LOCUS       NM_138540               4382 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus BUB1 mitotic checkpoint serine/threonine kinase B
            (Bub1b), mRNA.
ACCESSION   NM_138540 XM_001080736 XM_342494
VERSION     NM_138540.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4382)
  AUTHORS   Greising,S.M., Mantilla,C.B., Gorman,B.A., Ermilov,L.G. and
            Sieck,G.C.
  TITLE     Diaphragm muscle sarcopenia in aging mice
  JOURNAL   Exp Gerontol 48 (9), 881-887 (2013)
   PUBMED   23792145
REFERENCE   2  (bases 1 to 4382)
  AUTHORS   Han,S.S., Tompkins,V.S., Son,D.J., Kamberos,N.L., Stunz,L.L.,
            Halwani,A., Bishop,G.A. and Janz,S.
  TITLE     Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells
  JOURNAL   Biochem Biophys Res Commun 436 (4), 660-665 (2013)
   PUBMED   23764397
REFERENCE   3  (bases 1 to 4382)
  AUTHORS   Krenn,V., Wehenkel,A., Li,X., Santaguida,S. and Musacchio,A.
  TITLE     Structural analysis reveals features of the spindle checkpoint
            kinase Bub1-kinetochore subunit Knl1 interaction
  JOURNAL   J Cell Biol 196 (4), 451-467 (2012)
   PUBMED   22331848
REFERENCE   4  (bases 1 to 4382)
  AUTHORS   Lefebvre,C., Rajbhandari,P., Alvarez,M.J., Bandaru,P., Lim,W.K.,
            Sato,M., Wang,K., Sumazin,P., Kustagi,M., Bisikirska,B.C.,
            Basso,K., Beltrao,P., Krogan,N., Gautier,J., Dalla-Favera,R. and
            Califano,A.
  TITLE     A human B-cell interactome identifies MYB and FOXM1 as master
            regulators of proliferation in germinal centers
  JOURNAL   Mol Syst Biol 6, 377 (2010)
   PUBMED   20531406
REFERENCE   5  (bases 1 to 4382)
  AUTHORS   Lira,R.C., Miranda,F.A., Guimaraes,M.C., Simoes,R.T., Donadi,E.A.,
            Soares,C.P. and Soares,E.G.
  TITLE     BUBR1 expression in benign oral lesions and squamous cell
            carcinomas: correlation with human papillomavirus
  JOURNAL   Oncol Rep 23 (4), 1027-1036 (2010)
   PUBMED   20204288
REFERENCE   6  (bases 1 to 4382)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   7  (bases 1 to 4382)
  AUTHORS   Weaver,B.A., Bonday,Z.Q., Putkey,F.R., Kops,G.J., Silk,A.D. and
            Cleveland,D.W.
  TITLE     Centromere-associated protein-E is essential for the mammalian
            mitotic checkpoint to prevent aneuploidy due to single chromosome
            loss
  JOURNAL   J Cell Biol 162 (4), 551-563 (2003)
   PUBMED   12925705
REFERENCE   8  (bases 1 to 4382)
  AUTHORS   Chan,G.K., Schaar,B.T. and Yen,T.J.
  TITLE     Characterization of the kinetochore binding domain of CENP-E
            reveals interactions with the kinetochore proteins CENP-F and
            hBUBR1
  JOURNAL   J Cell Biol 143 (1), 49-63 (1998)
   PUBMED   9763420
REFERENCE   9  (bases 1 to 4382)
  AUTHORS   Taylor,S.S., Ha,E. and McKeon,F.
  TITLE     The human homologue of Bub3 is required for kinetochore
            localization of Bub1 and a Mad3/Bub1-related protein kinase
  JOURNAL   J Cell Biol 142 (1), 1-11 (1998)
   PUBMED   9660858
REFERENCE   10 (bases 1 to 4382)
  AUTHORS   Lewis,B.C., Shim,H., Li,Q., Wu,C.S., Lee,L.A., Maity,A. and
            Dang,C.V.
  TITLE     Identification of putative c-Myc-responsive genes: characterization
            of rcl, a novel growth-related gene
  JOURNAL   Mol Cell Biol 17 (9), 4967-4978 (1997)
   PUBMED   9271375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1, FN805744.1 and DY567136.1.
            
            On or before Jan 15, 2015 this sequence version replaced
            XM_342494.7, XM_001080736.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.12472.1,
                                           SRR26643294.14536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000003.1  126017067-126017074
            9-759               FN805744.1         1-751
            760-926             JAXUCZ010000003.1  126034126-126034292
            927-1141            JAXUCZ010000003.1  126036334-126036548
            1142-1233           JAXUCZ010000003.1  126036824-126036915
            1234-1463           JAXUCZ010000003.1  126038755-126038984
            1464-1520           JAXUCZ010000003.1  126042348-126042404
            1521-2223           DY567136.1         1-703
            2224-2306           JAXUCZ010000003.1  126056126-126056208
            2307-2447           JAXUCZ010000003.1  126056865-126057005
            2448-2548           JAXUCZ010000003.1  126057491-126057591
            2549-2698           JAXUCZ010000003.1  126062230-126062379
            2699-2841           JAXUCZ010000003.1  126063796-126063938
            2842-3016           JAXUCZ010000003.1  126065602-126065776
            3017-3123           JAXUCZ010000003.1  126066708-126066814
            3124-4382           JAXUCZ010000003.1  126068212-126069470
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..4382
                     /gene="Bub1b"
                     /note="BUB1 mitotic checkpoint serine/threonine kinase B"
                     /db_xref="GeneID:171576"
                     /db_xref="RGD:619791"
     exon            1..210
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3355
                     /gene="Bub1b"
                     /EC_number="2.7.11.1"
                     /note="budding uninhibited by benzimidazoles 1 beta;
                     budding uninhibited by benzimidazoles 1 homolog beta;
                     BUB1B, mitotic checkpoint serine/threonine kinase"
                     /codon_start=1
                     /product="mitotic checkpoint serine/threonine-protein
                     kinase BUB1 beta"
                     /protein_id="NP_612549.1"
                     /db_xref="GeneID:171576"
                     /db_xref="RGD:619791"
                     /translation="MAAASEATCVEGDEWELSKENVQPLRHGRIMATLQGALAQQESA
                     CSTTLQQQKWAFESEIRFYSGNDPLDVWDRYINWTEQNYPQGGKESNMSTLLERAIEA
                     LQGEKRYYSDPRFLNLWIKLGHLCNEPLDMYSYLHSQGIGISLAQFYISWAEEYEARE
                     NFKKADIVFQQGIECKAEPLDRLQSQHRQFQARVSRQALLALGNEEEEVLGSSEPQRS
                     TLAELKSRGKKMARAPINRVGGALKAPGQSRGFLNTLPQPVHSNRRITVFDENADSAS
                     RPELSKPVAQPWMAPPVPRAKENELQPGPWNTDRPLEYRPHSNPASVTSVPSVLPNFT
                     PYVEESAQQTVMTPCKIEPSINHVLSTRKPGREEGDPLQRVQSHQQGCEEKKEKMMYC
                     KEKIYAGVGEFSFEEIRAEVFRKKLKERREAELLTSAKKREEMQKQIEEMERKLKAMQ
                     TIQQERAGDQQEERMLSKDSARLEIASESQEMSGVPPSCSIWPLSSNPREISPAENIL
                     QEQPETKGPSMPFSIFDESLSDKKDKSPATDGPQVLNAQRRPLTVLKTTEVIPANEDI
                     SPDVCDELTEIEPLSEDAIITGFRNGILCPNPEDTCDFARAARFASTPFHEILPSKSI
                     ASDPKEGLQEEDLDGKATEGHHIVHLQTLSVKKLSPIIEDSREATHSSGFSRSSSSVT
                     STSSIKGFQILEKLELTTDAAENAIQSPWCSHYRLQLLKSLPELSAFAEFSVEDRPMP
                     MLELGKEIELGHEDYCIKQEHLTCEDYRLFWVAPRNSAELTMIKASSQPLPWDFYINL
                     KLKERLNEDCDQLCSCCQYQDGHVVWYQYINCSTLQDLLQHSEFVTHEIIVLIICNLL
                     TIVEKLHKAEIVHGDLSPRSLILRNRIHDPYDYINKDDHAVRIVDFSYSVDMRVQLDA
                     FAYSGFRTAQVLEGQKILANCSSPYQVDLLGIADLAHLLLFKEHLHVFWDGLLWRLSQ
                     NTSELKDGELWNKFFVQILNASDKSTVFILRELAAEMSGAFDTTFHSHLNKALWKLGK
                     VISPEASLIQQDKQSSLLQNPA"
     exon            211..357
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            358..417
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            418..562
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            563..759
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            760..926
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1141
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1233
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1463
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1576
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1692
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1742
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1800
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1909
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2172
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2306
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2447
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2548
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2698
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2841
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3016
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3123
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
     exon            3124..4382
                     /gene="Bub1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagttggcg gccctggcgt gatggggcgt gaggtagttt ctttgagacg gattcgggcg
       61 agtgattttg tttaggagta cgggataacg gtcttcgcag ctccagagtt agctgaaggt
      121 tgagggaagc tcagacagtt ggcactccga ggaaaaaggt ctgcggacgg gcgagagcaa
      181 gaacttggaa tgcaggatgg cggcggcgag tgaagccacg tgcgtggagg gagatgagtg
      241 ggaactgagt aaagaaaacg tacaaccctt acggcatgga cggatcatgg ccacacttca
      301 gggagcgttg gcacagcagg agtcagcctg cagcactacc ctgcagcagc agaagtgggc
      361 gtttgaatct gaaatccgct tttactctgg aaatgaccct ctggatgttt gggacaggta
      421 tattaattgg acagaacaga actaccctca gggcgggaag gagagtaaca tgtcaacgtt
      481 actagagaga gcgatagaag ccctccaagg ggagaagcgc tattacagtg acccccggtt
      541 tctcaatctc tggatcaaat tggggcattt gtgcaatgag cctttggata tgtatagcta
      601 tttacacagc caaggcattg gcatttccct ggcccagttc tatatctcgt gggctgaaga
      661 gtacgaagct agagaaaatt tcaagaaagc agatatagta ttccagcaag ggattgaatg
      721 caaggcggag cccctggaca gactgcagtc ccagcacaga cagttccagg ctcgagtgtc
      781 tcgacaagct ctcttggctc ttgggaatga agaggaggag gtcttggggt cctctgaacc
      841 acaaagaagc acgctcgctg agctgaagag cagagggaag aagatggcca gagcgcccat
      901 caaccgtgtt ggaggtgctc tgaaggctcc aggtcagagc agaggattcc taaatacact
      961 tcctcagcca gtacacagca atcgcaggat cactgttttt gatgaaaatg ctgatagtgc
     1021 ttctaggccg gagctctcta agcctgtagc ccagccatgg atggcacccc ctgtccctag
     1081 ggccaaagag aacgagcttc agccaggccc gtggaacaca gacaggccct tggaatatag
     1141 gcctcatagc aacccagcct ctgtgacatc tgtacccagt gtgcttccca actttactcc
     1201 gtatgtggaa gagagcgccc agcagacagt aatgacgcca tgtaaaatcg aacctagtat
     1261 caaccatgtt ctcagcacca gaaagccagg gagagaggaa ggagacccct tgcagagagt
     1321 tcagagtcat cagcaagggt gtgaggagaa gaaggagaag atgatgtact gtaaggagaa
     1381 gatttatgcc ggagttgggg agttctcctt tgaggagatc cgagccgaag tgttccggaa
     1441 gaagctgaaa gagcgaaggg aagccgaact gctgaccagt gcaaagaaga gggaagaaat
     1501 gcagaagcag attgaagaga tggagagaaa gctaaaagca atgcagacta ttcagcaaga
     1561 aagagctggt gaccagcaag aagagaggat gctttcaaag gactcagcca gattggagat
     1621 tgcttcagag tctcaggaaa tgtcgggagt gcctccgtcc tgttccatct ggccactaag
     1681 ctcgaatcct agggaaatct cacctgctga gaacattttg caagaacaac ctgagaccaa
     1741 aggtcccagt atgccgtttt ccatttttga tgagtctctt tcggacaaaa aggacaaaag
     1801 tcctgctaca gatggtccac aagttctcaa tgcccagcga agacccctta cagttctcaa
     1861 aactacagaa gtcatccctg caaatgagga catatctcct gatgtttgtg atgaacttac
     1921 agaaattgaa cctttgagtg aagatgccat catcaccggt ttcaggaatg gaattctttg
     1981 tcccaaccct gaggacactt gtgactttgc tagagcagct cgttttgctt ctactccgtt
     2041 ccatgagata ctgccctcga aaagcatcgc ttctgatccc aaggaagggt tgcaggaaga
     2101 ggatctggat gggaaggcca ctgagggtca tcacattgtt catctccaga ctctcagcgt
     2161 aaagaagctg agcccaatta ttgaagacag ccgtgaggcc acccactcat ctggcttctc
     2221 cagatcctct tcttcagtta ccagtacatc ctctatcaaa ggctttcaga ttctggaaaa
     2281 gctggagctg actactgatg cagcagaaaa tgctattcaa tcaccctggt gttcacatta
     2341 tcgcctacaa ctcttaaaat ccctaccaga actaagtgct tttgcagagt tttctgtgga
     2401 agacaggccg atgcctatgc tggaactagg gaaagaaatt gagttaggtc acgaagatta
     2461 ctgcatcaaa caagagcacc taacatgtga agattacagg ttattctggg tggcaccaag
     2521 gaactctgca gagctgacca tgataaaggc atcttctcag cctctcccgt gggattttta
     2581 tatcaacctc aagttaaagg agcgtctgaa tgaggactgc gaccagcttt gcagctgctg
     2641 tcagtatcaa gatggccatg ttgtgtggta ccagtatata aactgctcca cccttcagga
     2701 ccttctccaa cacagcgaat ttgttactca tgaaataata gtgttgatta tttgtaacct
     2761 tttgacaata gtggagaagc tgcacaaagc tgagatagtg catggagact tgagtccaag
     2821 gagtctgatt ctacggaaca gaatccacga cccctatgac tatataaata aggacgacca
     2881 tgctgtgagg atagtggact tttcctacag tgttgacatg agggtgcagc tggatgcatt
     2941 tgcctatagt ggctttcgga ctgcacaggt cctggaagga caaaagatcc tggctaactg
     3001 ttcttctccc taccaggtag atctgttggg tatagcagac ctagcacact tactgttgtt
     3061 caaggagcac ctgcatgtct tctgggatgg actcctctgg agacttagcc aaaatacctc
     3121 tgagctaaag gacggtgaat tgtggaataa attctttgtg cagattctga atgccagtga
     3181 caagtccacg gtgttcattc tgagggaact tgcagcagaa atgagtgggg cttttgacac
     3241 cacattccac agccacctca acaaagcctt gtggaagttg gggaaggtaa ttagtccgga
     3301 agcttcgctc attcagcaag acaagcagtc aagtctctta cagaaccctg cctaagccag
     3361 ggctgtattg tggaaactgg tctggagctg ctgtaatttg atttacttag agctggtcct
     3421 ttaccagagg ttactctcag tagcacagat tttaacagat ggttgtgctc tggcagcctc
     3481 atctggttta ttccagagcg attccataca aattgctact tcttaaccct ctggtttctg
     3541 ccttttctct tttgtaattt tgtaacatgt attctccctc tcaccatgta ttttataata
     3601 aaatagtttt tgttacattt ctgctgcagg cattctgtcc actgttgcaa actaatgtga
     3661 taaatgtttt cattttggag aggaattact ctacggcgga aacttaagta tcctaggtgt
     3721 tgagcctttg ggttataagc agtcagctgg ctggcggttt cttcaggtct ctctggcctt
     3781 ctagcaggtg tccagaagga aagcaggtaa agtgatgtac acaggccaac tttccttaag
     3841 tttcaaaggt gtgtttcata ctcacaggct agtggctcac gctagagcgt tttcagtttt
     3901 atttggtagt tgccttacag tgcttaccaa acatttggga cagggtactc aacggcctgt
     3961 cattttatgc aggacacagg gttgcagagg ggacaaaaga cagtttcact tagatgtgag
     4021 gaaagcaggg gtcagaacag aaagaggtct ctgaggcggg gactgattta gaaaatagta
     4081 aatctgatgg gacactggac acccaaaggg gagcaccagc tccacaaggc cttgtgtttc
     4141 taatgataat gaaagtcgtg tgtttatttc atgctaaaat atcagtcacc tgatagccat
     4201 ccatgctggc gtctgagtcc cctctacttg tcactcttgt tgctccaagt ttgttagaca
     4261 gtggattccc taagtaaatc tctcaactga aacaattaaa caaacttgac aggttaagcc
     4321 agaaaaaaat gttttgtatc taaaagacat caaaagaaaa taaatatttt ctttaaccaa
     4381 aa
//
