LOCUS       NM_001134555            2704 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus complement C1r (C1r), mRNA.
ACCESSION   NM_001134555 XM_001061611 XM_242644
VERSION     NM_001134555.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Grobner R, Kapferer-Seebacher I, Amberger A, Redolfi R, Dalonneau
            F, Bjorck E, Milnes D, Bally I, Rossi V, Thielens N, Stoiber H,
            Gaboriaud C and Zschocke J.
  TITLE     C1R Mutations Trigger Constitutive Complement 1 Activation in
            Periodontal Ehlers-Danlos Syndrome
  JOURNAL   Front Immunol 10, 2537 (2019)
   PUBMED   31749804
  REMARK    Erratum:[Front Immunol. 2019 Dec 04;10:2837. PMID: 31879527]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez
            L, Borras FE and Falcon-Perez JM.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Lang A, Major B, Szilagyi K, Gaspari Z, Gal P, Zavodszky P and
            Perczel A.
  TITLE     Interaction between separated consecutive complement control
            modules of human C1r: implications for dimerization of the
            full-length protease
  JOURNAL   FEBS Lett 584 (22), 4565-4569 (2010)
   PUBMED   20970424
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Major B, Kardos J, Kekesi KA, Lorincz Z, Zavodszky P and Gal P.
  TITLE     Calcium-dependent conformational flexibility of a CUB domain
            controls activation of the complement serine protease C1r
  JOURNAL   J Biol Chem 285 (16), 11863-11869 (2010)
   PUBMED   20178990
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Zhang J, Wright W, Bernlohr DA, Cushman SW and Chen X.
  TITLE     Alterations of the classic pathway of complement in adipose tissue
            of obesity and insulin resistance
  JOURNAL   Am J Physiol Endocrinol Metab 292 (5), E1433-E1440 (2007)
   PUBMED   17244723
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Budayova-Spano M, Lacroix M, Thielens NM, Arlaud GJ,
            Fontecilla-Camps JC and Gaboriaud C.
  TITLE     The crystal structure of the zymogen catalytic domain of complement
            protease C1r reveals that a disruptive mechanical stress is
            required to trigger activation of the C1 complex
  JOURNAL   EMBO J 21 (3), 231-239 (2002)
   PUBMED   11823416
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000150.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001134555.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001134555.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168673.1, SRR8487227.234157.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JACYVU010000150.1  211599-211679
            82-310              JACYVU010000150.1  212404-212632
            311-503             JACYVU010000150.1  214210-214402
            504-650             JACYVU010000150.1  215242-215388
            651-847             JACYVU010000150.1  215491-215687
            848-995             JACYVU010000150.1  215981-216128
            996-1117            JACYVU010000150.1  216319-216440
            1118-1196           JACYVU010000150.1  218148-218226
            1197-1352           JACYVU010000150.1  218514-218669
            1353-1427           JACYVU010000150.1  220555-220629
            1428-2704           JACYVU010000150.1  221088-222364
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2704
                     /gene="C1r"
                     /note="complement C1r"
                     /db_xref="GeneID:312705"
                     /db_xref="RGD:1309091"
     exon            1..81
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2203
                     /gene="C1r"
                     /EC_number="3.4.21.41"
                     /note="complement component 1, r subcomponent; complement
                     C1r subcomponent"
                     /codon_start=1
                     /product="complement C1r subcomponent precursor"
                     /protein_id="NP_001128027.1"
                     /db_xref="GeneID:312705"
                     /db_xref="RGD:1309091"
                     /translation="MRLIPLLLVTLFCGVEGSIYLPQKLYGEVTSPLYPKPYPSDLET
                     TTVITVPTGYRVKLVFWQFDVEPSEGCFYDYVKISADKKTLGRFCGQQDSPQGNPPGR
                     KEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECTSQPNSVEEGLQPR
                     CQHLCHNYVGGYFCSCRPGYELQKDRQSCQAECSSGLYTEPSGYISSLEYPKPYPPDL
                     RCNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQIYANGKNLGEFCGTQRPPDL
                     DTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKALDEFTIIQDPQPQYQFRDYF
                     IVTCKQGYQLMEGSQALLSFTAVCQHDGTWHRAMPRCKIKDCGQPRSLSNGDFRYLTT
                     RGVNTYEARIQYYCHDPYYKMMTRAGSSESVRGIYTCTPQGIWKNEEEGEKMPRCLPV
                     CGKPVNPVTQKQRIIGGQKANPGNFPWQAFTNIHGRGGGALLGDRWILTAAHTIYPKE
                     HNKENNVNVSKDVFLGHTNVEEIKKLGHHPVRRVIIHPDYRQDEPNNFEGDIALLELE
                     NSVTLGPNLLPICLPDNETFYDKDLMGYVSGFGITEDKIAFNLRFVRLPIADREACQR
                     WLRTKNSNDVFSQNMFCSGDPTLKHDACQGDSGGVFAVRDRSRDIWVATGIVSWGIGC
                     GEGYGFYTKLLNYVDWIKKEIGDEN"
     exon            82..310
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            311..503
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            504..650
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            651..847
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            848..995
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1117
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1196
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1352
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1427
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2704
                     /gene="C1r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccactccct ccttcaactt acagtgcctg aagactcttg caggagagct gaggacccaa
       61 aacaaactgg ccttgagaca tgcgtctcat ccccctcctc ctggtgaccc tgttctgtgg
      121 ggtggagggc tccatctacc tccctcagaa gctctatgga gaggtgacct cccctctgta
      181 tcccaagcct taccccagtg acttggagac gaccaccgtg atcactgtcc ccacggggta
      241 cagggtgaag ctggtcttct ggcagtttga tgtggagcct tctgaaggct gtttctatga
      301 ctacgtcaag atttctgctg ataagaaaac tctggggagg ttctgtgggc agcaggattc
      361 tcctcagggc aaccccccag gaaggaagga attcatgtcc caaggaaaca agatgctgct
      421 gacctttcac acagacttct ccaacgagga gaatgggacc atcatgttct acaagggctt
      481 cctggcctac taccaggctg tggaccttga tgaatgtacg tcccagccca actcagtgga
      541 ggagggtttg cagccccgat gccaacacct gtgccacaac tatgttggag gttacttctg
      601 ttcctgccgt cctggctacg agcttcagaa agacaggcaa tcctgccagg ccgagtgcag
      661 cagtgggctc tacacggagc cctcgggcta catctccagc ctcgagtacc cgaagcccta
      721 tccacccgat ctgcgctgta actacagcat ccgggtagag aggggcctca ctgtgcacct
      781 caagttcctg gatccttttg aaattgatga ccaccagcaa gtacactgcc cctatgacca
      841 gctccagatc tacgctaatg ggaagaactt gggtgaattc tgtggaacgc aaaggcctcc
      901 agaccttgac accagcagca acgccgtgga tctgctgttc ttcacggatg agtccgggga
      961 cagccgaggc tggaagcttc gctacaccac tgaaatcatc aagtgccccc aacccaaggc
     1021 cctggatgag ttcaccatca tccaggatcc acagcctcag taccagttcc gggattactt
     1081 cattgtcacc tgcaaacaag gctaccagct catggaggga agtcaggcgc tgctctcctt
     1141 cacggctgtt tgccagcatg atggcacgtg gcaccgtgcc atgcccaggt gcaagatcaa
     1201 ggactgtgga cagccccgca gcctgtctaa tggggacttc cgctacctca ccacaagagg
     1261 cgtgaacacc tatgaagcca ggatccagta ttactgccat gacccatatt acaagatgat
     1321 gaccagagct ggcagcagcg agtccgtacg agggatatat acctgcacac cccaaggcat
     1381 ttggaagaac gaagaggaag gagagaaaat gccccggtgt ctgccagtat gtgggaagcc
     1441 tgtcaacccc gtgacacaga agcagcgcat catcggaggg cagaaagcca atccgggcaa
     1501 cttcccctgg caggcattca ccaatatcca cgggcgaggg ggcggggccc tgcttggaga
     1561 ccgctggatc ctcacggcag cccacaccat ctaccccaag gaacacaaca aagaaaacaa
     1621 cgtcaacgtc agtaaagatg ttttcctggg ccacacaaac gtggaagaga tcaaaaaact
     1681 gggacatcac cctgtccgtc gggtcatcat acacccagac taccgccaag atgagcctaa
     1741 caattttgaa ggagacattg ccctactgga gctggaaaac agtgtcacac tgggtcccaa
     1801 cctcctcccc atctgtctcc cagacaatga gaccttctat gacaaagacc ttatgggtta
     1861 tgtcagcggc ttcgggataa cagaagataa aatagctttt aatctcaggt ttgtccgtct
     1921 gcccatagcc gatcgagagg catgccagag gtggctccgg acgaaaaaca gtaatgatgt
     1981 attttctcaa aatatgttct gttctgggga cccaactctc aagcatgacg cctgccaggg
     2041 ggacagtggg ggtgtttttg cagtcaggga ccgcagtcgt gatatctggg tggctacagg
     2101 catcgtatcc tggggcattg ggtgtggtga gggatacggc ttttacacca agttactgaa
     2161 ttatgttgac tggatcaaga aagagattgg agatgaaaac tgaagccagc attcactggg
     2221 ttagaatcca gtgtgtagta tattaaaaaa aaaagtatct aaccaatttt tgataagcac
     2281 tacgtttctc atattaaaat cacggaggca gacagtgtat agaataaatt ctcttttcta
     2341 taatctcatc agcattctgg cgtcttgttt tcaacatagt ttgactatgt ggcccaggct
     2401 gccctagaat atacagtcct cctgcttgag gctcagggtt agagctaaca atgttaggtt
     2461 ggaggattgc ttcccagcta agagtgtgga ctgtcggcta ggcagtgctg gcacaggcct
     2521 ttaatcccag cactctggaa gctgagaggt aggtgggtgg gtctcagtga gttcgaggcc
     2581 agcctgttct atagagtgag ttccagaaca gccagaagta cacggaaaaa acatgtcctg
     2641 aaaaacaata aataaataaa taaataaata aataaataaa taaataaata aataaaaata
     2701 aata
//
