LOCUS       NM_001107745            1348 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus C1q and TNF related 4 (C1qtnf4), mRNA.
ACCESSION   NM_001107745 XM_001077863 XM_230306
VERSION     NM_001107745.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Duan L, Liu Z, Wang L, Ma B, Fan Y, Xu Y and Guo F.
  TITLE     [C1q and tumor necrosis factor related protein 4 (CTRP4) suppresses
            caspase-1/IL-1beta inflammatory pathway in trophoblasts of rat
            models with preeclampsia]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 32 (11), 1441-1445 (2016)
   PUBMED   27774931
  REMARK    GeneRIF: CTRP4 can significantly inhibit the activation of
            caspase-1/IL-1beta inflammatory pathway, and suppress the
            pyroptosis of trophoblasts derived from rats with preeclampsia.
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E,
            Wei Z, Ronnett GV and Wong GW.
  TITLE     C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with
            two tandem C1q domains that functions in the hypothalamus to
            modulate food intake and body weight
  JOURNAL   J Biol Chem 289 (7), 4055-4069 (2014)
   PUBMED   24366864
  REMARK    GeneRIF: These results establish CTRP4 as a novel
            nutrient-responsive central regulator of food intake and energy
            balance.
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Li Q, Wang L, Tan W, Peng Z, Luo Y, Zhang Y, Zhang G, Na D, Jin P,
            Shi T, Ma D and Wang L.
  TITLE     Identification of C1qTNF-related protein 4 as a potential cytokine
            that stimulates the STAT3 and NF-kappaB pathways and promotes cell
            survival in human cancer cells
  JOURNAL   Cancer Lett 308 (2), 203-214 (2011)
   PUBMED   21658842
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230306.4, XM_001077863.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB760854.1, BC168928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1348
                     /gene="C1qtnf4"
                     /note="C1q and TNF related 4"
                     /db_xref="GeneID:311184"
                     /db_xref="RGD:1311006"
     exon            1..208
                     /gene="C1qtnf4"
                     /inference="alignment:Splign:2.1.0"
     exon            209..1348
                     /gene="C1qtnf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1194
                     /gene="C1qtnf4"
                     /note="complement C1q tumor necrosis factor-related
                     protein 4; C1q and tumor necrosis factor related protein
                     4"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 4 precursor"
                     /protein_id="NP_001101215.1"
                     /db_xref="GeneID:311184"
                     /db_xref="RGD:1311006"
                     /translation="MLLLLLGFLGPVACWALGRAGPGSSELRSAFSAARTTPLEGTSE
                     MAVTFDKVYVNIGGDFDAATGRFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQA
                     LAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGATFSGYLVYADAD
                     ADAPARGPAALEPRSAFSAARTRSLVGSDAGPGPRHRPLAFDTELVNIGGDFDAAAGV
                     FRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVMLPL
                     QRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLTAASPPALKPPEL"
ORIGIN      
        1 cccttgcgct tctccgcttc agcttctgct gtccttccca ctcgctcacg cctcccttgc
       61 cggggtcccc actcgtcgcc ggctgagccc cccgccaccc ccggaggcct ggtcaagccg
      121 cagcgtgggc gaccagtgtg cagcccggcg tcctcaccga gcaggatcgc cggctgggac
      181 cgaagccgac ccgccggccg ccagccaggt gccatgctgc tcctcctgct cggcttccta
      241 ggcccggtgg cctgctgggc actgggccgg gctgggcctg gctcctcgga gctgcggtca
      301 gccttctcgg cggctcgcac caccccactg gagggcacgt cggagatggc ggtgaccttc
      361 gacaaggtat acgtgaacat cggaggtgac ttcgacgcag ccaccgggag gttccgctgt
      421 cgcgtgcccg gcgcctattt cttctccttc acagcgggca aggccccgca taagagcctg
      481 tcggtgatgc tggtgcgcaa ccgcgacgag gtgcaggcgc tggccttcga cgagcagcgg
      541 cggccgggcg cacggcgcgc cgccagccag agtgccatgc tgcagctcga ctacggcgac
      601 acggtgtggc tgcggctgca cggcgccccg cagtacgcgc tcggcgcgcc cggcgccacc
      661 tttagcggct acctggtgta cgcggacgcc gatgctgacg cgcctgcgcg cggccccgca
      721 gccctggagc cgcgctcggc cttctccgcg gcgcgcacgc gcagcctggt gggctcggac
      781 gcgggacccg gaccgcgcca ccggccgctg gccttcgaca ccgagctggt aaacataggc
      841 ggcgacttcg acgcggcggc cggcgtgttc cgctgccgcc taccgggagc ctatttcttc
      901 tccttcacgc tgggcaagct gccgcgcaag acgctgtcgg tgaagctgat gaagaaccgc
      961 gacgaggtgc aggccatgat ttacgacgat ggcgcttcga ggcgccgtga gatgcagagt
     1021 cagagcgtga tgctgccact gcagcgtggc gatgccgtct ggctgcttag ccacgatcat
     1081 gatggctatg gcgcctacag caaccacggc aagtacatca ctttctctgg cttcctggtg
     1141 taccctgacc tcactgctgc ctccccgccg gccctcaagc ccccagagct ctgagcctct
     1201 gcttggagga gcctgggaga gccgtggggc atgcatgccg agccgggacc gcggcccgaa
     1261 cgccccaccg gccggagcat gactacctgc ccagcacgcc tggactctac caataaagtg
     1321 gggctgcctg tcagccttat ggtcctgc
//
