LOCUS       NM_001034932            2359 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Rattus norvegicus C1q and TNF related 6 (C1qtnf6), mRNA.
ACCESSION   NM_001034932 XM_235470
VERSION     NM_001034932.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2359)
  AUTHORS   Li,G., Ma,X., Zhao,H., Fan,J., Liu,T., Luo,Y. and Guo,Y.
  TITLE     Long non-coding RNA H19 promotes leukocyte inflammation in ischemic
            stroke by targeting the miR-29b/C1QTNF6 axis
  JOURNAL   CNS Neurosci Ther 28 (6), 953-963 (2022)
   PUBMED   35322553
REFERENCE   2  (bases 1 to 2359)
  AUTHORS   Li,Y., Sun,J., Gu,L. and Gao,X.
  TITLE     Protective effect of CTRP6 on cerebral ischemia/reperfusion injury
            by attenuating inflammation, oxidative stress and apoptosis in PC12
            cells
  JOURNAL   Mol Med Rep 22 (1), 344-352 (2020)
   PUBMED   32377750
  REMARK    GeneRIF: Protective effect of CTRP6 on cerebral
            ischemia/reperfusion injury by attenuating inflammation, oxidative
            stress and apoptosis in PC12 cells.
REFERENCE   3  (bases 1 to 2359)
  AUTHORS   Chi,L., Hu,X., Zhang,W., Bai,T., Zhang,L., Zeng,H., Guo,R.,
            Zhang,Y. and Tian,H.
  TITLE     Adipokine CTRP6 improves PPARgamma activation to alleviate
            angiotensin II-induced hypertension and vascular endothelial
            dysfunction in spontaneously hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 482 (4), 727-734 (2017)
   PUBMED   27871858
  REMARK    GeneRIF: CTRP6 improves PPARgamma activation and alleviates
            AngII-induced hypertension and vascular endothelial dysfunction
REFERENCE   4  (bases 1 to 2359)
  AUTHORS   Li,R., Yang,X., Yu,Y., Zhou,M., Tian,X., Feng,S. and Wang,H.
  TITLE     [C1q/tumor necrosis factor related protein 6 (CTRP6) is involved in
            gentamicin-induced acute kidney injury in rats]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 32 (11), 1458-1461 (2016)
   PUBMED   27774934
  REMARK    GeneRIF: C1q/tumor necrosis factor related protein 6 (CTRP6) is
            involved in gentamicin-induced acute kidney injury in rats
REFERENCE   5  (bases 1 to 2359)
  AUTHORS   Lei,H., Wu,D., Wang,J.Y., Li,L., Zhang,C.L., Feng,H., Fu,F.Y. and
            Wu,L.L.
  TITLE     C1q/tumor necrosis factor-related protein-6 attenuates post-infarct
            cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting
            myofibroblast differentiation
  JOURNAL   Basic Res Cardiol 110 (4), 35 (2015)
   PUBMED   25962701
REFERENCE   6  (bases 1 to 2359)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC101907.1.
            
            On Oct 21, 2005 this sequence version replaced XM_235470.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC101907.1, EV780829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2359
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2359
                     /gene="C1qtnf6"
                     /gene_synonym="Adiq; Ctrp6"
                     /note="C1q and TNF related 6"
                     /db_xref="GeneID:315114"
                     /db_xref="RGD:1307057"
     exon            1..68
                     /gene="C1qtnf6"
                     /gene_synonym="Adiq; Ctrp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..854
                     /gene="C1qtnf6"
                     /gene_synonym="Adiq; Ctrp6"
                     /note="complement C1q tumor necrosis factor-related
                     protein 6; C1q and tumor necrosis factor related protein
                     6; adiponectin q"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 6 precursor"
                     /protein_id="NP_001030104.1"
                     /db_xref="GeneID:315114"
                     /db_xref="RGD:1307057"
                     /translation="MRVIMGTASLGSIWAVFLLPLVFGVPTEEPTFGESVASHLPKNC
                     QRCCDPEDPLSPADTVNAVPPYVLPEVRPYINITILKGDKGDRGPSGTPGKPGKNGTR
                     GDRGSQGIKGDKGQAGSPGSSCQTHYSAFSVGRKTGLHSSENFLSLLFDRVFVNTDGH
                     FDMATGRFVAPLRGLYFFSLNVHSWNYKETYVHIVHNEQAVVILYAQPSERSIMQSQS
                     VMLPLVPGDYVWVRLFKRERENGIYSDDMDTYITFSGHLIKAEDN"
     exon            69..306
                     /gene="C1qtnf6"
                     /gene_synonym="Adiq; Ctrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            307..2310
                     /gene="C1qtnf6"
                     /gene_synonym="Adiq; Ctrp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacatggg ccaaggagcc agaggccgtt cggggtctgt gagttgagct tgaggctgca
       61 ggatgagggt catcatgggg acagccagcc tggggtccat ctgggcagta ttccttcttc
      121 ctcttgtgtt tggggtcccc acagaagagc ctacctttgg ggagtctgtg gcctcccatc
      181 tccccaaaaa ctgtcaacga tgttgtgacc ctgaggaccc actgtcccct gctgacacgg
      241 tcaatgctgt tcccccctat gtcctgcccg aggtcaggcc gtacatcaac atcaccatcc
      301 tgaaaggtga caaaggggac agaggtcctt caggaacgcc agggaagcca ggcaagaatg
      361 gtacccgagg ggaccgtggc tctcagggta tcaaaggtga caaggggcag gcaggtagcc
      421 ctggcagctc gtgccagacg cattactcgg ccttctctgt gggccgcaag acgggcttgc
      481 acagcagcga gaacttcctc tcactgctgt tcgacagggt cttcgtgaac acggacggcc
      541 acttcgacat ggccactggc cgcttcgtgg ctcccctgcg aggcctctac ttcttcagcc
      601 tcaatgtgca cagctggaat tacaaggaga cctacgtgca catagtccac aacgagcagg
      661 cggtcgtgat tctgtatgca cagcccagcg aacgcagcat catgcagagt cagagcgtga
      721 tgctgcccct ggtgccaggt gactacgtgt gggtgcggct cttcaagcgg gagcgggaga
      781 atggcatcta cagcgatgac atggacacgt acatcacctt cagcggccac ctgatcaagg
      841 cagaggacaa ctgagcttcc ccggccgcct tcacagctgg gtggctggtg gctagggcag
      901 gtcctgtagg tcctagggct cggtctgctg ccctccattc cttgtctcca ctgtaatctg
      961 tccccatccc ctcccctgtt ggcttcattt ccccatactt ttgggctcac ttattccaga
     1021 ctttgccagc ctctagagtg gctctcctga cactccacca tgctatttgt ccccgtggac
     1081 tttgttatat gatggattct ggcttctcat tctagaccca ggattctgca tttctagcga
     1141 tttcttctgg aatactgttg ctactggttg atggatcaca cttgaggaat tgtgctccct
     1201 agaatgttcc cagcatttct agggacttca cgaacactct ggaattcccc ccaaactcta
     1261 ttcttcccca tatcctcctc cccctgggct tcacccacct ctgacctttc acctccccgc
     1321 cattttccag acgctgttca tttgtgaatt catcaaatgc cgaacgctca cttggtctca
     1381 ggccttagga aggcccagaa gtgggtacta agacttgagc atatactggg tgctcctcta
     1441 aactgggttt ttaggcactg tgggcccttc tccactgctt ccatggtgcc atagatcctg
     1501 gagatgggga tgatgtccct tttccactcc ctgcattctt gtccagtacc cagcattaat
     1561 gcaaatataa gaatagtctt ggctgggagg agacccaggg gtttggatgc acctagacga
     1621 aggggcatct gggaactgga gctgttctct tatctgacct ttgaaggctc ctgcccttcc
     1681 tctttcccca ttctccagga cattagccac ggtcagacca tgtaccagtg ctctctggcc
     1741 ctcctggctt ctcaaaggcc caggctcaca ctgggtttat gaaggtgctt aagcgcccac
     1801 ccgtccccct ggaggcggct cccatttcag agcttctcct gcctgtattg cccttgtaga
     1861 catcgtgggc aagtcaggca ggatagaggt ggcaggtttc agcccaaagc aggtctgggg
     1921 tctgaagcca gtgacattca ggttacccgg gggtcttctc tgagccatgc tgccaagaca
     1981 ggccctgggg gaggttgtag aaaagcaagg ggcaccaaga cccccatgcc tttctcaggg
     2041 tgtgtggcct ggtgaccctc caaccttccc ctcttccact gtagcctgcc cgagcttctc
     2101 aggggaaggt ggcctccgtc cattggtgct tctgcagatc tagggcaggg ctggccctag
     2161 gagggtatct ctggtgctta cagccaaggg agccgtggca aggtgacaga agccatgtgc
     2221 tgtgatggct ggttccataa aaccatcctc agcccaactg tccttgcctg cttggccagt
     2281 gtgaataaag atattggatt ctcttggcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaa
//
