LOCUS       NM_053619               1814 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus complement C5a receptor 1 (C5ar1), mRNA.
ACCESSION   NM_053619
VERSION     NM_053619.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Okada,A., Shimizu,K., Kawashima,A., Kayahara,T., Itani,M.,
            Kurita,H., Miyamoto,S., Kataoka,H. and Aoki,T.
  TITLE     C5a-C5AR1 axis as a potential trigger of the rupture of
            intracranial aneurysms
  JOURNAL   Sci Rep 14 (1), 3105 (2024)
   PUBMED   38326494
  REMARK    GeneRIF: C5a-C5AR1 axis as a potential trigger of the rupture of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Shen,B., Shen,Q., Zeng,Q., Zhang,L. and Li,X.
  TITLE     Silenced-C5ar1 improved multiple organ injury in sepsis rats via
            inhibiting neutrophil extracellular trap
  JOURNAL   J Mol Histol 55 (1), 69-81 (2024)
   PUBMED   38165570
  REMARK    GeneRIF: Silenced-C5ar1 improved multiple organ injury in sepsis
            rats via inhibiting neutrophil extracellular trap.
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Shi,Y., Jin,Y., Li,X., Chen,C., Zhang,Z., Liu,X., Deng,Y., Fan,X.
            and Wang,C.
  TITLE     C5aR1 Mediates the Progression of Inflammatory Responses in the
            Brain of Rats in the Early Stage after Ischemia and Reperfusion
  JOURNAL   ACS Chem Neurosci 12 (21), 3994-4006 (2021)
   PUBMED   34637270
  REMARK    GeneRIF: C5aR1 Mediates the Progression of Inflammatory Responses
            in the Brain of Rats in the Early Stage after Ischemia and
            Reperfusion.
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Jiang,Y., Li,J., Teng,Y., Sun,H., Tian,G., He,L., Li,P., Chen,Y.,
            Guo,Y., Li,J., Zhao,G., Zhou,Y. and Sun,S.
  TITLE     Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in
            hDPP4-Transgenic Mice Infected with MERS-CoV
  JOURNAL   Viruses 11 (1), 39 (2019)
   PUBMED   30634407
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Shi,Y.W., Zhang,X.C., Chen,C., Tang,M., Wang,Z.W., Liang,X.M.,
            Ding,F. and Wang,C.P.
  TITLE     Schisantherin A attenuates ischemia/reperfusion-induced neuronal
            injury in rats via regulation of TLR4 and C5aR1 signaling pathways
  JOURNAL   Brain Behav Immun 66, 244-256 (2017)
   PUBMED   28690033
  REMARK    GeneRIF: Study concludes, Toll-like receptor 4 (TLR4) and C5aR1
            played a vital role during ischemia and reperfusion brain injury in
            rats, and schisantherin A exhibited neuroprotective effects by TLR4
            and C5aR1 signaling pathways.
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Akatsu,H., Miwa,T., Sakurada,C., Fukuoka,Y., Ember,J.A.,
            Yamamoto,T., Hugli,T.E. and Okada,H.
  TITLE     cDNA cloning and characterization of rat C5a anaphylatoxin receptor
  JOURNAL   Microbiol Immunol 41 (7), 575-580 (1997)
   PUBMED   9272704
REFERENCE   7  (bases 1 to 1814)
  AUTHORS   Perret,J.J., Raspe,E., Vassart,G. and Parmentier,M.
  TITLE     Cloning and functional expression of the canine anaphylatoxin C5a
            receptor. Evidence for high interspecies variability
  JOURNAL   Biochem J 288 (Pt 3) (Pt 3), 911-917 (1992)
   PUBMED   1472004
REFERENCE   8  (bases 1 to 1814)
  AUTHORS   Gerard,C., Bao,L., Orozco,O., Pearson,M., Kunz,D. and Gerard,N.P.
  TITLE     Structural diversity in the extracellular faces of peptidergic
            G-protein-coupled receptors. Molecular cloning of the mouse C5a
            anaphylatoxin receptor
  JOURNAL   J Immunol 149 (8), 2600-2606 (1992)
   PUBMED   1401897
REFERENCE   9  (bases 1 to 1814)
  AUTHORS   Hirsch,R.S. and Clarke,N.G.
  TITLE     Has small-scale audio-visual dental health education a viable
            future?
  JOURNAL   Community Dent Oral Epidemiol 5 (4), 160-163 (1977)
   PUBMED   70320
REFERENCE   10 (bases 1 to 1814)
  AUTHORS   Caspi,E., Herczeg,E., Solomon,F. and Sompolinsky,D.
  TITLE     Amnionitis and T strain mycoplasmemia
  JOURNAL   Am J Obstet Gynecol 111 (8), 1102-1106 (1971)
   PUBMED   5129564
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053619.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078770.1, AB003042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676806
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                JAXUCZ010000001.1  86087656-86087749   c
            95-1814             JAXUCZ010000001.1  86077316-86079035   c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1814
                     /gene="C5ar1"
                     /gene_synonym="C5a-R; C5aR; C5r1"
                     /note="complement C5a receptor 1"
                     /db_xref="GeneID:113959"
                     /db_xref="RGD:70553"
     exon            1..94
                     /gene="C5ar1"
                     /gene_synonym="C5a-R; C5aR; C5r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1150
                     /gene="C5ar1"
                     /gene_synonym="C5a-R; C5aR; C5r1"
                     /note="complement component 5, receptor 1; complement
                     component 5a receptor 1"
                     /codon_start=1
                     /product="C5a anaphylatoxin chemotactic receptor 1"
                     /protein_id="NP_446071.1"
                     /db_xref="GeneID:113959"
                     /db_xref="RGD:70553"
                     /translation="MDPISNDSSEITYDYSDGTPNPDMPADGVYIPKMEPGDIAALII
                     YLAVFLVGVTGNALVVWVTAFEAKRTVNAIWFLNLAVADLLSCLALPILFTSIVKHNH
                     WPFGDQACIVLPSLILLNMYSSILLLATISADRFLLVFKPIWCQKFRRPGLAWMACGV
                     TWVLALLLTIPSFVFRRIHKDPYSDSILCNIDYSKGPFFIEKAIAILRLMVGFVLPLL
                     TLNICYTFLLIRTWSRKATRSTKTLKVVMAVVTCFFVFWLPYQVTGVILAWLPRSSST
                     FQSVERLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLRRSLPSIIRNVLSEDSLGRDS
                     KSFTRSTMDTSTQKSQAV"
     exon            95..1814
                     /gene="C5ar1"
                     /gene_synonym="C5a-R; C5aR; C5r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttcttga ggctttaaga agtgcagccc gagtgacagg aggggccttc aggcatcgtt
       61 ggtcaccaca gagcccagga gaagccagga catggacccc ataagtaacg acagcagtga
      121 aatcacctat gattactctg atggaacccc aaatcctgac atgcctgcag atggcgttta
      181 cattccgaag atggaacctg gggacattgc agcccttatt atctacttgg ccgtgttcct
      241 ggtaggagtt accggaaatg ccctggtggt gtgggtgaca gcctttgagg ccaaacgtac
      301 tgtcaacgcc atttggtttc tgaatctggc ggtggccgac ctcctctcgt gcttggcact
      361 gcctatcctg tttacgtcca ttgtaaagca taaccactgg cccttcggtg accaggcctg
      421 tatagtcctg ccctcgctca ttctgctcaa catgtactcc agcatcctgc tgctggccac
      481 tattagtgcc gaccgtttcc tgctggtgtt caaacccatc tggtgtcaga agttccgccg
      541 gcctggcctg gcctggatgg cttgcggagt aacctgggtc ttagcattgc tcctcaccat
      601 tccgtccttc gtgttccggc ggatacataa ggacccctac tcagatagca ttctatgtaa
      661 tattgactat agtaagggtc cgttcttcat agagaaggct atagccatcc tgcggctgat
      721 ggtgggtttc gtgttgcctc tgctcactct taacatctgc tacaccttcc tcctgatccg
      781 gacctggagt cgcaaggcca cgcgctccac caagacgctc aaagtggtga tggcggtggt
      841 cacatgtttc tttgtcttct ggctacccta ccaggtaaca ggggtgatat tagcttggct
      901 gccccggtcc tcatccactt ttcagtcagt ggagaggctg aactccttgt gcgtttccct
      961 ggcctacatc aactgctgtg ttaaccctat catctacgtc atggctggcc agggtttcca
     1021 tgggagactc cgaaggtcac tccccagcat catacgaaac gtgctctctg aggactcctt
     1081 gggcagggac agcaagagtt tcactcggtc cacgatggat acctccaccc agaagagtca
     1141 ggcagtgtag aggagatgcc acaactgcct agctgctcct tttccagtcc tcctcccctt
     1201 cctccttcct cctctcaccc ctcctccctt cctcccatct ctttgcatgt ttaattttat
     1261 gtgattctct ttaaattgcc ctgactagcc ttgagcccag gatgctcacg gatgctgaga
     1321 ttataggtaa aaattccttt ggagagaaac attacattaa gatattactg ggcttttttt
     1381 ctgaggcagg ccttggcctc gttgcccatc tgcagtgtct aggcagatac acctagtgat
     1441 gacgtctagg ggtcaggtaa cagagaaccc aggtctcgag ggaacccggg gctcacggat
     1501 acactacgtg agtaagctat agccctagac tccaggcaac aaataagcac ccacccttta
     1561 tttcttttct atgtctgatt tttttgttta tttgagacaa agtccatgta ggctagtcta
     1621 gccatggact cctcctgtga tcatcctcca gaggtcgaga ctgtagacct gtgctaccat
     1681 gcccgaccta tcctttattt ctgcaatttt gtcttttcaa aaatggtatt cgacagaacc
     1741 caacatatcc aagttttgta aaaacaactg tgcacggctt acacgataaa aaatttttgt
     1801 ttttttaaaa aggt
//
