LOCUS       NM_001106507            4583 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus BUB1 mitotic checkpoint serine/threonine kinase
            (Bub1), mRNA.
ACCESSION   NM_001106507 XM_001078727 XM_215849
VERSION     NM_001106507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4583)
  AUTHORS   Liu,H., Jia,L. and Yu,H.
  TITLE     Phospho-H2A and cohesin specify distinct tension-regulated Sgo1
            pools at kinetochores and inner centromeres
  JOURNAL   Curr Biol 23 (19), 1927-1933 (2013)
   PUBMED   24055156
REFERENCE   2  (bases 1 to 4583)
  AUTHORS   Krenn,V., Wehenkel,A., Li,X., Santaguida,S. and Musacchio,A.
  TITLE     Structural analysis reveals features of the spindle checkpoint
            kinase Bub1-kinetochore subunit Knl1 interaction
  JOURNAL   J Cell Biol 196 (4), 451-467 (2012)
   PUBMED   22331848
REFERENCE   3  (bases 1 to 4583)
  AUTHORS   Kawashima,S.A., Yamagishi,Y., Honda,T., Ishiguro,K. and Watanabe,Y.
  TITLE     Phosphorylation of H2A by Bub1 prevents chromosomal instability
            through localizing shugoshin
  JOURNAL   Science 327 (5962), 172-177 (2010)
   PUBMED   19965387
REFERENCE   4  (bases 1 to 4583)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 4583)
  AUTHORS   Klebig,C., Korinth,D. and Meraldi,P.
  TITLE     Bub1 regulates chromosome segregation in a kinetochore-independent
            manner
  JOURNAL   J Cell Biol 185 (5), 841-858 (2009)
   PUBMED   19487456
REFERENCE   6  (bases 1 to 4583)
  AUTHORS   Le Cam,L., Lacroix,M., Ciemerych,M.A., Sardet,C. and Sicinski,P.
  TITLE     The E4F protein is required for mitotic progression during
            embryonic cell cycles
  JOURNAL   Mol Cell Biol 24 (14), 6467-6475 (2004)
   PUBMED   15226446
REFERENCE   7  (bases 1 to 4583)
  AUTHORS   Johnson,V.L., Scott,M.I., Holt,S.V., Hussein,D. and Taylor,S.S.
  TITLE     Bub1 is required for kinetochore localization of BubR1, Cenp-E,
            Cenp-F and Mad2, and chromosome congression
  JOURNAL   J Cell Sci 117 (Pt 8), 1577-1589 (2004)
   PUBMED   15020684
REFERENCE   8  (bases 1 to 4583)
  AUTHORS   Hodges,C.A. and Hunt,P.A.
  TITLE     Simultaneous analysis of chromosomes and chromosome-associated
            proteins in mammalian oocytes and embryos
  JOURNAL   Chromosoma 111 (3), 165-169 (2002)
   PUBMED   12355205
REFERENCE   9  (bases 1 to 4583)
  AUTHORS   Cahill,D.P., Lengauer,C., Yu,J., Riggins,G.J., Willson,J.K.,
            Markowitz,S.D., Kinzler,K.W. and Vogelstein,B.
  TITLE     Mutations of mitotic checkpoint genes in human cancers
  JOURNAL   Nature 392 (6673), 300-303 (1998)
   PUBMED   9521327
REFERENCE   10 (bases 1 to 4583)
  AUTHORS   Pangilinan,F., Li,Q., Weaver,T., Lewis,B.C., Dang,C.V. and
            Spencer,F.
  TITLE     Mammalian BUB1 protein kinases: map positions and in vivo
            expression
  JOURNAL   Genomics 46 (3), 379-388 (1997)
   PUBMED   9441741
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215849.4, XM_001078727.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4583
                     /gene="Bub1"
                     /note="BUB1 mitotic checkpoint serine/threonine kinase"
                     /db_xref="GeneID:296137"
                     /db_xref="RGD:1311707"
     exon            1..325
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..3479
                     /gene="Bub1"
                     /EC_number="2.7.11.1"
                     /note="budding uninhibited by benzimidazoles 1 homolog"
                     /codon_start=1
                     /product="mitotic checkpoint serine/threonine-protein
                     kinase BUB1"
                     /protein_id="NP_001099977.1"
                     /db_xref="GeneID:296137"
                     /db_xref="RGD:1311707"
                     /translation="MDNLGNVFRMFEAHMQSYKGNDPLGEWESFMKWVEENFPDNKEH
                     LVTILEHLMKEFLDKKNYHNDSRFISYCLKFAEYNSDRHQFFEFLYSQGVGTKSSYLY
                     LSWAGHLEAQGEQQHASAIFQTGIHNQAEPMELLQQQYRLFQARLTGTHLPDQATTSE
                     PLHSAQILNQVMLTKSSPETENSACVPRSQGSECSGVAPSTCDEKSNIREQRVIMISK
                     SECSVSSSMAPKPEAQQVMYCKEKLIRGDSEFSFEELRAQKYNQRKKHEQWVSEDRNY
                     MKRKEANAFEEQLLKQKMDELHKKLHQVVELSHKDLPASENRPDANLVCVGQNTCSHQ
                     ELRGLSLSSINQQTSENSGEKPLEEPSVPLMVNAVNSTLLFPAISLPSLPIPVSGQSE
                     TDSRGVNQSIREFMTQSGPDKKEVCETNKVANINDFHTTPNTSLGMVQGTPCKVQPSP
                     TVHTKEALGFIMDMFQAPTLPDISDDKDEWPSLDQNEDAFEAQFQKNAVFSEDWGVKK
                     IMTLSSAFPIFEDGNKENYGLPQPKNKPLGARTFGERSLSKCSSRSNEMPHTDEFMDD
                     STVCGIRYNKTLAPSPKSIGDFTSAAQLSSTPFHKFPADPLQIPEDKENVVATQYTHM
                     ALDSCKENMVDPSKDRKLGLIQEKISASLSCPSQPATGGLLTQEAVFSLETYKCTGTD
                     RAIMEDLSDASAGLQVEWVQTSSFGNVNAPNFTIENPWDDELILKLLSGLSKPVTSYS
                     NTFEWQSKLPAIKTKTEFQLGSLLVYVNHLLGEGAFAQVFEAIHGDTKSKQKCILKVQ
                     KPANSWEFYIGMQLMERLKPEVHHMFIKFYSAHLFQNGSILVGELYSYGTLLNVINLY
                     KNTSEKVMPQALVITFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQDDEDLAT
                     GLTLIDLGQSIDMKLFPKGTVFTGKCETSGFQCPEMLSNKPWNYQVDYYGVAASIYCM
                     LFGTYMKVKNEGGVWKPEGLFRRLPHLDMWEEFFHIMLNIPDCHNLPSLDFLRQKMNK
                     LLEQQYSNKIKTLRNRLIVLLSEYKRSRK"
     exon            326..385
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..524
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..721
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..765
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            766..869
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..922
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1107
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1259
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1486
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1545
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1674
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1785
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1882
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1964
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2139
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2227
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2436
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2580
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2687
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2849
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            2850..3007
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3176
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3283
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..4583
                     /gene="Bub1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacctcag ccagcaccta gcctaggatt cactaaaggc ctaagggcaa gtgaaagaac
       61 ggctgaggag ggcgaggggg tgggggcggg actttgtctc ccagcaacgg gcgcagcgat
      121 tggccaactt tcccgcagcg gaaaccaata gtcaggcgcg ctgccaacgc tcgacattac
      181 aagtgcggct gcgcggggaa ttcgaatcgc tggccgcctt cgaggctcgg ggtgggggct
      241 gatggggtgt ttagtcggcg gctgatgggg tatttcaccg ctgcgcgctt tttctcgtca
      301 tggacaacct cggaaatgtc tttcgtatgt ttgaagccca tatgcaaagc tacaagggta
      361 atgacccact tggagaatgg gaaagcttta tgaagtgggt agaagaaaat tttcctgaca
      421 ataaagaaca cttggtgaca atattagaac atttaatgaa ggaattctta gataagaaga
      481 actaccacaa tgattcaaga ttcatcagtt attgcttaaa atttgctgag tacaacagtg
      541 accgtcatca gttttttgag tttctgtaca gccagggagt tggaaccaag tcatcatatc
      601 tatacctgtc ctgggcaggg catctggaag cccagggaga gcagcagcat gccagtgcta
      661 tttttcaaac aggaattcac aatcaggctg aacctatgga actactacaa caacaataca
      721 ggctattcca ggcacgcctt actggaacac atttgccaga tcaagctaca acctcagaac
      781 ctttgcatag tgcacagatt ttaaaccaag ttatgttaac aaagtcaagt ccagaaacag
      841 aaaactcagc ttgcgttcct aggagtcagg gttcagaatg ttctggtgtg gcaccttcta
      901 cttgtgacga aaagtctaat attagggaac aaagagtgat catgatttcc aagtcagaat
      961 gctctgtcag ctcatctatg gcacccaagc ctgaagctca gcaagttatg tactgcaaag
     1021 aaaagcttat ccgtggagat tcggaatttt catttgaaga gctgagagcc cagaaataca
     1081 atcaacgaaa gaagcatgaa cagtgggtta gtgaagacag aaattatatg aaaaggaaag
     1141 aagcaaatgc ttttgaagag caattattaa aacagaaaat ggatgaactt cacaagaaat
     1201 tgcatcaagt ggtggaattg tctcacaagg acctgcctgc ttctgagaac aggcctgacg
     1261 ctaatctagt atgtgtggga caaaatacat gctcccacca agaactgagg ggtctaagtc
     1321 tttcatccat caatcagcag acctcagaga actcaggaga gaaaccactg gaagaacctt
     1381 ctgttcctct tatggtaaat gctgttaaca gcactttgct gttcccagcc atcagcctgc
     1441 catctcttcc tattcctgta agtggccagt cagagacaga ttccagaggt gtgaatcaaa
     1501 gtattcgtga attcatgaca cagagtggac cagacaaaaa agaagtatgt gaaacaaata
     1561 aagttgccaa cattaatgac tttcatacaa ctccaaacac atcattggga atggttcaag
     1621 gaacaccatg caaagtgcag ccatcaccaa ctgtccacac caaggaagca ttaggtttca
     1681 tcatggatat gtttcaggct ccaacacttc ctgacatttc tgatgataaa gatgaatggc
     1741 catctctaga ccaaaatgaa gatgcatttg aagcccagtt tcaaaaaaat gcagtatttt
     1801 cagaggactg gggagttaaa aagattatga ctttatcatc tgcttttcct atttttgaag
     1861 acggaaacaa agaaaattat ggcttaccac agcctaaaaa taagccttta ggagctagga
     1921 cctttggaga acgatctctc agcaaatgtt catcaagatc aaatgaaatg cctcacactg
     1981 atgagtttat ggatgactca acagtatgtg gtattcgcta caacaaaacc ctagctccca
     2041 gtcctaaaag tataggagac tttacatctg ctgcccagct ttcatctaca ccattccaca
     2101 aatttccagc agatccattg cagattccag aagataaaga aaatgtggta gccacacaat
     2161 atacacatat ggctttggat tcttgtaaag aaaacatggt ggacccctca aaagacagaa
     2221 agcttggtct aattcaagag aaaatttcag catctttatc ctgtcctagt cagcctgcca
     2281 caggtggttt gctcacccag gaagcagtgt tcagccttga gacttataaa tgcacaggca
     2341 ctgaccgtgc gatcatggaa gacctatcag atgccagcgc tgggctccaa gttgaatggg
     2401 tgcagactag ttcatttgga aatgttaatg ctccaaactt tactattgag aacccatggg
     2461 atgatgaatt gattcttaaa cttctatctg ggctttctaa gccagttact tcctattcaa
     2521 atacttttga gtggcagagt aaacttccag ccatcaagac caagacagaa ttccagttgg
     2581 gttctttgct ggtctatgtg aatcaccttc ttggagaagg agcctttgct caagtctttg
     2641 aagctattca tggagatacc aaaagtaaac agaaatgtat tttgaaggtg cagaaacctg
     2701 ccaactcctg ggaattctac attgggatgc agctgatgga aagactaaag ccagaagtac
     2761 atcacatgtt catcaagttt tattctgctc acttattcca gaatggcagc atattagtag
     2821 gggagctcta tagctatggg acattactaa atgtcattaa cctctataaa aatacctctg
     2881 agaaagtgat gccccaagct ctcgtcatta ctttcgctat cagaatgctt tacatggttg
     2941 aacaagtcca cagctgcgaa atcattcatg gagacattaa gccagataac ttcatactag
     3001 gacacagatt tttggaacag gatgatgaag acttagctac cggcttgaca ttgattgacc
     3061 tgggtcagag tatagatatg aaacttttcc ctaaaggaac tgtatttaca ggaaagtgtg
     3121 aaacatctgg ttttcagtgc cctgagatgc tcagtaacaa gccatggaac taccaggttg
     3181 attactatgg agttgctgca tcaatatatt gtatgctctt tggcacttac atgaaagtaa
     3241 aaaatgaagg aggagtctgg aaacctgaag gtctttttag aaggcttcct catttggata
     3301 tgtgggagga attctttcac atcatgttga atataccgga ttgtcataat cttccatctt
     3361 tggactttct gagacaaaag atgaacaagt tacttgaaca acaatattcc aacaaaatta
     3421 agaccttgcg caataggcta attgtgcttc tttcagaata taagcgttca agaaaataaa
     3481 atatgaatat ggaccttctc caaaacatac tttgtaaatt taaactctca ctttggatcc
     3541 tattttttca tacttattat ttatgtatgt taaaaaaata aagctacata tgatacaccc
     3601 atgtgaccta gttgttataa atattctaac aaagaaagga gacccatgta agctagctga
     3661 tctgttggct tgcttttggt gtacaagtct tcatgagaat gattcaaatt taaatgcttt
     3721 ctagaagtca ttcccctgcc cccaacccta agacagggtt tctcagtgta gccagagctc
     3781 tggctattct ggatgtgatt tgtaaaccat cctggcctca agctcataga aaactgcctg
     3841 cctttgcctc ccaagtgctg ggattacagg ggtgcaccaa cattccctgc tttaaaaacc
     3901 taccttttta aacactgacc tatttaagtc aaaagtaaac caaaaagaat taaaaaatgt
     3961 ttaattagca tatgtaggat taagtttcct tttggcattt taagaaaaaa aattgtgttt
     4021 gttgattttt cttccccgtc cttctggccc ctttgttctc tttcacaccc catagctttc
     4081 atgtctcatc tgtcccttcc tcctttctca acatcttttt cccttaaggt ctttttaatt
     4141 cataacccac acttattttc catcccattt atatgatata aacattattt tagggtctgc
     4201 atatgagaga aactttttgt ctttctgact gagttcctta tactttctaa ctccatctat
     4261 tttcatacaa atttcatggt gtacatctga gcagaattgt gttataaatg atacatacac
     4321 attacacatc catcagttgg ttgataaaca tctgagctga ttctgtttcc ttgctgttgt
     4381 gaatagagga acagttgaca tggatgtgca tgttgctctt gtagaagatt gaatcctttg
     4441 tgtgctcagg agtggggagc taggtcataa acagttctgg ttttctttct gtttgttttt
     4501 taagagacca ccatactgat tccacaatgg ccatactagg ttgcatttca accaataatg
     4561 aatacaaatt tcctctttac tca
//
