LOCUS       NP_788263                934 aa            linear   ROD 28-MAR-2024
DEFINITION  complement component C6 precursor [Rattus norvegicus].
ACCESSION   NP_788263 XP_008758971
VERSION     NP_788263.2
DBSOURCE    REFSEQ: accession NM_176074.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 934)
  AUTHORS   Sta,M., Cappaert,N.L., Ramekers,D., Ramaglia,V., Wadman,W.J. and
            Baas,F.
  TITLE     C6 deficiency does not alter intrinsic regeneration speed after
            peripheral nerve crush injury
  JOURNAL   Neurosci Res 87, 26-32 (2014)
   PUBMED   25011063
  REMARK    GeneRIF: Findings suggest that C6 deficiency by itself does not
            alter the regrowth capacity of the peripheral nerve after crush
            injury.
REFERENCE   2  (residues 1 to 934)
  AUTHORS   Hadders,M.A., Bubeck,D., Roversi,P., Hakobyan,S., Forneris,F.,
            Morgan,B.P., Pangburn,M.K., Llorca,O., Lea,S.M. and Gros,P.
  TITLE     Assembly and regulation of the membrane attack complex based on
            structures of C5b6 and sC5b9
  JOURNAL   Cell Rep 1 (3), 200-207 (2012)
   PUBMED   22832194
REFERENCE   3  (residues 1 to 934)
  AUTHORS   Holtman,L., van Vliet,E.A., Baas,F., Aronica,E. and Gorter,J.A.
  TITLE     Complement protein 6 deficiency in PVG/c rats does not lead to
            neuroprotection against seizure induced cell death
  JOURNAL   Neuroscience 188, 109-116 (2011)
   PUBMED   21575686
  REMARK    GeneRIF: C6 deficiency did not lead to neuroprotection after status
            epilepticus
REFERENCE   4  (residues 1 to 934)
  AUTHORS   Ramaglia,V., Tannemaat,M.R., de Kok,M., Wolterman,R., Vigar,M.A.,
            King,R.H., Morgan,B.P. and Baas,F.
  TITLE     Complement inhibition accelerates regeneration in a model of
            peripheral nerve injury
  JOURNAL   Mol Immunol 47 (2-3), 302-309 (2009)
   PUBMED   19833392
  REMARK    GeneRIF: Pathology showed improved nerve regeneration in tibials of
            C6 deficient animals compared to wildtypes.
REFERENCE   5  (residues 1 to 934)
  AUTHORS   Ruseva,M.M., Hughes,T.R., Donev,R.M., Sivasankar,B.,
            Pickering,M.C., Wu,X., Harris,C.L. and Morgan,B.P.
  TITLE     Crry deficiency in complement sufficient mice: C3 consumption
            occurs without associated renal injury
  JOURNAL   Mol Immunol 46 (5), 803-811 (2009)
   PUBMED   18947875
REFERENCE   6  (residues 1 to 934)
  AUTHORS   Nangaku,M., Pippin,J. and Couser,W.G.
  TITLE     C6 mediates chronic progression of tubulointerstitial damage in
            rats with remnant kidneys
  JOURNAL   J Am Soc Nephrol 13 (4), 928-936 (2002)
   PUBMED   11912252
REFERENCE   7  (residues 1 to 934)
  AUTHORS   Nauta,A.J., Daha,M.R., Tijsma,O., van de Water,B., Tedesco,F. and
            Roos,A.
  TITLE     The membrane attack complex of complement induces caspase
            activation and apoptosis
  JOURNAL   Eur J Immunol 32 (3), 783-792 (2002)
   PUBMED   11870622
  REMARK    GeneRIF: The membrane attack complex of complement induces caspase
            activation and apoptosis.
REFERENCE   8  (residues 1 to 934)
  AUTHORS   Hughes,J., Nangaku,M., Alpers,C.E., Shankland,S.J., Couser,W.G. and
            Johnson,R.J.
  TITLE     C5b-9 membrane attack complex mediates endothelial cell apoptosis
            in experimental glomerulonephritis
  JOURNAL   Am J Physiol Renal Physiol 278 (5), F747-F757 (2000)
   PUBMED   10807586
REFERENCE   9  (residues 1 to 934)
  AUTHORS   Brauer,R.B., Baldwin,W.M. 3rd, Wang,D., Horwitz,L.R., Hess,A.D.,
            Klein,A.S. and Sanfilippo,F.
  TITLE     Hepatic and extrahepatic biosynthesis of complement factor C6 in
            the rat
  JOURNAL   J Immunol 153 (7), 3168-3176 (1994)
   PUBMED   8089494
REFERENCE   10 (residues 1 to 934)
  AUTHORS   Baker,P.J., Ochi,R.F., Schulze,M., Johnson,R.J., Campbell,C. and
            Couser,W.G.
  TITLE     Depletion of C6 prevents development of proteinuria in experimental
            membranous nephropathy in rats
  JOURNAL   Am J Pathol 135 (1), 185-194 (1989)
   PUBMED   2672823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Feb 26, 2021 this sequence version replaced
            XP_008758971.2, NP_788263.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.6450.1,
                                           SRR26643295.8152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     Protein         1..934
                     /product="complement component C6 precursor"
                     /note="complement component C6; complement component 6"
                     /calculated_mol_wt=102705
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2440
     mat_peptide     22..934
                     /product="Complement component C6. /id=PRO_0000023582"
                     /note="propagated from UniProtKB/Swiss-Prot (Q811M5.1)"
                     /calculated_mol_wt=102705
     Region          28..78
                     /region_name="TSP1_spondin"
                     /note="Spondin-like TSP1 domain; cl46269"
                     /db_xref="CDD:480609"
     Site            29
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Site            32
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Site            38
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) serine.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          82..127
                     /region_name="TSP1_spondin"
                     /note="Spondin-like TSP1 domain; cl46269"
                     /db_xref="CDD:480609"
     Site            90
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          142..173
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(144,152,163..164)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(156,159,163,169..170)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            166..170
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          292..514
                     /region_name="MACPF"
                     /note="MAC/Perforin domain; pfam01823"
                     /db_xref="CDD:460349"
     Site            324
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Site            392
                     /site_type="glycosylation"
                     /note="O-linked (Fuc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          568..612
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Site            568
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Site            571
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Site            574
                     /site_type="glycosylation"
                     /note="C-linked (Man) tryptophan.
                     /evidence=ECO:0000250|UniProtKB:P13671; propagated from
                     UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          611..688
                     /region_name="CCP 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          642..934
                     /region_name="C5B-binding domain"
                     /note="propagated from UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          <644..>764
                     /region_name="PHA02831"
                     /note="EEV host range protein; Provisional"
                     /db_xref="CDD:165176"
     Region          644..700
                     /region_name="CCP"
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
                     cd00033"
                     /db_xref="CDD:153056"
     Site            order(654,673)
                     /site_type="active"
                     /note="receptor-ligand interactions [active]"
                     /db_xref="CDD:153056"
     Region          689..765
                     /region_name="CCP 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          766..840
                     /region_name="Factor I module (FIM) 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          768..839
                     /region_name="FIMAC"
                     /note="factor I membrane attack complex; smart00057"
                     /db_xref="CDD:214493"
     Region          858..934
                     /region_name="Factor I module (FIM) 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q811M5.1)"
     Region          862..934
                     /region_name="FIMAC"
                     /note="factor I membrane attack complex; smart00057"
                     /db_xref="CDD:214493"
     CDS             1..934
                     /gene="C6"
                     /coded_by="NM_176074.4:161..2965"
                     /db_xref="GeneID:24237"
                     /db_xref="RGD:2238"
ORIGIN      
        1 mtrhlplcfi lliilidkse acfcdhypwt hwsscskscn sgtqsrqrqi vvndyyrdns
       61 cdqlctkqet rqcnvetcpi ncvlgdygtw sdcdpcirkq vkvrsvlrps qfggqpctep
      121 lvtfqpcvps elckieetdc knkflcdsgr cipsklecng endcgdnsde rncgrtkpvc
      181 srtytpipsv qlmgagfhfl ageprgdvld nsftggicks vrssrtsnph rvpanlenvn
      241 fevqtieddl ktdfykdlat igknknedrs lsgekkdsfy vpifysskks enfqrnsgfk
      301 naieashkkd ssfvrihkvi kvlnftmktt dlqlsdvflk alihlpleyn falysrifdd
      361 fgthyftsgs lggkydllyq fsrqelqnsg lteeetrncv ryetkkrflf ftktykedrc
      421 ttnrlsekyk gsflqgseks islvqggrsq qaaalawekg ssgpeanvfs ewlesvkenp
      481 avvdyelapi idlvrnipca vtkrnnlrka lqeyaakfdp cqcapcpnng rprlsgtecl
      541 cvcqsgtyge ncekrspdyk snavdgnwgc wsswsacnaa yrrsrsrecn npepqrggqr
      601 cegkhwqeed ctfsimekvg qpcisddeei kevdlaepea dsgcpqpplp enafvwnekk
      661 lysvgeevei scltgfkavg yqyfrclpdr twrqgdvecq rteclkpvvq dvltispfqs
      721 vykigesiel tcprgfvvag psrytckgds wtppipnsls cekdiltksk glcqpgqkqs
      781 gsecvcmspe edcssysedl cifdegssqy ftssackfla ekclnsnqfh fvhagscqeg
      841 pqlewglerl klamkstkrv pcgydtcydw ekcsahtsnc vcllppqcpk denqlhcvkm
      901 gssmrgktvn ictlgavrca nrkveilnpg rcld
//
