LOCUS       NM_016995               1144 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus complement component 4 binding protein, beta
            (C4bpb), mRNA.
ACCESSION   NM_016995
VERSION     NM_016995.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Hair,P.S., Wagner,S.M., Friederich,P.T., Drake,R.R., Nyalwidhe,J.O.
            and Cunnion,K.M.
  TITLE     Complement regulator C4BP binds to Staphylococcus aureus and
            decreases opsonization
  JOURNAL   Mol Immunol 50 (4), 253-261 (2012)
   PUBMED   22333221
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Pilling,D., Buckley,C.D., Salmon,M. and Gomer,R.H.
  TITLE     Inhibition of fibrocyte differentiation by serum amyloid P
  JOURNAL   J Immunol 171 (10), 5537-5546 (2003)
   PUBMED   14607961
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Webb,J.H., Blom,A.M. and Dahlback,B.
  TITLE     Vitamin K-dependent protein S localizing complement regulator
            C4b-binding protein to the surface of apoptotic cells
  JOURNAL   J Immunol 169 (5), 2580-2586 (2002)
   PUBMED   12193728
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Hillarp,A., Wiklund,H., Thern,A. and Dahlback,B.
  TITLE     Molecular cloning of rat C4b binding protein alpha- and
            beta-chains: structural and functional relationships among human,
            bovine, rabbit, mouse, and rat proteins
  JOURNAL   J Immunol 158 (3), 1315-1323 (1997)
   PUBMED   9013975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088152.1.
            
            On Apr 5, 2005 this sequence version replaced NM_016995.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088152.1, FQ209636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1144
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /note="complement component 4 binding protein, beta"
                     /db_xref="GeneID:24236"
                     /db_xref="RGD:2236"
     exon            1..338
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1063
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /note="C4b-binding protein beta chain"
                     /codon_start=1
                     /product="C4b-binding protein beta chain precursor"
                     /protein_id="NP_058691.2"
                     /db_xref="GeneID:24236"
                     /db_xref="RGD:2236"
                     /translation="MLCLVVCCLIWLISALDGSCSEPPPVNNSVFVGKETEEQILGIY
                     LCIKGYHLVGKKSLVFDPSKEWNATLPECLLGHCPDPVLENGKINSSGPVNISGKIMF
                     ECNDGYILKGSNWSQCLEDHTWAPPLPICRSRDCEPPETPVHGYFEGETFTSGSVVTY
                     YCEDGYHLVGTQKVQCSDGEWSPSYPTCESIQEPPKSAEQSALEKAILAFQESKDLCN
                     ATENFVRQLREGGITMEELKCSLEMKKTKLKSDILLNYHS"
     exon            339..509
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..686
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..907
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1112
                     /gene="C4bpb"
                     /gene_synonym="C4bp-ps1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcaactg caggtccact gattcgcatt tctagaaact gggaaatttc ttaagatttt
       61 aattctggca gctctttaat tgtctctttg tggttgcaaa tccactggat acactgtctt
      121 atttctgcta ttcttctcta ttacagggta gactttcttt ttcccatctg ttacagggga
      181 aatataattc cttagaagga agttgttttg atctgacgtc tttagaggat gcttttgact
      241 gatatcagag tttaagtcca tcgtgggtca agtaactggt caccaaatgc tttgtttggt
      301 tgtgtgctgt ctgatatggt tgatttctgc cttagatggg agctgttcag aaccccctcc
      361 ggtgaacaat agtgtgtttg ttggaaagga aactgaagaa cagattctgg gaatttacct
      421 ttgtatcaaa ggctaccact tggtgggaaa gaagtctttg gtctttgatc cctcgaagga
      481 atggaatgcg accctccctg agtgcctcct gggccactgt cctgaccctg tactggaaaa
      541 tggcaagatc aattcttctg ggcctgtgaa tataagtggc aaaatcatgt ttgagtgtaa
      601 tgatggttac atcctcaagg gaagcaattg gagccagtgc ctagaggacc acacctgggc
      661 acctcccttg cccatctgcc gaagtagaga ctgtgaacct cctgagactc ctgtccatgg
      721 ctattttgaa ggagaaactt tcacttcagg atctgtcgtt acttattact gtgaagatgg
      781 gtaccaccta gtgggcacac agaaggtgca gtgcagtgat ggagagtgga gcccgtccta
      841 tcctacctgt gagtccatcc aggaaccccc caaatcagct gaacagagtg cacttgagaa
      901 agctattctt gcctttcagg agagtaagga cctttgcaat gctacagaga actttgtgag
      961 acagctaagg gaaggtggaa taacaatgga agaacttaaa tgttctctgg agatgaagaa
     1021 aactaagctg aagtcggata ttttactgaa ctaccatagc taagcagaat ggttacagac
     1081 agacacctat gaataaattg cttctaaagg tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aaaa
//
