LOCUS       NM_053815               2528 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus butyrophilin-like 2 (Btnl2), mRNA.
ACCESSION   NM_053815 XM_001077327 XM_228004
VERSION     NM_053815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2528)
  AUTHORS   Brown,R.S., Lombardi,A., Hasham,A., Greenberg,D.A., Gordon,J.,
            Concepcion,E., Hammerstad,S.S., Lotay,V., Zhang,W. and Tomer,Y.
  TITLE     Genetic analysis in young-age-of-onset Graves' disease reveals new
            susceptibility loci
  JOURNAL   J Clin Endocrinol Metab 99 (7), E1387-E1391 (2014)
   PUBMED   24684463
REFERENCE   2  (bases 1 to 2528)
  AUTHORS   Mitsunaga,S., Hosomichi,K., Okudaira,Y., Nakaoka,H., Kunii,N.,
            Suzuki,Y., Kuwana,M., Sato,S., Kaneko,Y., Homma,Y., Kashiwase,K.,
            Azuma,F., Kulski,J.K., Inoue,I. and Inoko,H.
  TITLE     Exome sequencing identifies novel rheumatoid arthritis-susceptible
            variants in the BTNL2
  JOURNAL   J Hum Genet 58 (4), 210-215 (2013)
   PUBMED   23364395
REFERENCE   3  (bases 1 to 2528)
  AUTHORS   Suzuki,H., Ota,M., Meguro,A., Katsuyama,Y., Kawagoe,T.,
            Ishihara,M., Asukata,Y., Takeuchi,M., Ito,N., Shibuya,E.,
            Nomura,E., Uemoto,R., Nishide,T., Namba,K., Kitaichi,N.,
            Morimoto,S., Kaburaki,T., Ando,Y., Takenaka,S., Nakamura,J.,
            Saeki,K., Ohno,S., Inoko,H. and Mizuki,N.
  TITLE     Genetic characterization and susceptibility for sarcoidosis in
            Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA
            class II alleles
  JOURNAL   Invest Ophthalmol Vis Sci 53 (11), 7109-7115 (2012)
   PUBMED   22991420
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2528)
  AUTHORS   Hsueh,K.C., Lin,Y.J., Chang,J.S., Wan,L. and Tsai,F.J.
  TITLE     BTNL2 gene polymorphisms may be associated with susceptibility to
            Kawasaki disease and formation of coronary artery lesions in
            Taiwanese children
  JOURNAL   Eur J Pediatr 169 (6), 713-719 (2010)
   PUBMED   19882345
REFERENCE   5  (bases 1 to 2528)
  AUTHORS   Lian,Y., Yue,J., Han,M., Liu,J. and Liu,L.
  TITLE     Analysis of the association between BTNL2 polymorphism and
            tuberculosis in Chinese Han population
  JOURNAL   Infect Genet Evol 10 (4), 517-521 (2010)
   PUBMED   20176143
REFERENCE   6  (bases 1 to 2528)
  AUTHORS   Sato,H., Spagnolo,P., Silveira,L., Welsh,K.I., du Bois,R.M.,
            Newman,L.S. and Maier,L.A.
  TITLE     BTNL2 allele associations with chronic beryllium disease in
            HLA-DPB1*Glu69-negative individuals
  JOURNAL   Tissue Antigens 70 (6), 480-486 (2007)
   PUBMED   17927685
REFERENCE   7  (bases 1 to 2528)
  AUTHORS   Moller,M., Kwiatkowski,R., Nebel,A., van Helden,P.D., Hoal,E.G. and
            Schreiber,S.
  TITLE     Allelic variation in BTNL2 and susceptibility to tuberculosis in a
            South African population
  JOURNAL   Microbes Infect 9 (4), 522-528 (2007)
   PUBMED   17347014
REFERENCE   8  (bases 1 to 2528)
  AUTHORS   Nguyen,T., Liu,X.K., Zhang,Y. and Dong,C.
  TITLE     BTNL2, a butyrophilin-like molecule that functions to inhibit T
            cell activation
  JOURNAL   J Immunol 176 (12), 7354-7360 (2006)
   PUBMED   16751379
REFERENCE   9  (bases 1 to 2528)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   10 (bases 1 to 2528)
  AUTHORS   Wallis,A.E. and McMaster,W.R.
  TITLE     Sequence of a cDNA coding for a rat class II A alpha chain:
            extensive DNA and protein sequence identity to H-2 A alpha and
            HLA-DC1 alpha chains
  JOURNAL   Immunogenetics 19 (1), 53-62 (1984)
   PUBMED   6319276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 9, 2022 this sequence version replaced NM_053815.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.42763.1,
                                           SRR26643288.62807.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000020.1  4505687-4505932     c
            247-330             JAXUCZ010000020.1  4504410-4504493     c
            331-678             JAXUCZ010000020.1  4502468-4502815     c
            679-960             JAXUCZ010000020.1  4499807-4500088     c
            961-981             JAXUCZ010000020.1  4498331-4498351     c
            982-1329            JAXUCZ010000020.1  4497489-4497836     c
            1330-1608           JAXUCZ010000020.1  4495627-4495905     c
            1609-1704           JAXUCZ010000020.1  4494674-4494769     c
            1705-2528           JAXUCZ010000020.1  4492100-4492923     c
FEATURES             Location/Qualifiers
     source          1..2528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2528
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /note="butyrophilin-like 2"
                     /db_xref="GeneID:309620"
                     /db_xref="RGD:620731"
     exon            1..246
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            247..330
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1793
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /note="butyrophilin-like 2 (MHC class II associated)"
                     /codon_start=1
                     /product="butyrophilin-like protein 2"
                     /protein_id="NP_446267.1"
                     /db_xref="GeneID:309620"
                     /db_xref="RGD:620731"
                     /translation="MVDFPGYSLSGVAASFLFVLLTMKHPDDFRVVGPALPILANVGE
                     DALLTCRLLPKRTTARMEVRWYRSDPDTPVMLYRDGAEVPGLAMEGYRGRVEWMEDST
                     EEGSVALKIRQVQPGDDGQYWCRIQEGDYWREASVLLQVAALGSSPNIHVEGPGEEGV
                     QLVCTSRGWFPEPEVYWEGIRGEKLMSLSENHVYGEDGLFSVEDTLVVRNDSVETISC
                     FIYNRGLREPQEATIALPEKLQTELASSRVIGPSQAIPVRVGETIELTCQLSPQTDAQ
                     SLEVRWLRARYYPVVHVYTNGAHEAGEQMAEYRGRTSLVTDAIHEGKLTLQIHNARTS
                     DEGQYRCLFGKDGVYQEARVDVQVMAVGSTPQITREVLKDGGTQLRCTSDGWFPRPHV
                     QWRDRDGRTLPSFSEAFRQGSQELFQVETLLLVTNGSMVNVTCSISLPLGEEKTARFP
                     LSDSRIALLWMTLPVLVLPLAMAVDLIKVKRRTKDQKHNGNRENDRNGESQRRRLSSD
                     DERLR"
     exon            331..678
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            679..960
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            961..981
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1329
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1608
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1704
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..2528
                     /gene="Btnl2"
                     /gene_synonym="BTL-II; Ng9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggaggtg aatgtgctgt tctgactgga gcctcatttt agagtgatcc tcagggactt
       61 gactctgcct ccaagttgac aacattcaaa tcttggttca cccaagccag agacgcttcc
      121 actttccttg gctgctccat ctccagtgct ctcccgtctt tagacacctg ctatgtgatt
      181 gaaggacaca cctgtggctg agtgcgacca agagcctcca tttcacccta ggggagagag
      241 cgacaggcag gatggtggat ttcccaggct acagtctatc tggcgtagct gcctccttcc
      301 tcttcgttct gctgactatg aagcacccag atgacttcag agtggtcggt cctgccctcc
      361 ctatcctggc caatgttgga gaagacgcac tgctaacgtg tcggcttctc cccaagagga
      421 caacagcacg catggaggtg aggtggtacc gctccgaccc tgacacgcct gtgatgctgt
      481 accgggatgg agctgaggtg cctgggctag cgatggaggg ctacagaggc cgggtagagt
      541 ggatggagga cagcactgaa gaggggagtg tggctctgaa gattcgacag gtgcagccag
      601 gtgacgatgg ccagtactgg tgccgcatcc aggagggaga ctactggaga gaggcaagtg
      661 tgctactcca agtggcagct ctaggatcct ccccaaacat ccatgtggag gggcccggag
      721 aagaaggggt ccagctcgtg tgcacgtccc gaggctggtt ccctgagccg gaggtctatt
      781 gggagggcat caggggagag aagttgatga gtctctctga gaaccatgtg tacggtgaag
      841 atgggctgtt ctctgtggaa gacacactgg tggtcaggaa cgacagtgta gagacgattt
      901 cctgcttcat ctacaatcgt ggcctcagag agccccaaga ggccaccatt gcccttccag
      961 agaaactcca gacagaactg gcttcctcga gggtaatcgg accttcccaa gccatccctg
     1021 tccgagtcgg agagaccata gaattaactt gtcagctctc acctcaaacg gacgctcaga
     1081 gcttggaggt gaggtggctc cgagcccgct attaccctgt agtccacgtg tatacaaatg
     1141 gggcccatga ggccggagag cagatggcag aatacagagg gaggacttca ctggtgactg
     1201 acgccatcca cgaaggaaaa ctgaccctgc agatccacaa cgccagaact tcggatgagg
     1261 ggcagtaccg gtgccttttt ggaaaagatg gtgtctacca ggaggcccgt gtagatgtgc
     1321 aggtgatggc ggtgggttcc accccacaga tcaccaggga ggtcttgaaa gatggaggaa
     1381 cacagctgag gtgtacgtcc gatgggtggt tcccacgacc ccacgtgcag tggagggaca
     1441 gagacggaag gaccctgcca tcgttttctg aggcctttcg gcaaggaagc caggagctgt
     1501 tccaggtgga gactctcctg ctggtcacaa atggctccat ggtgaatgtg acctgctcca
     1561 tcagcctccc tctgggcgag gagaaaactg cacgttttcc tctctcagac tccaggatag
     1621 ctttgttatg gatgaccctg cctgtcctgg tgctgcctct cgccatggct gtcgacctga
     1681 tcaaggtgaa acggcggacg aaagaccaaa aacacaacgg caatcgggaa aatgacagga
     1741 atggtgaaag ccaaaggcga aggctttcct ctgatgatga gaggctcaga taaaaatgta
     1801 ccccgaaagc ccagcgcaca ccatccttcc tctcatcttt cccctcaata agcagctctg
     1861 cgctgacatg gagtggtttc acctgctgct gaccaaaggt ttttcatgga cccggaccca
     1921 ttcctgatgg agctgacacc cacagtcggg gacgcctaga cctgagccaa cccaacatag
     1981 tcttggtccc gccctcacag tgatggaatc ttctctgcct ttgcctcttt ctgctgcccc
     2041 tcaggtgatg gttccttgcc tgtgcatagc agctttctct cttcaccttc tgggctcacc
     2101 atgaggatgg aagaatctag acctggggag aaatgtcgct catctgagac ccggatgggt
     2161 ttttctagaa actcccactc cagtagcacc agagggacaa agcaggtggg aggagagagt
     2221 gttttgcctc tttcctcaag agaaaggact gtgagtcacg gttatggaag acccaacact
     2281 tgcactacaa atcaggccag gggtcataga aataactaag gggttaaaag cactgcctgc
     2341 tcttgcagag gaccccagtt ccattcccag cacccacatg gtaggtcacg accatctata
     2401 actccagttc taggggatcg gacacccatt ttgaccgtct aagggcacag gcacacgcct
     2461 ggtacacaga cgtacatgta ggccaaacat ccatacatat aagatataaa tgattttaaa
     2521 aaagaatt
//
