LOCUS       NM_213630               3354 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus B and T lymphocyte associated (Btla), mRNA.
ACCESSION   NM_213630
VERSION     NM_213630.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3354)
  AUTHORS   Zhang,H., Wang,Z., Zhang,J., Gui,Z., Han,Z., Tao,J., Chen,H.,
            Sun,L., Fei,S., Yang,H., Tan,R., Chandraker,A. and Gu,M.
  TITLE     Combined Immunotherapy With Belatacept and BTLA Overexpression
            Attenuates Acute Rejection Following Kidney Transplantation
  JOURNAL   Front Immunol 12, 618737 (2021)
   PUBMED   33732243
  REMARK    GeneRIF: Combined Immunotherapy With Belatacept and BTLA
            Overexpression Attenuates Acute Rejection Following Kidney
            Transplantation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3354)
  AUTHORS   Sedy,J.R., Gavrieli,M., Potter,K.G., Hurchla,M.A., Lindsley,R.C.,
            Hildner,K., Scheu,S., Pfeffer,K., Ware,C.F., Murphy,T.L. and
            Murphy,K.M.
  TITLE     B and T lymphocyte attenuator regulates T cell activation through
            interaction with herpesvirus entry mediator
  JOURNAL   Nat Immunol 6 (1), 90-98 (2005)
   PUBMED   15568026
REFERENCE   3  (bases 1 to 3354)
  AUTHORS   Zang,X., Loke,P., Kim,J., Murphy,K., Waitz,R. and Allison,J.P.
  TITLE     B7x: a widely expressed B7 family member that inhibits T cell
            activation
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10388-10392 (2003)
   PUBMED   12920180
REFERENCE   4  (bases 1 to 3354)
  AUTHORS   Watanabe,N., Gavrieli,M., Sedy,J.R., Yang,J., Fallarino,F.,
            Loftin,S.K., Hurchla,M.A., Zimmerman,N., Sim,J., Zang,X.,
            Murphy,T.L., Russell,J.H., Allison,J.P. and Murphy,K.M.
  TITLE     BTLA is a lymphocyte inhibitory receptor with similarities to
            CTLA-4 and PD-1
  JOURNAL   Nat Immunol 4 (7), 670-679 (2003)
   PUBMED   12796776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Oct 22, 2022 this sequence version replaced NM_213630.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.45716.1,
                                           SRR26643284.14985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               JAXUCZ010000011.1  69092912-69093224   c
            314-634             JAXUCZ010000011.1  69082088-69082408   c
            635-670             JAXUCZ010000011.1  69078607-69078642   c
            671-829             JAXUCZ010000011.1  69077000-69077158   c
            830-882             JAXUCZ010000011.1  69074910-69074962   c
            883-3354            JAXUCZ010000011.1  69069734-69072205   c
FEATURES             Location/Qualifiers
     source          1..3354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..3354
                     /gene="Btla"
                     /note="B and T lymphocyte associated"
                     /db_xref="GeneID:407756"
                     /db_xref="RGD:1303280"
     exon            1..313
                     /gene="Btla"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1131
                     /gene="Btla"
                     /note="B- and T-lymphocyte attenuator; B- and
                     T-lymphocyte-associated protein"
                     /codon_start=1
                     /product="B- and T-lymphocyte attenuator precursor"
                     /protein_id="NP_998795.2"
                     /db_xref="GeneID:407756"
                     /db_xref="RGD:1303280"
                     /translation="MKTLPAMLVTPRSFREFFILLLGLWSILCKEPTKRIGEECRVQL
                     KIKRNSSRSAWTGELFKIECPVTYCVHRPNVTWCKHNGTRCVPLEVGPQLHTSWVEND
                     QASAFVLYFEPIHLSDDGVYTCSANLNSEVINSHSVVIHVTERTQNCSEHPLITASDI
                     PNATNASGPSTMEERPGRTWLLYALLPLGTSLLLLACVCLLCFLRRIQGKEKKPSDLA
                     GRERETNLVDIPVSSRTNSQILTSETGIYDNDPWSSRLGESESTISSQLEGNKQGIVY
                     ASLNHCVIGRTPRQASKIQEAPTEYASICVRS"
     exon            314..634
                     /gene="Btla"
                     /inference="alignment:Splign:2.1.0"
     exon            635..670
                     /gene="Btla"
                     /inference="alignment:Splign:2.1.0"
     exon            671..829
                     /gene="Btla"
                     /inference="alignment:Splign:2.1.0"
     exon            830..882
                     /gene="Btla"
                     /inference="alignment:Splign:2.1.0"
     exon            883..3354
                     /gene="Btla"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggcctctc gctttcacaa atccttcagg ctgctcatac tgtcctctcc caccaggtct
       61 cctgatttta ttttatttta attaattaat ttttccccta agattctgct agggtgaata
      121 atatgaccca gctctgaaga tctccaggga ggaagaggaa gccttctact tgaagagttt
      181 cctcttacct gacattggct gggaatgaaa acactgcctg ccatgcttgt cactccccgg
      241 tcctttaggg aattcttcat ccttcttctg ggcctctgga gcatcctttg taaggaacct
      301 actaagagga tcggtgaaga atgcagagtg caacttaaaa ttaagaggaa ttctagccgc
      361 tctgcctgga caggagagtt atttaaaatt gaatgtcctg tgacatactg tgttcacaga
      421 cctaatgtga cttggtgtaa gcacaatgga acaagatgtg taccccttga ggttggaccc
      481 cagctgcaca ctagttgggt tgaaaatgac caggcttcag cttttgttct ctattttgaa
      541 ccaatacatc tcagtgatga cggggtatat acctgttctg cgaacttgaa ttctgaggtt
      601 attaatagcc actcagtagt catccatgtg acagaaagga ctcaaaactg ttcagaacac
      661 cctctaataa cagcatctga catcccaaat gctaccaatg cctcaggacc atctaccatg
      721 gaagagaggc caggcaggac ctggctgctt tacgccttgc ttcccttggg gacatcgctt
      781 ctgctccttg cctgtgtctg cctgctctgc tttctgagaa ggatccaagg gaaagaaaag
      841 aagccttctg acttagcagg aagagaaagg gaaactaact tggttgatat tccagtgagt
      901 tccaggacaa actcccaaat actgacatca gaaactggaa tttatgacaa tgacccctgg
      961 tccagtaggc tgggagaatc tgaatcaacc attagctcac aattggaggg aaacaaacag
     1021 ggcattgttt atgcctctct gaaccattgt gttattggaa ggaccccaag acaggcaagc
     1081 aagattcagg aggcacccac agaatatgca tccatttgtg tgagaagtta aaccggccgc
     1141 tgacccagtc ggtgggcact gcacgagtgc atgtcaatac ctcagtctgt caaataacct
     1201 tcaacctggg aattttcaat taagatgcct tgtgctggtg ctgtgtctta aaggtccatg
     1261 aaatatttag ttaaaatttc tctgaaaacc tgaagagttt tgtacaagag ccttgaacaa
     1321 cagactcttc tttgggaaaa ctcatattac aaatagctaa ataataggat agttaaaatt
     1381 gatcatgtct tacccaatgt gtgaattcaa tattttcttt ggaactacca cggagactta
     1441 cagggaagaa agaagagtgt tatttggatc tgttcactac acagtctaga aaaagaatgg
     1501 tccaatttga ctaatcataa atacagaaat gattgtatgt tctcagtctg tcataaggag
     1561 acaatttccc atgcccatct atagatagtg ttttataatt ttttaatgga aaagaaagtt
     1621 atcttggact caattcagta aaagattaga aagggtaatt agtacaatgc agatatagaa
     1681 tatgtcaaat agatgtgggg tcaagcttta ttatccccac cgatgagatg ttcatcttca
     1741 cccggcttga ttgagaaagt aaggtagtaa agggttcatc agtatatatg agtgcatttg
     1801 taatcaagga atgtacatga atgtgattca atgctgctga actaatacag atgggtctat
     1861 gaacaagagt ctatgagcat agatattatc aattgagact gaacttttaa cccacttttt
     1921 gttttacctg agaacacact caaaggacaa tttatgaaag gaacatctgg aatattgagt
     1981 tgatcagtag gggttggcat acaatcatga acgtctgttt cttgattctt atgaagtgag
     2041 tcaggatgaa gcatttgtaa tgaggtacgg catatggaga tcattcaggt ttaaattctg
     2101 acattgcagc tgctcaggaa gatgattaaa attttcaggt gttctgaatt ttcagattga
     2161 gtctaattac ttaaaaatag ctcagacttt tattcatcag cttgaggctt gagttctcag
     2221 accccgaaat atgtcgtagt cttagtatac agccgattgt ggcatgagtt tgaagccact
     2281 ggatcaaaca cgtgaactat tgaatgagtg aatgtggtct atgtaattgc atgcatatat
     2341 gcgggtgtgc ctgtgtgtgt gtgtgctagc atgcaaatgc aagatgtgac ttccggaaat
     2401 gagacaagag aaacgagttg tattgccatt ctatttttag tctgcttaga aggtgcaaag
     2461 cactgaggga aattagtcat ttgtagaaaa tacatgtgga atggtgagaa tgggagggag
     2521 gtgagaatgg gagggagttg agaatgtgtc cataaaaagg gaataaagag gcctaactac
     2581 acagcttttt ttttcacctc ctgctcacct caggtttcag ttctctaaat ttgagacaac
     2641 ggtgttttca gacactgttg taaccaattc tagtgaaggt tgttcaggca ggtgcacttg
     2701 tgggaattta tgcaaaaagg acctcagaat agctgctcat cctcaaaata gaaacaggaa
     2761 gtgtgggagg gagatgagta ctgcactctg ttgacaggca acttatacaa ttctttcagg
     2821 attttctctg attttaaaaa caaaatactt ctacctagct taaaacaatc ttttaaaaac
     2881 tttgtgtgtg catgtatatt tgggtataca tgtatgcatg tgtgtggtgt atgcacatgt
     2941 atgtacagga gccagaagcc aaagtcaggc acccttttct attgctctcc actctattct
     3001 gttaagaaaa ggtctctcat tgaacctgga gctaggctag tgggcagcaa gccagtgatg
     3061 gatcctcctg tccctgtccc ccactccccc actgctaggg atctatttgc tcatgttcaa
     3121 ctttttacaa ggatgtggag aacgcaaact cgggtcctca tgcttgcaca acaagcatgc
     3181 tcgcttgcta agcatgttct taatatgttt tacaatgaaa gacactgctc ggggatttca
     3241 cctccatgaa tgatcagttc tgtttgaacc ttgtttgtca atcacatatc atttatgctc
     3301 ttattcctgc ttagtacata tgtgtatctc ctcaaataaa tacgttccag tatt
//
