LOCUS       NM_031504               5377 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus complement C4A (C4a), mRNA.
ACCESSION   NM_031504 XM_346596
VERSION     NM_031504.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Sekar,A., Bialas,A.R., de Rivera,H., Davis,A., Hammond,T.R.,
            Kamitaki,N., Tooley,K., Presumey,J., Baum,M., Van Doren,V.,
            Genovese,G., Rose,S.A., Handsaker,R.E., Daly,M.J., Carroll,M.C.,
            Stevens,B. and McCarroll,S.A.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Schizophrenia risk from complex variation of complement component 4
  JOURNAL   Nature 530 (7589), 177-183 (2016)
   PUBMED   26814963
  REMARK    Erratum:[Nature. 2022 Jan;601(7892):E4-E5. doi:
            10.1038/s41586-021-04202-x.. PMID: 34912127]
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   Dominguez-Rodriguez,A., Ruiz-Hurtado,G., Sabourin,J., Gomez,A.M.,
            Alvarez,J.L. and Benitah,J.P.
  TITLE     Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat
            ventricular cardiomyocytes
  JOURNAL   J Mol Cell Cardiol 87, 74-78 (2015)
   PUBMED   26219954
  REMARK    GeneRIF: Our study provides the first evidence that sustained
            selective EPAC activation leads to an increase in TRPC3 and C4
            protein expression and induces a proarrhythmic SOCE-like activity
            in adult rat ventricular cardiomyocytes
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Bao,Y., Xiu,D.R. and Zhang,L.
  TITLE     Proteomic profiling of heterotopic heart-transplanted rats using
            surface-enhanced laser desorption/ionization time-of-flight mass
            spectrometry: potential biomarkers and drug targets
  JOURNAL   J Int Med Res 41 (3), 628-635 (2013)
   PUBMED   23613499
  REMARK    GeneRIF: The expression of the complement component C3f and
            complement component 4A have potential for use in post-transplant
            diagnosis of rejection.
REFERENCE   5  (bases 1 to 5377)
  AUTHORS   Liu,Y.H., Wan,L., Chang,C.T., Liao,W.L., Chen,W.C., Tsai,Y.,
            Tsai,C.H. and Tsai,F.J.
  TITLE     Association between copy number variation of complement component
            C4 and Graves' disease
  JOURNAL   J Biomed Sci 18 (1), 71 (2011)
   PUBMED   21943165
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5377)
  AUTHORS   Van den Berg,C.W. and Van Dijk,H.
  TITLE     Rapid, activity-guided isolation of sex-limited protein (Slp) from
            mouse serum by fractionated precipitation and high-performance
            liquid chromatography
  JOURNAL   J Immunol Methods 169 (2), 251-256 (1994)
   PUBMED   8133084
REFERENCE   7  (bases 1 to 5377)
  AUTHORS   van den Berg,C.W., Demant,P., Aerts,P.C. and Van Dijk,H.
  TITLE     Slp is an essential component of an EDTA-resistant activation
            pathway of mouse complement
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10711-10715 (1992)
   PUBMED   1438267
REFERENCE   8  (bases 1 to 5377)
  AUTHORS   Carroll,M.C., Fathallah,D.M., Bergamaschini,L., Alicot,E.M. and
            Isenman,D.E.
  TITLE     Substitution of a single amino acid (aspartic acid for histidine)
            converts the functional activity of human complement C4B to C4A
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6868-6872 (1990)
   PUBMED   2395880
REFERENCE   9  (bases 1 to 5377)
  AUTHORS   Cui,L., Ferreri,K. and Hugli,T.E.
  TITLE     Structural characterization of the C4a anaphylatoxin from rat
  JOURNAL   Mol Immunol 25 (7), 663-671 (1988)
   PUBMED   3262196
REFERENCE   10 (bases 1 to 5377)
  AUTHORS   Robins,D.M., Malissen,M., Hood,L., Ferreira,A., Walthall,D. and
            Mitchell,M.
  TITLE     Multiple C4/Slp genes distinguished by expression after
            transfection
  JOURNAL   Mol Cell Biol 6 (1), 134-141 (1986)
   PUBMED   3023818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM045174.1, AY149995.1, FM042803.1, CK600071.1, CO564028.1 and
            CO555571.1.
            
            On Sep 22, 2009 this sequence version replaced NM_031504.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               FM045174.1         1-602
            603-2627            AY149995.1         561-2585
            2628-3087           FM042803.1         165-624
            3088-3624           AY149995.1         3046-3582
            3625-4162           CK600071.1         121-658
            4163-4714           CO564028.1         85-636
            4715-5353           AY149995.1         4673-5311
            5354-5377           CO555571.1         457-480
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..5377
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /note="complement C4A"
                     /db_xref="GeneID:24233"
                     /db_xref="RGD:620005"
     exon            1..107
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..5256
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /note="complement component 4, gene 1; complement C4;
                     complement component 4B (Childo blood group); complement
                     component 4 (within H-2S); complement component 4B (Chido
                     blood group); complement component 4A (Rodgers blood
                     group); complement C4-like"
                     /codon_start=1
                     /product="complement C4 precursor"
                     /protein_id="NP_113692.2"
                     /db_xref="GeneID:24233"
                     /db_xref="RGD:620005"
                     /translation="MRLLWGLAWAFSFFASSLQKPRLLLFSPSVVNLGTPLSVGVQLL
                     DAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGNDFVLLRLEVPLKDVRSCGLFGLRR
                     APHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFA
                     LDQKMRPSTDTLTVTVENSHGLRVRKKEVFAPTSIFQDDFIIPDISEPGTWKISARFS
                     DGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDVQARYVYGKPVQG
                     VAYTRFALMDEQGKKSFLRGLETQTKLVEGQTHISISRDQFQAALGKVNTEIGDLEGL
                     RLYAAVAVIESPGGEMEEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLLQALVREMS
                     GSEASDVPVKVSATLLSGSDSKVLDFQQNTNGIGQVSFSIHVPPTITELRLLVSAGSL
                     YPAVAKLTVQAPPSRGPGFLSIEPLDLRSPRVGDTFVLSLRTVGIPMPTFSHYYYMII
                     SRGQIMAMSREPRRALTSISVLVDHHLAPSFYFVAYFYHQGLPVANSLLINVQPGDCE
                     GKLELKVDGAKEYRNGDSMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFE
                     VMNSYNLGCGPGGGDDALQVFQTAGLAFSDGDRLTQTKENLSCPKEKKSRQKRNVNFQ
                     KAISEKLGQYSSPDTKRCCQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDL
                     RRNQTRSQAGLARAQDMLQEEDLIDEDDILVRSFFPENWLWRVEPVDRSKLLTVWLPD
                     SLTTWEIHGVSLSKSKGLCVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYL
                     SEDVTVSVHVSPVEGLCLAGGGLLAQQVSVPAGSARPVAFSVVPTAAASIPLKVVARG
                     SFTIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGRSLEIPGSSDPNVIPDGDFSSF
                     VRVTASEPLETLGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWS
                     KLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQI
                     GDSPEKLQETAGWLLGQQLDDGSFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHH
                     GLAVFQDENSQQLKKRVEASITKANSFLGQKASAGLLGAHASAITAYALTLTKASEDL
                     RNVAHNSLMAMAEETGENLYWGSAIGSQDNVVSSTPAPRNPSEPVPQAPALWIETTAY
                     GLLHLLLREGKGEMADKVATWLTHQGSFQGGFRSTQDTVVTLDALSAYWIASHTTEEK
                     ALNVTLSSMGRNGYKSHLLQLNNHQVKGLEEELKFSLGSTINVKVGGNSKGTLKILRT
                     YNVLDMKNTTCQDLRIEVTVTGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQL
                     FEGRRSRRRREAPKAADEQESRVQYTVCIWRNGNLGLSGMAIADITLLSGFQALRADL
                     EKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGALQEVAVGLVQPASAVLYDY
                     YSPDHKCSVFYAAPTKSKLLSTLCSADVCQCAEGKCPRQRRSLERGVEDKDGYRMKFA
                     CYYPRVEYGFQVKVLREDSRAAFRLFETKITQVLHFTKDAKASIGQTRNFLVRASCRL
                     RLEPSKEYLIMGMDGVTSDLKGDPQYLLDSNTWIEEMPSERLCRSTRQRAACGQLNDF
                     LQEYSSQGCQV"
     exon            108..300
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            301..502
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            503..573
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            574..662
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            663..745
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            746..842
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            843..948
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1081
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1197
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1374
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1560
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1746
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1905
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2032
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2107
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2302
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2414
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2485
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2625
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2829
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2881
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2971
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3181
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3257
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3414
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3531
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3703
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3936
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4104
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4164
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4258
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4439
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4530
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4531..4605
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4708
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4709..4798
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4799..4897
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..4981
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5114
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
     exon            5115..5359
                     /gene="C4a"
                     /gene_synonym="C4; C4-1; C4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtcagact agacgggctg acctctcctg gatcctccaa ccatgcggct cctctggggc
       61 ctggcctggg cattcagctt cttcgcctcc tctctgcaga agcccaggtt gctcctgttc
      121 tccccttctg tggttaattt ggggaccccc ctgtcagtag gggtgcagct cctggatgcc
      181 cctgcaggac aggaggtgaa aggctcagtg tacctcagaa acccaacaag cggtccctgc
      241 tccccaaaga aggactttaa gctcagctcg ggaaatgact ttgtgcttct cagacttgag
      301 gtcccactga aagatgtgag gagttgtggc ctctttggcc tgcgcagagc cccccacatc
      361 cagctggtgg ctcactctcc gtggctaaag aacacagcat ccaaagccac cgagactcag
      421 ggggtcaacc tgcttttctc ttcccgacga ggccacatct ttgtgcagac cgatcagcct
      481 atctataacc ctgggcagcg ggttcgttat cgggtctttg cactggatca aaagatgcgt
      541 ccatctactg acaccctcac ggtcacagtg gagaactccc atggcctccg tgtacgcaag
      601 aaggaggtat ttgcccccac atccatcttc caagatgact tcataattcc agacatctca
      661 gagccgggga cctggaagat ctcagctagg ttctcagatg gcctcgagtc caacagaagc
      721 acccacttcg aagtgaagaa atatgtcctt cccaactttg aggtgaagct tactccttgg
      781 aagccatata tcctgacagt gcctagctac cgtgaagaaa tacaattaga cgtccaggcc
      841 agatacgtct acgggaagcc cgtgcagggc gtggcatata cccgcttcgc actcatggat
      901 gagcagggga agaagtcttt cctccggggc ctagagaccc agaccaagtt ggtggaaggc
      961 cagactcaca tctccatctc aagggaccag ttccaggctg ccctgggtaa agtgaatact
     1021 gagatcggag acctggaggg gctgcggctc tacgctgccg tagctgtcat tgagtctcca
     1081 ggaggagaga tggaggaggc ggagctcaca tcctggccct tcgtgtcatc tgccttctcc
     1141 ttggatctca gccacaccaa gcagcatctt gtgcccgggg cccccttcct gctgcaggcc
     1201 ctggttcgag aaatgtcagg ctctgaagcc tctgatgttc ctgtcaaagt ctctgccaca
     1261 ttgttgtctg ggtccgactc gaaagtcctt gactttcaac agaacaccaa tgggattggc
     1321 caagtcagct tttccatcca tgtcccgcca accatcaccg aacttcgact cttggtatct
     1381 gccggttccc tctacccagc tgtagccaag ctcaccgtgc aagccccacc ttcaagaggc
     1441 cccggctttc tgtccattga gccattagac cttcggtccc ctcgtgtggg ggacaccttc
     1501 gtcctgagcc ttcgaaccgt gggcatccct atgcctacct tctctcatta ctactacatg
     1561 atcatctcca gaggccagat catggccatg agtcgggagc ccaggagggc cctgacctcc
     1621 atctctgtct tggtggacca tcacctggct ccctctttct actttgtggc ctacttctat
     1681 caccaaggac tcccagtggc caactccctg ctcatcaacg tccagcccgg ggactgtgag
     1741 ggcaagctgg aattgaaggt ggatggtgcc aaggagtatc gcaatggaga cagcatgaag
     1801 ctccaacttc aaactgactc tgaagccctg gtggcactgg gagctgtgga cacagctctg
     1861 tatgctgtgg gtggccggtc tcacaaaccc ctcgacatga gcaaggtctt tgaagtaatg
     1921 aacagctaca accttggctg tggtcccgga ggcggggacg atgcccttca ggtgttccag
     1981 actgctggtc tggccttttc tgacggtgat cgactaactc agaccaaaga gaacctgagc
     2041 tgtcccaagg agaagaaaag tcggcaaaag cgaaatgtta acttccagaa ggctattagc
     2101 gagaagttgg gccagtattc ctctccagac accaagcgct gctgccagga tgggatgacc
     2161 aagctgccca tggcacgcac ctgcgagcag agggcagccc gcgtgcctca gccagcctgc
     2221 cgggagccct tcttgtcctg ttgcaagttt gctgaggacc tccgcaggaa ccagaccagg
     2281 agccaggcgg gcctcgcccg agcccaggac atgctgcagg aggaggatct gatagatgaa
     2341 gatgacattc tcgtgcgcag cttcttccca gagaactggc tctggagagt ggaacctgtg
     2401 gaccgctcca aactgttgac tgtgtggctc cctgactctc tgaccacatg ggagattcat
     2461 ggtgtgagcc tgtccaaaag caaaggcttg tgtgtagcca agccaactcg cgtgcgagtg
     2521 ttccgagaat tccacctgca cctgcgcctg cccatctctg tccggcgctt cgagcagctt
     2581 gaattacggc ccgttctcta caactatctg agtgaggacg tgactgtaag tgtccatgtg
     2641 tccccagtgg aggggctgtg cctggctggt ggtggattgc tggcccagca agtatcagtg
     2701 cctgcaggct ccgcccggcc tgtggccttc tctgtggtac ccacagctgc tgccagcata
     2761 cccctgaaag tggtggctcg ggggtctttt actatagggg atgctgtgtc taagattctc
     2821 caaattgaga aggaaggggc catccacaga gaagagatag tctacaacct cgacccccta
     2881 aataaccttg gtcggagttt ggaaatccct ggcagctcag accccaacgt cattcctgat
     2941 ggagatttca gcagcttcgt cagggttaca gcctccgaac ccttggagac tttgggctcc
     3001 gaaggcgcct tgtccccagg cggagtggcc tccctcctga ggctccctag aggctgtgca
     3061 gaacaaacca tgatctattt ggcccctacc ctgactgctt cccactacct ggacaggacg
     3121 gagcagtgga gcaaactgcc ccctgagaca aaggaccatg ctgtggatct gattcagaaa
     3181 ggccacatgc ggatccagca gtttcggaag aaagatggct cctttggggc atggttacac
     3241 cgggacagca gcacctggct cacggctttt gtgctgaaga ttctgagtct ggcccaggaa
     3301 cagattggtg actcccccga gaagctgcaa gagaccgctg ggtggctgct gggccagcag
     3361 ctggacgatg gctcattcca cgacccgtgt ccagtcatcc acagaggcat gcaggggggc
     3421 ttggtgggaa ccgatgagac cgtggcactg accgcctttg tggtcatcgc ccttcaccac
     3481 gggctggccg tcttccagga cgagaactca cagcagctga agaagagggt ggaagcctcc
     3541 atcacgaagg cgaactcgtt cttggggcag aaggcaagtg ctgggctcct gggtgcacac
     3601 gcatccgcca tcacagccta tgccctgaca ctgaccaagg cctcggagga cctgcggaat
     3661 gttgcccaca acagcctgat ggccatggct gaggaaacag gggaaaacct ctactggggc
     3721 tcagccattg gctctcagga caacgttgtg tcgtccaccc cagcccctcg taatccctca
     3781 gaacctgtgc cccaggcccc agccctgtgg atcgaaacca cagcctacgg cctgctacat
     3841 ctgctgctgc gggaggggaa gggagaaatg gctgacaagg tggcaacctg gctcacacac
     3901 cagggaagct tccaaggggg attccgcagt acccaggaca ctgtggtcac cctggatgcc
     3961 ctgtctgcat actggatcgc ttcacacacc accgaggaga aggcactcaa tgtgactctc
     4021 agctccatgg gccgcaatgg gtacaagtcc cacctgctac agctgaacaa ccaccaagtc
     4081 aagggcctgg aggaggagct gaagttctcc ctgggcagca ccatcaatgt gaaagtggga
     4141 ggaaacagca aaggcacctt aaagatcctt cgtacctaca acgtcctgga catgaagaac
     4201 acaacatgcc aagaccttcg gatagaagtg acggtcacag gctatgtgga atatacaagg
     4261 gaggccaacg aagactatga atacgactat gatatgccag ccgcagatga ccccagtgtc
     4321 cactcgcagc ctgtgacacc cctgcagctg tttgagggtc gtcggagccg ccgcaggagg
     4381 gaggccccca aggctgcgga tgagcaggag tccagagtgc agtacaccgt gtgcatctgg
     4441 cggaacggta acctggggct gtctgggatg gccattgctg acatcaccct cctgagtgga
     4501 ttccaagccc tgagggccga cctggagaag ctgacctccc tctctgaccg ttacgtgagt
     4561 cactttgaga ccgacgggcc ccacgtccta ctatactttg actcggtccc gaccacccgg
     4621 gagtgtgtgg gctttggagc cttgcaggag gtggccgtgg ggctggtgca gccagccagt
     4681 gctgtcctat atgactacta cagccctgat cacaagtgct ctgtgttcta tgctgcaccc
     4741 accaagagca agctcctctc caccttgtgc tctgcagacg tctgccagtg cgctgaaggg
     4801 aagtgtcctc gacagcgaag gtcactggag cgaggggtgg aggacaagga tggttaccgg
     4861 atgaagttcg cctgctatta tccccgagtg gagtatggct tccaggttaa ggttctccga
     4921 gaagacagca gagctgcctt ccgcctcttt gagaccaaga tcacccaagt cctgcatttc
     4981 acaaaggatg ccaaggcctc cataggtcag acccgcaact ttctggtccg ggcctcttgc
     5041 cgccttcgtt tggagcctag caaagagtac ttaatcatgg ggatggacgg agtcaccagt
     5101 gacctcaagg gagaccccca gtacttgctg gactcaaata cttggatcga ggagatgcca
     5161 tctgagcgcc tgtgcaggag cacccgtcag cgggcagcct gtggccagct caatgacttt
     5221 ctgcaggagt acagcagcca ggggtgccag gtgtgagggc gtcggactct ggatccctga
     5281 gctcagcccc agggtcaggg cctctcacga tgcagggcct gcttaacagg gtaaataaaa
     5341 taaaactttt gacagtaaaa aaaaaaaaaa aaaaaaa
//
