
            Pickering,M.C., Wu,X., Harris,C.L. and Morgan,B.P.
  TITLE     Crry deficiency in complement sufficient mice: C3 consumption
            occurs without associated renal injury
  JOURNAL   Mol Immunol 46 (5), 803-811 (2009)
   PUBMED   18947875
REFERENCE   6  (bases 1 to 3170)
  AUTHORS   Nangaku,M., Pippin,J. and Couser,W.G.
  TITLE     C6 mediates chronic progression of tubulointerstitial damage in
            rats with remnant kidneys
  JOURNAL   J Am Soc Nephrol 13 (4), 928-936 (2002)
   PUBMED   11912252
REFERENCE   7  (bases 1 to 3170)
  AUTHORS   Nauta,A.J., Daha,M.R., Tijsma,O., van de Water,B., Tedesco,F. and
            Roos,A.
  TITLE     The membrane attack complex of complement induces caspase
            activation and apoptosis
  JOURNAL   Eur J Immunol 32 (3), 783-792 (2002)
   PUBMED   11870622
  REMARK    GeneRIF: The membrane attack complex of complement induces caspase
            activation and apoptosis.
REFERENCE   8  (bases 1 to 3170)
  AUTHORS   Hughes,J., Nangaku,M., Alpers,C.E., Shankland,S.J., Couser,W.G. and
            Johnson,R.J.
  TITLE     C5b-9 membrane attack complex mediates endothelial cell apoptosis
            in experimental glomerulonephritis
  JOURNAL   Am J Physiol Renal Physiol 278 (5), F747-F757 (2000)
   PUBMED   10807586
REFERENCE   9  (bases 1 to 3170)
  AUTHORS   Brauer,R.B., Baldwin,W.M. 3rd, Wang,D., Horwitz,L.R., Hess,A.D.,
            Klein,A.S. and Sanfilippo,F.
  TITLE     Hepatic and extrahepatic biosynthesis of complement factor C6 in
            the rat
  JOURNAL   J Immunol 153 (7), 3168-3176 (1994)
   PUBMED   8089494
REFERENCE   10 (bases 1 to 3170)
  AUTHORS   Baker,P.J., Ochi,R.F., Schulze,M., Johnson,R.J., Campbell,C. and
            Couser,W.G.
  TITLE     Depletion of C6 prevents development of proteinuria in experimental
            membranous nephropathy in rats
  JOURNAL   Am J Pathol 135 (1), 185-194 (1989)
   PUBMED   2672823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Feb 26, 2021 this sequence version replaced
            XM_008760749.3, NM_176074.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.6450.1,
                                           SRR26643295.8152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               JAXUCZ010000002.1  55573633-55573766
            135-303             JAXUCZ010000002.1  55579545-55579713
            304-460             JAXUCZ010000002.1  55581247-55581403
            461-605             JAXUCZ010000002.1  55582645-55582789
            606-747             JAXUCZ010000002.1  55587254-55587395
            748-886             JAXUCZ010000002.1  55596362-55596500
            887-1087            JAXUCZ010000002.1  55607150-55607350
            1088-1328           JAXUCZ010000002.1  55612027-55612267
            1329-1451           JAXUCZ010000002.1  55616514-55616636
            1452-1618           JAXUCZ010000002.1  55624244-55624410
            1619-1844           JAXUCZ010000002.1  55625691-55625916
            1845-2016           JAXUCZ010000002.1  55627478-55627649
            2017-2128           JAXUCZ010000002.1  55627962-55628073
            2129-2261           JAXUCZ010000002.1  55631471-55631603
            2262-2450           JAXUCZ010000002.1  55632735-55632923
            2451-2541           JAXUCZ010000002.1  55640121-55640211
            2542-2783           JAXUCZ010000002.1  55642258-55642499
            2784-3170           JAXUCZ010000002.1  55648471-55648857
FEATURES             Location/Qualifiers
     source          1..3170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3170
                     /gene="C6"
                     /note="complement C6"
                     /db_xref="GeneID:24237"
                     /db_xref="RGD:2238"
     exon            1..134
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            135..303
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2965
                     /gene="C6"
                     /note="complement component C6; complement component 6"
                     /codon_start=1
                     /product="complement component C6 precursor"
                     /protein_id="NP_788263.2"
                     /db_xref="GeneID:24237"
                     /db_xref="RGD:2238"
                     /translation="MTRHLPLCFILLIILIDKSEACFCDHYPWTHWSSCSKSCNSGTQ
                     SRQRQIVVNDYYRDNSCDQLCTKQETRQCNVETCPINCVLGDYGTWSDCDPCIRKQVK
                     VRSVLRPSQFGGQPCTEPLVTFQPCVPSELCKIEETDCKNKFLCDSGRCIPSKLECNG
                     ENDCGDNSDERNCGRTKPVCSRTYTPIPSVQLMGAGFHFLAGEPRGDVLDNSFTGGIC
                     KSVRSSRTSNPHRVPANLENVNFEVQTIEDDLKTDFYKDLATIGKNKNEDRSLSGEKK
                     DSFYVPIFYSSKKSENFQRNSGFKNAIEASHKKDSSFVRIHKVIKVLNFTMKTTDLQL
                     SDVFLKALIHLPLEYNFALYSRIFDDFGTHYFTSGSLGGKYDLLYQFSRQELQNSGLT
                     EEETRNCVRYETKKRFLFFTKTYKEDRCTTNRLSEKYKGSFLQGSEKSISLVQGGRSQ
                     QAAALAWEKGSSGPEANVFSEWLESVKENPAVVDYELAPIIDLVRNIPCAVTKRNNLR
                     KALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCEKRSPDYKSNAVDG
                     NWGCWSSWSACNAAYRRSRSRECNNPEPQRGGQRCEGKHWQEEDCTFSIMEKVGQPCI
                     SDDEEIKEVDLAEPEADSGCPQPPLPENAFVWNEKKLYSVGEEVEISCLTGFKAVGYQ
                     YFRCLPDRTWRQGDVECQRTECLKPVVQDVLTISPFQSVYKIGESIELTCPRGFVVAG
                     PSRYTCKGDSWTPPIPNSLSCEKDILTKSKGLCQPGQKQSGSECVCMSPEEDCSSYSE
                     DLCIFDEGSSQYFTSSACKFLAEKCLNSNQFHFVHAGSCQEGPQLEWGLERLKLAMKS
                     TKRVPCGYDTCYDWEKCSAHTSNCVCLLPPQCPKDENQLHCVKMGSSMRGKTVNICTL
                     GAVRCANRKVEILNPGRCLD"
     exon            304..460
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            461..605
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            606..747
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            748..886
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1087
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1328
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1451
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1618
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1844
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2016
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2128
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2261
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2450
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2541
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2783
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3170
                     /gene="C6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accatcttgt gttgcccagt agtataaaga agggctctct gggagtacca cacaaattgc
       61 ttcttaacgt gtgtgccttt tgtttctatg gccattcagc ttaggttcct ggacatagct
      121 agatcgcttt aaagggcctg ggaaaaggtc ctgtggaagc atgaccagac atctcccctt
      181 gtgtttcatt ttgctgatca tactgattga caagagtgaa gcctgtttct gtgaccacta
      241 cccatggact cactggtcca gctgttctaa gtcctgcaat tctggaaccc agagcagaca
      301 gagacaaatc gtagtgaacg attactatcg ggataactca tgcgatcagc tctgtaccaa
      361 gcaggagacc agacagtgca acgtggagac atgtcccatc aactgtgtcc taggagacta
      421 tggaacatgg tcagactgtg acccttgtat tagaaaacag gttaaagtta gatctgttct
      481 gcgcccaagt cagtttgggg gacaaccatg cacagagccc ctggtgacct ttcaaccatg
      541 tgtcccatct gagctctgca aaattgaaga gactgattgc aagaataaat tcctctgtga
      601 cagtgggcgc tgtattccca gcaagttaga atgcaatgga gaaaatgact gtggagacaa
      661 ttcagacgaa aggaactgtg ggaggacaaa gccagtatgc tcacggacat acactcctat
      721 ccccagtgtg cagctgatgg gcgctgggtt tcattttctg gcaggagagc ccagaggaga
      781 tgtccttgat aactccttca ctggaggaat atgtaaatcc gtcaggagca gccgaacgag
      841 taatccacac cgagttccag ccaatctgga aaatgtcaac tttgaggtac aaactataga
      901 agatgacttg aaaacagatt tctacaagga tttagccact attggaaaaa ataaaaatga
      961 agaccgttca ttgtctggtg agaagaaaga ctctttctac gtaccaattt tttattcctc
     1021 aaagaaaagt gaaaatttcc aacgtaactc aggcttcaaa aacgccattg aagcctccca
     1081 caagaaggat tcgagctttg ttaggatcca taaagtgata aaagtcttaa acttcacaat
     1141 gaaaacgaca gacctgcagc tttcagacgt cttcctaaaa gccctcatcc acctgccttt
     1201 agaatacaac tttgctttgt acagccggat atttgatgac tttgggaccc actatttcac
     1261 ctcaggctcc cttgggggca agtatgacct tctctaccaa ttcagccgcc aggagctaca
     1321 gaactcaggt ttaacagaag aagaaactcg aaactgtgtc cggtatgaaa caaagaaacg
     1381 tttcttattt tttacgaaaa catacaagga agaccggtgt accacaaata ggctgtctga
     1441 aaagtacaaa ggttcctttt tacagggatc agagaaatct atatccctgg tccagggcgg
     1501 gaggagtcag caggcagcag ccttggcttg ggagaagggc agctctggtc cagaggcgaa
     1561 tgtcttctct gagtggttag agtcggtgaa ggaaaaccct gctgtggttg attatgagct
     1621 tgctccaatc atcgacttgg tcagaaacat cccatgtgca gtgacaaaac ggaacaacct
     1681 caggaaagcc cttcaagaat atgcagccaa gtttgaccct tgccaatgtg ctccatgtcc
     1741 taataatggc cgccccaggc tctcaggcac agaatgtttg tgtgtgtgcc agagtggtac
     1801 ctacggtgag aactgtgaaa aacggtcccc agattataaa tcgaatgcag tggatgggaa
     1861 ctggggctgc tggtcttcct ggagcgcatg caatgctgct tataggaggt caaggagccg
     1921 ggagtgtaat aaccctgagc cacagcgagg agggcagcgc tgtgagggca agcattggca
     1981 agaagaagac tgtacattct caataatgga aaaagttgga caaccgtgca tcagtgatga
     2041 tgaagaaata aaagaagtag accttgctga gccagaagca gattcagggt gtcctcagcc
     2101 acctctccca gaaaatgcat ttgtctggaa tgaaaagaaa ctgtactcag tcggggagga
     2161 agttgaaatt tcatgtctca ctggattcaa agctgtggga taccagtact tcagatgctt
     2221 accagacaga acctggaggc aaggggatgt cgaatgccaa cggaccgagt gcctcaaacc
     2281 agtcgttcag gatgtcctga ccatctcccc atttcagagt gtgtacaaga ttggggaatc
     2341 cattgagctg acctgtccca gaggctttgt tgttgctggc ccatcgaggt atacatgcaa
     2401 gggagactcc tggacacctc ccattccaaa ttcactgagc tgtgaaaaag atattctgac
     2461 aaagtcaaag ggcctttgtc aaccaggaca aaagcaatca ggatccgagt gtgtttgtat
     2521 gtccccagaa gaagactgta gcagttattc ggaagatctc tgtatatttg atgagggatc
     2581 cagtcagtac ttcacttcat ctgcttgcaa atttttggct gaaaaatgtt taaacagcaa
     2641 ccagttccac tttgtccatg ctggttcctg ccaagaaggc ccacagttag aatggggtct
     2701 tgagaggcta aaactcgcaa tgaagagcac aaagagagtg ccctgtggat atgatacctg
     2761 ctatgactgg gaaaaatgtt cagcccacac ctccaactgt gtctgcctat tgcccccaca
     2821 atgccccaag gatgaaaacc aactccactg tgtcaaaatg ggatcatcaa tgcgtgggaa
     2881 aacagtaaac atctgtacac tgggagccgt gaggtgtgca aacaggaagg tggaaatact
     2941 gaatcctggg aggtgcttgg attagcactg ctagtgatga atgaatttat tattcaaaaa
     3001 caacggacag gaagtgagga aagtgaatgg atgggagcaa agtatgataa cacatatctt
     3061 caggaatgta atgataaaaa cccattactt tgtataataa cctaaacaaa ctctttttta
     3121 aaaaaaactc attatatgta aactaacata gccataaatt gctgacagaa
//
