LOCUS       NM_019259               1139 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus complement C1q binding protein (C1qbp), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_019259 XM_346398
VERSION     NM_019259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Udvari,E.B., Volgyi,K., Gulyassy,P., Dimen,D., Kis,V., Barna,J.,
            Szabo,E.R., Lubec,G., Juhasz,G., Kekesi,K.A. and Dobolyi,A.
  TITLE     Synaptic proteome changes in the hypothalamus of mother rats
  JOURNAL   J Proteomics 159, 54-66 (2017)
   PUBMED   28286321
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Arif,M., Thakur,S.C. and Datta,K.
  TITLE     Disrupted hyaluronan binding protein 1 (HABP1) expression: one of
            the key mediator for ovarian dysfunction in polycystic ovary rat
  JOURNAL   Mol Cell Biochem 398 (1-2), 233-244 (2015)
   PUBMED   25300617
  REMARK    GeneRIF: Data indicate that disrupted ovarian hyaluronan binding
            protein 1 (HABP1) along with concurrent altered expression and
            hyperactivation of related MMPs can lead to abnormal follicular
            maturation resulting into ovarian dysfunction in polycystic ovary
            (PCO).
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   4  (bases 1 to 1139)
  AUTHORS   Yagi,M., Uchiumi,T., Takazaki,S., Okuno,B., Nomura,M., Yoshida,S.,
            Kanki,T. and Kang,D.
  TITLE     p32/gC1qR is indispensable for fetal development and mitochondrial
            translation: importance of its RNA-binding ability
  JOURNAL   Nucleic Acids Res 40 (19), 9717-9737 (2012)
   PUBMED   22904065
REFERENCE   5  (bases 1 to 1139)
  AUTHORS   Yoshikawa,H., Komatsu,W., Hayano,T., Miura,Y., Homma,K.,
            Izumikawa,K., Ishikawa,H., Miyazawa,N., Tachikawa,H., Yamauchi,Y.,
            Isobe,T. and Takahashi,N.
  TITLE     Splicing factor 2-associated protein p32 participates in ribosome
            biogenesis by regulating the binding of Nop52 and fibrillarin to
            preribosome particles
  JOURNAL   Mol Cell Proteomics 10 (8), M110.006148 (2011)
   PUBMED   21536856
REFERENCE   6  (bases 1 to 1139)
  AUTHORS   Lynch,N.J., Reid,K.B., van den Berg,R.H., Daha,M.R., Leigh,L.A.,
            Ghebrehiwet,B., Lim,W.B. and Schwaeble,W.J.
  TITLE     Characterisation of the rat and mouse homologues of gC1qBP, a 33
            kDa glycoprotein that binds to the globular 'heads' of C1q
  JOURNAL   FEBS Lett 418 (1-2), 111-114 (1997)
   PUBMED   9414106
REFERENCE   7  (bases 1 to 1139)
  AUTHORS   Muta,T., Kang,D., Kitajima,S., Fujiwara,T. and Hamasaki,N.
  TITLE     p32 protein, a splicing factor 2-associated protein, is localized
            in mitochondrial matrix and is functionally important in
            maintaining oxidative phosphorylation
  JOURNAL   J Biol Chem 272 (39), 24363-24370 (1997)
   PUBMED   9305894
REFERENCE   8  (bases 1 to 1139)
  AUTHORS   Herwald,H., Dedio,J., Kellner,R., Loos,M. and Muller-Esterl,W.
  TITLE     Isolation and characterization of the kininogen-binding protein p33
            from endothelial cells. Identity with the gC1q receptor
  JOURNAL   J Biol Chem 271 (22), 13040-13047 (1996)
   PUBMED   8662673
REFERENCE   9  (bases 1 to 1139)
  AUTHORS   Deb,T.B. and Datta,K.
  TITLE     Molecular cloning of human fibroblast hyaluronic acid-binding
            protein confirms its identity with P-32, a protein co-purified with
            splicing factor SF2. Hyaluronic acid-binding protein as P-32
            protein, co-purified with splicing factor SF2
  JOURNAL   J Biol Chem 271 (4), 2206-2212 (1996)
   PUBMED   8567680
REFERENCE   10 (bases 1 to 1139)
  AUTHORS   Ghebrehiwet,B., Lim,B.L., Peerschke,E.I., Willis,A.C. and Reid,K.B.
  TITLE     Isolation, cDNA cloning, and overexpression of a 33-kD cell surface
            glycoprotein that binds to the globular 'heads' of C1q
  JOURNAL   J Exp Med 179 (6), 1809-1821 (1994)
   PUBMED   8195709
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070510.1.
            
            On or before Aug 30, 2004 this sequence version replaced
            XM_346398.1, NM_019259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070510.1, FQ214480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1139
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /note="complement C1q binding protein"
                     /db_xref="GeneID:29681"
                     /db_xref="RGD:2230"
     exon            1..227
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..841
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /note="complement component 1 Q subcomponent-binding
                     protein, mitochondrial; GC1q-R protein; glycoprotein
                     gC1qBP; complement component 1, q subcomponent binding
                     protein"
                     /codon_start=1
                     /product="complement component 1 Q subcomponent-binding
                     protein, mitochondrial precursor"
                     /protein_id="NP_062132.2"
                     /db_xref="GeneID:29681"
                     /db_xref="RGD:2230"
                     /translation="MLPLLRCVPRALGAAATGLRASIPAPPLRHLLQPAPRPCLRPFG
                     LLSVRAGSARRSGLLQPPVPCACGCGALHTEGDKAFVEFLTDEIKEEKKIQKHKSLPK
                     MSGDWELEVNGTEAKLLRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKAEEQEPEL
                     TSTPNFVVEVTKTDGKKTLVLDCHYPEDEIGHEDEAESDIFSIKEVSFQTTGDSEWRD
                     TNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFV
                     KSQ"
     exon            228..378
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..472
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..568
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..691
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1089
                     /gene="C1qbp"
                     /gene_synonym="gC1qR; Habp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgctccct ctgctgcgct gcgtgccccg cgccctgggt gccgccgcca cgggcctccg
       61 agcctccatc ccggccccgc cgcttcggca tttactgcag cccgcgcccc ggccatgcct
      121 ccggcccttc ggtttgctca gcgtacgagc cggctccgct cggcgctctg gcctcctgca
      181 gcccccggtt ccctgcgcgt gcggctgcgg cgctctgcac acggaaggag acaaggcctt
      241 tgttgaattt ttgactgatg aaattaagga agaaaagaag atccagaagc ataagtccct
      301 tcccaaaatg tctggagatt gggagctgga agtgaacggc acggaggcta aattattgcg
      361 caaagttgcc ggagaaaaga tcactgtcac tttcaacatt aacaatagca tccctccaac
      421 ctttgatggt gaagaggagc cctcacaggg gcagaaggcc gaagagcagg agccagaact
      481 gacatcaact cccaattttg tggttgaagt tacaaagact gatggcaaga agacccttgt
      541 actggactgc cactatcctg aggacgagat cggacacgaa gatgaggccg agagtgacat
      601 tttctctatt aaggaagtga gctttcagac cactggtgac tctgagtgga gggatacaaa
      661 ctacacactc aacacagact ccctggactg ggccttgtat gaccacctaa tggatttcct
      721 tgcggaccga ggggtggata acacttttgc agatgagttg gtggagctca gcacagccct
      781 ggagcaccag gaatatatca cctttcttga ggacctcaaa agctttgtca agagtcagta
      841 gaactgtgag actgaaggcc tcaatctaaa cggccagctc tggtgggcga gcaaaagctg
      901 ccttgacatc acaactatgc tttgaaatgg ctgtcatcct aatatatggg ggaaagcaag
      961 tttaaattat cgccgttaca cctccattta ctattccttt gggctctttt cctgtacaca
     1021 tctattattt gtagattttt gtatgacatg atgatgaaca ataaatctga cttcatctcc
     1081 tccaggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
