LOCUS       NM_001012123            1364 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus C1q and TNF related 5 (C1qtnf5), mRNA.
ACCESSION   NM_001012123 XM_236180
VERSION     NM_001012123.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Yang,W.M. and Lee,W.
  TITLE     CTRP5 ameliorates palmitate-induced apoptosis and insulin
            resistance through activation of AMPK and fatty acid oxidation
  JOURNAL   Biochem Biophys Res Commun 452 (3), 715-721 (2014)
   PUBMED   25195818
  REMARK    GeneRIF: CTRP5 ameliorates palmitate-induced apoptosis and insulin
            resistance through activation of AMPK and fatty acid oxidation.
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Park,S.Y., Choi,J.H., Ryu,H.S., Pak,Y.K., Park,K.S., Lee,H.K. and
            Lee,W.
  TITLE     C1q tumor necrosis factor alpha-related protein isoform 5 is
            increased in mitochondrial DNA-depleted myocytes and activates
            AMP-activated protein kinase
  JOURNAL   J Biol Chem 284 (41), 27780-27789 (2009)
   PUBMED   19651784
  REMARK    GeneRIF: These results highlight C1QTNF5 as a putative biomarker
            for mitochondrial dysfunction and a potent activator of AMPK.
REFERENCE   4  (bases 1 to 1364)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   5  (bases 1 to 1364)
  AUTHORS   Mandal,M.N., Vasireddy,V., Reddy,G.B., Wang,X., Moroi,S.E.,
            Pattnaik,B.R., Hughes,B.A., Heckenlively,J.R., Hitchcock,P.F.,
            Jablonski,M.M. and Ayyagari,R.
  TITLE     CTRP5 is a membrane-associated and secretory protein in the RPE and
            ciliary body and the S163R mutation of CTRP5 impairs its secretion
  JOURNAL   Invest Ophthalmol Vis Sci 47 (12), 5505-5513 (2006)
   PUBMED   17122142
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089992.1.
            
            On Feb 11, 2005 this sequence version replaced XM_236180.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089992.1, CO404596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1364
                     /gene="C1qtnf5"
                     /gene_synonym="Adie"
                     /note="C1q and TNF related 5"
                     /db_xref="GeneID:315598"
                     /db_xref="RGD:1308802"
     exon            1..179
                     /gene="C1qtnf5"
                     /gene_synonym="Adie"
                     /inference="alignment:Splign:2.1.0"
     exon            180..445
                     /gene="C1qtnf5"
                     /gene_synonym="Adie"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..963
                     /gene="C1qtnf5"
                     /gene_synonym="Adie"
                     /note="complement C1q tumor necrosis factor-related
                     protein 5; C1q and tumor necrosis factor related protein
                     5; adiponectin e"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 5 precursor"
                     /protein_id="NP_001012123.1"
                     /db_xref="GeneID:315598"
                     /db_xref="RGD:1308802"
                     /translation="MRPLLALLLLGLASGSPPLDDNKIPSLCPGQPGLPGTPGHHGSQ
                     GLPGRDGRDGRDGAPGAPGEKGEGGRPGLPGPRGEPGPRGEAGPVGAIGPAGECSVPP
                     RSAFSAKRSESRVPPPADTPLPFDRVLLNEQGHYDATTGKFTCQVPGVYYFAVHATVY
                     RASLQFDLVKNGQSIASFFQFFGGWPKPASLSGGAMVRLEPEDQVWVQVGVGDYIGIY
                     ASIKTDSTFSGFLVYSDWHSSPVFA"
     exon            446..1335
                     /gene="C1qtnf5"
                     /gene_synonym="Adie"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtttcct ctaggagtct gggaggagtg ctgtggagca agaagcaacc cgaagctagg
       61 agtctgtcag cgagggcagg ggctgcctgg ttggggtagg agtgggagca gggccagcag
      121 gagggtctga ggaagccatt caaagcgagc agctgggaga gctggggagc cgggaagggc
      181 ctacagacta caagagagga tcctggcgtc tgggcctcct gggtcatcac catgaggcca
      241 cttcttgccc tgctgcttct gggtctggca tcaggctctc ctcctctgga cgacaacaag
      301 atccccagcc tgtgtcccgg gcagcccggc ctcccaggca caccaggcca ccacggcagc
      361 caaggcctgc ctggccgtga cggccgtgat ggccgcgacg gtgcacccgg agctccggga
      421 gagaaaggcg agggcgggag accgggacta cctgggccac gtggggagcc cgggccgcgt
      481 ggagaggcag gacctgtggg ggctatcggg cctgcggggg agtgctcggt gcccccacga
      541 tcagccttca gtgccaagcg atcagagagc cgggtacctc cgccagccga cacaccccta
      601 cccttcgacc gtgtgctgct caatgagcag ggacattacg atgccactac cggcaagttc
      661 acctgccaag tgcctggtgt ctactacttt gctgtccatg ccactgtcta ccgggccagc
      721 ctacagtttg atcttgtcaa aaatggccaa tccatagctt ctttcttcca gttttttggg
      781 gggtggccaa agccagcctc gctctcaggg ggtgcgatgg tgaggctaga acctgaggac
      841 caggtatggg ttcaggtggg tgtgggtgat tacattggca tctatgccag catcaaaaca
      901 gacagtacct tctctggatt tctcgtctat tctgactggc acagctcccc agtcttcgct
      961 taaaatacag tgaacccgga gctggcactt gctcctagtg gagggtgtga cactgaccag
     1021 cgcgcatacc aggagggctg gccccctgga ctattgtgaa tgactaagaa gagagggagc
     1081 cacctctggt ccccctcctg gcaatgaata gtcagaggct gtctgaggtc aggacagaca
     1141 gcgtggagca gttgctgggt ttctgcccag gactttagaa tgcagcaggc tggcagctgt
     1201 ggaatcctgg ctcaggactc caagatggga tgctcccttc ctagtcctgt gcccctctag
     1261 gtctttgact ccatctctcc tgctcccaag gcaggccttt ttctcagagg tcacttaata
     1321 aacctacaat cctccaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
