LOCUS       NM_001007798            2514 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus Bruton tyrosine kinase (Btk), mRNA.
ACCESSION   NM_001007798 XM_039099951 XM_346344
VERSION     NM_001007798.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2514)
  AUTHORS   Patel,N.M., Oliveira,F.R.M.B., Ramos,H.P., Aimaretti,E.,
            Alves,G.F., Coldewey,S.M., Collino,M., Sordi,R. and Thiemermann,C.
  TITLE     Inhibition of Bruton's Tyrosine Kinase Activity Attenuates
            Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats
  JOURNAL   Ann Surg 277 (3), e624-e633 (2023)
   PUBMED   35129479
  REMARK    GeneRIF: Inhibition of Bruton's Tyrosine Kinase Activity Attenuates
            Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats.
REFERENCE   2  (bases 1 to 2514)
  AUTHORS   Roschewski,M., Lionakis,M.S., Sharman,J.P., Roswarski,J., Goy,A.,
            Monticelli,M.A., Roshon,M., Wrzesinski,S.H., Desai,J.V.,
            Zarakas,M.A., Collen,J., Rose,K., Hamdy,A., Izumi,R., Wright,G.W.,
            Chung,K.K., Baselga,J., Staudt,L.M. and Wilson,W.H.
  TITLE     Inhibition of Bruton tyrosine kinase in patients with severe
            COVID-19
  JOURNAL   Sci Immunol 5 (48) (2020)
   PUBMED   32503877
REFERENCE   3  (bases 1 to 2514)
  AUTHORS   Angst,D., Gessier,F., Janser,P., Vulpetti,A., Walchli,R.,
            Beerli,C., Littlewood-Evans,A., Dawson,J., Nuesslein-Hildesheim,B.,
            Wieczorek,G., Gutmann,S., Scheufler,C., Hinniger,A., Zimmerlin,A.,
            Funhoff,E.G., Pulz,R. and Cenni,B.
  TITLE     Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective
            Covalent Inhibitor of Bruton's Tyrosine Kinase
  JOURNAL   J Med Chem 63 (10), 5102-5118 (2020)
   PUBMED   32083858
REFERENCE   4  (bases 1 to 2514)
  AUTHORS   Bi,K.W., Wei,X.G., Qin,X.X. and Li,B.
  TITLE     BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma
            and an Indicator for Tumor Microenvironment Remodeling: A Study
            Based on TCGA Data Mining
  JOURNAL   Front Oncol 10, 424 (2020)
   PUBMED   32351880
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2514)
  AUTHORS   Zhang,C. and Tian,B.
  TITLE     Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible
            BTK Inhibitor
  JOURNAL   Int J Toxicol 39 (3), 232-240 (2020)
   PUBMED   32484067
REFERENCE   6  (bases 1 to 2514)
  AUTHORS   Mahajan,S., Fargnoli,J., Burkhardt,A.L., Kut,S.A., Saouaf,S.J. and
            Bolen,J.B.
  TITLE     Src family protein tyrosine kinases induce autoactivation of
            Bruton's tyrosine kinase
  JOURNAL   Mol Cell Biol 15 (10), 5304-5311 (1995)
   PUBMED   7565679
REFERENCE   7  (bases 1 to 2514)
  AUTHORS   Price,D.J., Kawakami,Y., Kawakami,T. and Rivnay,B.
  TITLE     Purification of a major tyrosine kinase from RBL-2H3 cells
            phosphorylating Fc epsilon RI gamma-cytoplasmic domain and
            identification as the Btk tyrosine kinase
  JOURNAL   Biochim Biophys Acta 1265 (2-3), 133-142 (1995)
   PUBMED   7696342
REFERENCE   8  (bases 1 to 2514)
  AUTHORS   Kawakami,Y., Yao,L., Miura,T., Tsukada,S., Witte,O.N. and
            Kawakami,T.
  TITLE     Tyrosine phosphorylation and activation of Bruton tyrosine kinase
            upon Fc epsilon RI cross-linking
  JOURNAL   Mol Cell Biol 14 (8), 5108-5113 (1994)
   PUBMED   7518558
REFERENCE   9  (bases 1 to 2514)
  AUTHORS   de Weers,M., Mensink,R.G., Kraakman,M.E., Schuurman,R.K. and
            Hendriks,R.W.
  TITLE     Mutation analysis of the Bruton's tyrosine kinase gene in X-linked
            agammaglobulinemia: identification of a mutation which affects the
            same codon as is altered in immunodeficient xid mice
  JOURNAL   Hum Mol Genet 3 (1), 161-166 (1994)
   PUBMED   8162018
REFERENCE   10 (bases 1 to 2514)
  AUTHORS   Narendran,A., Ramsden,D., Cumano,A., Tanaka,T., Wu,G.E. and
            Paige,C.J.
  TITLE     B cell developmental defects in X-linked immunodeficiency
  JOURNAL   Int Immunol 5 (2), 139-144 (1993)
   PUBMED   7680896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Jul 21, 2021 this sequence version replaced
            XM_039099951.1, NM_001007798.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215667.1, SRR26643292.65864.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000021.1  102055014-102055143 c
            131-301             JAXUCZ010000021.1  102046490-102046660 c
            302-406             JAXUCZ010000021.1  102045704-102045808 c
            407-475             JAXUCZ010000021.1  102041396-102041464 c
            476-557             JAXUCZ010000021.1  102038221-102038302 c
            558-686             JAXUCZ010000021.1  102031868-102031996 c
            687-754             JAXUCZ010000021.1  102031382-102031449 c
            755-942             JAXUCZ010000021.1  102029305-102029492 c
            943-1005            JAXUCZ010000021.1  102028869-102028931 c
            1006-1060           JAXUCZ010000021.1  102028070-102028124 c
            1061-1140           JAXUCZ010000021.1  102027254-102027333 c
            1141-1268           JAXUCZ010000021.1  102026970-102027097 c
            1269-1343           JAXUCZ010000021.1  102024711-102024785 c
            1344-1515           JAXUCZ010000021.1  102023817-102023988 c
            1516-1732           JAXUCZ010000021.1  102023080-102023296 c
            1733-1797           JAXUCZ010000021.1  102021582-102021646 c
            1798-1916           JAXUCZ010000021.1  102020592-102020710 c
            1917-2074           JAXUCZ010000021.1  102019591-102019748 c
            2075-2514           JAXUCZ010000021.1  102016074-102016513 c
FEATURES             Location/Qualifiers
     source          1..2514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..2514
                     /gene="Btk"
                     /note="Bruton tyrosine kinase"
                     /db_xref="GeneID:367901"
                     /db_xref="RGD:1359683"
     exon            1..130
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            131..301
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2146
                     /gene="Btk"
                     /EC_number="2.7.10.1"
                     /note="Bruton agammaglobulinemia tyrosine kinase"
                     /codon_start=1
                     /product="tyrosine-protein kinase BTK"
                     /protein_id="NP_001007799.2"
                     /db_xref="GeneID:367901"
                     /db_xref="RGD:1359683"
                     /translation="MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDF
                     ERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPVPRRGEESSEMEQISIIERFPY
                     PFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQT
                     AKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSEL
                     KKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAED
                     SIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIR
                     HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGL
                     GYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKV
                     MMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVC
                     EAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS
                     PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLA
                     SDRVYTIMYSCWHEKADERPSFKILLSNILDVMDEES"
     exon            302..406
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            407..475
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            476..557
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            558..686
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            687..754
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            755..942
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1005
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1060
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1140
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1268
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1343
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1515
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1732
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1797
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1916
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2074
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2514
                     /gene="Btk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgtcct tcctctctgg actgtaagaa tatgtctcca gggccagtgt cttcagagat
       61 caagtcccac cttccaagtc ctggcatctc actacgtctg ggaagctacc tgcattaagt
      121 gagaactgag cacacagaca agttccagag agaggaagcc atggctgctg tgatactgga
      181 gagcatcttt ctgaagcgct cccagcagaa aaagaaaaca tcacctttaa attttaagaa
      241 gcgcctattt ctcctgactg tgcacaaact ttcatactat gaatatgact ttgaacgtgg
      301 gagaagaggc agtaagaaag gttcaataga tgtcgagaag atcacctgtg ttgaaacagt
      361 agttcctgaa aaaaatcccc caccagaaag acagattcca gttccgagga ggggtgagga
      421 gtccagtgaa atggaacaga tttcaatcat tgaaaggttc ccgtacccat ttcaggtcgt
      481 atatgatgaa ggacctctct atgttttctc cccaaccgaa gagctgagaa aacgctggat
      541 tcaccagctc aaaaatgtaa tccggtacaa tagtgacctg gtgcagaaat atcatccttg
      601 cttctggatt gatggacagt atctctgctg ctctcagaca gccaagaatg ctatgggctg
      661 ccaaattttg gagaacagga atggaagctt aaaacctgga agttctcatc gaaaaacaaa
      721 aaagcctctt ccccctaccc cagaggaaga tcagatcttg aaaaagccac tcccccctga
      781 gccaacagca gcaccaatct ccacaagtga gctgaaaaag gtcgtggccc tttatgatta
      841 tatgccaatg aatgcaaatg acttacaatt gcgaaagggc gaggagtatt ttatcctgga
      901 ggagagcaac ctaccatggt ggcgagcacg agataaaaat gggcaggaag gctatatccc
      961 cagtaactat gtcaccgaag cagaggactc catagagatg tatgagtggt attccaagca
     1021 catgactcga agtcaagctg agcaacttct aaagcaagag gggaaagaag gaggtttcat
     1081 tgtcagagac tccagcaaag ctggaaaata cactgtgtct gtgtttgcta aatctacagg
     1141 ggagcctcaa ggggtgatac gccattatgt tgtgtgctcc acacctcaga gccagtatta
     1201 cctggctgag aagcaccttt tcagcaccat tcctgagctc atcaactacc atcaacataa
     1261 ctctgcaggc ctcatatcca ggctgaaata tcctgtatcg aaacaaaaca aaaacgcgcc
     1321 ttctacggca ggcctgggct atggatcatg ggaaattgat ccaaaggact tgaccttctt
     1381 gaaggagctt gggactggac aatttggtgt cgtcaaatat gggaagtgga ggggccaata
     1441 tgatgtggcc atcaagatga tcagagaagg ttccatgtct gaggatgaat tcattgaaga
     1501 agccaaagtc atgatgaatc tttcccatga gaagctagtg cagttgtatg gagtctgcac
     1561 caaacagcgc cccatcttca tcatcactga atacatggct aatggctgcc tcttgaacta
     1621 cctgagggag atgcggcacc gcttccagac acagcagctg cttgagatgt gcaaagatgt
     1681 ctgtgaagca atggaatact tggagtcaaa gcagttcctt catagagacc tggcagctcg
     1741 aaactgtctg gtaaatgatc aaggagttgt gaaagtatct gactttggcc tgtctaggta
     1801 tgttcttgat gatgaataca ccagctcggt aggctccaaa tttccagtcc ggtggtctcc
     1861 accagaagtg ctcatgtata gcaaattcag cagcaaatct gacatctggg cttttggggt
     1921 tctaatgtgg gaaatttact ccctggggaa aataccatat gagagattta ctaacagtga
     1981 gacagcagaa cacattgctc aaggcttacg tctctacagg cctcatttgg catcagacag
     2041 ggtatatacc atcatgtaca gctgctggca tgagaaagca gatgaacgtc ctagtttcaa
     2101 aattctcttg agtaacattc tagatgtcat ggatgaagaa tcttgagctg gctgataagc
     2161 ttcatggatc tactcctctc ttctacaagc cccaattcca ttttttcctg aggaactccc
     2221 tggttcaagg gctctagcct tccacgctcc tactgtacat ctaggaatgc ctttcttctc
     2281 taactcccca gcatagtgct tctgagcaaa ggccaaggaa tttctgggcc tggtattact
     2341 tcaagactcc taacagactg aatttgggat gggaacattt caggggaggg aagatgtaaa
     2401 tagccccact agttgttcaa cagcttgttg gttaagtgtt aagagtttgg gggtaagaat
     2461 ggtgccatta aaatgggagg gattgttttg atacaataaa attactggaa agag
//
