LOCUS       NM_001077590            1479 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus popeye domain cAMP effector 1 (Popdc1), mRNA.
ACCESSION   NM_001077590 XM_001066786
VERSION     NM_001077590.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Holt,I., Fuller,H.R., Schindler,R.F.R., Shirran,S.L., Brand,T. and
            Morris,G.E.
  TITLE     An interaction of heart disease-associated proteins POPDC1/2 with
            XIRP1 in transverse tubules and intercalated discs
  JOURNAL   BMC Mol Cell Biol 21 (1), 88 (2020)
   PUBMED   33261556
  REMARK    GeneRIF: An interaction of heart disease-associated proteins
            POPDC1/2 with XIRP1 in transverse tubules and intercalated discs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Kliminski,V., Uziel,O. and Kessler-Icekson,G.
  TITLE     Popdc1/Bves Functions in the Preservation of Cardiomyocyte
            Viability While Affecting Rac1 Activity and Bnip3 Expression
  JOURNAL   J Cell Biochem 118 (6), 1505-1517 (2017)
   PUBMED   27886395
  REMARK    GeneRIF: Study demonstrated that Popdc1/Bves plays a role in the
            preservation of cardiomyocyte viability by affecting Rac1 activity
            and Bnip3 expression.
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Schindler,R.F., Scotton,C., Zhang,J., Passarelli,C.,
            Ortiz-Bonnin,B., Simrick,S., Schwerte,T., Poon,K.L., Fang,M.,
            Rinne,S., Froese,A., Nikolaev,V.O., Grunert,C., Muller,T.,
            Tasca,G., Sarathchandra,P., Drago,F., Dallapiccola,B., Rapezzi,C.,
            Arbustini,E., Di Raimo,F.R., Neri,M., Selvatici,R., Gualandi,F.,
            Fattori,F., Pietrangelo,A., Li,W., Jiang,H., Xu,X., Bertini,E.,
            Decher,N., Wang,J., Brand,T. and Ferlini,A.
  TITLE     POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting
            protein trafficking
  JOURNAL   J Clin Invest 126 (1), 239-253 (2016)
   PUBMED   26642364
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Benesh,E.C., Miller,P.M., Pfaltzgraff,E.R., Grega-Larson,N.E.,
            Hager,H.A., Sung,B.H., Qu,X., Baldwin,H.S., Weaver,A.M. and
            Bader,D.M.
  TITLE     Bves and NDRG4 regulate directional epicardial cell migration
            through autocrine extracellular matrix deposition
  JOURNAL   Mol Biol Cell 24 (22), 3496-3510 (2013)
   PUBMED   24048452
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Alcalay,Y., Hochhauser,E., Kliminski,V., Dick,J., Zahalka,M.A.,
            Parnes,D., Schlesinger,H., Abassi,Z., Shainberg,A., Schindler,R.F.,
            Brand,T. and Kessler-Icekson,G.
  TITLE     Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated
            protein involved in ischemia tolerance
  JOURNAL   PLoS One 8 (9), e71100 (2013)
   PUBMED   24066022
  REMARK    GeneRIF: The results indicate that Popdc1 is a caveolae-associated
            protein important for the preservation of caveolae structural and
            functional integrity and for heart protection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Smith,T.K., Hager,H.A., Francis,R., Kilkenny,D.M., Lo,C.W. and
            Bader,D.M.
  TITLE     Bves directly interacts with GEFT, and controls cell shape and
            movement through regulation of Rac1/Cdc42 activity
  JOURNAL   Proc Natl Acad Sci U S A 105 (24), 8298-8303 (2008)
   PUBMED   18541910
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Parnes,D., Jacoby,V., Sharabi,A., Schlesinger,H., Brand,T. and
            Kessler-Icekson,G.
  TITLE     The Popdc gene family in the rat: molecular cloning,
            characterization and expression analysis in the heart and cultured
            cardiomyocytes
  JOURNAL   Biochim Biophys Acta 1769 (9-10), 586-592 (2007)
   PUBMED   17662479
REFERENCE   8  (bases 1 to 1479)
  AUTHORS   Osler,M.E., Chang,M.S. and Bader,D.M.
  TITLE     Bves modulates epithelial integrity through an interaction at the
            tight junction
  JOURNAL   J Cell Sci 118 (Pt 20), 4667-4678 (2005)
   PUBMED   16188940
REFERENCE   9  (bases 1 to 1479)
  AUTHORS   Knight,R.F., Bader,D.M. and Backstrom,J.R.
  TITLE     Membrane topology of Bves/Pop1A, a cell adhesion molecule that
            displays dynamic changes in cellular distribution during
            development
  JOURNAL   J Biol Chem 278 (35), 32872-32879 (2003)
   PUBMED   12815060
  REMARK    GeneRIF: cell surface Bves/Pop1A is composed of an extracellular
            amino terminus, three transmembrane domains, and a cytoplasmic
            carboxyl terminus, which regulates cellular distribution of
            Bves/Pop1A during coronary vessel development.
REFERENCE   10 (bases 1 to 1479)
  AUTHORS   Andree,B., Hillemann,T., Kessler-Icekson,G., Schmitt-John,T.,
            Jockusch,H., Arnold,H.H. and Brand,T.
  TITLE     Isolation and characterization of the novel popeye gene family
            expressed in skeletal muscle and heart
  JOURNAL   Dev Biol 223 (2), 371-382 (2000)
   PUBMED   10882522
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            [WARNING] On Nov 18, 2024 this sequence was replaced by
            NM_001077590.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001077590.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY786529.2, SRR26643299.67289.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               JAXUCZ010000020.1  50404684-50404920
            238-362             JAXUCZ010000020.1  50408972-50409096
            363-550             JAXUCZ010000020.1  50411934-50412121
            551-659             JAXUCZ010000020.1  50413489-50413597
            660-827             JAXUCZ010000020.1  50421111-50421278
            828-969             JAXUCZ010000020.1  50422185-50422326
            970-1479            JAXUCZ010000020.1  50439334-50439843
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..1479
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /note="popeye domain cAMP effector 1"
                     /db_xref="GeneID:365603"
                     /db_xref="RGD:1561100"
     exon            1..237
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1082
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /note="popeye domain-containing 1; popeye protein 1;
                     popeye domain-containing protein 1"
                     /codon_start=1
                     /product="blood vessel epicardial substance"
                     /protein_id="NP_001071058.1"
                     /db_xref="GeneID:365603"
                     /db_xref="RGD:1561100"
                     /translation="MNFTEPSPLAQSTVVGFLPELESLTPVPSNETSCENWREVHHLV
                     FHAANVCFAVGLLIPTTLHLHMILLRVMLSIGCTLYVVWATLYRCALDMMIWNSVFLG
                     INILHLSYLLYKKRPVKIEKDLGGVYHRLFEPLRVPPDLFRRLTGQFCVIQTLKRGQV
                     YATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVT
                     IVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKK
                     LEPQMSLSTQISMLEMRNSITSSSDIEDGLHHFLRGSSSTASLPMSSPQQRASPKMKP
                     IEEGLEDDDEVFVPVSPAHQLP"
     exon            238..362
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
     exon            363..550
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
     exon            551..659
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
     exon            660..827
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
     exon            828..969
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1479
                     /gene="Popdc1"
                     /gene_synonym="Bves"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttttcaa catgaatttt acggagccca gcccactggc gcaatcaact gtggtgggtt
       61 ttctgcctga gttagaaagt ctcacacccg tgccttccaa tgagaccagt tgtgaaaact
      121 ggcgggaggt tcaccatctg gtgtttcacg cggccaacgt ttgcttcgca gttggtttgc
      181 taattcccac cactctccac ctccatatga tactgctcag agtgatgctg tctataggat
      241 gtaccctcta cgtggtctgg gccactctct accgctgtgc cttggatatg atgatctgga
      301 actcggtgtt cttgggtatc aatattttgc atctttcata tcttttgtac aagaaaagac
      361 cggtcaagat tgaaaaggac ctgggcggtg tctaccaccg actgtttgaa cccctccgag
      421 tccctccgga tttgtttaga aggctaactg gacagttttg tgtgatccag accttgaaaa
      481 ggggccaggt ttatgccacg gaggacaaaa cctcagttga tgaccgtctt agcattctcc
      541 taaagggaag aatgaaggtc tcctatcgag gacattttct gcataacatt tacccgtgtg
      601 cctttataga ttctcctgaa ttcagatcaa cgcagatgca caagggtgag aaattccagg
      661 tcaccattgt tgcggacgat aactgcaggt ttttatgctg gtcgagagaa agactgacgt
      721 actttctgga gtcagagcct tttctgtatg aaatttttag gtaccttata gggaaagaca
      781 tcacaaataa gctgtactca ctgaatgacc ccaccttaaa tgataaaaaa gtgaagaagt
      841 tggagcccca gatgagcctc agcacacaga tctccatgct ggagatgagg aacagcatca
      901 ctagctccag cgacatcgag gacggcctcc accacttcct gcggggctcc tccagcacgg
      961 cttctctccc catgtcctcc ccgcagcagc gagcctctcc caagatgaag ccaatcgagg
     1021 aagggctaga agatgacgat gaggtctttg tgccggtgtc tcccgctcat cagttgcctt
     1081 gagcagcacc tggcgaccac gacagaggct gacctgagga gcagaagacc cacactctgc
     1141 tatgaccttt ggtggtttgc ttcagtcctg ccagatggga agtgaggggc ggccgcagac
     1201 aggagttgag tgctgcctgt cccgctagcc agctccttgt gctagccgag ccttctgagt
     1261 agacctcact ctattttcag acatgtattt ttgcagtaga tatattaata ttgttttaat
     1321 tgaccttgaa gctgtcaaca catcgccttt tcgcttattt ttctaagttg tggctctttt
     1381 ctcacgtgtg cttccccccc ctgtcgtggg aatttggaac gagtagttgt tttgatcatc
     1441 ttagcgatgt aagccaaagt tgaggctgac acgacatta
//
