LOCUS       NM_019262               1078 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus complement C1q B chain (C1qb), mRNA.
ACCESSION   NM_019262
VERSION     NM_019262.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Ji,L. and Guo,W.
  TITLE     Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in
            the pancreatic islet immune microenvironment in type 1 diabetes
            mellitus
  JOURNAL   Pharmacol Res 187, 106588 (2023)
   PUBMED   36464147
  REMARK    GeneRIF: Single-cell RNA sequencing highlights the roles of C1QB
            and NKG7 in the pancreatic islet immune microenvironment in type 1
            diabetes mellitus.
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Hong,S., Beja-Glasser,V.F., Nfonoyim,B.M., Frouin,A., Li,S.,
            Ramakrishnan,S., Merry,K.M., Shi,Q., Rosenthal,A., Barres,B.A.,
            Lemere,C.A., Selkoe,D.J. and Stevens,B.
  TITLE     Complement and microglia mediate early synapse loss in Alzheimer
            mouse models
  JOURNAL   Science 352 (6286), 712-716 (2016)
   PUBMED   27033548
REFERENCE   3  (bases 1 to 1078)
  AUTHORS   Feng,X.B., Ke,J.J., Rao,Y., Zhang,Z.Z. and Wang,Y.L.
  TITLE     Effect of complement C1q expression on hepatic ischemia-reperfusion
            injury in rats
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 34 (3), 403-407 (2014)
   PUBMED   24939307
  REMARK    GeneRIF: Data suggest that complement C1q expression may play a
            principal role in hepatic ischemia-reperfusion (I/R) injury,
            particularly at the early stage of perfusion.
REFERENCE   4  (bases 1 to 1078)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1078)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   6  (bases 1 to 1078)
  AUTHORS   Schwaeble,W., Schafer,M.K., Petry,F., Fink,T., Knebel,D., Weihe,E.
            and Loos,M.
  TITLE     Follicular dendritic cells, interdigitating cells, and cells of the
            monocyte-macrophage lineage are the C1q-producing sources in the
            spleen. Identification of specific cell types by in situ
            hybridization and immunohistochemical analysis
  JOURNAL   J Immunol 155 (10), 4971-4978 (1995)
   PUBMED   7594503
REFERENCE   7  (bases 1 to 1078)
  AUTHORS   Rozovsky,I., Morgan,T.E., Willoughby,D.A.,
            Dugichi-Djordjevich,M.M., Pasinetti,G.M., Johnson,S.A. and
            Finch,C.E.
  TITLE     Selective expression of clusterin (SGP-2) and complement C1qB and
            C4 during responses to neurotoxins in vivo and in vitro
  JOURNAL   Neuroscience 62 (3), 741-758 (1994)
   PUBMED   7870303
REFERENCE   8  (bases 1 to 1078)
  AUTHORS   Johnson,S.A., Pasinetti,G.M. and Finch,C.E.
  TITLE     Expression of complement C1qB and C4 mRNAs during rat brain
            development
  JOURNAL   Brain Res Dev Brain Res 80 (1-2), 163-174 (1994)
   PUBMED   7955342
REFERENCE   9  (bases 1 to 1078)
  AUTHORS   Wing,M.G., Seilly,D.J., Bridgman,D.J. and Harrison,R.A.
  TITLE     Rapid isolation and biochemical characterization of rat C1 and C1q
  JOURNAL   Mol Immunol 30 (5), 433-440 (1993)
   PUBMED   8464426
REFERENCE   10 (bases 1 to 1078)
  AUTHORS   Johnson,S.A., Lampert-Etchells,M., Pasinetti,G.M., Rozovsky,I. and
            Finch,C.E.
  TITLE     Complement mRNA in the mammalian brain: responses to Alzheimer's
            disease and experimental brain lesioning
  JOURNAL   Neurobiol Aging 13 (6), 641-648 (1992)
   PUBMED   1362796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1 and X71127.1.
            
            On Nov 20, 2020 this sequence version replaced NM_019262.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X71127.1, FQ227589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840116
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                JAXUCZ010000005.1  154407793-154407827 c
            36-169              X71127.1           48-181
            170-498             X71127.1           187-515
            499-995             JAXUCZ010000005.1  154402359-154402855 c
            996-1078            X71127.1           1013-1095
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1078
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /note="complement C1q B chain"
                     /db_xref="GeneID:29687"
                     /db_xref="RGD:2229"
     exon            1..149
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /inference="alignment:Splign:2.1.0"
     exon            150..351
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..932
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /note="complement component 1, q subcomponent, beta
                     polypeptide; complement C1q subcomponent subunit B;
                     complement component 1, q subcomponent, B chain;
                     adiponectin a"
                     /codon_start=1
                     /product="complement C1q subcomponent subunit B precursor"
                     /protein_id="NP_062135.2"
                     /db_xref="GeneID:29687"
                     /db_xref="RGD:2229"
                     /translation="MKTQWSEILTPLLLLLLGLLHVSWAQSSCTGSPGIPGVPGIPGV
                     PGSDGKPGTPGIKGEKGLPGLAGDHGELGEKGDAGIPGIPGKVGPKGPVGPKGAPGPP
                     GPRGPKGDSGDYKATQKVAFSALRTVNSALRPNQAIRFEKVITNVNDNYEPRSGKFTC
                     KVPGLYYFTYHASSRGNLCVNIVRGRDRDRMQKVLTFCDYAQNTFQVTTGGVVLKLEQ
                     EEVVHLQATDKNSLLGVEGANSIFTGFLLFPDMDV"
     exon            352..1078
                     /gene="C1qb"
                     /gene_synonym="Adia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttttggga ggggacagca agggaaggtc cttcctgcct ctagggaccc agacttccgc
       61 tttctgcaga cagcagcagg ctctgggctc tgggaatcca ctgctgtctg gcctagaagc
      121 atcatagaac acgaggattc catacacagg aggcccctga agctgagctg atgaagacac
      181 agtggagtga gatcttgaca cccctgttgc tgctgctcct gggtttgctc catgtctcct
      241 gggcccaaag cagctgtact gggtcccctg gcatccctgg ggtccctggc atccctgggg
      301 tccctggctc tgatggcaaa ccaggcactc cagggataaa aggagagaaa gggctccccg
      361 gactggctgg agaccatggt gagttaggag agaaagggga tgcagggatc cctgggatcc
      421 caggcaaagt tggccccaag ggtcccgtcg gccctaaggg tgctccaggc ccccctggac
      481 cccgcggtcc caaaggtgac tctggagact acaaggctac ccagaaagta gccttctctg
      541 ccctgaggac ggtcaacagc gccctgcgac caaaccaggc cattcgcttt gaaaaggtga
      601 tcaccaatgt taatgataac tacgagccgc gcagtggcaa gttcacctgc aaggtacctg
      661 gcctctacta cttcacctac cacgccagtt cccgcgggaa tctgtgtgtg aacatcgtgc
      721 gcggccgcga ccgagaccgc atgcagaaag ttctcacctt ctgcgactat gcccaaaaca
      781 ccttccaggt caccacgggt ggggtagtct tgaagctgga gcaggaagag gttgttcacc
      841 tgcaggccac agacaagaac tccctgctgg gcgtcgaggg agccaatagc atcttcactg
      901 gctttctgct tttccctgac atggatgtat gatcacgggg tcaaatcact cctatccaaa
      961 acctcctccc tgccagtaat cctccctgga cccctgacac tgccctttga ctgcccaaag
     1021 ccctgaccag agccctgtag atgttacaga atgggtaaat aaactcttca aggccaag
//
