LOCUS       NM_001007148            2334 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus beta-transducin repeat containing E3 ubiquitin
            protein ligase (Btrc), mRNA.
ACCESSION   NM_001007148 XM_342056
VERSION     NM_001007148.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S,
            Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y and
            Fan Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Cuadrado A.
  TITLE     Structural and functional characterization of Nrf2 degradation by
            glycogen synthase kinase 3/beta-TrCP
  JOURNAL   Free Radic Biol Med 88 (Pt B), 147-157 (2015)
   PUBMED   25937177
  REMARK    Review article
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Hayes JD and Dinkova-Kostova AT.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   4  (bases 1 to 2334)
  AUTHORS   Wiseman SL, Shimizu Y, Palfrey C and Nairn AC.
  TITLE     Proteasomal degradation of eukaryotic elongation factor-2 kinase
            (EF2K) is regulated by cAMP-PKA signaling and the SCFbetaTRCP
            ubiquitin E3 ligase
  JOURNAL   J Biol Chem 288 (24), 17803-17811 (2013)
   PUBMED   23640883
  REMARK    GeneRIF: Expression of betaTRCP1 increases the polyubiquitylation
            of EEF2K in PC12 cells.
REFERENCE   5  (bases 1 to 2334)
  AUTHORS   Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M and
            Kobayashi A.
  TITLE     Dual regulation of the transcriptional activity of Nrf1 by
            beta-TrCP- and Hrd1-dependent degradation mechanisms
  JOURNAL   Mol Cell Biol 31 (22), 4500-4512 (2011)
   PUBMED   21911472
REFERENCE   6  (bases 1 to 2334)
  AUTHORS   Nakayama K, Hatakeyama S, Maruyama S, Kikuchi A, Onoe K, Good RA
            and Nakayama KI.
  TITLE     Impaired degradation of inhibitory subunit of NF-kappa B (I kappa
            B) and beta-catenin as a result of targeted disruption of the
            beta-TrCP1 gene
  JOURNAL   Proc Natl Acad Sci U S A 100 (15), 8752-8757 (2003)
   PUBMED   12843402
REFERENCE   7  (bases 1 to 2334)
  AUTHORS   Wu G, Xu G, Schulman BA, Jeffrey PD, Harper JW and Pavletich NP.
  TITLE     Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction
            motif binding and lysine specificity of the SCF(beta-TrCP1)
            ubiquitin ligase
  JOURNAL   Mol Cell 11 (6), 1445-1456 (2003)
   PUBMED   12820959
REFERENCE   8  (bases 1 to 2334)
  AUTHORS   Guardavaccaro D, Kudo Y, Boulaire J, Barchi M, Busino L, Donzelli
            M, Margottin-Goguet F, Jackson PK, Yamasaki L and Pagano M.
  TITLE     Control of meiotic and mitotic progression by the F box protein
            beta-Trcp1 in vivo
  JOURNAL   Dev Cell 4 (6), 799-812 (2003)
   PUBMED   12791266
REFERENCE   9  (bases 1 to 2334)
  AUTHORS   Heissmeyer V, Krappmann D, Hatada EN and Scheidereit C.
  TITLE     Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated
            ubiquitination and degradation for the NF-kappaB precursor p105 and
            IkappaBalpha
  JOURNAL   Mol Cell Biol 21 (4), 1024-1035 (2001)
   PUBMED   11158290
REFERENCE   10 (bases 1 to 2334)
  AUTHORS   Kitagawa M, Hatakeyama S, Shirane M, Matsumoto M, Ishida N, Hattori
            K, Nakamichi I, Kikuchi A, Nakayama K and Nakayama K.
  TITLE     An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of
            beta-catenin
  JOURNAL   EMBO J 18 (9), 2401-2410 (1999)
   PUBMED   10228155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB584165.1, EV771066.1 and BC085125.1.
            
            On Nov 27, 2007 this sequence version replaced NM_001007148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CB584165.1         14-103
            91-774              EV771066.1         31-714
            775-2334            BC085125.1         596-2155
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2334
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /note="beta-transducin repeat containing E3 ubiquitin
                     protein ligase"
                     /db_xref="GeneID:361765"
                     /db_xref="RGD:1359721"
     exon            1..141
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1953
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /note="beta-transducin repeat containing protein"
                     /codon_start=1
                     /product="F-box/WD repeat-containing protein 1A"
                     /protein_id="NP_001007149.2"
                     /db_xref="GeneID:361765"
                     /db_xref="RGD:1359721"
                     /translation="MDPAEAVLQEKALKFMAAVPAGGYWRNNKKCSMPRSLWLGCSSL
                     ADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCI
                     NQETVCLTSTAMKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSE
                     SDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDARS
                     LCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPPDENA
                     PPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGL
                     RDNTIKIWDKSTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNT
                     LIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDD
                     KYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIE
                     CGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLMAALDPRAPAGTLCLRTLV
                     EHSGRVFRLQFDEFQIVSSSHDDTILIWDFLNDPATHAEPPRSPSRTYTYISR"
     exon            142..183
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..291
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..369
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..459
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..691
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..878
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..975
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1113
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1232
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1482
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1601
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1712
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1791
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1984
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2313
                     /gene="Btrc"
                     /gene_synonym="beta-TrCP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagaggagg cgggatccgg gcgctgcgtt ggctgcggcc tgccacgaaa ggggcggccc
       61 cggcggagag cagacccagt agcccgggcg attatggacc cggcagaggc ggtgctgcag
      121 gagaaagcgc tcaagtttat ggctgcagtt ccggctggtg gatattggag gaataataaa
      181 aagtgctcta tgcccaggtc tctgtggctg ggctgctcca gcctggcgga cagcatgccc
      241 tcgctgcgat gcctgtataa cccagggact ggcgcactca cagctttcca gaattcctca
      301 gagagagaag actgtaataa tggcgaaccc cctaggaaga taataccaga gaagaattca
      361 cttagacaga cttacaacag ctgtgccagg ctctgcataa accaagagac agtatgtcta
      421 acaagcactg ctatgaagac tgaaaattgt gtggccaaaa caaaacttgc caatggcacc
      481 tccagcatga ttgtgcccaa gcagcggaaa ctctcagcaa gctatgagaa ggaaaaggag
      541 ctgtgtgtca agtactttga gcagtggtca gagtctgatc aagtggaatt tgtagaacac
      601 cttatatctc aaatgtgtca ttaccagcat gggcacatca actcctatct aaagcctatg
      661 ctgcagaggg atttcataac tgcactgcca gcacggggtc tggaccatat tgctgagaac
      721 attctgtcat acttggacgc cagatcactg tgtgctgctg agcttgtgtg caaggaatgg
      781 taccgcgtga cgtcggacgg catgctgtgg aagaagctca tcgagaggat ggtcaggaca
      841 gactctctgt ggcgaggcct ggcagagcgc agagggtggg gacaatactt attcaaaaac
      901 aaacctcctg atgagaatgc gcctcccaac tccttttata gagcgcttta tcctaaaatt
      961 atacaagaca ttgagacaat agagtccaat tggagatgtg ggcgacacag tttacagaga
     1021 atccactgcc ggagtgaaac aagtaaaggg gtctactgtt tacagtatga tgaccagaag
     1081 atagtcagtg gccttcgaga caacaccatc aagatctggg ataaaagcac actggaatgc
     1141 aagcggattc tcacaggcca cacaggctct gtcctgtgtc tgcagtatga cgagagggtg
     1201 atcatcacgg gctcctcaga ctccaccgtc agagtgtggg acgtaaatgc aggggagatg
     1261 ctaaacacat tgattcacca ctgtgaagcc gtcctgcacc tgcgcttcaa taacggcatg
     1321 atggtgacct gctccaaaga ccgatccatt gctgtgtggg atatggcttc cccaactgac
     1381 atcaccctca ggagggtgct ggtgggccac cgagctgcgg tcaatgttgt cgactttgat
     1441 gacaagtaca tcgtttctgc ctctggagac agaaccataa aggtgtggaa cacaagtacc
     1501 tgtgaatttg taaggaccct aaatgggcac aagcgtggta tcgcctgttt gcagtacaga
     1561 gacaggctgg tggtgagcgg ctcctctgac aacaccatca ggctgtggga catagagtgc
     1621 ggtgcatgtc tgcgagtgtt ggaaggccat gaggaattgg tacgctgtat tcgatttgat
     1681 aacaaaagga tagtgagtgg ggcctatgat ggaaaaatta aagtgtggga tcttatggct
     1741 gctctggacc cgcgtgctcc tgcagggact ctttgtctac ggacgcttgt ggagcattct
     1801 ggaagagttt tccgactcca gtttgatgaa ttccagattg tcagtagttc acatgatgac
     1861 acaattctca tctgggactt cctaaatgat ccagccactc atgctgaacc gccccgctcc
     1921 ccttctcgga catacaccta catctccaga taaataacgc gacactggcc tcataattgc
     1981 ccaggactcg ttaacgttgc agtatttaac atgcctgcca agaccaggat gaacaacaac
     2041 aatcaaactc ccacccggat tcctggacgg accagcgagg agcaggcctt tgagactcct
     2101 gttgggacac agccggtcag cagccgacca ggacggtctg ctcggcacac cggctgcttc
     2161 agtgctgcta tcagaagatg tctttatctt gtgtgaatga ttggaacttt caagcctccc
     2221 tcccctctcc ttcccccttc ctctgcacct gtttctctcc cattgggttc cagacaaaga
     2281 tgacttataa atatatttag tgttttgcca gaaaaaaaaa aaaaaaaaaa aaaa
//
