LOCUS       NM_172222               2629 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus complement C2 (C2), mRNA.
ACCESSION   NM_172222
VERSION     NM_172222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Wu L, Tao Q, Chen W, Wang Z, Song Y, Sheng S, Li P and Zhou J.
  TITLE     Association between polymorphisms of complement pathway genes and
            age-related macular degeneration in a Chinese population
  JOURNAL   Invest Ophthalmol Vis Sci 54 (1), 170-174 (2013)
   PUBMED   23233260
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Zhao Q, Peng L, Huang W, Li Q, Pei Y, Yuan P, Zheng L, Zhang Y,
            Deng J, Zhong C, Hu B, Ding H, Fang W, Li R, Liao Q, Lin C, Deng W,
            Yan H, Hou J, Wu Q, Xu T, Liu J, Hu L, Peng T, Chen S, Lai KN, Yuen
            MF, Wang Y, Maini MK, Li C, Li M, Wang J, Zhang X, Sham PC, Wang J,
            Gao ZL and Wang Y.
  TITLE     Rare inborn errors associated with chronic hepatitis B virus
            infection
  JOURNAL   Hepatology 56 (5), 1661-1670 (2012)
   PUBMED   22610944
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Yang MM, Lai TY, Tam PO, Chiang SW, Ng TK, Liu K and Pang CP.
  TITLE     Association of C2 and CFB polymorphisms with anterior uveitis
  JOURNAL   Invest Ophthalmol Vis Sci 53 (8), 4969-4974 (2012)
   PUBMED   22714898
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Buentello-Volante B, Rodriguez-Ruiz G, Miranda-Duarte A, Pompa-Mera
            EN, Graue-Wiechers F, Bekker-Mendez C, Ayala-Ramirez R, Quezada C,
            Rodriguez-Loaiza JL and Zenteno JC.
  TITLE     Susceptibility to advanced age-related macular degeneration and
            alleles of complement factor H, complement factor B, complement
            component 2, complement component 3, and age-related maculopathy
            susceptibility 2 genes in a Mexican population
  JOURNAL   Mol Vis 18, 2518-2525 (2012)
   PUBMED   23112567
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Walter L, Hurt P, Himmelbauer H, Sudbrak R and Gunther E.
  TITLE     Physical mapping of the major histocompatibility complex class II
            and class III regions of the rat
  JOURNAL   Immunogenetics 54 (4), 268-275 (2002)
   PUBMED   12136338
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Ueda,A., Kusaba,T. and Yanase,T.
  TITLE     Determination of the second component of complement (C2) by
            electroimmunoassay in sera from patients with systemic lupus
            erythematosus
  JOURNAL   Clin Exp Immunol 53 (1), 217-224 (1983)
   PUBMED   6409476
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Saha,K., Sharma,V., Chakrabarty,A.K. and Sehgal,V.N.
  TITLE     Breakdown product of factor B as an index of complement activation
            in lepromatous leprosy and its relation with bacillary load
  JOURNAL   Scand J Immunol 17 (1), 37-43 (1983)
   PUBMED   6342123
REFERENCE   9  (bases 1 to 2629)
  AUTHORS   Dewald,G., Lange,C.E., Schmeel,E. and Kreysel,H.W.
  TITLE     HLA-linked complement polymorphisms (C2, BF) in psoriasis
  JOURNAL   Arch Dermatol Res 275 (5), 301-304 (1983)
   PUBMED   6559061
REFERENCE   10 (bases 1 to 2629)
  AUTHORS   Petersen,B.H., Watson,R.D. and Holmes,D.H.
  TITLE     Protein Malnutrition and complement activity in guinea pigs,
            germ-free and conventional rats
  JOURNAL   J Nutr 110 (11), 2159-2165 (1980)
   PUBMED   6776243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070923.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_172222.3.
            
            On May 24, 2004 this sequence version replaced NM_172222.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070923.1, AY149994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2629
                     /gene="C2"
                     /note="complement C2"
                     /db_xref="GeneID:24231"
                     /db_xref="RGD:2231"
     exon            1..136
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2367
                     /gene="C2"
                     /EC_number="3.4.21.43"
                     /note="complement component 2"
                     /codon_start=1
                     /product="complement C2 precursor"
                     /protein_id="NP_757376.2"
                     /db_xref="GeneID:24231"
                     /db_xref="RGD:2231"
                     /translation="MAPLLALLALLQLGPGLAALSCPQNVNIVGGNFTLSRGWAPGSV
                     LIYSCPLGRYPSPAWRECQSNGQWQTPRASSLPTLRSSRLAKAVCKPVRCPAPTSFEN
                     GIYIPRLGSYPVGGNLSFECEHGFTLRGSPVRYCRPNGVWDGETAVCDNGASHCPNPG
                     ISVGTMRTGSSFDLGDKVSYRCSSTNLVLTGSVERECLSNGVWSGSEPICRQPYSYDF
                     PEDVASALGTSFTHLLGATNPIQKRTENLGRKIQIQRSGHLNLYLLLDASQSVSEKDF
                     NIFKESAFLMVDRIFSFEIKVSVAIITFASRPKIIMSVLNERSQNVMEVMDSLDSVCY
                     KDHENATGTNTYEALNSVYLMMNNQMDRLGMETSAWQEIRHAIILLTDGKSNMGGSPK
                     PAVDNIREILGISRNRNDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKA
                     VQQVFEHILDVSKLTDTICGVGNMSVNASDQERTPWQVTFKPKSKETCQGSLISDQWV
                     LTAAHCFHDAQMEDRHLWRVIVGDPTSHHGKEFHVEEVLVAPGFNVHAKQSQGISEFY
                     ADDIALLKLSQRVKMSSHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAH
                     FVALNGNRMNINLRTGPERTSCIEAVSQNKGSFPGLTNVSEVVTDQFLCSGMEGDDSP
                     CKGESGGAVFLERRYRFFQVGLVSWGLFDPCHGSSNKNLRRKPPHGVVPRDFHISLFR
                     LQPWLRQHLDGVLDFLPL"
     exon            137..361
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..547
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            548..724
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..823
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..957
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1096
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1237
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1327
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1468
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1563
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1681
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1847
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1924
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2016
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2143
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2193
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2604
                     /gene="C2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcggagcc tactcaaccc gcagtgattt cggggaagtc agatgacctt ttctctcccc
       61 tggctctccc gttctactgt tctggaaacc atggcccctc tgctggctct cctcgccctg
      121 ctgcagctgg gcccaggcct ggctgctctt tcctgccctc agaatgtcaa tattgtcggg
      181 gggaatttca ctctcagccg tggctgggct cctgggagcg tcctcatcta ctcctgcccc
      241 ctgggcaggt acccgtcccc agcctggcgg gaatgccaga gcaacgggca gtggcagaca
      301 ccaagagcta gctcacttcc caccctgaga tcctctcggt tggctaaagc cgtctgcaaa
      361 cctgttcgat gtccagctcc cacgtccttt gagaatggca tctatatccc tcggctgggg
      421 tcctaccccg tgggtggcaa cctgagcttc gagtgtgagc atggtttcac cttgcggggc
      481 tcgcccgtga ggtactgtcg ccccaacggc gtgtgggatg gagagacggc tgtgtgtgac
      541 aatggcgcta gccactgccc caacccaggc atctcagtgg gcacaatgcg gacaggctcg
      601 agctttgacc ttggagacaa ggtcagttac cgctgttcct ccacgaatct ggtattgacc
      661 ggctctgtag agcgggagtg tctgagtaac ggagtgtgga gtgggtcgga gcccatctgc
      721 cgacagccat actcttacga cttccctgag gatgtagcat ctgccctagg cacctccttc
      781 acccacctgc ttggagccac caatcccatc cagaagagga cagaaaacct gggccgtaaa
      841 atccaaatcc agcgctcggg ccacctgaac ctctatctgc tgcttgatgc ctctcagagc
      901 gtatcggaaa aagactttaa catcttcaag gagagcgcct tcctcatggt ggacaggatc
      961 ttcagcttcg agataaaggt cagcgtagct atcatcacct tcgcctcacg gcccaaaatc
     1021 atcatgtccg tcctgaatga gagatcccag aatgtgatgg aggtgatgga cagtctagac
     1081 tctgtctgct acaaagatca cgaaaatgcc actggcacta acacttacga ggctctcaac
     1141 agcgtctacc tcatgatgaa taaccagatg gatcgcctcg gcatggagac ctctgcctgg
     1201 caggaaatcc gccatgccat catcctgttg actgacggaa agtccaacat gggtggctct
     1261 cccaagccgg cagtcgacaa catcagagag atcctgggca tcagtcggaa cagaaacgac
     1321 tacctggaca tctatgcgat tggggtgggt aagctggatg tggactggaa ggaactgaac
     1381 gagctggggt ccaagaagga cggcgagagg cacgccttca tcttgcagga cgcaaaagct
     1441 gtgcagcagg tctttgagca cattctggat gtctctaagc tcacagacac catctgtggg
     1501 gtggggaaca tgtccgtcaa tgcctctgac caggagagga caccttggca agtcaccttt
     1561 aagcccaaga gtaaggagac ttgccagggg tcgcttatct ctgaccagtg ggtgctgact
     1621 gcggctcact gcttccatga cgctcagatg gaggaccgcc acctgtggag ggtcatcgtg
     1681 ggggatccca cctctcatca cggcaaagaa ttccatgtgg aggaggtgtt agttgcccct
     1741 gggtttaatg tccacgcaaa gcagagccag ggcatctcgg agttctacgc tgatgacatt
     1801 gccctgctga agctgtctca gagagtgaaa atgtccagcc acgccaggcc catctgcctt
     1861 ccttgcacag tgggggccaa catggctctg cggagatccc caggtagtac ctgtaaagac
     1921 catgagacag aacttctgtc acagcagaag gttcctgcgc atttcgtagc tctgaacggg
     1981 aacagaatga acatcaacct caggacagga cctgagagga caagctgtat cgaggctgtc
     2041 tcccaaaaca agggcagctt ccccggcttg acaaacgtca gtgaggtggt gacagaccag
     2101 ttcctatgta gcgggatgga gggagatgac agtccttgca aaggagaatc cgggggagcc
     2161 gttttccttg agcggaggta caggtttttc caggtgggcc tggtgagttg gggtcttttt
     2221 gacccttgtc acggttcctc caacaaaaac ttgcgcagga agcctccgca tggcgttgtg
     2281 cctagggact tccacatcag tctcttccgg ctgcagccct ggttgaggca gcacctggat
     2341 ggtgtcctcg actttttgcc cctttaacac ggtcaccgac tcctttgctg gtctgtccct
     2401 cctgtcttct gcctctgagt gttcttgctc ccaggtacat aaatcctgga acgcagagac
     2461 aaaagctagg aatccccagg gttgtgccag aaccactgtg ccctcccgag aagcaagtgt
     2521 ctctctagtg tggatgaccc gtgctccttt tgctttcaca cagaatttcc cagttatgaa
     2581 attaataaaa atcaatgatt tccaaaaaaa aaaaaaaaaa aaaaaaaaa
//
