LOCUS       NM_001398710            5763 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus core 1 synthase,
            glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
            (C1galt1), transcript variant 1, mRNA.
ACCESSION   NM_001398710 XM_039108325
VERSION     NM_001398710.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5763)
  AUTHORS   Fu,J., Wei,B., Wen,T., Johansson,M.E., Liu,X., Bradford,E.,
            Thomsson,K.A., McGee,S., Mansour,L., Tong,M., McDaniel,J.M.,
            Sferra,T.J., Turner,J.R., Chen,H., Hansson,G.C., Braun,J. and
            Xia,L.
  TITLE     Loss of intestinal core 1-derived O-glycans causes spontaneous
            colitis in mice
  JOURNAL   J Clin Invest 121 (4), 1657-1666 (2011)
   PUBMED   21383503
REFERENCE   2  (bases 1 to 5763)
  AUTHORS   Li,G.S., Zhang,H., Lv,J.C., Shen,Y. and Wang,H.Y.
  TITLE     Variants of C1GALT1 gene are associated with the genetic
            susceptibility to IgA nephropathy
  JOURNAL   Kidney Int 71 (5), 448-453 (2007)
   PUBMED   17228361
REFERENCE   3  (bases 1 to 5763)
  AUTHORS   Xia,L., Ju,T., Westmuckett,A., An,G., Ivanciu,L., McDaniel,J.M.,
            Lupu,F., Cummings,R.D. and McEver,R.P.
  TITLE     Defective angiogenesis and fatal embryonic hemorrhage in mice
            lacking core 1-derived O-glycans
  JOURNAL   J Cell Biol 164 (3), 451-459 (2004)
   PUBMED   14745002
REFERENCE   4  (bases 1 to 5763)
  AUTHORS   Ju,T., Brewer,K., D'Souza,A., Cummings,R.D. and Canfield,W.M.
  TITLE     Cloning and expression of human core 1
            beta1,3-galactosyltransferase
  JOURNAL   J Biol Chem 277 (1), 178-186 (2002)
   PUBMED   11677243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 22, 2021 this sequence version replaced XM_039108325.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.31398.1,
                                           SRR26643296.12666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000004.1  36897316-36897471
            157-393             JAXUCZ010000004.1  36918696-36918932
            394-1061            JAXUCZ010000004.1  36922854-36923521
            1062-5763           JAXUCZ010000004.1  36927733-36932434
FEATURES             Location/Qualifiers
     source          1..5763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..5763
                     /gene="C1galt1"
                     /note="core 1 synthase, glycoprotein-N-acetylgalactosamine
                     3-beta-galactosyltransferase, 1"
                     /db_xref="GeneID:65044"
                     /db_xref="RGD:621105"
     exon            1..156
                     /gene="C1galt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1265
                     /gene="C1galt1"
                     /EC_number="2.4.1.122"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycoprotein-N-acetylgalactosamine
                     3-beta-galactosyltransferase 1; core 1 beta3-Gal-T; core 1
                     O-glycan T-synthase; core 1 beta1,3-galactosyltransferase
                     1; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta
                     1,3-galactosyltransferase 1; core 1 beta3-Gal-T1; core 1
                     UDP-galactose:N-acetylgalactosamine-alpha-R beta
                     1,3-galactosyltransferase 1; core1
                     UDP-galactose:N-acetylgalactosamine-alpha-R beta
                     1,3-galactosyltransferase (C1galt1); core1
                     UDP-galactose:N-acetylgalactosamine-alpha-R beta
                     13-galactosyltransferase (C1galt1)"
                     /codon_start=1
                     /product="glycoprotein-N-acetylgalactosamine
                     3-beta-galactosyltransferase 1 isoform 1"
                     /protein_id="NP_001385639.1"
                     /db_xref="GeneID:65044"
                     /db_xref="RGD:621105"
                     /translation="MSEIHSQEMASKSWLNFLTFLCGSAIGFFLCSQLLNILLQEQAD
                     VQPNMLHNDPHARHSDDSGHNHLKGQMDFNADSSQHKDENTDVAENLYQKVKVLCWVM
                     TSPQNLEKKAKHVKATWAQRCNKVLFMSSEENKDFPTVGLETKEGREQLYWKTIKAFQ
                     YVHDHYLEDADWFMKADDDTYVILDNLRWLLSKYNPEQPIYFGRRFKPYVKQGYMSGG
                     AGYVLSKEALRRFVDAFKTEKCTHSSSIEDLALGRCMEIIKVEAGDSRDPTGKETFHP
                     FVPEHHLIKGYLPKTFWYWNYNYYPPVEGPGCCSDIAVSFHYVDSTTMYELEYLVYHL
                     RPYGYLYRYQPALPENILKEINQVNKKEDTKIKLGNP"
     exon            157..393
                     /gene="C1galt1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..1061
                     /gene="C1galt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..5763
                     /gene="C1galt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgccgcc gggggatgat ctgggcggcc gcgggcggcc ctggctagca gcccctgccg
       61 gtgctgcggc gggccagggc agcgaaggtc gagggttggg ggtcgttctc ctccccgcct
      121 ctgggagggg cgagagagag ccgcggctga tgtcagaaat acattcccag gaaatggcct
      181 ctaaatcttg gctgaatttt ttaactttcc tctgtggatc agcaatagga tttttcttat
      241 gttctcaact cttgaatatt ttgttgcaag aacaggctga cgttcagcct aacatgcttc
      301 ataatgatcc tcatgccaga cattcagacg acagtggaca taatcacctc aaaggacaga
      361 tggacttcaa tgcagattct agccaacata aagatgagaa cacagacgtt gctgagaacc
      421 tctatcagaa agttaaagtt ctttgttggg ttatgacaag ccctcaaaat ctagagaaaa
      481 aggccaaaca cgtcaaagct acatgggccc agcgttgtaa taaagtgtta tttatgagtt
      541 cagaagaaaa taaagacttc cctactgtgg ggctggaaac caaagaaggc agagagcaac
      601 tgtactggaa aacaattaaa gcgtttcagt acgtacatga ccattactta gaagatgctg
      661 actggtttat gaaagcagac gatgacacct atgtcatact ggacaatctg agatggcttc
      721 tatcaaagta taaccctgaa cagcccattt actttgggag aagatttaag ccctatgtga
      781 agcagggata catgagtgga ggagcaggat atgtcctaag caaggaagcc ttgagaagat
      841 ttgtggatgc atttaaaaca gaaaaatgta cgcacagttc ctccattgaa gacttggccc
      901 tgggaaggtg catggagatt ataaaggtag aagctggaga ttccagagat cccactggga
      961 aggaaacctt ccaccccttt gtaccagaac accacttaat caaaggctat ctgccaaaaa
     1021 cattttggta ctggaattac aactactatc ctcccgtaga gggtcctggt tgctgttctg
     1081 atattgcagt ttcttttcac tatgttgatt ctacaactat gtatgaatta gaatacctcg
     1141 tttatcatct tcgtccatat ggttatttat atagatatca acctgcctta cctgagaata
     1201 tactaaaaga aattaatcaa gtaaacaaaa aggaagatac aaaaataaaa ttaggcaacc
     1261 cctgaaagca gaccaggagt ggactgtggt caaatggtct acattgcact gaaggactcc
     1321 tgcctttgtg acagaacact gaaatcccag tgaggaactc atctgaagtg gacattccgt
     1381 atagaaagtt ttcaaatgga tgactataaa ctgaagcatt taaagagctg tgaagtttgc
     1441 taaaatgtgt tttgatacag taatatataa atataaataa atctatatga agaatttgtg
     1501 tttttaaatg gtgacagaag agctagaaag actgactgtt cctgacagtg tatgtggttt
     1561 tccactaaag ttggttagtt tgtagtcacc ttctgtacca cacaagttag aacacactgc
     1621 tgaacagatc tgccttaaaa aagaaagaaa tactattgct cagtattgtt tctcagctaa
     1681 tatgtatatg ctacaaacca gccttccaat tgctggatga aaacttataa ttggcaatgt
     1741 ttccgcaaga aaaaatagag taaaaatggc acttacccca aagtgcacta atgaaccaca
     1801 tttctgataa ttatgggcct tgactgcatt ccatacttag ttctctatat aatcagtctt
     1861 acaccaagtc cccattgtct ctttttgaaa tgtttgactc ttgaatacca ttttcattat
     1921 taatacttat ttactcaaag cattggcagc attctgtaaa ataatgcatt tttaaatatt
     1981 ttgttcccag attcatccat tgttaattgt aggtaacagt tgaatttaat gctgcttgga
     2041 caaacttttc ttgtattggc accacgctca ggaactattg attatttaga agtctttccc
     2101 aactacataa ttgtttcttc tattttcacc ctgtggagat gagacttgtt tgtgcctttc
     2161 ataacttgtt taaagcactt ttaaaattaa tttttatgtc tgatgtgaca ggtaacaccg
     2221 tcaaaaattt ttaattgcag cttttggcca gaataaatct aaaacatgag caagtaaagg
     2281 gtacttagag aagctaaaac gtcgagtgct ttgtttagaa atccggacat atttcctgct
     2341 gacttctgat ttggggatag gtcctgccag cagtaactcc gtcagagcga gcagagtcag
     2401 ccccgttcag tctgctgtca ggtagtctgt accactccag attgactggc tgcttaaaga
     2461 gcttccgaca ggatagaacc ttaacttttt tgtgtcatca tcaacactga atgtagagca
     2521 gaatatttta cagatttcct ataagattgt ttttaactgt taatgattta catttcctca
     2581 tgctaatttt gcctgatcaa tacaccactg agtctatatc ttggctaaat aataaatata
     2641 atttatactt atggtgccaa aatcataacc tttataggtg atctgcttgg caggatatgt
     2701 atttcattgg ctagttatgg attacgctgt ccctgtaatg aaactacaaa gtccaactta
     2761 cagatttaat ttggtttacg ttgttcttat ggtggtgcca tctaccagta tcctactttc
     2821 tagtctgctt tttgcacagc tctttaccat ggtttggata tgaatttgtc tgtattccat
     2881 atgggctact cttctttact agcagagtaa atgatttatc ataatcatcc aaaattctta
     2941 acattcattc atagcaagtg aacgctgcaa tgaatcctgg gctgcaaagc caggcagcct
     3001 ggcttttaag ttcctcctcc atcactattt atgtaacctt gaacaattac ttaatttctc
     3061 tgtgcctcca tttcctcatc tatagattag ggataatgat actacctacc tcacaggatt
     3121 ttaatgagga tcatataaat gaatatacat aaagttatta gaacactggc tcagaaaagg
     3181 gcatgacttt taagtataca gttttattct gttaccttgg agtgtaagta atttgattta
     3241 gatggatgaa attatcaact gagatctgaa gaaatggttt gcacatttct tacaatatgt
     3301 aatatgtagt attcatctag tacctgctgt gtgccagatg ctggtcttat tctgtatgtt
     3361 tgtgttaatc cttataattg ggtgttagtc ccatactata ggtgaggaga ctgaggctca
     3421 aagaattcaa gtaatgtttc cactgtcaca aagctagtaa gtgagaaggc tgggatctgt
     3481 aatcaaaacc tgtgtgttgt ttgtattatg ttagccttag ggttagtcac atgagtatgt
     3541 ggaataatta cacacacata cacgtatgaa tagtacgtaa cttctggaac ttttggccag
     3601 caatagtaaa cattggtcag acagctaaat gggcatgctg attgttaaat tgtgattctc
     3661 gtactctagc tataagtttg tcgagatgaa catctcaagg tttgattttt agcatggggc
     3721 cctagagtat gcattcttac cagatgactt ctagtgagaa ttattaaagt agcactgccg
     3781 agagcttgtt ggagcttgtt cttctcttca ccccagctca gacctaagtc agtttggttt
     3841 gaaaaagctc tgaaggttta ttttactaat cctatgttga gaaccattgc ctgtttacct
     3901 acacgatttt ggtgcaaata gtctttggaa cacactcagg atttctgccc aggagagagg
     3961 catttttcaa agactctgaa atatgtgtta aatcagtgta gtccaggatc atactatatt
     4021 aaaaaaatct tataaagttt aatgggtcca tgcatcattg gttttggcaa aattcttccc
     4081 ttcactctaa ttgttattac caggacctta aaaaaaatct ataattctac aagtttagtc
     4141 atttcacact gagtagaaag ggttcagtga gtactaatat gtacatatga attcattaaa
     4201 acatatgtaa atgaatatca tgaaaaaaat gtccactagt tactgaaatt tccaatagaa
     4261 atagaaaaat gctactttat aatatgccaa gtattttctg ctaatttata ttgtcagtat
     4321 aagtaagttt tgtcactttc aaaacctatg tacctatcct gtgatctaat gaagcaaaaa
     4381 aaaaaaaatt ctcccaaata tttgatagag cacataaaac aagattttat ggtgaaatga
     4441 ttaattcact atcttttaga taaagatctc tgtcacatga ataattgatt gtagtgtggt
     4501 ttcaagaaga cataagactt ttagtaaagt cttatgttat ctattaataa tatgcttgtg
     4561 tttttctagt gagcagctca tagatacgaa gcaggttttt accccagagt tttggctgtt
     4621 tgaacatatc taaatttcac agatcagttt gttactacaa aaggattcaa aaataaatca
     4681 ctgaccagtt catactatgt cttgaatatg gtaattgggt ttgagcatta cagtgtttgc
     4741 taactggttg tgttcatagt tgttttttga ggtttgcttt gttttttgtt ttgtttttac
     4801 actcttagcc tgtcaaactg tattgctaga ttgaggccct gttatacttg aaagacatct
     4861 gcacttggtt tgtcagatcc tacctagctt tgttcttgca ctttcagttt cattctgttt
     4921 ttgatagttc cttcatgctt aacttctagt tacttggagt agttgatttg ggtgatcaga
     4981 atgtttatcc tttaagatag ttttatacct agcacaggtt tcccatgaga ctaaaagtcc
     5041 aacaatagtc tgctgactct caggctattt gccctaattg aacttgtaca acctaaaaca
     5101 attctacatc tataattaag aaagcaaagt tatttacccc ccctcttaaa agcaaaaggc
     5161 aaacacattg ccttcgtttc tattgttttg tattaggact taaagaaaca tcatgagaaa
     5221 tatgggagac aagctgtggt atattttaca ctaatgtaac ctcttgatta aaaatgattt
     5281 acagttctat atcagctgta ttgacatttt aacaccaatg gaagtgagaa ctttgtacag
     5341 attctcttta gagaagcaac tgtaaaatca gcatcagagt tgaatgtact tcatttcgac
     5401 tcccttacct cctttgagtt ttcagttaca ttaaagtttt cagttacatt aattaagttt
     5461 gagtaacttt gcagggctct ataaattaat gatctacatg aagtgtatta ttagagggaa
     5521 actaatctta ctgctaagca gtgtgttgta ttatacagta aatgtttgtg tttgggaatt
     5581 taaaaattat ttaaagtagt agtgtcaatg aagggtttaa aaatgtctgg tgacttgctt
     5641 attttaagtg atcaccatta agtcagaaaa aatgtatttt taaatgtttt ttaaagtgcc
     5701 ttttgagaat ttttaaacaa ttgattcaaa caactgcata aaataaacta ccatgttcaa
     5761 aaa
//
