LOCUS       NM_012516               2340 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus complement component 4 binding protein, alpha
            (C4bpa), mRNA.
ACCESSION   NM_012516
VERSION     NM_012516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2340)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   2  (bases 1 to 2340)
  AUTHORS   Colley,S.M., Wintle,L., Searles,R., Russell,V., Firman,R.C.,
            Smith,S., Deboer,K., Merriner,D.J., Genevieve,B., Bentel,J.M.,
            Stuckey,B.G., Phillips,M.R., Simmons,L.W., de Kretser,D.M.,
            O'Bryan,M.K. and Leedman,P.J.
  TITLE     Loss of the nuclear receptor corepressor SLIRP compromises male
            fertility
  JOURNAL   PLoS One 8 (8), e70700 (2013)
   PUBMED   23976951
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2340)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 2340)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2340)
  AUTHORS   Hair,P.S., Wagner,S.M., Friederich,P.T., Drake,R.R., Nyalwidhe,J.O.
            and Cunnion,K.M.
  TITLE     Complement regulator C4BP binds to Staphylococcus aureus and
            decreases opsonization
  JOURNAL   Mol Immunol 50 (4), 253-261 (2012)
   PUBMED   22333221
REFERENCE   6  (bases 1 to 2340)
  AUTHORS   Kim,K.S., Cha,M.C. and Gerton,G.L.
  TITLE     Mouse sperm protein sp56 is a component of the acrosomal matrix
  JOURNAL   Biol Reprod 64 (1), 36-43 (2001)
   PUBMED   11133656
REFERENCE   7  (bases 1 to 2340)
  AUTHORS   Cohen,N. and Wassarman,P.M.
  TITLE     Association of egg zona pellucida glycoprotein mZP3 with sperm
            protein sp56 during fertilization in mice
  JOURNAL   Int J Dev Biol 45 (3), 569-576 (2001)
   PUBMED   11417900
REFERENCE   8  (bases 1 to 2340)
  AUTHORS   Hardy,C.M. and Mobbs,K.J.
  TITLE     Expression of recombinant mouse sperm protein sp56 and assessment
            of its potential for use as an antigen in an immunocontraceptive
            vaccine
  JOURNAL   Mol Reprod Dev 52 (2), 216-224 (1999)
   PUBMED   9890753
REFERENCE   9  (bases 1 to 2340)
  AUTHORS   Hillarp,A., Wiklund,H., Thern,A. and Dahlback,B.
  TITLE     Molecular cloning of rat C4b binding protein alpha- and
            beta-chains: structural and functional relationships among human,
            bovine, rabbit, mouse, and rat proteins
  JOURNAL   J Immunol 158 (3), 1315-1323 (1997)
   PUBMED   9013975
REFERENCE   10 (bases 1 to 2340)
  AUTHORS   Bookbinder,L.H., Cheng,A. and Bleil,J.D.
  TITLE     Tissue- and species-specific expression of sp56, a mouse sperm
            fertilization protein
  JOURNAL   Science 269 (5220), 86-89 (1995)
   PUBMED   7604284
  REMARK    Erratum:[Science 1995 Aug 25;269(5227):1120]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088165.1.
            
            On Oct 12, 2005 this sequence version replaced NM_012516.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2340
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /note="complement component 4 binding protein, alpha"
                     /db_xref="GeneID:24235"
                     /db_xref="RGD:2235"
     exon            1..160
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            161..251
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            252..422
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2062
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /codon_start=1
                     /product="C4b-binding protein alpha chain"
                     /protein_id="NP_036648.2"
                     /db_xref="GeneID:24235"
                     /db_xref="RGD:2235"
                     /translation="MWTKQHQALRPTRAAHGKLHRNRDAVAWPLSTFCRASGPTLFQM
                     SLTAALWVAVFGKCGPPPDLPYALPASEMNQTDFESHTTLRYNCRPGYSRASSSQSLY
                     CKPLGKWQINIACVKKSCRNPGDLQNGKVEVKTDFLFGSQIEFSCSEGYILIGSSTSY
                     CEIQGKGVSWSDPLPECVIAKCGMPPDISNGKHNGREEEFFTYRSSVTYKCDPDFTLL
                     GNASITCTVVNKTVGVWSPSPPTCERIICPWPKVLHGTINSGFKHTYKYKDSVRFVCQ
                     KGFVLRGSGVIHCEADGSWSPVPVCELNSCTDIPDIPNAALITSPRPRKEDVYPVGTV
                     LRYICRPGYEPATRQPMTVICQKDLSWSMLRGCKEICCPVPDPKSVRVIQHEKAHPDN
                     DCTYFFGDEVSYTCQNDIMLTATCKSDGTWHPRTPSCHQSCDFPPAIAHGRYTKSSSY
                     YVRTQVTYECEEGYRLVGEATISCWYSQWTPAAPQCKALCRKPEIGNGVLSTNKDQYV
                     ETENVTIQCDSGFVMLGSQSITCSENGTWYPKVPRCEQEVPKDCEHVFAGKKLMQCLP
                     NSNDVKMALEVYKLTLEIKQLQLQIDKAKHVDREL"
     exon            423..605
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            606..705
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            706..791
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            792..986
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1166
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1361
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1550
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1718
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1894
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2311
                     /gene="C4bpa"
                     /gene_synonym="C4BP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaatgcaa ggatcacctg cgcgtgggtc gactccagga actttttgat agagcaatta
       61 ctggccagtt ttaggataat gtgatcaact ctcatcttgg gagaaactag tacaggagag
      121 atccagtcag caccacaggg tcctttctct gctactgcag aacacggggc tctggcgtgt
      181 cctcctctgc aaattctctt cctttttcca tgtggactga atttctcttc ctagaggtgg
      241 cttttgcaga gaacaaatgt ggacaaagca gcaccaggcc ctgcgcccca caagagctgc
      301 ccacgggaag cttcatagaa acagagacgc cgtggcctgg cccttgtcta cgttctgcag
      361 agcctccggt ccaactttgt tccaaatgag cctcactgct gctctttggg ttgctgtatt
      421 cggaaaatgt ggcccaccac ctgatttacc ctacgccctg ccagcaagtg agatgaacca
      481 gacagacttt gaaagtcaca ctaccctgag atacaattgt cgccctggct atagtagagc
      541 gagctcaagc cagagtctct actgtaaacc tctggggaaa tggcagatta atatcgcctg
      601 cgtcaaaaag tcatgcagga atccaggaga cttacaaaat ggaaaggtgg aagttaagac
      661 agatttcttg tttggatcac agatagaatt cagctgctca gagggatata tcttaattgg
      721 ctcatccact agttattgtg agatccaagg caaaggagtt tcctggagtg atcctctccc
      781 agaatgtgta attgccaagt gtgggatgcc tccagacatc agcaatggga agcacaatgg
      841 tagagaggaa gaattcttca catatcgttc ctcagtcacc tataagtgtg atcctgactt
      901 cacactcctt ggcaatgcct ccattacctg cactgtggtg aacaaaacag taggtgtttg
      961 gagcccaagc cctcctacct gtgaaagaat catctgtcct tggccaaaag ttttgcatgg
     1021 aacaattaat tctggattca agcataccta taaatacaaa gactctgtga gatttgtctg
     1081 ccagaaaggg tttgtcctca gaggcagcgg tgtaatccat tgtgaggctg atggcagctg
     1141 gagtcccgta ccagtgtgtg agctcaatag ttgcactgat attccagaca ttcctaatgc
     1201 tgccctgata accagtccca ggccaagaaa ggaagatgta tatccagtgg gtactgtgct
     1261 ccgttacatc tgtcgtcctg gctatgaacc tgctacgaga cagcccatga ctgtgatttg
     1321 tcagaaagat ctcagctgga gcatgcttag ggggtgtaag gagatatgct gtccagtacc
     1381 agacccaaag agtgttagag tcattcaaca tgaaaaggca catcctgaca acgactgtac
     1441 ttacttcttt ggtgacgaag tgtcatacac atgtcaaaat gatataatgc ttacagctac
     1501 ttgcaagtca gatggcacct ggcatccccg gacaccatca tgtcatcaga gttgtgattt
     1561 tccgcctgcc attgctcacg gacgttatac aaaatcttct tcatactacg tcagaactca
     1621 ggttacatat gaatgtgaag aaggatacag actggttgga gaggcaacca tctcctgctg
     1681 gtattcacaa tggacaccag cagctccaca gtgtaaagct ctatgtcgga aaccagagat
     1741 aggaaatgga gtactgtcta ctaataaaga tcaatatgtc gaaactgaaa atgtcaccat
     1801 ccaatgtgac tcgggctttg tcatgctagg ttcccaaagc atcacttgtt cggagaatgg
     1861 aacctggtac ccaaaggtgc ccagatgtga gcaggaggtc cctaaagact gtgagcacgt
     1921 gtttgcaggc aagaagctca tgcaatgtct gccaaattca aatgacgtga aaatggccct
     1981 ggaggtctac aagctgactc tggagattaa acaattacag ctccagatag acaaggcaaa
     2041 gcacgttgac cgggagttat gagcgggtgt tctctcaagg aggaagaagt acctcatggg
     2101 ctttctgact tcagtgccaa gcagaacgtc tgcattttta gcaacctttg taactttggc
     2161 accaatgttc atggtaataa atatctgctt agaataattc attaaagcat aatgtaagtt
     2221 tatgaaataa ttagtcatct tgtgactcaa atttgctttt tggaatgcaa tgtgtacttt
     2281 ttttcaatta aaatcaatct tgctcttgta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
