LOCUS       NM_001134436            1950 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus C1q and TNF related 3 (C1qtnf3), mRNA.
ACCESSION   NM_001134436 XM_001059843 XM_226833
VERSION     NM_001134436.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1950)
  AUTHORS   Liu,Y., Wu,P., Xu,X., Shen,T., Wang,X., Liu,Y., Yuan,C., Wang,T.,
            Zhou,L. and Liu,A.
  TITLE     C1q/TNF-related protein 3 alleviates heart failure via attenuation
            of oxidative stress in myocardial infarction rats
  JOURNAL   Peptides 163, 170980 (2023)
   PUBMED   36842629
  REMARK    GeneRIF: C1q/TNF-related protein 3 alleviates heart failure via
            attenuation of oxidative stress in myocardial infarction rats.
REFERENCE   2  (bases 1 to 1950)
  AUTHORS   Zhang,J., Lin,X., Xu,J., Tang,F. and Tan,L.
  TITLE     CTRP3 protects against uric acid-induced endothelial injury by
            inhibiting inflammation and oxidase stress in rats
  JOURNAL   Exp Biol Med (Maywood) 247 (2), 174-183 (2022)
   PUBMED   34601891
  REMARK    GeneRIF: CTRP3 protects against uric acid-induced endothelial
            injury by inhibiting inflammation and oxidase stress in rats.
            Erratum:[Exp Biol Med (Maywood). 2023 Dec;248(23):2492. doi:
            10.1177/15353702231223093. PMID: 38205625]
REFERENCE   3  (bases 1 to 1950)
  AUTHORS   Zhang,J., Xu,J., Lin,X., Tang,F. and Tan,L.
  TITLE     CTRP3 ameliorates fructose-induced metabolic associated fatty liver
            disease via inhibition of xanthine oxidase-associated oxidative
            stress
  JOURNAL   Tissue Cell 72, 101595 (2021)
   PUBMED   34303283
  REMARK    GeneRIF: CTRP3 ameliorates fructose-induced metabolic associated
            fatty liver disease via inhibition of xanthine oxidase-associated
            oxidative stress.
REFERENCE   4  (bases 1 to 1950)
  AUTHORS   Zhang,B., Zhang,P., Tan,Y., Feng,P., Zhang,Z., Liang,H., Duan,W.,
            Jin,Z., Wang,X., Liu,J., Gao,E., Yu,S., Yi,D., Sun,Y. and Yi,W.
  TITLE     C1q-TNF-related protein-3 attenuates pressure overload-induced
            cardiac hypertrophy by suppressing the p38/CREB pathway and
            p38-induced ER stress
  JOURNAL   Cell Death Dis 10 (7), 520 (2019)
   PUBMED   31285424
  REMARK    GeneRIF: CTRP3 protects the host against pathological cardiac
            remodeling and left ventricular dysfunction induced by pressure
            overload largely by inhibiting the p38/CREB pathway and alleviating
            p38-induced endoplasmic reticulum stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1950)
  AUTHORS   Ma,Z.G., Yuan,Y.P., Xu,S.C., Wei,W.Y., Xu,C.R., Zhang,X., Wu,Q.Q.,
            Liao,H.H., Ni,J. and Tang,Q.Z.
  TITLE     CTRP3 attenuates cardiac dysfunction, inflammation, oxidative
            stress and cell death in diabetic cardiomyopathy in rats
  JOURNAL   Diabetologia 60 (6), 1126-1137 (2017)
   PUBMED   28258411
  REMARK    GeneRIF: CTRP3 attenuates cardiac dysfunction, inflammation,
            oxidative stress and cell death in diabetic cardiomyopathy in rats
REFERENCE   6  (bases 1 to 1950)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
REFERENCE   7  (bases 1 to 1950)
  AUTHORS   Wolfing,B., Buechler,C., Weigert,J., Neumeier,M., Aslanidis,C.,
            Schoelmerich,J. and Schaffler,A.
  TITLE     Effects of the new C1q/TNF-related protein (CTRP-3) 'cartonectin'
            on the adipocytic secretion of adipokines
  JOURNAL   Obesity (Silver Spring) 16 (7), 1481-1486 (2008)
   PUBMED   18421280
REFERENCE   8  (bases 1 to 1950)
  AUTHORS   Schaffler,A., Weigert,J., Neumeier,M., Scholmerich,J. and
            Buechler,C.
  TITLE     Regulation and function of collagenous repeat containing sequence
            of 26-kDa protein gene product 'cartonectin'
  JOURNAL   Obesity (Silver Spring) 15 (2), 303-313 (2007)
   PUBMED   17299102
REFERENCE   9  (bases 1 to 1950)
  AUTHORS   Weigert,J., Neumeier,M., Schaffler,A., Fleck,M., Scholmerich,J.,
            Schutz,C. and Buechler,C.
  TITLE     The adiponectin paralog CORS-26 has anti-inflammatory properties
            and is produced by human monocytic cells
  JOURNAL   FEBS Lett 579 (25), 5565-5570 (2005)
   PUBMED   16213490
REFERENCE   10 (bases 1 to 1950)
  AUTHORS   Maeda,T., Abe,M., Kurisu,K., Jikko,A. and Furukawa,S.
  TITLE     Molecular cloning and characterization of a novel gene, CORS26,
            encoding a putative secretory protein and its possible involvement
            in skeletal development
  JOURNAL   J Biol Chem 276 (5), 3628-3634 (2001)
   PUBMED   11071891
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162048.1.
            
            On or before Aug 29, 2008 this sequence version replaced
            XM_001059843.1, XM_226833.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1950
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1950
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /note="C1q and TNF related 3"
                     /db_xref="GeneID:294806"
                     /db_xref="RGD:1305010"
     exon            1..369
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1026
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /EC_number="5.1.99.4"
                     /note="complement C1q tumor necrosis factor-related
                     protein 3; C1q and tumor necrosis factor related protein
                     3; adiponectin m"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 3 precursor"
                     /protein_id="NP_001127908.1"
                     /db_xref="GeneID:294806"
                     /db_xref="RGD:1305010"
                     /translation="MLRRQLVWWHLLALLFLPFCLCQDEYMEVSRRANKAVARIVQSH
                     QQTGRSGSRREKVREQSHAKTGTVDNNTSTDLKSLRPDELPHPEVEDLAQINPFWGQS
                     PQAGGLPPDCSKCCHGDYGFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKG
                     DKGDLGPRGERGQHGPKGEKGYPGVPPELQIAFMASLATHFSNQNSGIIFSSVETNIG
                     NFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYETKGKSDT
                     SSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK"
     exon            370..481
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /inference="alignment:Splign:2.1.0"
     exon            482..636
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /inference="alignment:Splign:2.1.0"
     exon            637..766
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /inference="alignment:Splign:2.1.0"
     exon            767..866
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1926
                     /gene="C1qtnf3"
                     /gene_synonym="Adim"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtgccgg gtgcctacag cccccatcag cttccccggg gagattctgc cgatttgtca
       61 cgagccatgc tcaggaggca gctcgtctgg tggcacctgc tggctttgct tttcctccca
      121 ttttgcctgt gtcaagatga atacatggag gtgagcagaa gagctaataa agcggtggcc
      181 aggatagtcc agagccacca gcagactggc cgtagcggct ccaggaggga gaaagtgaga
      241 gagcagagcc atgctaaaac ggggactgtg gataataaca cttctacaga cctaaaatcc
      301 ctgagaccag atgagcttcc gcaccctgag gtagaggacc tagcccagat caacccattc
      361 tggggccagt ctccacaagc tggaggactg cccccagact gcagcaagtg ttgccatgga
      421 gattatggat tccgtggtta ccaagggccc cctggacccc caggtcctcc tggcattcca
      481 ggaaaccatg gaaacaatgg aaataacgga gccactggcc acgaaggggc caagggtgag
      541 aaaggagaca aaggcgacct ggggcctcga ggggaacggg ggcagcatgg ccccaaagga
      601 gagaagggat acccaggggt gccaccagag ctgcagattg cgttcatggc ttctctagcg
      661 actcacttca gcaatcagaa cagtggcatt atcttcagca gtgttgagac caacattgga
      721 aacttcttcg atgtcatgac tggtagattt ggggcccccg tatcaggcgt gtatttcttc
      781 accttcagca tgatgaagca tgaggacgtg gaggaagtgt atgtgtacct tatgcacaat
      841 ggtaacacgg tgttcagcat gtacagctat gaaacaaagg gaaaatcaga tacatccagc
      901 aaccatgcag tgctgaagtt ggccaaagga gatgaagtct ggctaagaat gggcaacggt
      961 gccctccatg gggaccacca gcgcttctct accttcgcag gctttctgct ttttgaaact
     1021 aagtgatgag gaagtcagga tagctccatg ctaagggcga tttgtaggtg agctagggtt
     1081 gttaggatct gaggggtgtt ggagttgggc ttctctatgg agtatttaac tgttacattg
     1141 gtcacactgc tactcattct aatggcatac caattatgtt ggatacttta ggggctagga
     1201 agaatagacc acaaggtaat attcccagac gactttggga aatactcagc atttttgtta
     1261 ctctttacat ctaaagggat cgccacctga tacaggttgg aaataagcgt tcacctcaaa
     1321 gaatgcattt gcaaagagtt ttggtgctct gtttaaatgt agtggtggct ctggagtcag
     1381 ccaagtttga gctcactgtt cttcaaaata tttcagagac tagcctgact gggacagggc
     1441 tagggcaaga ataagagtac ttacttacat aggagagaca cttctgaagt ctagactggg
     1501 aaatagcatt tgcttttgtg ggttttattc ttatattcat taataaaata catctagtca
     1561 tttcagagaa cctttaaata gtacaattgt ttacagtgct cagaaataat tggctcctct
     1621 tttaaaaaac aaacaaataa aaaaatccca tgtagataat attgagctct actggcttag
     1681 actttcagat aaaaattttt ctcaacattt ggcttgccac accttctctt tgccattgca
     1741 ttactggggc tgtggtagag ctctcttgac tctgcacaac ctgttgaggt aagattaagt
     1801 tgatatagta tagatgttat cacttttttt taaatttggg aattatcccc aaagttttta
     1861 tatacaccat gttatgttga atgggctgta aacttattaa atactggcag acaaatggat
     1921 acaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
