LOCUS       NM_001002805            5354 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus complement C4B (C4b), mRNA.
ACCESSION   NM_001002805 XM_579081
VERSION     NM_001002805.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5354)
  AUTHORS   Sekar,A., Bialas,A.R., de Rivera,H., Davis,A., Hammond,T.R.,
            Kamitaki,N., Tooley,K., Presumey,J., Baum,M., Van Doren,V.,
            Genovese,G., Rose,S.A., Handsaker,R.E., Daly,M.J., Carroll,M.C.,
            Stevens,B. and McCarroll,S.A.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Schizophrenia risk from complex variation of complement component 4
  JOURNAL   Nature 530 (7589), 177-183 (2016)
   PUBMED   26814963
  REMARK    Erratum:[Nature. 2022 Jan;601(7892):E4-E5. doi:
            10.1038/s41586-021-04202-x.. PMID: 34912127]
REFERENCE   2  (bases 1 to 5354)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (bases 1 to 5354)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 5354)
  AUTHORS   Rigby,W.F., Wu,Y.L., Zan,M., Zhou,B., Rosengren,S., Carlson,C.,
            Hilton,W. and Yu,C.Y.
  TITLE     Increased frequency of complement C4B deficiency in rheumatoid
            arthritis
  JOURNAL   Arthritis Rheum 64 (5), 1338-1344 (2012)
   PUBMED   22076784
REFERENCE   5  (bases 1 to 5354)
  AUTHORS   Hair,P.S., Wagner,S.M., Friederich,P.T., Drake,R.R., Nyalwidhe,J.O.
            and Cunnion,K.M.
  TITLE     Complement regulator C4BP binds to Staphylococcus aureus and
            decreases opsonization
  JOURNAL   Mol Immunol 50 (4), 253-261 (2012)
   PUBMED   22333221
REFERENCE   6  (bases 1 to 5354)
  AUTHORS   Gadjeva,M., Verschoor,A., Brockman,M.A., Jezak,H., Shen,L.M.,
            Knipe,D.M. and Carroll,M.C.
  TITLE     Macrophage-derived complement component C4 can restore humoral
            immunity in C4-deficient mice
  JOURNAL   J Immunol 169 (10), 5489-5495 (2002)
   PUBMED   12421924
REFERENCE   7  (bases 1 to 5354)
  AUTHORS   Walter,L., Hurt,P., Himmelbauer,H., Sudbrak,R. and Gunther,E.
  TITLE     Physical mapping of the major histocompatibility complex class II
            and class III regions of the rat
  JOURNAL   Immunogenetics 54 (4), 268-275 (2002)
   PUBMED   12136338
REFERENCE   8  (bases 1 to 5354)
  AUTHORS   Fimmel,C.J., Brown,K.E., O'Neill,R. and Kladney,R.D.
  TITLE     Complement C4 protein expression by rat hepatic stellate cells
  JOURNAL   J Immunol 157 (6), 2601-2609 (1996)
   PUBMED   8805663
REFERENCE   9  (bases 1 to 5354)
  AUTHORS   Carroll,M.C., Fathallah,D.M., Bergamaschini,L., Alicot,E.M. and
            Isenman,D.E.
  TITLE     Substitution of a single amino acid (aspartic acid for histidine)
            converts the functional activity of human complement C4B to C4A
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6868-6872 (1990)
   PUBMED   2395880
REFERENCE   10 (bases 1 to 5354)
  AUTHORS   Robins,D.M., Malissen,M., Hood,L., Ferreira,A., Walthall,D. and
            Mitchell,M.
  TITLE     Multiple C4/Slp genes distinguished by expression after
            transfection
  JOURNAL   Mol Cell Biol 6 (1), 134-141 (1986)
   PUBMED   3023818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883044.1.
            
            On Sep 22, 2009 this sequence version replaced NM_001002805.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BX883044.1         164245-164346       c
            103-295             BX883044.1         163947-164139       c
            296-497             BX883044.1         163323-163524       c
            498-568             BX883044.1         163049-163119       c
            569-657             BX883044.1         162881-162969       c
            658-740             BX883044.1         162584-162666       c
            741-837             BX883044.1         162381-162477       c
            838-943             BX883044.1         161736-161841       c
            944-1076            BX883044.1         161510-161642       c
            1077-1192           BX883044.1         161077-161192       c
            1193-1369           BX883044.1         160814-160990       c
            1370-1555           BX883044.1         160491-160676       c
            1556-1741           BX883044.1         160208-160393       c
            1742-1900           BX883044.1         159375-159533       c
            1901-2027           BX883044.1         158947-159073       c
            2028-2102           BX883044.1         158520-158594       c
            2103-2297           BX883044.1         158074-158268       c
            2298-2409           BX883044.1         157861-157972       c
            2410-2480           BX883044.1         157699-157769       c
            2481-2620           BX883044.1         157372-157511       c
            2621-2824           BX883044.1         157044-157247       c
            2825-2876           BX883044.1         156481-156532       c
            2877-2966           BX883044.1         156306-156395       c
            2967-3176           BX883044.1         155983-156192       c
            3177-3252           BX883044.1         155752-155827       c
            3253-3409           BX883044.1         155486-155642       c
            3410-3526           BX883044.1         155248-155364       c
            3527-3698           BX883044.1         154984-155155       c
            3699-3931           BX883044.1         154567-154799       c
            3932-4099           BX883044.1         154323-154490       c
            4100-4159           BX883044.1         153748-153807       c
            4160-4253           BX883044.1         152713-152806       c
            4254-4434           BX883044.1         152450-152630       c
            4435-4525           BX883044.1         152229-152319       c
            4526-4600           BX883044.1         152031-152105       c
            4601-4703           BX883044.1         151368-151470       c
            4704-4793           BX883044.1         151164-151253       c
            4794-4892           BX883044.1         150990-151088       c
            4893-4976           BX883044.1         150817-150900       c
            4977-5109           BX883044.1         150412-150544       c
            5110-5354           BX883044.1         150033-150277       c
FEATURES             Location/Qualifiers
     source          1..5354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..5354
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /note="complement C4B"
                     /db_xref="GeneID:406161"
                     /db_xref="RGD:1591983"
     exon            1..102
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..5251
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /note="complement C4-like protein; complement component 4,
                     gene 2; complement component 4B (Chido blood group);
                     complement C4B (Chido blood group)"
                     /codon_start=1
                     /product="complement component 4, gene 2 precursor"
                     /protein_id="NP_001002805.1"
                     /db_xref="GeneID:406161"
                     /db_xref="RGD:1591983"
                     /translation="MRLLWGLAWAFSFFASSLQKPRLLLFSPSVVNLGTPLSVGVQLL
                     DAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGNDFVLLRLEVPLEDVRNCGLFDLRR
                     APHIQLVAYSPWLKNTAPKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFA
                     LDQKMRPSTDTLTVTVENSHGLRVRKKVVFAPTSIFTDDFVIPDISEPGTWKISARFS
                     DGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDIQARYVYGKPVQG
                     VAYTRFALMDEQGKKTFLRGLETQTKLVEGQTHISISRDQFQAALGKVNTEIGDLEGL
                     RLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVREMS
                     GSEASDVPVKVSATLLSGSDSKVLDFQQNTNGIGQVSFSIHVPPTITELRLLVSAGSL
                     YPAVAKLTVQAPPSRGPGFLSIEPLDLRSPRVGDTFILNLRTVGIPVPTFSHYYYMII
                     SRGQIMAMSREPRTTLTSISVLVDHHLAPSFYFVAYFYHQGLPVANSLLINVQPGDCE
                     GKLELKVDGAKEYRNGESMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFE
                     VMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKEDLSCPKEKISRQKRNVNFQ
                     KAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDL
                     RRNQTRSQAGLARAQNVMQEEDLIDEDDILVRSFFPENWLWKVEPVDRSKLLTVWLPD
                     SLTTWEIHGVSLSKSKGLCVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYL
                     SEDVTVSVHVSPVEGLCLAGGGLLAQQVSVPAGSARPVAFSVVPTAAASMPLKVVARG
                     SFDIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSF
                     VRVTASEPLETLGSEGALSPGGVASLLKLPTGCAEQTMVLLAPTLTASRYLDRTEQWS
                     KLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLDRDSSTWLTAFVLKILSLAQEQI
                     GDSPEKLQETAGWLLGQQLDDGSFHDPCPVIQRGMQGGLVGTDETVALTAFVVIALHH
                     GLAVFQDENSQQLKKRVEASIMKANSFLGQKASAGLLGAHASAITAYALTLTKASEDL
                     RNVAHNSLMAMAEETGENLYWGLAIGSQDNVVSSTAAPRNPSEPVPQAPALWIETTAY
                     GLLHLLLREGKGEMADKAATWLTHQGSFQGGFRSTQDTVVALDALSAYWIASHTTEEK
                     ALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRT
                     YNVLDMKNTTCQDLRIEVTITGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQL
                     FEGRRSRRRREAPKAADEQESRVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADL
                     EKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDY
                     YSPDHKCSVFYAGPTKSKLLSTLCSADVCQCAEGKCPRQRRSLERGVEDKDGYRMKFA
                     CYYPRVEYGFQVKVLREDSRSAFRLFETKITQVLHFTKDAKASIGQTRNFLVRASCRL
                     RLEPSKEYLIMGMDGVTSDLKGDPQYLLDSNSWIEEMPSERLCRSTRQRAACGQLNDF
                     LQEYRSQGCQV"
     exon            103..295
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            296..497
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            498..568
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            569..657
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            658..740
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            741..837
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            838..943
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1076
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1192
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1369
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1555
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1741
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1900
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2027
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2102
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2297
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..2409
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2480
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2620
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2824
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2876
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2966
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3176
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3252
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3409
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3526
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3698
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3931
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4099
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4159
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4253
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4434
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4435..4525
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4600
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4703
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4793
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4794..4892
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..4976
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            4977..5109
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5354
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactagacg ggctgacctc tcctggatcc tccaaccatg cggctcctct ggggcctggc
       61 ctgggcattc agcttcttcg cctcctctct gcagaagccc aggttgctcc tgttctcccc
      121 ttctgtggtt aatttgggga cccccctgtc agtaggggtg cagctcctgg atgcccctgc
      181 aggacaggag gtgaaaggct cagtgtacct cagaaaccca acaagcggtc cctgctcccc
      241 aaagaaggac tttaagctca gctcgggaaa tgactttgtg cttctcagac ttgaggtccc
      301 actggaagat gtgaggaatt gtggcctctt tgacctacgc agagcccccc acatccagct
      361 ggtggcttac tctccgtggc taaagaacac agcacccaaa gccaccgaga ctcagggggt
      421 caacctgctt ttctcttccc gacgaggcca catctttgtg cagaccgatc agcctatcta
      481 taaccctggg cagcgggtac gttatcgggt ctttgcactg gatcaaaaga tgcgtccatc
      541 tacggacacc ctcacggtca cagtagagaa ctcccatggc ctccgtgtac gcaagaaggt
      601 ggtatttgcc cccacatcca tcttcacaga tgacttcgta attccagaca tctcagagcc
      661 ggggacctgg aagatctcag ctaggttctc agatggcctc gagtccaaca gaagcaccca
      721 ctttgaagtg aagaaatatg tccttcccaa ctttgaggtg aagcttactc cttggaagcc
      781 atatatcctg acagtgccta gctaccgtga agaaatccag ttagacatcc aggccagata
      841 cgtctacggg aagcccgtgc agggcgtggc atatacccgc ttcgcactca tggatgagca
      901 ggggaagaag actttccttc ggggcctaga gacccagacc aagttggtgg aaggccagac
      961 tcacatctcc atctcaaggg accagttcca ggctgccctg ggtaaagtga atactgagat
     1021 cggagacctg gaggggctgc ggctctacgc tgctgtagct gtcattgagt ctccaggagg
     1081 agagatggag gaagcagagc tcacatcctg gcccttcgtg tcatctgcct tctccttgga
     1141 tctcagccac accaagcagc atcttgtgcc cggggccccc ttcctgctgc aggccctggt
     1201 tcgagaaatg tcaggctctg aagcctctga tgttcctgtc aaagtctctg ccacattgtt
     1261 atctgggtcc gactcgaaag tccttgactt tcaacagaac accaacggga ttggccaagt
     1321 cagcttttct atccatgtcc cgccaaccat cacagaactt cgactcttgg tatctgccgg
     1381 ttccctctac ccagctgtag ccaagctcac tgtgcaagcc ccaccttcaa gaggccctgg
     1441 ctttctgtcc attgagccac tagaccttcg gtcccctcgt gtgggggaca ccttcatcct
     1501 gaaccttcga accgtgggca tccctgtgcc taccttctct cattactact acatgatcat
     1561 ctccagaggc cagatcatgg ccatgagtcg ggagcccagg acgaccctga cctccatctc
     1621 tgtcttggtg gaccatcacc tggctccctc tttctacttt gtggcctact tctatcacca
     1681 aggactccca gtggccaact ccctgctcat caatgtccag cctggggact gtgagggcaa
     1741 gctggaattg aaggtggacg gtgccaagga gtatcgaaat ggggagagca tgaagctcca
     1801 acttcaaact gactccgaag ccctggtggc actgggagct gtggacacag ctctgtatgc
     1861 tgtgggtggc cggtctcaca aacccctcga catgagcaag gtctttgaag taatgaacag
     1921 ttataacctt ggctgtggtc ctggaggtgg ggacgatgcc cttcaggtgt tccagactgc
     1981 tggtttggcc ttttctgacg gtgatcgact aactcagacc aaagaggact tgagctgtcc
     2041 caaggagaag ataagtcggc aaaagagaaa tgttaacttc cagaaggcta ttagcgagaa
     2101 gttgggccag tattcctctc cagacaccaa gcgctgctgc caggatggga tgaccaagct
     2161 gcccatggca cgcacctgcg agcagcgggc agcccgagtg cctcagccgg cctgccggga
     2221 gcccttcttg tcctgttgca agtttgctga ggacctccgc aggaaccaga ccaggagcca
     2281 ggcgggcctc gcccgagccc agaacgtgat gcaggaggag gatctgatag atgaagatga
     2341 cattcttgtg cgcagcttct tcccagagaa ctggctctgg aaagtggaac ctgtggaccg
     2401 ctccaaactg ttgactgtgt ggctccctga ctctctgacc acatgggaga ttcatggtgt
     2461 gagcctgtcc aaaagcaaag gcctgtgtgt agccaagcca actcgcgtgc gagtgttccg
     2521 agaattccac ctgcacctgc gcctgcccat ctctgtccgg cgcttcgagc agcttgaatt
     2581 acggcccgtt ctctacaact atctgagtga ggacgtgact gtgagtgtcc atgtgtcccc
     2641 agtggagggg ctgtgcctgg ctggtggtgg attgctggcc cagcaggtat cagtgcctgc
     2701 aggctccgcc cggcctgtgg ccttctctgt ggtacccaca gctgctgcca gcatgcccct
     2761 gaaagtggtg gctcgggggt cttttgatat aggggatgct gtgtctaaga ttctccaaat
     2821 tgagaaggaa ggggccatcc acagagaaga gatagtctac aacctcgacc ccctaaataa
     2881 ccttggtcgg agtttggaaa tccctggcag ctcagacccc aacgtcattc ctgatggaga
     2941 tttcagcagc ttcgtcaggg ttacagcctc cgaacccttg gagactttgg gctctgaagg
     3001 cgccttgtcc ccagggggag tggcctccct cctgaagctc cccacgggct gcgcagaaca
     3061 aaccatggtc cttttggccc ctaccctgac tgcttcccgc tacctggaca ggaccgagca
     3121 gtggagcaaa ctgccccctg agacaaagga ccatgctgtg gatctgatcc agaaaggcca
     3181 catgcggatc cagcagttta ggaagaaaga tggctccttt ggggcgtggt tagaccggga
     3241 cagcagcacc tggctcacgg cctttgtgct gaagattctg agtctggccc aggaacagat
     3301 tggtgactcc cccgagaagc tgcaagagac cgccgggtgg ctgctgggcc agcagctgga
     3361 cgatggctca ttccacgacc cgtgtccggt cattcaaaga ggcatgcagg ggggcttggt
     3421 ggggaccgac gagacagtgg cactgaccgc ctttgtggtc atcgcccttc accacgggct
     3481 ggccgtcttc caagacgaga actcgcagca gctgaagaag agggtggaag cctccatcat
     3541 gaaggcaaac tcgttcttgg ggcagaaggc aagtgctggg ctcctgggtg cacacgcatc
     3601 cgccatcaca gcctatgccc tgacactgac caaggcctcg gaggacctgc ggaatgttgc
     3661 ccacaacagc ctgatggcca tggctgagga aacaggggaa aacctctact ggggcttagc
     3721 cattggctct caggacaacg ttgtgtcatc caccgcagcc cctcgtaatc cctcagaacc
     3781 tgtgccccag gccccagccc tgtggatcga aaccacagcc tacggcctgc tacatctgct
     3841 gctgcgggag gggaagggag aaatggctga caaggcggca acctggctca cacaccaggg
     3901 aagcttccaa gggggattcc gcagtaccca ggacactgtg gtcgccctgg atgccctgtc
     3961 tgcatactgg atcgcttcac acaccaccga ggagaaggca ctcaatgtga ctctcagctc
     4021 catgggccgc aatgggtaca agtcccacct gctacagctg aacaaccacc aagtcaaggg
     4081 cctggaggag gagctgaagt tctccctggg cagcaccatc aatgtgaaag tgggaggaaa
     4141 tagcaaaggc accttaaaga tccttcgtac ctacaatgtc ctggacatga agaacacaac
     4201 atgccaagac cttcggatag aagtgacaat cacaggctat gtggaatata caagggaggc
     4261 caacgaagac tatgaatacg actatgatat gccagccgca gatgacccca gtgtccactc
     4321 gcagcctgtg acacccctgc agctgtttga gggtcgtcgg agccgccgca ggagggaggc
     4381 ccccaaggct gcggatgagc aggagtccag agtgcagtac accgtgtgca tctggcggaa
     4441 cggtaacctg gggctgtctg ggatggccat tgctgacatc accctcctga gtggattcca
     4501 agccctgagg gctgacctgg agaagctgac ctccctctct gaccgttacg tgagtcactt
     4561 tgagaccgac gggccccacg tcctactgta ctttgactcg gtcccgacca cccgggagtg
     4621 tgtgggcttt ggagctttgc aggaggtggc cgtggggctg gtgcagccag ccagtgctgt
     4681 cctgtatgac tactacagcc ctgatcacaa gtgctctgtg ttctatgctg gacccaccaa
     4741 gagcaagctc ctctccacct tgtgctctgc agacgtctgc cagtgcgctg aagggaagtg
     4801 tcctcgacag cgaaggtcac tggagcgagg ggtggaggac aaggatggtt accggatgaa
     4861 gttcgcctgc tattatcccc gagtggagta tggcttccag gttaaggttc tccgagaaga
     4921 cagcagatct gccttccgcc tctttgagac caagatcacc caagtcctgc atttcacaaa
     4981 ggatgccaag gcctccatag gtcagacccg caactttctg gtccgggctt cttgccgcct
     5041 tcgtttggag cctagcaaag agtacttaat catggggatg gacggagtca ccagtgacct
     5101 caagggagac ccccagtact tgctggactc aaacagttgg atcgaggaga tgccatctga
     5161 gcgcctgtgc aggagcaccc gtcagcgggc agcctgtggc cagctcaatg acttcctgca
     5221 ggagtacaga agccaggggt gccaggtgtg agggcgtcgg actctggatc cctgagctca
     5281 gccccagggt cagggcctct cacgaagcag ggcctgctta acagggtaaa taaaataaaa
     5341 cttttgacag taaa
//
