LOCUS       NM_016994               5091 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus complement C3 (C3), mRNA.
ACCESSION   NM_016994 XM_346863
VERSION     NM_016994.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5091)
  AUTHORS   Huang,Q., Su,J., Xu,J., Yu,H., Jin,X., Wang,Y., Yan,M., Yu,J.,
            Chen,S., Wang,Y. and Lv,G.
  TITLE     Beneficial effects of Panax notoginseng (Burkill) F. H. Chen flower
            saponins in rats with metabolic hypertension by inhibiting the
            activation of the renin-angiotensin-aldosterone system through
            complement 3
  JOURNAL   BMC Complement Med Ther 23 (1), 13 (2023)
   PUBMED   36653797
  REMARK    Erratum:[BMC Complement Med Ther. 2023 Mar 8;23(1):76. doi:
            10.1186/s12906-023-03893-1.. PMID: 36890530]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5091)
  AUTHORS   Zhang,X., Chen,Y., Yu,S., Jin,B. and Liu,W.
  TITLE     Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis
            Affected the Prognosis of UC by Modulating the Pyroptosis and
            Expression of Caspase-11
  JOURNAL   Inflammation 43 (6), 2128-2136 (2020)
   PUBMED   32617860
  REMARK    GeneRIF: Inhibition of C3a/C3aR Axis in Diverse Stages of
            Ulcerative Colitis Affected the Prognosis of UC by Modulating the
            Pyroptosis and Expression of Caspase-11.
            Erratum:[Inflammation. 2021 Jun;44(3):1203-1204. doi:
            10.1007/s10753-020-01380-0.. PMID: 33174140]
REFERENCE   3  (bases 1 to 5091)
  AUTHORS   Ramlall,V., Thangaraj,P.M., Meydan,C., Foox,J., Butler,D., Kim,J.,
            May,B., De Freitas,J.K., Glicksberg,B.S., Mason,C.E.,
            Tatonetti,N.P. and Shapira,S.D.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   4  (bases 1 to 5091)
  AUTHORS   Zhang,X., Tan,Y., Ling,Y., Lu,G., Liu,F., Yi,Z., Jia,X., Wu,M.,
            Shi,B., Xu,S., Chen,J., Wang,W., Chen,B., Jiang,L., Yu,S., Lu,J.,
            Wang,J., Xu,M., Yuan,Z., Zhang,Q., Zhang,X., Zhao,G., Wang,S.,
            Chen,S. and Lu,H.
  TITLE     Viral and host factors related to the clinical outcome of COVID-19
  JOURNAL   Nature 583 (7816), 437-440 (2020)
   PUBMED   32434211
REFERENCE   5  (bases 1 to 5091)
  AUTHORS   Wang,J., Zhang,Y., Liu,Y.M., Yang,X.C., Chen,Y.Y., Wu,G.J.,
            He,X.H., Duan,L., Dong,Y. and Ma,R.F.
  TITLE     Uncovering the protective mechanism of Huoxue Anxin Recipe against
            coronary heart disease by network analysis and experimental
            validation
  JOURNAL   Biomed Pharmacother 121, 109655 (2020)
   PUBMED   31734577
REFERENCE   6  (bases 1 to 5091)
  AUTHORS   Milot,J., Fremont,P., Cote,C. and Tremblay,R.R.
  TITLE     Differential modulation of carbonic anhydrase (CA III) in slow- and
            fast-twitch skeletal muscles of rat following denervation and
            reinnervation
  JOURNAL   Biochem Cell Biol 69 (10-11), 702-710 (1991)
   PUBMED   1799436
REFERENCE   7  (bases 1 to 5091)
  AUTHORS   Botto,M., Fong,K.Y., So,A.K., Rudge,A. and Walport,M.J.
  TITLE     Molecular basis of hereditary C3 deficiency
  JOURNAL   J Clin Invest 86 (4), 1158-1163 (1990)
   PUBMED   2212005
REFERENCE   8  (bases 1 to 5091)
  AUTHORS   Jacobs,J.W., Rubin,J.S., Hugli,T.E., Bogardt,R.A., Mariz,I.K.,
            Daniels,J.S., Daughaday,W.H. and Bradshaw,R.A.
  TITLE     Purification, characterization, and amino acid sequence of rat
            anaphylatoxin (C3a)
  JOURNAL   Biochemistry 17 (23), 5031-5038 (1978)
   PUBMED   309768
REFERENCE   9  (bases 1 to 5091)
  AUTHORS   Sahashi,K., Engel,A.G., Linstrom,J.M., Lambert,E.H. and Lennon,V.A.
  TITLE     Ultrastructural localization of immune complexes (IgG and C3) at
            the end-plate in experimental autoimmune myasthenia gravis
  JOURNAL   J Neuropathol Exp Neurol 37 (2), 212-223 (1978)
   PUBMED   147324
REFERENCE   10 (bases 1 to 5091)
  AUTHORS   Coonrod,J.D. and Rylko-Bauer,B.
  TITLE     Complement levels in pneumococcal pneumonia
  JOURNAL   Infect Immun 18 (1), 14-22 (1977)
   PUBMED   20405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X52477.1, JAXUCZ010000009.1, CK366193.1, CO569380.1, CO800063.1,
            CO796620.1, CO565011.1 and BI281644.1.
            
            On Oct 11, 2007 this sequence version replaced NM_016994.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X52477.1, SRR23984936.756514.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               X52477.1           1-202
            203-304             JAXUCZ010000009.1  2199970-2200071     c
            305-776             X52477.1           305-776
            777-1172            CK366193.1         283-678
            1173-1250           JAXUCZ010000009.1  2197227-2197304     c
            1251-1309           X52477.1           1251-1309
            1310-1517           JAXUCZ010000009.1  2196490-2196697     c
            1518-2150           X52477.1           1518-2150
            2151-2573           CO569380.1         272-694
            2574-3152           CO800063.1         51-629
            3153-3808           CO796620.1         20-675
            3809-4295           CO565011.1         92-578
            4296-4497           X52477.1           4296-4497
            4498-5091           BI281644.1         1-594               c
FEATURES             Location/Qualifiers
     source          1..5091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..5091
                     /gene="C3"
                     /note="complement C3"
                     /db_xref="GeneID:24232"
                     /db_xref="RGD:2232"
     exon            1..121
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..5033
                     /gene="C3"
                     /EC_number="3.4.21.43"
                     /note="complement component 3"
                     /codon_start=1
                     /product="complement C3 precursor"
                     /protein_id="NP_058690.2"
                     /db_xref="GeneID:24232"
                     /db_xref="RGD:2232"
                     /translation="MGPTSGSQLLVLLLLLASSLLALGSPMYSIITPNVLRLESEETF
                     ILEAHDAQGDVPVTVTVQDFLKKQVLTSEKTVLTGATGHLNRVSIKIPASKEFNADKG
                     HKYVTVVANFGATVVEKAVLVSFQSGYLFIQTDKTIYTPGSTVFYRIFTVDNNLLPVG
                     KTVVIVIETPDGVPIKRDILSSHNQYGILPLSWNIPELVNMGQWKIRAFYEHAPKQTF
                     SAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKGLEVSITARFLYGKNVDGTAFVIFGVQ
                     DEDKKISLAQSLTRVLIEDGSGEAVLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHS
                     GSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAMPFDLMVFVTNPDGSPARRVPVVTQ
                     GSDAQALTQDDGVAKLSVNTPNNRQPLTITVRTKKEGIPDARQATRTMQAQPYSTMHN
                     SNNYLHLSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVMNKGKLLKAGRQVRE
                     PGQDLVVLSLPITPEFIPSFRLVAYYTLIGANGQREVVADSVWVDVKDSCVGTLVVKG
                     DPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADI
                     GCTPGSGKNYAGVFMDAGLTFKTNQGLQTDQREDPECAKPAARRRRSVQLMERRMDKA
                     GQYTDKGLRKCCEDGMRDIPMKYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRR
                     DHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDS
                     ITTWEILAVSLSDKKGICVADPYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYRE
                     QEKLKVRVELLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKA
                     AVFNHFISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLGQGGVQREDVPAADLSDQVP
                     DTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQ
                     TEQWEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAFNNRPPSTWLTAYVVKVFSL
                     AANLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAF
                     VLIALQEARDICEGQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMNKLEE
                     PYLTKFLNTAKDRNRWEEPGQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNEQRYY
                     GGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLR
                     SEETKQNEGFSLTAKGKGQGTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETAKKPQ
                     DAKSSMILDICTRYLGDVDATMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDK
                     AFSNKNTLIIYLEKISHSEEDCLSFKVHQFFNVGLIQPGSVKVYSYYNLEESCTRFYH
                     PEKDDGMLSKLCHNEMCRCAEENCFMHQSQDQVSLNERLDKACEPGVDYVYKTKLTTI
                     ELSDDFDEYIMTIEQVIKSGSDEVQAGQERRFISHVKCRNALKLQKGKQYLMWGLSSD
                     LWGEKPNTSYIIGKDTWVEHWPEAEECQDQKNQKQCEDLGAFTETMVVFGCPN"
     exon            122..311
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..474
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..545
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            546..640
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..723
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            724..814
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..917
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1044
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1160
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1307
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1517
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1724
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1883
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2013
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2085
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2286
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2395
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2481
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2624
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2837
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2904
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2991
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3195
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3271
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3431
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            3432..3530
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..3687
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3851
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..4010
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4070
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4161
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4213
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4301
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4302..4391
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4392..4497
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4498..4587
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4588..4671
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4672..4755
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..4891
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
     exon            4892..5073
                     /gene="C3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctacccctta cccctcactc cttccacctt tgtcctttac catgggaccc acgtcagggt
       61 cccagctact agtgctactg ctgctgttgg ccagctccct gctagctctg gggagcccca
      121 tgtactccat cattactccc aatgtcctgc ggctggagag tgaagagact ttcatactag
      181 aggcccatga tgctcagggt gatgtcccag tcactgtcac tgtgcaagac ttcctaaaga
      241 agcaagtgct gaccagtgag aagacagtgt tgacaggagc cactggacat ctgaacaggg
      301 tctccatcaa gattccagcc agtaaggaat tcaatgcaga taaggggcac aagtacgtga
      361 cagtggtggc aaacttcggg gcaacagtgg tggagaaagc ggtgctagta agctttcaga
      421 gtggttacct cttcatccag acagacaaga ccatctacac cccaggctcc actgttttct
      481 atcggatctt cactgtggac aacaacctat tgcctgtggg caagacagtc gtcatcgtca
      541 ttgagacccc ggacggcgtt cccatcaaga gagacattct atcttcccac aaccaatatg
      601 gcatcttgcc tttgtcttgg aacattccag aactggtcaa catggggcag tggaagatcc
      661 gagccttcta tgaacatgca ccaaagcaga ccttctctgc agagtttgag gtgaaggaat
      721 acgtgctgcc cagtttcgaa gtcctggtgg agcctacaga gaaattttat tacatcgatg
      781 acccaaaggg cctggaagtt tccatcacag ccagattcct gtatgggaag aacgtggacg
      841 ggacagcttt cgtgatcttt ggggtccagg atgaggataa gaagatttct ctggcccagt
      901 ccctcacccg cgtgctgatc gaggatggtt caggggaggc agtgctcagc cgaaaagtgc
      961 tgatggacgg ggtacggccc tccagcccag aagccctagt ggggaagtcc ctgtacgtct
     1021 ctgtcactgt tatcctgcac tcaggtagcg acatggtaga ggcagagcgc agtgggatcc
     1081 caattgtcac ttccccgtac cagatccact tcaccaagac acccaaattc ttcaagccag
     1141 ccatgccttt cgacctcatg gtgtttgtga ccaaccctga tggctctcca gcccgcagag
     1201 tgccagtagt cactcaggga tccgacgcgc aggctctcac ccaggatgat ggtgtggcca
     1261 agctgagcgt caacacaccc aacaaccgcc aacccctgac tatcacggtc cgcaccaaga
     1321 aggagggtat cccggacgcg cggcaggcca ccaggacgat gcaggcccag ccctacagca
     1381 ctatgcacaa ttccaacaac tacctgcact tgtcagtgtc tcgggtggag ctcaagcctg
     1441 gggacaacct caatgtcaac ttccacctgc gcacggacgc tggccaagag gccaagatcc
     1501 gatactacac ctatctggtt atgaacaagg ggaagttact gaaggcaggc cgtcaggttc
     1561 gggagcctgg ccaggacctg gtggtcttgt cactgcccat cactccagaa tttatacctt
     1621 ccttccgcct ggtggcttac tacaccctga ttggagctaa tggccaaagg gaggtggtgg
     1681 ccgactcagt gtgggtggat gtgaaggact cctgtgtagg cacgctggtg gtgaaaggtg
     1741 acccaagaga taaccgacag cccgcgcctg ggcatcaaac gacactaagg atcgagggga
     1801 accagggggc ccgagtgggg ctagtggctg tggacaaggg ggtgtttgtg ctgaacaaga
     1861 agaacaaact cacacagagc aagatctggg atgtagtaga gaaggcagac attggctgca
     1921 ccccaggcag tgggaagaac tatgcgggtg tcttcatgga tgctggcctg accttcaaga
     1981 caaaccaagg cctgcagact gatcagagag aagatcctga gtgcgccaag ccagctgccc
     2041 gccgccgtcg ctcagtgcag ttgatggaaa ggaggatgga caaagctggt cagtacaccg
     2101 acaagggtct gcggaagtgt tgtgaggatg gcatgcgtga tatccctatg aagtacagct
     2161 gccagcgccg ggctcgcctc atcacccagg gcgagagctg cctgaaggcc ttcatggact
     2221 gctgcaacta tatcaccaag cttcgtgagc agcacagaag agaccatgtg ctgggcctgg
     2281 ccaggagtga tgtggatgaa gacataatcc cagaagaaga tattatctct agaagccact
     2341 tcccagagag ctggttgtgg accatagaag agttgaaaga accagagaaa aatggaatct
     2401 ctacgaaggt catgaacatc tttctcaaag attccatcac cacctgggag attctggcag
     2461 tgagcttgtc cgacaagaaa gggatctgtg tggcagaccc ctatgagatc acagtgatgc
     2521 aggacttctt cattgacctg cgactgccct actctgtggt gcgcaatgaa caggtggaga
     2581 tcagagctgt gctcttcaat taccgtgaac aggagaaact taaggtaagg gtggaactgt
     2641 tgcataaccc agccttctgc agcatggcca ctgccaagaa gcggtactac cagaccatcg
     2701 aaatccctcc caagtcctct gtggctgtgc cttatgtcat tgtccccttg aagatcggcc
     2761 tccaggaggt ggaggtcaag gccgccgtct tcaaccactt catcagtgat ggtgtcaaga
     2821 agatactgaa ggtcgtgcca gaaggaatga gagtcaacaa aactgtggct gtccgtacac
     2881 tggatccaga acacctcggt caagggggag tgcagaggga ggatgtacct gcagcagacc
     2941 tcagtgacca agtgccagac acagattctg agaccagaat tctcctgcaa gggaccccgg
     3001 tggctcagat ggccgaggac gctgtggacg gggagcggct gaaacacctg atcgtgaccc
     3061 cctctggctg tggggagcag aacatgattg gcatgacacc cacggtcatt gcagtacact
     3121 atctggatca gaccgaacag tgggagaaat tcggcctaga gaagaggcaa gaagctctgg
     3181 agctcatcaa gaaagggtac acccagcagc tggctttcaa acagcccagc tctgcctatg
     3241 ctgccttcaa caaccggcct cccagcacct ggctgacagc ctatgtggtc aaggtcttct
     3301 ctctggctgc caacctcatc gccatcgact ctcaggtcct gtgtggggct gtcaaatggc
     3361 tgattctgga gaaacagaag ccagatggtg tctttcagga ggacggacca gtgattcacc
     3421 aagaaatgat tggtggcttc cggaacacca aggaggcaga tgtgtcgctt acagcctttg
     3481 tcctcatcgc actgcaggaa gccagagata tctgtgaggg gcaggtcaac agccttcccg
     3541 ggagcatcaa caaggcaggg gagtatcttg aagccagtta cctgaacctg cagagaccat
     3601 acacagtagc cattgctggg tatgccctgg ccctgatgaa caaactggag gaaccttacc
     3661 tcaccaagtt tctgaacaca gccaaagatc ggaaccgctg ggaggagcct ggccagcagc
     3721 tctacaatgt ggaggccacc tcctacgccc tcctggccct gctgctgctg aaagactttg
     3781 actctgtgcc tcctgtggtg cgctggctca acgagcaaag atactacgga ggtggctatg
     3841 gctccacgca ggctaccttc atggtattcc aagccttggc tcaataccaa acagatgtcc
     3901 ctgaccacaa ggacttgaac atggatgtgt ccctccacct ccccagccgc agctccccaa
     3961 ctgtgtttcg cctgctatgg gaaagtggca gtctcctgag atcagaagag accaagcaga
     4021 atgagggctt ttctctgaca gccaaaggaa aaggccaagg cacactgtcg gtggtgacag
     4081 tgtatcacgc caaagtcaaa ggcaaagcca cctgcaagaa gtttgacctc agggtcacca
     4141 taaaaccagc ccctgagaca gccaagaagc cccaggatgc caagagttct atgatccttg
     4201 acatctgcac caggtacttg ggagacgtgg atgctactat gtccatcctg gacatctcca
     4261 tgatgactgg ctttattcca gacacaaacg acctggaact gctgagctct ggagtagaca
     4321 gatacatttc caagtatgag atggacaaag ccttctccaa caagaacacc ctcatcatct
     4381 acctagaaaa gatctcacac tccgaagaag actgcctgtc cttcaaagtc caccagttct
     4441 ttaacgtggg acttatccag ccggggtcgg tcaaggtcta ctcctactac aatctagagg
     4501 agtcatgcac ccggttctat catccggaga aggacgatgg aatgctgagc aagctgtgcc
     4561 acaatgaaat gtgccgctgt gcagaggaga actgcttcat gcatcagtca caggatcagg
     4621 tcagcctgaa tgaacgacta gacaaggctt gtgagcctgg agtggactac gtgtacaaga
     4681 ccaagctaac gacgatagag ctgtcggatg attttgatga gtacatcatg accatcgagc
     4741 aggtcatcaa gtcaggctca gatgaggtgc aggcaggtca ggaacgaagg ttcatcagcc
     4801 acgtcaagtg cagaaacgcc ctaaagctgc agaaagggaa gcagtacctc atgtggggcc
     4861 tctcctccga cctctgggga gaaaagccca ataccagcta catcattggg aaggacacgt
     4921 gggtggagca ctggcccgag gcagaggaat gtcaggatca gaagaaccag aaacagtgcg
     4981 aagacctcgg ggcattcaca gaaacaatgg tggttttcgg ctgccccaac tgaccacaac
     5041 ctccaataaa gcttcagttg tattttaccc atcaaaaaaa aaaaaaaaaa a
//
