LOCUS       NM_001003710            1275 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus complement C5a receptor 2 (C5ar2), mRNA.
ACCESSION   NM_001003710
VERSION     NM_001003710.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   van Werkhoven,M.B., Damman,J., Daha,M.R., Krikke,C., van Goor,H.,
            van Son,W.J., Hillebrands,J.L., van Dijk,M.C. and Seelen,M.A.
  TITLE     Novel insights in localization and expression levels of C5aR and
            C5L2 under native and post-transplant conditions in the kidney
  JOURNAL   Mol Immunol 53 (3), 237-245 (2013)
   PUBMED   22960554
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Cao,Q., McIsaac,S.M. and Stadnyk,A.W.
  TITLE     Human colonic epithelial cells detect and respond to C5a via
            apically expressed C5aR through the ERK pathway
  JOURNAL   Am J Physiol Cell Physiol 302 (12), C1731-C1740 (2012)
   PUBMED   22496247
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Tokodai,K., Goto,M., Inagaki,A., Imura,T., Nakanishi,W. and
            Satomi,S.
  TITLE     Expression of receptors for anaphylatoxins C3a and C5a on rat islet
            preparations
  JOURNAL   Transplant Proc 43 (9), 3179-3180 (2011)
   PUBMED   22099750
  REMARK    GeneRIF: C5aR and C5L2, but not C3aR, are expressed on
            CD11b-positive leukocytes in islet preparations
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Francis,K., Lewis,B.M., Monk,P.N. and Ham,J.
  TITLE     Complement C5a receptors in the pituitary gland: expression and
            function
  JOURNAL   J Endocrinol 199 (3), 417-424 (2008)
   PUBMED   19020281
  REMARK    GeneRIF: C5a receptors and C5L2 were demonstrated in the rat
            anterior pituitary gland and they may play a role in dampening down
            inflammation by inhibiting the release of MIF and stimulating the
            release of ACTH.
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Scola,A.M., Higginbottom,A., Partridge,L.J., Reid,R.C.,
            Woodruff,T., Taylor,S.M., Fairlie,D.P. and Monk,P.N.
  TITLE     The role of the N-terminal domain of the complement fragment
            receptor C5L2 in ligand binding
  JOURNAL   J Biol Chem 282 (6), 3664-3671 (2007)
   PUBMED   17158873
  REMARK    GeneRIF: C5L2 appears to bind complement factor C5a and its
            C-terminal cleavage product C5a des Arg by different mechanisms,
            and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its
            N-terminal domain for binding only to C5a des Arg.
REFERENCE   6  (bases 1 to 1275)
  AUTHORS   Gerard,N.P., Lu,B., Liu,P., Craig,S., Fujiwara,Y., Okinaga,S. and
            Gerard,C.
  TITLE     An anti-inflammatory function for the complement anaphylatoxin
            C5a-binding protein, C5L2
  JOURNAL   J Biol Chem 280 (48), 39677-39680 (2005)
   PUBMED   16204243
REFERENCE   7  (bases 1 to 1275)
  AUTHORS   Gao,H., Neff,T.A., Guo,R.F., Speyer,C.L., Sarma,J.V., Tomlins,S.,
            Man,Y., Riedemann,N.C., Hoesel,L.M., Younkin,E., Zetoune,F.S. and
            Ward,P.A.
  TITLE     Evidence for a functional role of the second C5a receptor C5L2
  JOURNAL   FASEB J 19 (8), 1003-1005 (2005)
   PUBMED   15784721
  REMARK    GeneRIF: data provide the first evidence for a role for C5a
            receptor C5L2 in balancing the biological responses to Complement
            5a
REFERENCE   8  (bases 1 to 1275)
  AUTHORS   Gavrilyuk,V., Kalinin,S., Hilbush,B.S., Middlecamp,A., McGuire,S.,
            Pelligrino,D., Weinberg,G. and Feinstein,D.L.
  TITLE     Identification of complement 5a-like receptor (C5L2) from
            astrocytes: characterization of anti-inflammatory properties
  JOURNAL   J Neurochem 92 (5), 1140-1149 (2005)
   PUBMED   15715664
  REMARK    GeneRIF: A C5aR isoform expressed by glia and neurons is regulated
            by NA and exerts anti-inflammatory functions. Changes in C5aR
            isoform levels in diseased brain could therefore contribute to the
            progression of inflammatory damage.
REFERENCE   9  (bases 1 to 1275)
  AUTHORS   Huber-Lang,M., Sarma,J.V., Rittirsch,D., Schreiber,H., Weiss,M.,
            Flierl,M., Younkin,E., Schneider,M., Suger-Wiedeck,H., Gebhard,F.,
            McClintock,S.D., Neff,T., Zetoune,F., Bruckner,U., Guo,R.F.,
            Monk,P.N. and Ward,P.A.
  TITLE     Changes in the novel orphan, C5a receptor (C5L2), during
            experimental sepsis and sepsis in humans
  JOURNAL   J Immunol 174 (2), 1104-1110 (2005)
   PUBMED   15634936
  REMARK    GeneRIF: Following cecal ligation and puncture-induced sepsis in
            rats, neutrophils demonstrated a time-dependent decrease in C5L2.
REFERENCE   10 (bases 1 to 1275)
  AUTHORS   Okinaga,S., Slattery,D., Humbles,A., Zsengeller,Z., Morteau,O.,
            Kinrade,M.B., Brodbeck,R.M., Krause,J.E., Choe,H.R., Gerard,N.P.
            and Gerard,C.
  TITLE     C5L2, a nonsignaling C5A binding protein
  JOURNAL   Biochemistry 42 (31), 9406-9415 (2003)
   PUBMED   12899627
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001003710.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY741660.1, SRR26643295.1066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000001.1  86070441-86070553   c
            114-1275            JAXUCZ010000001.1  86060211-86061372   c
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1275
                     /gene="C5ar2"
                     /gene_synonym="C5L2; Gpr77"
                     /note="complement C5a receptor 2"
                     /db_xref="GeneID:445269"
                     /db_xref="RGD:1303027"
     exon            1..113
                     /gene="C5ar2"
                     /gene_synonym="C5L2; Gpr77"
                     /inference="alignment:Splign:2.1.0"
     exon            114..1275
                     /gene="C5ar2"
                     /gene_synonym="C5L2; Gpr77"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1160
                     /gene="C5ar2"
                     /gene_synonym="C5L2; Gpr77"
                     /note="C5a anaphylatoxin chemotactic receptor C5L2; C5A
                     receptor beta; complement 5A receptor beta; G
                     protein-coupled receptor 77; complement component 5a
                     receptor 2"
                     /codon_start=1
                     /product="C5a anaphylatoxin chemotactic receptor 2"
                     /protein_id="NP_001003710.3"
                     /db_xref="GeneID:445269"
                     /db_xref="RGD:1303027"
                     /translation="MLNDTTSKDYEYEYDQEQYSDLLNVPVDCPAGNCFSNDAYLIVL
                     LGLYSVIFLVGVPGNTLLAWVTWKESRHRLGASWFLHLTMADLLCCVSLPFLAVPIAQ
                     KGHWPYGTAGCWLLSSITVLSMYASVLLLTGLSGDLFLLAFRPSWKNADQRTCGVRVV
                     QVSSWMLALLLTVPGAVYRKLLQEHYPPRLVCGTNYGGSVTAEVTITTVRFLFGFLVP
                     LVFMASCHGILQRQMARRHWPLGTAVVVGFFICWTPFHLLRVIIAVASSHSPLLAWAL
                     EAEPLVTGLALAHSALNPIMFLYFGRKQLCKSLQAACHWALRDLQDEEESAVTKVSTS
                     QEMVSEMPV"
ORIGIN      
        1 agggttggat tggcgagact cacacccacg actgtccctg gtggagagac tctgggcctc
       61 cctgtgtact tgttagcggc attcagccaa cgtgggagca gtcggaagag aaggtgtctg
      121 gggccaggat gctgaacgac accaccagca aggattatga gtatgagtat gatcaggaac
      181 agtatagtga ccttctgaac gtccccgtag actgcccagc tggcaactgc ttctctaatg
      241 atgcctacct catagtcctg cttggcctgt attcagtcat cttcctggtg ggtgtgccag
      301 gcaacaccct gttggcgtgg gtgacctgga aagagtctcg ccacaggctc ggggcctctt
      361 ggttcctgca cttgaccatg gcggacttgc tttgctgtgt gtctctgccc ttcctggctg
      421 tgcccatcgc ccaaaagggc cactggccat acgggacagc aggctgctgg ctgttgtcct
      481 ccatcaccgt tctgtctatg tatgccagtg tgctgctcct gacgggcctc agtggcgacc
      541 tcttcctatt ggctttcagg ccctcctgga agaatgcaga tcaacgaaca tgtggggtgc
      601 gtgtggtcca ggtctcctcc tggatgctgg ccctgttgct gactgtgcct ggtgctgtct
      661 atcgtaagct gcttcaggag cactatcctc cccggcttgt gtgtggcaca aactatgggg
      721 gatcggtcac cgcggaagtt accatcacca ctgttcgatt cctctttggc ttcctggtgc
      781 cattggtgtt catggccagt tgccacggca tcctccaacg gcagatggct cgccgccact
      841 ggcccctggg cacagctgtt gtggtggggt ttttcatttg ctggacccct tttcacctcc
      901 tgcgggtcat cattgcagtg gcttcttcac actccccgct ccttgcctgg gccctggagg
      961 ctgagccttt ggttacgggc ctggcccttg ctcacagtgc tctcaatcct attatgtttt
     1021 tgtatttcgg aagaaaacaa ctctgcaagt cactccaggc tgcatgtcac tgggccctga
     1081 gggatctaca ggatgaggag gaaagtgccg tgaccaaggt atccaccagc caggaaatgg
     1141 tgtctgagat gccggtgtag gcgggaggga tttggatttc ctaggccagc tcacaactgt
     1201 gcagcttcag gcacagctgg atgcaggagc tcggagatgg cttttattct tcgttcaata
     1261 aacattcatt gtgca
//
