LOCUS       NM_032060               2025 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus complement C3a receptor 1 (C3ar1), mRNA.
ACCESSION   NM_032060
VERSION     NM_032060.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2025)
  AUTHORS   Zhu,A., Cui,H., Su,W., Liu,C., Yu,X. and Huang,Y.
  TITLE     C3aR in astrocytes mediates post-thoracotomy pain by inducing A1
            astrocytes in male rats
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166672 (2023)
   PUBMED   36871753
  REMARK    GeneRIF: C3aR in astrocytes mediates post-thoracotomy pain by
            inducing A1 astrocytes in male rats.
REFERENCE   2  (bases 1 to 2025)
  AUTHORS   Zhang,X., Chen,Y., Yu,S., Jin,B. and Liu,W.
  TITLE     Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis
            Affected the Prognosis of UC by Modulating the Pyroptosis and
            Expression of Caspase-11
  JOURNAL   Inflammation 43 (6), 2128-2136 (2020)
   PUBMED   32617860
  REMARK    GeneRIF: Inhibition of C3a/C3aR Axis in Diverse Stages of
            Ulcerative Colitis Affected the Prognosis of UC by Modulating the
            Pyroptosis and Expression of Caspase-11.
            Erratum:[Inflammation. 2021 Jun;44(3):1203-1204. doi:
            10.1007/s10753-020-01380-0.. PMID: 33174140]
REFERENCE   3  (bases 1 to 2025)
  AUTHORS   Li,L., Yin,Q., Tang,X., Bai,L., Zhang,J., Gou,S., Zhu,H., Cheng,J.,
            Fu,P. and Liu,F.
  TITLE     C3a receptor antagonist ameliorates inflammatory and fibrotic
            signals in type 2 diabetic nephropathy by suppressing the
            activation of TGF-beta/smad3 and IKBalpha pathway
  JOURNAL   PLoS One 9 (11), e113639 (2014)
   PUBMED   25422985
  REMARK    GeneRIF: C3aRA ameliorated T2DN by inhibiting IKBalpha
            phosphorylation and cytokine release, and also TGF-beta/Smad3
            signaling and ECM deposition
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2025)
  AUTHORS   Ikeda,K., Fukuda,N., Ueno,T., Endo,M., Kobayashi,N., Soma,M. and
            Matsumoto,K.
  TITLE     Role of complement 3a in the growth of mesangial cells from
            stroke-prone spontaneously hypertensive rats
  JOURNAL   Clin Exp Hypertens 36 (1), 58-63 (2014)
   PUBMED   23713944
  REMARK    GeneRIF: The C3 and C3a receptor system may primarily be involved
            in the pathogenesis of renal remodeling in hypertensive rats.
REFERENCE   5  (bases 1 to 2025)
  AUTHORS   Hannedouche,S., Beck,V., Leighton-Davies,J., Beibel,M., Roma,G.,
            Oakeley,E.J., Lannoy,V., Bernard,J., Hamon,J., Barbieri,S.,
            Preuss,I., Lasbennes,M.C., Sailer,A.W., Suply,T., Seuwen,K.,
            Parker,C.N. and Bassilana,F.
  TITLE     Identification of the C3a receptor (C3AR1) as the target of the
            VGF-derived peptide TLQP-21 in rodent cells
  JOURNAL   J Biol Chem 288 (38), 27434-27443 (2013)
   PUBMED   23940034
  REMARK    GeneRIF: The binding of TLQP-21 to C3AR1 not only has effects on
            signaling but also modulates cellular functions
REFERENCE   6  (bases 1 to 2025)
  AUTHORS   Hasegawa,K., Tamari,M., Shao,C., Shimizu,M., Takahashi,N.,
            Mao,X.Q., Yamasaki,A., Kamada,F., Doi,S., Fujiwara,H., Miyatake,A.,
            Fujita,K., Tamura,G., Matsubara,Y., Shirakawa,T. and Suzuki,Y.
  TITLE     Variations in the C3, C3a receptor, and C5 genes affect
            susceptibility to bronchial asthma
  JOURNAL   Hum Genet 115 (4), 295-301 (2004)
   PUBMED   15278436
REFERENCE   7  (bases 1 to 2025)
  AUTHORS   Proctor,L.M., Arumugam,T.V., Shiels,I., Reid,R.C., Fairlie,D.P. and
            Taylor,S.M.
  TITLE     Comparative anti-inflammatory activities of antagonists to C3a and
            C5a receptors in a rat model of intestinal ischaemia/reperfusion
            injury
  JOURNAL   Br J Pharmacol 142 (4), 756-764 (2004)
   PUBMED   15159277
REFERENCE   8  (bases 1 to 2025)
  AUTHORS   Sohn,J.H., Bora,P.S., Suk,H.J., Molina,H., Kaplan,H.J. and
            Bora,N.S.
  TITLE     Tolerance is dependent on complement C3 fragment iC3b binding to
            antigen-presenting cells
  JOURNAL   Nat Med 9 (2), 206-212 (2003)
   PUBMED   12514742
REFERENCE   9  (bases 1 to 2025)
  AUTHORS   Feild,J.A., Foley,J.J., Testa,T.T., Nuthulaganti,P., Ellis,C.,
            Sarau,H.M. and Ames,R.S.
  TITLE     Cloning and characterization of a rabbit ortholog of human Galpha16
            and mouse G(alpha)15
  JOURNAL   FEBS Lett 460 (1), 53-56 (1999)
   PUBMED   10571060
REFERENCE   10 (bases 1 to 2025)
  AUTHORS   Fukuoka,Y., Ember,J.A. and Hugli,T.E.
  TITLE     Cloning and characterization of rat C3a receptor: differential
            expression of rat C3a and C5a receptors by LPS stimulation
  JOURNAL   Biochem Biophys Res Commun 242 (3), 663-668 (1998)
   PUBMED   9464274
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 3, 2020 this sequence version replaced NM_032060.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U86379.1, SRR26643290.17825.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000004.1  157756415-157756530 c
            117-2025            JAXUCZ010000004.1  157749684-157751592 c
FEATURES             Location/Qualifiers
     source          1..2025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2025
                     /gene="C3ar1"
                     /note="complement C3a receptor 1"
                     /db_xref="GeneID:84007"
                     /db_xref="RGD:620537"
     exon            1..116
                     /gene="C3ar1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..2025
                     /gene="C3ar1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1543
                     /gene="C3ar1"
                     /note="C3AR; C3a-R; complement component 3a receptor 1"
                     /codon_start=1
                     /product="C3a anaphylatoxin chemotactic receptor"
                     /protein_id="NP_114449.2"
                     /db_xref="GeneID:84007"
                     /db_xref="RGD:620537"
                     /translation="MESFTADTNSTDLHSRPLFKPQDIASMVILSLTCLLGLPGNGLV
                     LWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVI
                     ILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVAFVMCIPVFVY
                     RDLLVVDDYSVCGYNFDSSRAYDYWDYMYNSHLPEINPPDNSTGHVDDRTAPSSVPAR
                     DLWTATTALQSQTFHTSPEDPFSQDSASQQPHYGGKPPTVLIATIPGGFPVEDHKSNT
                     LNTGAFLSAHTEPSLTASSSPLYAHDFPDDYFDQLMYGNHAWTPQVAITISRLVVGFL
                     VPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITD
                     QESALREVVLPWDHMSIALASANSCFNPFLYALLGKDFRKKARQSVKGILEAAFSEEL
                     THSTSCTQDKAPSKRNHMSTDV"
ORIGIN      
        1 agtaagcact cagcaactag tccaacatcc tccacggcgg ctggaccaga taggatttgt
       61 tggtggctca cagatcatca gtcctggagc cttctgattc cacctcagtg ctcttgactg
      121 agcaatggag tctttcactg ctgacaccaa ctcaactgac ctacactcac ggcctctgtt
      181 taaaccccaa gacattgcct ccatggtcat tctcagtctc acgtgtttat tgggactgcc
      241 aggcaatggg ctggtgctgt gggtcgctgg cgtaaagatg aagaggaccg tgaacacagt
      301 ctggttcctc cacctcaccc tggccgattt cctctgctgc ctctccttgc ccttctccgt
      361 ggctcacctg attctccgag gacactggcc ctatggcttg ttcctgtgca aacttatccc
      421 gtccgtcatt atcctcaaca tgtttgccag tgtcttcctg cttactgcca ttagcctgga
      481 ccgctgtctg atggtgcaca agccgatctg gtgccagaac catcggagcg tgagaacagc
      541 cttcgccgtc tgtggatgcg tctgggtggt agcctttgtg atgtgtatac cggtatttgt
      601 ataccgtgat ctgctcgttg tggatgatta cagtgtatgt ggctataact ttgattcctc
      661 cagggcatat gattattggg actacatgta caattcacat ctaccagaaa tcaaccctcc
      721 tgacaactcc actggacatg tggatgacag gacagctcct tcctctgtac cagcaaggga
      781 cctttggaca gctaccactg ctctccagtc acaaacgttc cacacatctc ctgaagaccc
      841 attctctcaa gactcagcaa gtcagcaacc ccattatggg gggaagcctc ctactgtgct
      901 catagccacc atacccggcg ggtttcctgt tgaagatcat aaatccaaca cactgaacac
      961 tggtgctttt ctctctgccc acacagagcc gtccctcact gcttctagca gtcctttata
     1021 cgcccatgat ttcccggatg attattttga ccaactgatg tatggcaatc acgcgtggac
     1081 acctcaggtg gcaatcacca tctcgaggct ggtggtgggc ttcctggtgc cctttttcat
     1141 catgataacc tgttacagcc tcatcgtctt cagaatgcga aaaaccaacc tcaccaagtc
     1201 gaggaacaaa acccttcggg tggccgtggc ggtggtcacc gtcttttttg tctgctggat
     1261 tccataccat attgttggaa tcctgttagt gattactgac caagaaagcg ccttgagaga
     1321 agttgtgcta ccctgggacc acatgtccat tgctttagca tctgccaata gttgtttcaa
     1381 ccctttcctt tatgccctct tgggaaaaga cttcaggaag aaagcaagac agtccgtaaa
     1441 gggcattctg gaagcagcct tcagcgaaga gctcacgcac tctaccagtt gtacccagga
     1501 caaagccccc tcaaaaagaa accatatgag tacggatgtg tgaagatgct gcactgggga
     1561 cctaagcaga tgttctgagg tgaatactgg tgatgggtga cctgtgagcg ggacacctta
     1621 gacagcctgg ccaccctcag agaaaggtct cttattgaca tcagcatcat ttgaaaacac
     1681 taaaggcaca aaatttcaag ccccatccca gatgtgttga ctccgaatct ctggcccgtg
     1741 gggaccaatg tcttaacagg cccccttgtt tccaccaatg ttaagtttta ttcaactcat
     1801 tctattccca tccctgactc ggccatgtgc aatgaataac gttctcatct gtttccagta
     1861 ttaatctctt cttgcatagc atcatctaaa tcctctagtt tgtgcgggag gctgctattg
     1921 tccagagtga aagatatttc tttattgtac atttgtgtgg tggtagcagt gattttttag
     1981 tggggaggca ggggagaaag acacagaaat aaaaggtctc tggaa
//
