LOCUS       NM_053020               5480 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus complement C5 (C5), mRNA.
ACCESSION   NM_053020 XM_001079130
VERSION     NM_053020.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5480)
  AUTHORS   Okada,A., Shimizu,K., Kawashima,A., Kayahara,T., Itani,M.,
            Kurita,H., Miyamoto,S., Kataoka,H. and Aoki,T.
  TITLE     C5a-C5AR1 axis as a potential trigger of the rupture of
            intracranial aneurysms
  JOURNAL   Sci Rep 14 (1), 3105 (2024)
   PUBMED   38326494
  REMARK    GeneRIF: C5a-C5AR1 axis as a potential trigger of the rupture of
            intracranial aneurysms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5480)
  AUTHORS   Yang,Z., Nunn,M.A., Le,T.D., Simovic,M.O., Edsall,P.R., Liu,B.,
            Barr,J.L., Lund,B.J., Hill-Pryor,C.D., Pusateri,A.E., Cancio,L.C.
            and Li,Y.
  TITLE     Immunopathology of terminal complement activation and complement C5
            blockade creating a pro-survival and organ-protective phenotype in
            trauma
  JOURNAL   Br J Pharmacol 180 (4), 422-440 (2023)
   PUBMED   36251578
  REMARK    GeneRIF: Immunopathology of terminal complement activation and
            complement C5 blockade creating a pro-survival and organ-protective
            phenotype in trauma.
REFERENCE   3  (bases 1 to 5480)
  AUTHORS   Vinay,P., Karen,C., Balamurugan,K. and Rajan,K.E.
  TITLE     Cronobacter sakazakii Infection in Early Postnatal Rats Impaired
            Contextual-Associated Learning: a Putative Role of C5a-Mediated
            NF-kappabeta and ASK1 Pathways
  JOURNAL   J Mol Neurosci 71 (1), 28-41 (2021)
   PUBMED   32567007
  REMARK    GeneRIF: Cronobacter sakazakii Infection in Early Postnatal Rats
            Impaired Contextual-Associated Learning: a Putative Role of
            C5a-Mediated NF-kappabeta and ASK1 Pathways.
REFERENCE   4  (bases 1 to 5480)
  AUTHORS   Cugno,M., Meroni,P.L., Gualtierotti,R., Griffini,S., Grovetti,E.,
            Torri,A., Panigada,M., Aliberti,S., Blasi,F., Tedesco,F. and
            Peyvandi,F.
  TITLE     Complement activation in patients with COVID-19: A novel
            therapeutic target
  JOURNAL   J Allergy Clin Immunol 146 (1), 215-217 (2020)
   PUBMED   32417135
REFERENCE   5  (bases 1 to 5480)
  AUTHORS   Tan,S.M., Ziemann,M., Thallas-Bonke,V., Snelson,M., Kumar,V.,
            Laskowski,A., Nguyen,T.V., Huynh,K., Clarke,M.V., Libianto,R.,
            Baker,S.T., Skene,A., Power,D.A., MacIsaac,R.J., Henstridge,D.C.,
            Wetsel,R.A., El-Osta,A., Meikle,P.J., Wilson,S.G., Forbes,J.M.,
            Cooper,M.E., Ekinci,E.I., Woodruff,T.M. and Coughlan,M.T.
  TITLE     Complement C5a Induces Renal Injury in Diabetic Kidney Disease by
            Disrupting Mitochondrial Metabolic Agility
  JOURNAL   Diabetes 69 (1), 83-98 (2020)
   PUBMED   31624141
  REMARK    GeneRIF: Evidence for a pivotal role of the C5a/C5aR1 axis in
            propagating renal injury in the development of diabetic kidney
            disease (DKD) by disrupting mitochondrial agility, thereby
            establishing a new immunometabolic signaling pathway in DKD.
REFERENCE   6  (bases 1 to 5480)
  AUTHORS   Dromer,F., Perronne,C., Barge,J., Vilde,J.L. and Yeni,P.
  TITLE     Role of IgG and complement component C5 in the initial course of
            experimental cryptococcosis
  JOURNAL   Clin Exp Immunol 78 (3), 412-417 (1989)
   PUBMED   2612053
REFERENCE   7  (bases 1 to 5480)
  AUTHORS   Langlois,P.F. and Gawryl,M.S.
  TITLE     Accentuated formation of the terminal C5b-9 complement complex in
            patient plasma precedes development of the adult respiratory
            distress syndrome
  JOURNAL   Am Rev Respir Dis 138 (2), 368-375 (1988)
   PUBMED   3264125
REFERENCE   8  (bases 1 to 5480)
  AUTHORS   Fowler,S.R., Seidenfeld,J.J., Collins,J.F. and Kolb,W.P.
  TITLE     Induction of acute pulmonary inflammation. A differential effect of
            C5 and the 200,000 molecular weight form of trypsin-activated C5
            (C5')
  JOURNAL   Am Rev Respir Dis 136 (3), 691-697 (1987)
   PUBMED   3631740
REFERENCE   9  (bases 1 to 5480)
  AUTHORS   Robbins,R.A., Russ,W.D., Rasmussen,J.K. and Clayton,M.M.
  TITLE     Activation of the complement system in the adult respiratory
            distress syndrome
  JOURNAL   Am Rev Respir Dis 135 (3), 651-658 (1987)
   PUBMED   3826891
REFERENCE   10 (bases 1 to 5480)
  AUTHORS   Fick,R.B. Jr., Robbins,R.A., Squier,S.U., Schoderbek,W.E. and
            Russ,W.D.
  TITLE     Complement activation in cystic fibrosis respiratory fluids: in
            vivo and in vitro generation of C5a and chemotactic activity
  JOURNAL   Pediatr Res 20 (12), 1258-1268 (1986)
   PUBMED   3540828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 6, 2019 this sequence version replaced XM_001079130.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.9999.1,
                                           SRR26643287.7688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               JAXUCZ010000003.1  38759331-38759468   c
            139-331             JAXUCZ010000003.1  38755459-38755651   c
            332-494             JAXUCZ010000003.1  38746964-38747126   c
            495-565             JAXUCZ010000003.1  38742937-38743007   c
            566-657             JAXUCZ010000003.1  38742314-38742405   c
            658-740             JAXUCZ010000003.1  38740382-38740464   c
            741-831             JAXUCZ010000003.1  38737922-38738012   c
            832-946             JAXUCZ010000003.1  38737457-38737571   c
            947-1073            JAXUCZ010000003.1  38732285-38732411   c
            1074-1189           JAXUCZ010000003.1  38731134-38731249   c
            1190-1375           JAXUCZ010000003.1  38730841-38731026   c
            1376-1579           JAXUCZ010000003.1  38729394-38729597   c
            1580-1789           JAXUCZ010000003.1  38727727-38727936   c
            1790-1939           JAXUCZ010000003.1  38727459-38727608   c
            1940-2072           JAXUCZ010000003.1  38726103-38726235   c
            2073-2144           JAXUCZ010000003.1  38723851-38723922   c
            2145-2342           JAXUCZ010000003.1  38722401-38722598   c
            2343-2433           JAXUCZ010000003.1  38714950-38715040   c
            2434-2507           JAXUCZ010000003.1  38713000-38713073   c
            2508-2647           JAXUCZ010000003.1  38712259-38712398   c
            2648-2875           JAXUCZ010000003.1  38708671-38708898   c
            2876-2936           JAXUCZ010000003.1  38707328-38707388   c
            2937-3026           JAXUCZ010000003.1  38704028-38704117   c
            3027-3239           JAXUCZ010000003.1  38702414-38702626   c
            3240-3315           JAXUCZ010000003.1  38701940-38702015   c
            3316-3475           JAXUCZ010000003.1  38698694-38698853   c
            3476-3571           JAXUCZ010000003.1  38696501-38696596   c
            3572-3743           JAXUCZ010000003.1  38694611-38694782   c
            3744-3949           JAXUCZ010000003.1  38691315-38691520   c
            3950-4102           JAXUCZ010000003.1  38688769-38688921   c
            4103-4165           JAXUCZ010000003.1  38685434-38685496   c
            4166-4247           JAXUCZ010000003.1  38683845-38683926   c
            4248-4305           JAXUCZ010000003.1  38681983-38682040   c
            4306-4408           JAXUCZ010000003.1  38677054-38677156   c
            4409-4483           JAXUCZ010000003.1  38676652-38676726   c
            4484-4589           JAXUCZ010000003.1  38676436-38676541   c
            4590-4673           JAXUCZ010000003.1  38675311-38675394   c
            4674-4763           JAXUCZ010000003.1  38674582-38674671   c
            4764-4847           JAXUCZ010000003.1  38671121-38671204   c
            4848-4986           JAXUCZ010000003.1  38669600-38669738   c
            4987-5480           JAXUCZ010000003.1  38668174-38668667   c
FEATURES             Location/Qualifiers
     source          1..5480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..5480
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /note="complement C5"
                     /db_xref="GeneID:362119"
                     /db_xref="RGD:2237"
     exon            1..138
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..5125
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /note="anaphylatoxin; complement component 5"
                     /codon_start=1
                     /product="complement C5 precursor"
                     /protein_id="NP_444179.1"
                     /db_xref="GeneID:362119"
                     /db_xref="RGD:2237"
                     /translation="MPLPAMGLWGLLCLLIFLDKTWGQEQTYVISAPKIFRVGSSENV
                     VIQAHGYTEAFDATISLKSYPDKKVTYSSGYVNLSPENKFQNSALLTLPPKQFPRDEN
                     PVSHVYLEVVSMHFSKSKKIPITYDNGFLFIHTDKPVYTPDQSVKIRVYSLSDDLKPA
                     KRETVLTFVDPEGTEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKAKYKKDFTTTG
                     TAYFEVKEYVLPRFSVSIEPESNFIGYKNFKNFEITVKARYFYNKMVPDAEVYIFFGL
                     REDIKEDEKQMMHKAMQAATLVNGVAQISFDSETAVKELSYESLEDLNNKYLYIAVTV
                     TESSGGFSEEAEIPGIKYVLSPYTLNLVATPLFLKPGIPFSIKVQVKDSLEQLVGGVP
                     VTLMAQTVNVNQETSDLEPKRSITHSADGVASFVVNLPSEVTSLKFEVKTDAPELPEE
                     NQASKEYEAVTYSSLSQSYIYIGWTENYKPMLVGEYLNIIVTPKSPYIDKITHYNYLI
                     LSKGKIVQYGTKEKLLYSSYQNINIPVTQDMVPSARLLVYYIVTGEQTAELVADAVWI
                     NIEEKCGNQLQVHLSPDKDVYSPGQTVSLDMVTEADSWVALSAVDSAVYGVRGKAKRA
                     MQRVFQAFDDKSDLGCGAGGGRDNVDVFHLAGLTFLTNANADDSQYHDDSCKEILRPK
                     RDLQLLHQKVEEQAAKYKHRVPKKCCYDGARENKYETCEQRVARVTIGPHCIRAFNEC
                     CTIADKIRKESHHKGMLLGRIQIKALLPVMKAEIRSYFPESWLWEVHRVPKRNQLQVA
                     LPDSLTTWEIQGIGISDNGICVADTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYN
                     YRTSGTMFCVKMSAVEGICTPGSSAASPQTSRSSRCVRQRIEGSSSHLVTFSLLPLEI
                     GLHSINFSLETSFGKEILVKTLRVVPEGIKRESYAGVTLDPRGVYGIVNRRKEFPYRI
                     PLDLVPKTNVKRILSVKGLLIGEFLSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYV
                     FHYLEAGNHWNIFHPDTLARKQSLQKKIKEGLVSVMSYRNADYSYSMWKGASSSAWLT
                     AFALRVLGQVNKYVKQDQYSICNSLLWLIEKCQLENGSFKENSQYLPIKLQGTLPAEA
                     QENTLYLTAFSVIGIRKAIGICPTEKIYTALAKADSFLLERTLPSKSTFTLAIVAYAL
                     SLGDRTHPKFRSIVSALKREALVKGDPPIYRFWRDTLQRPDSSAPNSGTAGMVETTAY
                     ALLTSLNLKETSYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLHLDM
                     DINVSYKHKGDFYQYKVTEKNFLGRPVEVPLNDDLIVTTGYSSGLATVYVKTVVHKTS
                     VAEEFCSFYLKIDTQEVEASSYLSYSDSGHKRIIACASYKPSKEESASGSSHAVMDIL
                     LPTGIGANQEDLRALVEGVDQLLTDYQIKDSHVILQLNSIPSRDFLCVRFRIFELFQV
                     GFLNPATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAACKCVEADCGQLQAELDLAI
                     SADTRKETACKPEIAYAYKVRITSATEENIFVKYTATLLDIYKTGEAAAEKDSEITFI
                     KKISCTNANLVKGKQYLIMGKEALQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQA
                     FVANLDEFAEDIFLNGCENA"
     exon            139..331
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            332..494
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            495..565
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            566..657
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            658..740
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            741..831
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            832..946
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1073
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1189
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1375
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1579
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1789
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1939
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2072
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2144
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2342
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2433
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2507
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2647
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2875
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2936
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3026
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3239
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3315
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3475
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3571
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3572..3743
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3744..3949
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4102
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..4165
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4247
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4248..4305
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4408
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4409..4483
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4484..4589
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4673
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4674..4763
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4764..4847
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4848..4986
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5480
                     /gene="C5"
                     /gene_synonym="C5a; Hc; RGD1561905"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcaaactcc gtttatttag aaggaaagtg gtcacaggaa ggtcatgccc gtgggtttat
       61 gccgcttcca gccatgggcc tttggggact actttgcctt ttaattttcc tggacaagac
      121 ctggggacag gaacaaacct acgtcatttc agcacccaaa atcttccggg tcggatcatc
      181 cgaaaatgtc gtaattcaag cccatggcta caccgaagcc tttgacgcaa cgatctctct
      241 gaaaagctat cctgacaaaa aagtgaccta ctcttccggc tatgttaact tgtcgccgga
      301 aaacaaattc cagaactcag cactgttgac attaccgccc aaacaatttc ccagagatga
      361 aaacccagtc tctcacgtgt atctggaagt tgtgtcaatg cacttttcga aatcgaagaa
      421 aataccaata acctatgaca atggatttct cttcatccat acagacaaac ctgtttacac
      481 tccagaccag tcagtaaaga ttagagtcta ctctctgagt gacgacttga agccagccaa
      541 acgggagact gtcttaactt tcgtagatcc cgaaggaaca gaagttgaca tcgtagaaga
      601 aaatgattat actggaatta tctcttttcc tgacttcaag attccatcta atcccaagta
      661 tggtgtatgg acaattaaag ctaaatataa gaaggatttt acaacgactg gaactgcata
      721 ctttgaagtt aaagaatatg tcttgccccg attctctgta tcaatagaac cagaaagcaa
      781 cttcattggc tataagaact ttaagaactt tgaaatcact gtgaaagcaa gatattttta
      841 taataaaatg gtccccgatg ctgaagtcta tatctttttt gggttgagag aggacataaa
      901 agaggatgag aaacagatga tgcataaagc catgcaagcc gcaacgttgg tcaatggagt
      961 tgctcagatc tcttttgact ctgaaacagc agtgaaagag ctgtcatatg aaagtctaga
     1021 agatctaaac aataagtacc tttatattgc tgtaacagtc acagagtctt caggtgggtt
     1081 ttcggaagag gcagaaattc ctggcatcaa atacgtcctc tctccctata cactgaattt
     1141 ggtcgctacc cctcttttcc tgaagcctgg gattccattt tccatcaagg tacaggttaa
     1201 ggattcactc gagcagttgg taggaggggt cccagtaact ctgatggcac aaacagtcaa
     1261 tgtgaatcaa gagacatctg acttggaacc aaagaggagc atcacacact ctgctgatgg
     1321 agtggcttca tttgtggtga acctcccatc agaagtgaca tcactgaagt ttgaggtcaa
     1381 aactgatgcc ccggaacttc ccgaagaaaa tcaagccagc aaagaatatg aagcagttac
     1441 atactcatcc ctcagccaga gttacattta cattggctgg actgaaaact acaagcccat
     1501 gcttgtggga gaatatctga atattatcgt cacccccaag agtccatata ttgacaaaat
     1561 aactcactat aattacttga ttttatccaa aggcaaaatt gtacagtatg gcacaaagga
     1621 gaaacttctc tattcatctt atcaaaatat aaacatccca gtgacacagg acatggttcc
     1681 ttcagcgcgg ctcctggtct attacatagt cacgggggag cagacagcag aattggtggc
     1741 tgacgcagtc tggataaaca ttgaggagaa gtgtggcaac cagctccagg tccatctgtc
     1801 tccagataaa gacgtgtatt ctccaggcca aactgtgtcc cttgacatgg tgactgaagc
     1861 agactcatgg gtggcactat ctgcggtgga cagcgctgtg tatggagtcc ggggaaaagc
     1921 caaaagggcc atgcaaagag tgttccaagc ttttgatgac aagagtgacc tgggctgtgg
     1981 ggcaggtggt ggccgtgaca atgtagatgt attccatcta gctgggctca ccttcctcac
     2041 caatgcaaac gcagatgact cccaatacca cgatgactct tgtaaggaaa ttctcaggcc
     2101 aaagagagac ctgcagctcc tgcatcagaa agtggaagaa caagctgcta aatacaaaca
     2161 ccgtgtgccc aagaaatgct gttatgatgg agcccgagaa aacaaatacg aaacctgtga
     2221 gcagcgagtt gcccgggtga ccataggccc acactgcatc agggccttca acgagtgttg
     2281 tactattgcg gataagatcc gaaaagaaag ccaccacaaa ggcatgctgt tgggaaggat
     2341 ccaaataaag gccctgttac cagtgatgaa ggcagaaatc cgaagctact ttccagagag
     2401 ctggctatgg gaagttcatc gtgttcccaa aagaaaccag ctgcaggttg cactgcctga
     2461 ctcactgacg acctgggaaa ttcaaggcat cggcatctca gacaatggta tatgtgttgc
     2521 tgacacactc aaggcaaagg tgttcaaaga tgtcttcctg gagatgaaca taccatattc
     2581 tgttgtacga ggggagcaga tccaattgaa gggaaccgtt tacaattata ggacctctgg
     2641 gacaatgttc tgtgttaaaa tgtctgccgt ggagggaatc tgcactccag gaagctcggc
     2701 tgctagccct cagacctcta ggtcctccag atgtgtgcgc cagagaatag agggctcctc
     2761 cagtcacttg gtgaccttca gcctgcttcc tctggaaatt ggccttcact ccataaactt
     2821 ctcactagag acttcatttg ggaaagaaat cttagtgaag acattacggg tagtgccaga
     2881 agggatcaaa agggaaagct atgctggtgt gactctggac cccaggggag tttatggtat
     2941 tgttaacaga cgaaaggaat tcccatacag gataccatta gatttggtcc ccaaaaccaa
     3001 cgtcaaaagg attttgagtg taaaaggact gcttataggg gaattcttgt ccacggttct
     3061 gagtaaagaa ggcatcgaca tcctaaccca cctccccaag ggcagcgccg aggcagaact
     3121 catgagcata gtcccggtgt tctacgtttt ccactacctg gaagcaggaa accattggaa
     3181 tattttccac cctgatacgt tagctagaaa acagagcctg cagaaaaaaa taaaagaagg
     3241 gctggtgagc gtcatgtcct acagaaacgc tgactattcc tacagcatgt ggaagggagc
     3301 aagctctagt gcctggctga cagcttttgc tctgagagtg cttggacagg tgaacaagta
     3361 tgtgaaacaa gaccaatact cgatctgtaa ctccttgtta tggctgattg agaagtgtca
     3421 gctggaaaac ggatctttca aggaaaattc ccaatatcta ccaataaaat tacagggtac
     3481 tttgcctgct gaagcccaag agaacacttt atatcttaca gccttttctg tgattggaat
     3541 tagaaaggct attggcatat gccccacgga gaaaatctac acagcgctgg ctaaagctga
     3601 ctccttccta cttgaaagga ccctgccttc caagagcacc ttcaccctgg ccattgtggc
     3661 ctatgctctc tccctgggag acagaaccca cccgaagttt cgttctattg tgtcagccct
     3721 gaagagggaa gctttggtta aaggagaccc gcccatttac cgtttctgga gagacactct
     3781 ccaacgtcca gacagctcag cacccaacag cggcacagca ggtatggtag aaaccacggc
     3841 ctatgctttg ctcaccagcc tgaacctgaa ggagacgagt tatgtcaacc cgatcatcaa
     3901 gtggctatct gaggagcaga ggtatggagg cggcttttat tccacccagg ataccattaa
     3961 cgccatcgag ggcctgacag agtattcact cctggttaaa caacttcatt tggatatgga
     4021 tatcaatgtc tcctacaaac acaaagggga tttctaccag tataaagtga cagagaagaa
     4081 cttcctcggg aggccagtgg aggtacccct caatgatgac ctcatcgtca ccacaggcta
     4141 tagcagtggc ttggctacag tatatgtaaa aactgtggtt cacaaaacta gtgtcgctga
     4201 ggaattttgc agcttttact tgaaaattga tacccaagaa gttgaagcct ccagctacct
     4261 cagctacagt gactcgggac acaagcgcat aatagcctgt gccagctaca agcccagcaa
     4321 ggaggagtca gcatctgggt cctcccatgc agtaatggat atactgctgc cgaccggaat
     4381 cggagcaaac caagaagatt tacgagctct tgtggaagga gtagatcaac tcctaactga
     4441 ttaccagatc aaagacagtc atgttattct gcaattgaat tcgattccct ccagagattt
     4501 cctttgtgtt cggttccgga tatttgaact tttccaagtt gggtttctga atcctgctac
     4561 gttcacggtg tacgagtatc acagaccaga taagcagtgt accatgattt acagcacttc
     4621 tgacaccaac cttcagagag tctgtgaagg agcggcatgc aaatgcgttg aagctgattg
     4681 tgggcaactg caggcagaac tggacctggc catctctgca gacaccagga aagaaacagc
     4741 atgtaaacca gagattgcat atgcttataa ggtcaggatc acgtcggcca cggaagaaaa
     4801 catttttgtc aagtacactg cgacgcttct ggatatttac aaaacagggg aagccgctgc
     4861 tgagaaggac tctgagatca ccttcattaa aaagataagc tgtaccaacg ccaacctggt
     4921 gaaaggaaag caatatttaa tcatgggcaa agaggctctg cagatcaaac acaatttcag
     4981 tttcaagtat atataccctc tagattcctc cacctggatt gaatattggc ccacagacac
     5041 aacgtgtcca tcctgccaag cgtttgtagc taatttggac gagttcgctg aagacatctt
     5101 tctaaatggc tgtgaaaatg cctgaggaag ttctgctgcg tggccttccc gggtactcct
     5161 gttggtggct cctaggagcc aggatcgctt ggaaacttag cctagaatcg gatacatttt
     5221 ctttatagta aagcgtaagt tgaagagtta ctttgtgaaa caaaatagcc ttgtggagag
     5281 ccgaaggcag gtcccccaag gctattggac atcagcacca ataagctgga acaagtctgt
     5341 aacgttagca gccaggggtg tttgttgggg ccggaagaag agactcactg aaattgtagc
     5401 cccttaggaa aacatggtct tgcttgaaaa aaaaaatacc aaggacagaa aatgccataa
     5461 aagcttgact ttgcactcaa
//
