LOCUS       NM_001008515            1025 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus complement C1q A chain (C1qa), mRNA.
ACCESSION   NM_001008515 XM_216554
VERSION     NM_001008515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1025)
  AUTHORS   Hong,S., Beja-Glasser,V.F., Nfonoyim,B.M., Frouin,A., Li,S.,
            Ramakrishnan,S., Merry,K.M., Shi,Q., Rosenthal,A., Barres,B.A.,
            Lemere,C.A., Selkoe,D.J. and Stevens,B.
  TITLE     Complement and microglia mediate early synapse loss in Alzheimer
            mouse models
  JOURNAL   Science 352 (6286), 712-716 (2016)
   PUBMED   27033548
REFERENCE   2  (bases 1 to 1025)
  AUTHORS   Feng,X.B., Ke,J.J., Rao,Y., Zhang,Z.Z. and Wang,Y.L.
  TITLE     Effect of complement C1q expression on hepatic ischemia-reperfusion
            injury in rats
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 34 (3), 403-407 (2014)
   PUBMED   24939307
  REMARK    GeneRIF: Data suggest that complement C1q expression may play a
            principal role in hepatic ischemia-reperfusion (I/R) injury,
            particularly at the early stage of perfusion.
REFERENCE   3  (bases 1 to 1025)
  AUTHORS   Rostami,E., Davidsson,J., Gyorgy,A., Agoston,D.V., Risling,M. and
            Bellander,B.M.
  TITLE     The terminal pathway of the complement system is activated in focal
            penetrating but not in mild diffuse traumatic brain injury
  JOURNAL   J Neurotrauma 30 (23), 1954-1965 (2013)
   PUBMED   23808389
REFERENCE   4  (bases 1 to 1025)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 1025)
  AUTHORS   Benoit,M.E., Hernandez,M.X., Dinh,M.L., Benavente,F., Vasquez,O.
            and Tenner,A.J.
  TITLE     C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer
            disease mouse models, are essential for the C1q-mediated protection
            against amyloid-beta neurotoxicity
  JOURNAL   J Biol Chem 288 (1), 654-665 (2013)
   PUBMED   23150673
  REMARK    GeneRIF: C1q-induced LRP1B and GPR6 proteins expressed early in
            Alzheimer disease mouse models, are essential for the C1q-mediated
            protection against amyloid-beta neurotoxicity
REFERENCE   6  (bases 1 to 1025)
  AUTHORS   Stevens,B., Allen,N.J., Vazquez,L.E., Howell,G.R.,
            Christopherson,K.S., Nouri,N., Micheva,K.D., Mehalow,A.K.,
            Huberman,A.D., Stafford,B., Sher,A., Litke,A.M., Lambris,J.D.,
            Smith,S.J., John,S.W. and Barres,B.A.
  TITLE     The classical complement cascade mediates CNS synapse elimination
  JOURNAL   Cell 131 (6), 1164-1178 (2007)
   PUBMED   18083105
REFERENCE   7  (bases 1 to 1025)
  AUTHORS   Fonseca,M.I., Zhou,J., Botto,M. and Tenner,A.J.
  TITLE     Absence of C1q leads to less neuropathology in transgenic mouse
            models of Alzheimer's disease
  JOURNAL   J Neurosci 24 (29), 6457-6465 (2004)
   PUBMED   15269255
REFERENCE   8  (bases 1 to 1025)
  AUTHORS   Azeredo da Silveira,S., Kikuchi,S., Fossati-Jimack,L., Moll,T.,
            Saito,T., Verbeek,J.S., Botto,M., Walport,M.J., Carroll,M. and
            Izui,S.
  TITLE     Complement activation selectively potentiates the pathogenicity of
            the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte
            autoantibody
  JOURNAL   J Exp Med 195 (6), 665-672 (2002)
   PUBMED   11901193
REFERENCE   9  (bases 1 to 1025)
  AUTHORS   Topaloglu,R., Bakkaloglu,A., Slingsby,J.H., Mihatsch,M.J.,
            Pascual,M., Norsworthy,P., Morley,B.J., Saatci,U., Schifferli,J.A.
            and Walport,M.J.
  TITLE     Molecular basis of hereditary C1q deficiency associated with SLE
            and IgA nephropathy in a Turkish family
  JOURNAL   Kidney Int 50 (2), 635-642 (1996)
   PUBMED   8840296
REFERENCE   10 (bases 1 to 1025)
  AUTHORS   Wing,M.G., Seilly,D.J., Bridgman,D.J. and Harrison,R.A.
  TITLE     Rapid isolation and biochemical characterization of rat C1 and C1q
  JOURNAL   Mol Immunol 30 (5), 433-440 (1993)
   PUBMED   8464426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086605.1.
            
            On Dec 16, 2004 this sequence version replaced XM_216554.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086605.1, CO404501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1025
                     /gene="C1qa"
                     /gene_synonym="Adic"
                     /note="complement C1q A chain"
                     /db_xref="GeneID:298566"
                     /db_xref="RGD:1306716"
     exon            1..30
                     /gene="C1qa"
                     /gene_synonym="Adic"
                     /inference="alignment:Splign:2.1.0"
     exon            31..200
                     /gene="C1qa"
                     /gene_synonym="Adic"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..775
                     /gene="C1qa"
                     /gene_synonym="Adic"
                     /note="complement C1q subcomponent subunit A; complement
                     component 1, q subcomponent, alpha polypeptide; complement
                     component 1, q subcomponent, A chain; adiponectin c"
                     /codon_start=1
                     /product="complement C1q subcomponent subunit A precursor"
                     /protein_id="NP_001008515.1"
                     /db_xref="GeneID:298566"
                     /db_xref="RGD:1306716"
                     /translation="METSQGWLVACVLAVTLVWTVAEDVCRAPNGKDGVAGIPGRPGR
                     PGLKGERGEPGAAGIRTGIRGLKGDMGESGPPGKPGNVGFPGPTGPLGNSGPQGLKGV
                     KGNPGNIRDQPRPAFSAIRQNPPTYGNVVVFDKVLTNQENPYQNRTGHFICAVPGFYY
                     FTFQVISKWDLCLSIVSSSRGQPRNSLGFCDTNSKGLFQVLAGGTVLQLQRGDEVWIE
                     KDPAKGRIYQGTEADSIFSGFLIFPSA"
     exon            201..1002
                     /gene="C1qa"
                     /gene_synonym="Adic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatccagtg cgagcggacc acggaggcag gaacatcatg gagacctctc agggatggct
       61 ggtggcttgt gtgctggccg tgaccctggt atggacagtg gctgaagatg tctgcagagc
      121 acccaacggg aaggacgggg ttgcaggaat tcctggccgc ccagggaggc cgggtctcaa
      181 aggagagaga ggggagccag gagctgccgg catccggacc ggtatccgag gtcttaaagg
      241 agacatgggg gaatctgggc cccctggcaa acccggcaat gtggggttcc cagggcccac
      301 tgggcccctg gggaacagcg gcccccaagg gttgaaaggt gtgaaaggca atccgggcaa
      361 tatcagggac cagccccggc cagctttctc agctattcgg cagaacccac cgacgtatgg
      421 caacgtggtt gtctttgaca aggtcctcac caaccaggag aatccatacc agaaccgcac
      481 aggtcacttc atctgtgcgg tgcccggttt ctattacttc accttccaag tgatctccaa
      541 gtgggacctt tgtctgtcta tcgtgtcctc ctcccggggc cagcccagga attcccttgg
      601 tttctgtgac accaacagca aggggctctt ccaggtgtta gcagggggca ctgtgcttca
      661 attgcaacga ggggacgagg tgtggattga gaaggaccca gcaaagggcc gcatttacca
      721 gggtactgaa gccgacagca tcttcagtgg attcctcatt tttccctcgg cctgagctgg
      781 gtagctgccc cacgttctgc catctcctgc actccctgtt gcggggcccc accctgcatc
      841 ccttctctct gtactctgca aagtgaaggg gctggggttt tagcactctg ggggaggggc
      901 tggctccgag ggcactgagg actgatgtct ctctgcacac ggcccagtgg tttctttaag
      961 tactttctgg aataaatgac cccatctgtg tctgtggctt gaaaaaaaaa aaaaaaaaaa
     1021 aaaaa
//
