LOCUS       NP_001002805            1737 aa            linear   ROD 09-FEB-2025
DEFINITION  complement component 4, gene 2 precursor [Rattus norvegicus].
ACCESSION   NP_001002805 XP_579081
VERSION     NP_001002805.1
DBSOURCE    REFSEQ: accession NM_001002805.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1737)
  AUTHORS   Sekar,A., Bialas,A.R., de Rivera,H., Davis,A., Hammond,T.R.,
            Kamitaki,N., Tooley,K., Presumey,J., Baum,M., Van Doren,V.,
            Genovese,G., Rose,S.A., Handsaker,R.E., Daly,M.J., Carroll,M.C.,
            Stevens,B. and McCarroll,S.A.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Schizophrenia risk from complex variation of complement component 4
  JOURNAL   Nature 530 (7589), 177-183 (2016)
   PUBMED   26814963
  REMARK    Erratum:[Nature. 2022 Jan;601(7892):E4-E5. doi:
            10.1038/s41586-021-04202-x.. PMID: 34912127]
REFERENCE   2  (residues 1 to 1737)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (residues 1 to 1737)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (residues 1 to 1737)
  AUTHORS   Rigby,W.F., Wu,Y.L., Zan,M., Zhou,B., Rosengren,S., Carlson,C.,
            Hilton,W. and Yu,C.Y.
  TITLE     Increased frequency of complement C4B deficiency in rheumatoid
            arthritis
  JOURNAL   Arthritis Rheum 64 (5), 1338-1344 (2012)
   PUBMED   22076784
REFERENCE   5  (residues 1 to 1737)
  AUTHORS   Hair,P.S., Wagner,S.M., Friederich,P.T., Drake,R.R., Nyalwidhe,J.O.
            and Cunnion,K.M.
  TITLE     Complement regulator C4BP binds to Staphylococcus aureus and
            decreases opsonization
  JOURNAL   Mol Immunol 50 (4), 253-261 (2012)
   PUBMED   22333221
REFERENCE   6  (residues 1 to 1737)
  AUTHORS   Gadjeva,M., Verschoor,A., Brockman,M.A., Jezak,H., Shen,L.M.,
            Knipe,D.M. and Carroll,M.C.
  TITLE     Macrophage-derived complement component C4 can restore humoral
            immunity in C4-deficient mice
  JOURNAL   J Immunol 169 (10), 5489-5495 (2002)
   PUBMED   12421924
REFERENCE   7  (residues 1 to 1737)
  AUTHORS   Walter,L., Hurt,P., Himmelbauer,H., Sudbrak,R. and Gunther,E.
  TITLE     Physical mapping of the major histocompatibility complex class II
            and class III regions of the rat
  JOURNAL   Immunogenetics 54 (4), 268-275 (2002)
   PUBMED   12136338
REFERENCE   8  (residues 1 to 1737)
  AUTHORS   Fimmel,C.J., Brown,K.E., O'Neill,R. and Kladney,R.D.
  TITLE     Complement C4 protein expression by rat hepatic stellate cells
  JOURNAL   J Immunol 157 (6), 2601-2609 (1996)
   PUBMED   8805663
REFERENCE   9  (residues 1 to 1737)
  AUTHORS   Carroll,M.C., Fathallah,D.M., Bergamaschini,L., Alicot,E.M. and
            Isenman,D.E.
  TITLE     Substitution of a single amino acid (aspartic acid for histidine)
            converts the functional activity of human complement C4B to C4A
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6868-6872 (1990)
   PUBMED   2395880
REFERENCE   10 (residues 1 to 1737)
  AUTHORS   Robins,D.M., Malissen,M., Hood,L., Ferreira,A., Walthall,D. and
            Mitchell,M.
  TITLE     Multiple C4/Slp genes distinguished by expression after
            transfection
  JOURNAL   Mol Cell Biol 6 (1), 134-141 (1986)
   PUBMED   3023818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883044.1.
            
            On Apr 19, 2005 this sequence version replaced XP_579081.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..1737
                     /product="complement component 4, gene 2 precursor"
                     /note="complement C4-like protein; complement component 4,
                     gene 2; complement component 4B (Chido blood group);
                     complement C4B (Chido blood group)"
                     /calculated_mol_wt=189914
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2232
     Region          <136..1326
                     /region_name="YfaS"
                     /note="Uncharacterized conserved protein YfaS,
                     alpha-2-macroglobulin family [General function prediction
                     only]; COG2373"
                     /db_xref="CDD:441940"
     Region          778..866
                     /region_name="A2M"
                     /note="Alpha-2-macroglobulin family; pfam00207"
                     /db_xref="CDD:459711"
     Region          977..1310
                     /region_name="TED_complement"
                     /note="A-macroglobulin TED domain; pfam07678"
                     /db_xref="CDD:462227"
     Region          1474..1563
                     /region_name="A2M_recep"
                     /note="A-macroglobulin receptor binding domain; pfam07677"
                     /db_xref="CDD:462226"
     Region          1581..1735
                     /region_name="NTR_complement_C4"
                     /note="NTR/C345C domain, complement C4 subfamily; The NTR
                     domain found in complement C4 is also known as the C345C
                     domain because it occurs at the C-terminus of complement
                     C3, C4 and C5. Complement C4 is a key player in the
                     activation of the component classical...; cd03584"
                     /db_xref="CDD:239639"
     CDS             1..1737
                     /gene="C4b"
                     /gene_synonym="C4-2; C4l"
                     /coded_by="NM_001002805.2:38..5251"
                     /db_xref="GeneID:406161"
                     /db_xref="RGD:1591983"
ORIGIN      
        1 mrllwglawa fsffasslqk prlllfspsv vnlgtplsvg vqlldapagq evkgsvylrn
       61 ptsgpcspkk dfklssgndf vllrlevple dvrncglfdl rraphiqlva yspwlkntap
      121 katetqgvnl lfssrrghif vqtdqpiynp gqrvryrvfa ldqkmrpstd tltvtvensh
      181 glrvrkkvvf aptsiftddf vipdisepgt wkisarfsdg lesnrsthfe vkkyvlpnfe
      241 vkltpwkpyi ltvpsyreei qldiqaryvy gkpvqgvayt rfalmdeqgk ktflrgletq
      301 tklvegqthi sisrdqfqaa lgkvnteigd leglrlyaav aviespggem eeaeltswpf
      361 vssafsldls htkqhlvpga pfllqalvre msgseasdvp vkvsatllsg sdskvldfqq
      421 ntngigqvsf sihvpptite lrllvsagsl ypavakltvq appsrgpgfl siepldlrsp
      481 rvgdtfilnl rtvgipvptf shyyymiisr gqimamsrep rttltsisvl vdhhlapsfy
      541 fvayfyhqgl pvansllinv qpgdcegkle lkvdgakeyr ngesmklqlq tdsealvalg
      601 avdtalyavg grshkpldms kvfevmnsyn lgcgpgggdd alqvfqtagl afsdgdrltq
      661 tkedlscpke kisrqkrnvn fqkaiseklg qysspdtkrc cqdgmtklpm artceqraar
      721 vpqpacrepf lscckfaedl rrnqtrsqag laraqnvmqe edlideddil vrsffpenwl
      781 wkvepvdrsk lltvwlpdsl ttweihgvsl skskglcvak ptrvrvfref hlhlrlpisv
      841 rrfeqlelrp vlynylsedv tvsvhvspve glclagggll aqqvsvpags arpvafsvvp
      901 taaasmplkv vargsfdigd avskilqiek egaihreeiv ynldplnnlg rsleipgssd
      961 pnvipdgdfs sfvrvtasep letlgsegal spggvasllk lptgcaeqtm vllaptltas
     1021 ryldrteqws klppetkdha vdliqkghmr iqqfrkkdgs fgawldrdss twltafvlki
     1081 lslaqeqigd speklqetag wllgqqlddg sfhdpcpviq rgmqgglvgt detvaltafv
     1141 vialhhglav fqdensqqlk krveasimka nsflgqkasa gllgahasai tayaltltka
     1201 sedlrnvahn slmamaeetg enlywglaig sqdnvvssta aprnpsepvp qapalwiett
     1261 aygllhlllr egkgemadka atwlthqgsf qggfrstqdt vvaldalsay wiashtteek
     1321 alnvtlssmg rngykshllq lnnhqvkgle eelkfslgst invkvggnsk gtlkilrtyn
     1381 vldmknttcq dlrievtitg yveytreane dyeydydmpa addpsvhsqp vtplqlfegr
     1441 rsrrrreapk aadeqesrvq ytvciwrngn lglsgmaiad itllsgfqal radlekltsl
     1501 sdryvshfet dgphvllyfd svpttrecvg fgalqevavg lvqpasavly dyyspdhkcs
     1561 vfyagptksk llstlcsadv cqcaegkcpr qrrslergve dkdgyrmkfa cyyprveygf
     1621 qvkvlredsr safrlfetki tqvlhftkda kasigqtrnf lvrascrlrl epskeylimg
     1681 mdgvtsdlkg dpqylldsns wieempserl crstrqraac gqlndflqey rsqgcqv
//
