LOCUS       XM_039099952            2523 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus Bruton tyrosine kinase (Btk),
            transcript variant X2, mRNA.
ACCESSION   XM_039099952
VERSION     XM_039099952.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051356.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039099952.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2523
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..2523
                     /gene="Btk"
                     /note="Bruton tyrosine kinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 7
                     ESTs, 1 long SRA read, 19 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 68 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:367901"
                     /db_xref="RGD:1359683"
     CDS             166..2151
                     /gene="Btk"
                     /codon_start=1
                     /product="tyrosine-protein kinase BTK isoform X1"
                     /protein_id="XP_038955880.1"
                     /db_xref="GeneID:367901"
                     /db_xref="RGD:1359683"
                     /translation="MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDF
                     ERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPVPRRGEESSEMEQISIIERFPY
                     PFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQT
                     AKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSEL
                     KKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAED
                     SIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIR
                     HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGL
                     GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKV
                     MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVC
                     EAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS
                     PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLA
                     SDRVYTIMYSCWHEKADERPSFKILLSNILDVMDEES"
ORIGIN      
        1 aagggtgggg tttgctcaga ctgtccttcc tctctggact gtaagaatat gtctccaggg
       61 ccagtgtctt cagagatcaa gtcccacctt ccaagtcctg gcatctcact acgtctggga
      121 agctacctgc attaacacac agacaagttc cagagagagg aagccatggc tgctgtgata
      181 ctggagagca tctttctgaa gcgctcccag cagaaaaaga aaacatcacc tttaaatttt
      241 aagaagcgcc tatttctcct gactgtgcac aaactttcat actatgaata tgactttgaa
      301 cgtgggagaa gaggcagtaa gaaaggttca atagatgtcg agaagatcac ctgtgttgaa
      361 acagtagttc ctgaaaaaaa tcccccacca gaaagacaga ttccagttcc gaggaggggt
      421 gaggagtcca gtgaaatgga acagatttca atcattgaaa ggttcccgta cccatttcag
      481 gtcgtatatg atgaaggacc tctctatgtt ttctccccaa ccgaagagct gagaaaacgc
      541 tggattcacc agctcaaaaa tgtaatccgg tacaatagtg acctggtgca gaaatatcat
      601 ccttgcttct ggattgatgg acagtatctc tgctgctctc agacagccaa gaatgctatg
      661 ggctgccaaa ttttggagaa caggaatgga agcttaaaac ctggaagttc tcatcgaaaa
      721 acaaaaaagc ctcttccccc taccccagag gaagatcaga tcttgaaaaa gccactcccc
      781 cctgagccaa cagcagcacc aatctccaca agtgagctga aaaaggtcgt ggccctttat
      841 gattatatgc caatgaatgc aaatgactta caattgcgaa agggcgagga gtattttatc
      901 ctggaggaga gcaacctacc atggtggcga gcacgagata aaaatgggca ggaaggctat
      961 atccccagta actatgtcac cgaagcagag gactccatag agatgtatga gtggtattcc
     1021 aagcacatga ctcgaagtca agctgagcaa cttctaaagc aagaggggaa agaaggaggt
     1081 ttcattgtca gagactccag caaagctgga aaatacactg tgtctgtgtt tgctaaatct
     1141 acaggggagc ctcaaggggt gatacgccat tatgttgtgt gctccacacc tcagagccag
     1201 tattacctgg ctgagaagca ccttttcagc accattcctg agctcatcaa ctaccatcaa
     1261 cataactctg caggcctcat atccaggctg aaatatcctg tatcgaaaca aaacaaaaac
     1321 gcgccttcta cggcaggcct gggctatgga tcatgggaaa ttgatccaaa ggacttgacc
     1381 ttcttgaagg agcttgggac tggacaattt ggtgtcgtca aatatgggaa gtggaggggc
     1441 caatatgatg tggccatcaa gatgatcaga gaaggttcca tgtctgagga tgaattcatt
     1501 gaagaagcca aagtcatgat gaatctttcc catgagaagc tagtgcagtt gtatggagtc
     1561 tgcaccaaac agcgccccat cttcatcatc actgaataca tggctaatgg ctgcctcttg
     1621 aactacctga gggagatgcg gcaccgcttc cagacacagc agctgcttga gatgtgcaaa
     1681 gatgtctgtg aagcaatgga atacttggag tcaaagcagt tccttcatag agacctggca
     1741 gctcgaaact gtctggtaaa tgatcaagga gttgtgaaag tatctgactt tggcctgtct
     1801 aggtatgttc ttgatgatga atacaccagc tcggtaggct ccaaatttcc agtccggtgg
     1861 tctccaccag aagtgctcat gtatagcaaa ttcagcagca aatctgacat ctgggctttt
     1921 ggggttctaa tgtgggaaat ttactccctg gggaaaatac catatgagag atttactaac
     1981 agtgagacag cagaacacat tgctcaaggc ttacgtctct acaggcctca tttggcatca
     2041 gacagggtat ataccatcat gtacagctgc tggcatgaga aagcagatga acgtcctagt
     2101 ttcaaaattc tcttgagtaa cattctagat gtcatggatg aagaatcttg agctggctga
     2161 taagcttcat ggatctactc ctctcttcta caagccccaa ttccattttt tcctgaggaa
     2221 ctccctggtt caagggctct agccttccac gctcctactg tacatctagg aatgcctttc
     2281 ttctctaact ccccagcata gtgcttctga gcaaaggcca aggaatttct gggcctggta
     2341 ttacttcaag actcctaaca gactgaattt gggatgggaa catttcaggg gagggaagat
     2401 gtaaatagcc ccactagttg ttcaacagct tgttggttaa gtgttaagag tttgggggta
     2461 agaatggtgc cattaaaatg ggagggattg ttttgataca ataaaattac tggaaagagt
     2521 gaa
//
