LOCUS       NM_001008524            1066 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus complement C1q C chain (C1qc), mRNA.
ACCESSION   NM_001008524 XM_342951
VERSION     NM_001008524.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1066)
  AUTHORS   Hong,S., Beja-Glasser,V.F., Nfonoyim,B.M., Frouin,A., Li,S.,
            Ramakrishnan,S., Merry,K.M., Shi,Q., Rosenthal,A., Barres,B.A.,
            Lemere,C.A., Selkoe,D.J. and Stevens,B.
  TITLE     Complement and microglia mediate early synapse loss in Alzheimer
            mouse models
  JOURNAL   Science 352 (6286), 712-716 (2016)
   PUBMED   27033548
REFERENCE   2  (bases 1 to 1066)
  AUTHORS   Feng,X.B., Ke,J.J., Rao,Y., Zhang,Z.Z. and Wang,Y.L.
  TITLE     Effect of complement C1q expression on hepatic ischemia-reperfusion
            injury in rats
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 34 (3), 403-407 (2014)
   PUBMED   24939307
  REMARK    GeneRIF: Data suggest that complement C1q expression may play a
            principal role in hepatic ischemia-reperfusion (I/R) injury,
            particularly at the early stage of perfusion.
REFERENCE   3  (bases 1 to 1066)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 1066)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 1066)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   6  (bases 1 to 1066)
  AUTHORS   Stevens,B., Allen,N.J., Vazquez,L.E., Howell,G.R.,
            Christopherson,K.S., Nouri,N., Micheva,K.D., Mehalow,A.K.,
            Huberman,A.D., Stafford,B., Sher,A., Litke,A.M., Lambris,J.D.,
            Smith,S.J., John,S.W. and Barres,B.A.
  TITLE     The classical complement cascade mediates CNS synapse elimination
  JOURNAL   Cell 131 (6), 1164-1178 (2007)
   PUBMED   18083105
REFERENCE   7  (bases 1 to 1066)
  AUTHORS   Yokota,T., Oritani,K., Takahashi,I., Ishikawa,J., Matsuyama,A.,
            Ouchi,N., Kihara,S., Funahashi,T., Tenner,A.J., Tomiyama,Y. and
            Matsuzawa,Y.
  TITLE     Adiponectin, a new member of the family of soluble defense
            collagens, negatively regulates the growth of myelomonocytic
            progenitors and the functions of macrophages
  JOURNAL   Blood 96 (5), 1723-1732 (2000)
   PUBMED   10961870
REFERENCE   8  (bases 1 to 1066)
  AUTHORS   Wing,M.G., Seilly,D.J., Bridgman,D.J. and Harrison,R.A.
  TITLE     Rapid isolation and biochemical characterization of rat C1 and C1q
  JOURNAL   Mol Immunol 30 (5), 433-440 (1993)
   PUBMED   8464426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Mar 12, 2021 this sequence version replaced NM_001008524.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228978.1, DV215111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840113, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000005.1  154414160-154414208 c
            50-231              JAXUCZ010000005.1  154413704-154413885 c
            232-1066            JAXUCZ010000005.1  154410845-154411679 c
FEATURES             Location/Qualifiers
     source          1..1066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1066
                     /gene="C1qc"
                     /gene_synonym="Adib; C1qg"
                     /note="complement C1q C chain"
                     /db_xref="GeneID:362634"
                     /db_xref="RGD:1306828"
     exon            1..49
                     /gene="C1qc"
                     /gene_synonym="Adib; C1qg"
                     /inference="alignment:Splign:2.1.0"
     exon            50..231
                     /gene="C1qc"
                     /gene_synonym="Adib; C1qg"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..788
                     /gene="C1qc"
                     /gene_synonym="Adib; C1qg"
                     /note="complement C1q subcomponent subunit C; complement
                     component 1, q subcomponent, gamma polypeptide;
                     adiponectin b; complement component 1, q subcomponent, C
                     chain"
                     /codon_start=1
                     /product="complement C1q subcomponent subunit C precursor"
                     /protein_id="NP_001008524.1"
                     /db_xref="GeneID:362634"
                     /db_xref="RGD:1306828"
                     /translation="MVVGTSCQPQHGLYLLLLLLALPLRSQANAGCYGIPGMPGLPGT
                     PGKDGHDGLQGPKGEPGIPAIPGTQGPKGQKGEPGMPGHRGKNGPMGTSGSPGDPGPR
                     GPPGEPGEEGRYKQKHQSVFTVTRQTAQYPAANGLVKFNSAITNPQGDYNTNTGKFTC
                     KVPGLYYFVHHTSQTANLCVQLLLNNAKVTSFCDHMSNSKQVSSGGVLLRLQRGDEVW
                     LAVNDYNGMVGTEGSDSVFSGFLLFPD"
     exon            232..1066
                     /gene="C1qc"
                     /gene_synonym="Adib; C1qg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaacagga cgtctctctg attaggcctg aagtccccta catgctcagg atggttgtag
       61 gaaccagctg ccagccccag catggactct acctgctgct gctccttctg gccctacccc
      121 tcaggagcca ggccaacgct ggctgctatg ggatcccagg gatgccaggc ctgccgggaa
      181 cccctgggaa ggatgggcat gatggacttc aggggcccaa gggtgagccg ggaatcccag
      241 ccatccctgg gacacaagga cccaagggtc agaagggcga gccgggtatg cctggccatc
      301 gtgggaaaaa cggccccatg gggacctctg ggtcgccagg ggatccaggc cccaggggtc
      361 ctcccgggga gccgggtgag gagggtcgat acaaacagaa gcatcagtcg gtgttcacgg
      421 tcacccggca gaccgcgcag tacccagcgg ccaatggcct tgtcaagttc aattccgcca
      481 tcaccaatcc tcagggggat tacaacacaa acacggggaa gttcacctgc aaagtgcccg
      541 gcctctacta cttcgtccac cacacatccc agacggccaa cctgtgcgtg cagctgctcc
      601 tcaacaatgc caaggtgacc agcttctgcg accacatgtc caacagcaag caggtcagct
      661 caggaggagt actcctgcgg ctgcagaggg gcgacgaggt gtggctggcc gtcaacgact
      721 acaacggcat ggtgggcact gagggctctg acagcgtctt ctctggtttc ctactgtttc
      781 ctgactagaa tggcaggctg ggtccagcac ccggacgccc gcctcgctcc ctctgctttc
      841 cccatcctca ctcagacctc ttccttcagg aagtccaccc tggttcctga cccatcagcc
      901 ctctgtctcc tcagagtttc tctgggaatc actgactggt tccattccag tggcagttta
      961 tcgagacctt tatgagacta tttttttttc aggtgggaag agagaaaaat aaatagatca
     1021 ctaaataaat atgcctggcc cagatttctc actagaaggc ctcaaa
//
