LOCUS       NM_001191891            1191 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus C1q and TNF related 9 (C1qtnf9), mRNA.
ACCESSION   NM_001191891 XM_344414
VERSION     NM_001191891.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Jin,Q., Su,H., Yang,R., Tan,Y., Li,B., Yi,W., Dong,Q., Zhang,H.,
            Xing,W. and Sun,X.
  TITLE     C1q/TNF-related protein-9 ameliorates hypoxia-induced pulmonary
            hypertension by regulating secretion of endothelin-1 and nitric
            oxide mediated by AMPK in rats
  JOURNAL   Sci Rep 11 (1), 11372 (2021)
   PUBMED   34059748
  REMARK    GeneRIF: C1q/TNF-related protein-9 ameliorates hypoxia-induced
            pulmonary hypertension by regulating secretion of endothelin-1 and
            nitric oxide mediated by AMPK in rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Niemann,B., Li,L., Siegler,D., Siegler,B.H., Knapp,F., Hanna,J.,
            Aslam,M., Kracht,M., Schulz,R. and Rohrbach,S.
  TITLE     CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and
            Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response
  JOURNAL   Cells 9 (5), 1229 (2020)
   PUBMED   32429302
  REMARK    GeneRIF: CTRP9 Mediates Protective Effects in Cardiomyocytes via
            AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant
            Response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Liu,M., Li,W., Wang,H., Yin,L., Ye,B., Tang,Y. and Huang,C.
  TITLE     CTRP9 Ameliorates Atrial Inflammation, Fibrosis, and Vulnerability
            to Atrial Fibrillation in Post-Myocardial Infarction Rats
  JOURNAL   J Am Heart Assoc 8 (21), e013133 (2019)
   PUBMED   31623508
  REMARK    GeneRIF: CTRP9 Ameliorates Atrial Inflammation, Fibrosis, and
            Vulnerability to Atrial Fibrillation in Post-Myocardial Infarction
            Rats.
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Liu,M., Yin,L., Li,W., Hu,J., Wang,H., Ye,B., Tang,Y. and Huang,C.
  TITLE     C1q/TNF-related protein-9 promotes macrophage polarization and
            improves cardiac dysfunction after myocardial infarction
  JOURNAL   J Cell Physiol 234 (10), 18731-18747 (2019)
   PUBMED   30953351
  REMARK    GeneRIF: CTRP9 improved post-myocardial infarction early cardiac
            function.
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Zhao,D., Feng,P., Sun,Y., Qin,Z., Zhang,Z., Tan,Y., Gao,E.,
            Lau,W.B., Ma,X., Yang,J., Yu,S., Xu,X., Yi,D. and Yi,W.
  TITLE     Cardiac-derived CTRP9 protects against myocardial
            ischemia/reperfusion injury via calreticulin-dependent inhibition
            of apoptosis
  JOURNAL   Cell Death Dis 9 (7), 723 (2018)
   PUBMED   29925877
  REMARK    GeneRIF: autocrine CTRP9 of cardiomyocyte origin protects against
            myocardial ischemia/reperfusion injury via CRT association.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Li,Y.X., Run,L., Shi,T. and Zhang,Y.J.
  TITLE     CTRP9 regulates hypoxia-mediated human pulmonary artery smooth
            muscle cell proliferation, apoptosis and migration via
            TGF-beta1/ERK1/2 signaling pathway
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1319-1325 (2017)
   PUBMED   28688765
  REMARK    GeneRIF: CTRP9 regulates hypoxia-mediated human pulmonary artery
            smooth muscle cell proliferation, apoptosis and migration via
            TGF-beta1/ERK1/ERK2 signaling pathway.
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Peterson,J.M., Wei,Z., Seldin,M.M., Byerly,M.S., Aja,S. and
            Wong,G.W.
  TITLE     CTRP9 transgenic mice are protected from diet-induced obesity and
            metabolic dysfunction
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 305 (5), R522-R533 (2013)
   PUBMED   23842676
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Kambara,T., Ohashi,K., Shibata,R., Ogura,Y., Maruyama,S.,
            Enomoto,T., Uemura,Y., Shimizu,Y., Yuasa,D., Matsuo,K., Miyabe,M.,
            Kataoka,Y., Murohara,T. and Ouchi,N.
  TITLE     CTRP9 protein protects against myocardial injury following
            ischemia-reperfusion through AMP-activated protein kinase
            (AMPK)-dependent mechanism
  JOURNAL   J Biol Chem 287 (23), 18965-18973 (2012)
   PUBMED   22514273
  REMARK    GeneRIF: CTRP9 protects against acute cardiac injury following
            ischemia-reperfusion via an AMPK-dependent mechanism.
REFERENCE   9  (bases 1 to 1191)
  AUTHORS   Peterson,J.M., Wei,Z. and Wong,G.W.
  TITLE     CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with
            C1q/TNF family members
  JOURNAL   Biochem Biophys Res Commun 388 (2), 360-365 (2009)
   PUBMED   19666007
REFERENCE   10 (bases 1 to 1191)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000015.1.
            
            [WARNING] On Aug 15, 2024 this sequence was replaced by
            NM_001191891.2.
            
            On Jul 17, 2010 this sequence version replaced XM_344414.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.57405.1,
                                           SRR22582419.1556025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000015.1  39091439-39091598
            161-223             JAXUCZ010000015.1  39095094-39095156
            224-1191            JAXUCZ010000015.1  39098123-39099090
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1191
                     /gene="C1qtnf9"
                     /gene_synonym="Adif1; Ctrp9; RGD1560876"
                     /note="C1q and TNF related 9"
                     /db_xref="GeneID:364395"
                     /db_xref="RGD:1560876"
     CDS             1..996
                     /gene="C1qtnf9"
                     /gene_synonym="Adif1; Ctrp9; RGD1560876"
                     /note="C1q and tumor necrosis factor related protein 9;
                     adiponectin f1"
                     /codon_start=1
                     /product="C1q and TNF related 9 precursor"
                     /protein_id="NP_001178820.1"
                     /db_xref="GeneID:364395"
                     /db_xref="RGD:1560876"
                     /translation="MRIWWLLLVMDAGSVFSQDTCRQGHSGIPGTPGHNGLPGRDGRD
                     GAKGDKGDTGEPGHPGGPGKDGIRGEKGEPGADGRVEAKGIKGDPGSRGSPGKHGPKG
                     SIGPTGEQGLPGETGPQGQKGDKGEVGPTGPEGLMGSTGPLGPKGLPGPVGPIGKPGP
                     RGEAGPMGPQGEPGVRGMRGWKGDRGEKGKVGEAPMVPKSAFTVGLTVISKFPPPDVP
                     IKFDKILYNEQNHYNVATGKFTCHVAGVYYFTYHITVFSRNVQVSLVKNGVKVLHTKD
                     GYMSSEDQASGGIVLELKLGDEVWMQVTGGERFNGLFADEDDDTTFTGFLLFSSS"
     exon            1..160
                     /gene="C1qtnf9"
                     /gene_synonym="Adif1; Ctrp9; RGD1560876"
                     /inference="alignment:Splign:2.1.0"
     exon            161..223
                     /gene="C1qtnf9"
                     /gene_synonym="Adif1; Ctrp9; RGD1560876"
                     /inference="alignment:Splign:2.1.0"
     exon            224..1191
                     /gene="C1qtnf9"
                     /gene_synonym="Adif1; Ctrp9; RGD1560876"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggattt ggtggcttct actggttatg gacgcaggga gcgtattctc ccaggacacc
       61 tgccggcaag ggcactctgg catccctggg actccaggtc acaatggcct acccggaaga
      121 gacggacgag acggtgccaa gggtgacaaa ggagacacag gagaaccagg acatcccggt
      181 gggccgggga aggatggaat tcgtggagag aaaggagagc caggagcaga tggaagagtt
      241 gaagcaaaag gcatcaaagg tgatccaggc tccagaggat ctccagggaa acatggccca
      301 aagggatcca ttggtcctac aggagagcaa ggactaccgg gagagactgg ccctcagggg
      361 cagaaggggg ataaaggcga ggtgggcccc actggaccgg aaggactaat gggcagtacc
      421 gggcctttgg gtcccaaggg cttacctggc ccagtgggcc ctattggcaa accaggtccc
      481 aggggagaag ctggacccat gggcccccag ggggagccag gagtcagggg aatgagaggc
      541 tggaaaggcg atcgaggaga gaaggggaaa gttggtgagg ctcccatggt gcccaagagt
      601 gctttcactg tggggctcac ggtgatcagt aagttccctc ccccagatgt gcccattaaa
      661 ttcgataaga tcctatacaa tgaacagaac cattacaatg tagcgacggg aaaattcacc
      721 tgccacgtgg cgggcgtcta ttactttacc taccacatca ccgtgttctc caggaacgtg
      781 caggtatctt tggtcaaaaa tggggtaaaa gtcctgcata ccaaggacgg ttacatgagc
      841 tctgaggacc aggcgtctgg tggcatcgtg ctggaactga agcttgggga cgaagtgtgg
      901 atgcaggtga caggaggaga gaggttcaat ggcttatttg cagatgagga tgacgatacc
      961 acattcacgg gcttccttct gttcagcagc tcttgacaca aaggactctg cacgtgggcc
     1021 tcatggaggg ctctgctggt gaatgtggtg cccacagaac cagcttggtg agggtaggat
     1081 gtgactacat ccattcctcc agttattgca tcgattctaa agtgtacaca cgacaagtta
     1141 atcccgcaga ttccgtcatt tgaacccgtg aataataaac taagactcac c
//
